DK3242955T3 - Modelering af ribosom-dynamikker til at optimere heterolog proteinproduktion - Google Patents

Modelering af ribosom-dynamikker til at optimere heterolog proteinproduktion Download PDF

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Publication number
DK3242955T3
DK3242955T3 DK16735384.6T DK16735384T DK3242955T3 DK 3242955 T3 DK3242955 T3 DK 3242955T3 DK 16735384 T DK16735384 T DK 16735384T DK 3242955 T3 DK3242955 T3 DK 3242955T3
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Denmark
Prior art keywords
ribosom
heterolog
dynamics
modeling
optimize
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DK16735384.6T
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English (en)
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Scott Khoi Vu
Donald L Bitzer
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Univ North Carolina State
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20Probabilistic models
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Probability & Statistics with Applications (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
DK16735384.6T 2015-01-06 2016-01-06 Modelering af ribosom-dynamikker til at optimere heterolog proteinproduktion DK3242955T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562100417P 2015-01-06 2015-01-06
PCT/US2016/012398 WO2016112142A1 (en) 2015-01-06 2016-01-06 Modeling ribosome dynamics to optimize heterologous protein production

Publications (1)

Publication Number Publication Date
DK3242955T3 true DK3242955T3 (da) 2020-08-03

Family

ID=56356405

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16735384.6T DK3242955T3 (da) 2015-01-06 2016-01-06 Modelering af ribosom-dynamikker til at optimere heterolog proteinproduktion

Country Status (11)

Country Link
US (2) US20170372001A1 (da)
EP (1) EP3242955B1 (da)
JP (1) JP2018509930A (da)
KR (1) KR102473180B1 (da)
CN (1) CN107109496B (da)
AU (1) AU2016205254B2 (da)
CA (1) CA2972473C (da)
DK (1) DK3242955T3 (da)
HK (1) HK1245849A1 (da)
SG (1) SG11201705275VA (da)
WO (1) WO2016112142A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3551758B1 (en) 2016-12-07 2024-05-29 Gottfried Wilhelm Leibniz Universität Hannover Method and computersystem for codon optimisation
CN108363904B (zh) * 2018-02-07 2019-06-28 南京林业大学 一种用于木本植物遗传密码子优化的CodonNX系统及其优化方法
WO2020194311A1 (en) * 2019-03-28 2020-10-01 Ramot At Tel-Aviv University Ltd. Methods for modifying translation
CN109979539B (zh) * 2019-04-10 2020-10-02 电子科技大学 基因序列优化方法、装置及数据处理终端
CN115960934A (zh) * 2022-08-24 2023-04-14 深圳柏垠生物科技有限公司 大肠杆菌表达外源基因优化方法及其序列
JP7261346B1 (ja) * 2022-12-20 2023-04-19 賢三 小俣 アミデーション反応のシミュレーション方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030073078A1 (en) 2000-07-21 2003-04-17 Rosnick David Ian Method for the recognition of translating genetic coding sequences
DE10205091B4 (de) 2002-02-07 2007-04-19 Biomax Informatics Ag Verfahren zur Vorhersage der Expressionseffizienz in zellfreien Expressionssystemen
CN101501694B (zh) 2006-08-04 2011-11-30 英国龙沙生物医药股份有限公司 用于对蛋白质聚集进行预测以及设计聚集抑制剂的方法
US20130149699A1 (en) 2011-10-31 2013-06-13 The University of Texas Medical Branch at Galveston Translation Kinetic Mapping, Modification and Harmonization

Also Published As

Publication number Publication date
US20200286578A1 (en) 2020-09-10
SG11201705275VA (en) 2017-07-28
US20170372001A1 (en) 2017-12-28
CN107109496A (zh) 2017-08-29
JP2018509930A (ja) 2018-04-12
EP3242955A4 (en) 2018-08-08
AU2016205254B2 (en) 2022-04-14
KR102473180B1 (ko) 2022-12-01
EP3242955A1 (en) 2017-11-15
KR20170094798A (ko) 2017-08-21
WO2016112142A1 (en) 2016-07-14
AU2016205254A1 (en) 2017-08-03
HK1245849A1 (zh) 2018-08-31
CN107109496B (zh) 2021-06-22
EP3242955B1 (en) 2020-05-06
CA2972473A1 (en) 2016-07-14
CA2972473C (en) 2023-09-19

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