DK3204150T3 - Fremgangsmåde til at producere nanopartikler - Google Patents

Fremgangsmåde til at producere nanopartikler Download PDF

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Publication number
DK3204150T3
DK3204150T3 DK15793857.2T DK15793857T DK3204150T3 DK 3204150 T3 DK3204150 T3 DK 3204150T3 DK 15793857 T DK15793857 T DK 15793857T DK 3204150 T3 DK3204150 T3 DK 3204150T3
Authority
DK
Denmark
Prior art keywords
procedure
producing nanoparticles
nanoparticles
producing
Prior art date
Application number
DK15793857.2T
Other languages
Danish (da)
English (en)
Inventor
Edward Haeggström
Jouko Yliruusi
Heikki Räikkönen
Jenni Pessi
Ilkka Lassila
Antti Meriläinen
Kai Falck
Original Assignee
Nanoform Finland Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanoform Finland Oyj filed Critical Nanoform Finland Oyj
Application granted granted Critical
Publication of DK3204150T3 publication Critical patent/DK3204150T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/02Crystallisation from solutions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/008Processes carried out under supercritical conditions
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/54Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Nanotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Optics & Photonics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Steroid Compounds (AREA)
DK15793857.2T 2014-10-06 2015-10-05 Fremgangsmåde til at producere nanopartikler DK3204150T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20140266A FI20140266A7 (fi) 2014-10-06 2014-10-06 Menetelmä ja laite nanopartikkeleiden valmistamiseksi
PCT/FI2015/050664 WO2016055696A1 (en) 2014-10-06 2015-10-05 A method and a device for producing nanoparticles

Publications (1)

Publication Number Publication Date
DK3204150T3 true DK3204150T3 (da) 2024-03-04

Family

ID=54540113

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15793857.2T DK3204150T3 (da) 2014-10-06 2015-10-05 Fremgangsmåde til at producere nanopartikler

Country Status (10)

Country Link
US (1) US10098842B2 (enExample)
EP (1) EP3204150B1 (enExample)
JP (1) JP6599995B2 (enExample)
CA (1) CA2961107C (enExample)
DK (1) DK3204150T3 (enExample)
ES (1) ES2969055T3 (enExample)
FI (2) FI20140266A7 (enExample)
PL (1) PL3204150T3 (enExample)
PT (1) PT3204150T (enExample)
WO (1) WO2016055696A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105641968B (zh) * 2016-01-07 2018-04-17 中国原子能科学研究院 一种具有在线光谱监测功能的超临界流体络合反应装置
FI127408B (en) 2016-09-29 2018-05-15 Nanoform Finland Oy Device, method and equipment for solubility testing
US11298668B2 (en) 2017-11-09 2022-04-12 Blh Ecology Concepts, Llc Process to produce nanoparticles
CN111012671B (zh) * 2019-11-25 2022-07-05 上海强德食品科技有限公司 一种微胶囊的物理制备方法
CN111215002B (zh) * 2020-01-20 2021-08-10 中南大学 高温高压超临界二氧化碳反应釜
FI129026B (en) 2020-01-29 2021-05-31 Nanoform Finland Oy System and method for producing particles of organic substances
EP3884930A1 (en) 2020-03-23 2021-09-29 Bayer AG Nano-dry-melting
CN111721495B (zh) * 2020-06-16 2022-02-08 中国人民解放军国防科技大学 一种新型纳米粒子平面激光散射实验的粒子生成装置
WO2024153733A1 (en) 2023-01-18 2024-07-25 Helm Ag Crystalline nanoparticles comprising enzalutamide
US12303845B2 (en) 2023-01-18 2025-05-20 Nanoform Finland Oyj Method for crystallization of active pharmaceutical ingredients
WO2025125509A1 (en) 2023-12-12 2025-06-19 Targtex S.A. Chemotherapeutic agent and compositions
WO2025153768A1 (en) 2024-01-18 2025-07-24 Nanoform Finland Oyj Composition comprising crystalline nanosized apalutamide

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06102124B2 (ja) * 1985-12-27 1994-12-14 日本分光工業株式会社 超臨界流体による試料の分離回収方法
JP2774349B2 (ja) * 1990-03-17 1998-07-09 株式会社神戸製鋼所 微粒の製造方法
WO1997014407A1 (en) 1995-10-17 1997-04-24 Research Triangle Pharmaceuticals Insoluble drug delivery
JP3986086B2 (ja) 1996-03-01 2007-10-03 ザ ユニバーシティ オブ カンザス 近臨界および超臨界反溶媒を用いる粒子析出方法および被覆方法
CA2294367A1 (en) * 1997-06-20 1998-12-30 Smithkline Beecham P.L.C. Treatment of a substance with a dense fluid (e.g. with a supercritical fluid)
US6177103B1 (en) 1998-06-19 2001-01-23 Rtp Pharma, Inc. Processes to generate submicron particles of water-insoluble compounds
FR2802445B1 (fr) * 1999-12-15 2002-02-15 Separex Sa Procede et dispositif de captage de fines particules par piegeage au sein d'un melange solide de type neige carbonique
US7279181B2 (en) 2003-06-03 2007-10-09 Ferro Corporation Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions
US7754243B2 (en) 2004-08-03 2010-07-13 Clemson University Research Foundation Aqueous suspension of nanoscale drug particles from supercritical fluid processing
GB0525852D0 (en) * 2005-12-20 2006-02-01 Accentus Plc Crystallisation apparatus and process
JP2007301534A (ja) 2006-05-15 2007-11-22 Ebara Corp 微細化装置
US8585943B2 (en) * 2007-12-07 2013-11-19 Xspray Microparticles Ab Method and arrangement for the production of particles
JP5933234B2 (ja) * 2011-11-24 2016-06-08 国立大学法人東北大学 微粒子作製装置

Also Published As

Publication number Publication date
CA2961107A1 (en) 2016-04-14
EP3204150B1 (en) 2023-11-29
FI3204150T3 (fi) 2023-12-04
PL3204150T3 (pl) 2024-05-13
US10098842B2 (en) 2018-10-16
PT3204150T (pt) 2024-03-04
CA2961107C (en) 2023-01-03
US20170231914A1 (en) 2017-08-17
JP6599995B2 (ja) 2019-10-30
EP3204150A1 (en) 2017-08-16
ES2969055T3 (es) 2024-05-16
JP2017536983A (ja) 2017-12-14
FI20140266A7 (fi) 2016-04-07
WO2016055696A1 (en) 2016-04-14

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