DK3157577T3 - Automatisk procesplatform til fremstilling af astatin-211 [at-211]-radiofarmaka - Google Patents
Automatisk procesplatform til fremstilling af astatin-211 [at-211]-radiofarmaka Download PDFInfo
- Publication number
- DK3157577T3 DK3157577T3 DK15809093.6T DK15809093T DK3157577T3 DK 3157577 T3 DK3157577 T3 DK 3157577T3 DK 15809093 T DK15809093 T DK 15809093T DK 3157577 T3 DK3157577 T3 DK 3157577T3
- Authority
- DK
- Denmark
- Prior art keywords
- astatin
- manufacture
- automatic process
- process platform
- pharmacy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0094—Other isotopes not provided for in the groups listed above
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462013678P | 2014-06-18 | 2014-06-18 | |
| PCT/SE2015/050714 WO2015195042A1 (en) | 2014-06-18 | 2015-06-17 | AUTOMATIC PROCESS PLATFORM FOR THE PRODUCTION OF ASTATINE-211 [At-211]-RADIOPHARMACEUTICALS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3157577T3 true DK3157577T3 (da) | 2021-01-18 |
Family
ID=54935878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15809093.6T DK3157577T3 (da) | 2014-06-18 | 2015-06-17 | Automatisk procesplatform til fremstilling af astatin-211 [at-211]-radiofarmaka |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10829423B2 (da) |
| EP (1) | EP3157577B8 (da) |
| JP (1) | JP6830435B2 (da) |
| CN (1) | CN107073141B (da) |
| DK (1) | DK3157577T3 (da) |
| ES (1) | ES2843625T3 (da) |
| PL (1) | PL3157577T3 (da) |
| WO (1) | WO2015195042A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2552151A (en) * | 2016-07-08 | 2018-01-17 | Univ Oslo | Cyclotron target |
| CN111465577B (zh) | 2017-12-07 | 2023-07-28 | 国立大学法人大阪大学 | 砹的制造方法 |
| EP3733216A4 (en) * | 2017-12-29 | 2021-08-11 | Osaka University | ASTATE SOLUTION AND ITS PRODUCTION PROCESS |
| US20210210244A1 (en) * | 2018-03-15 | 2021-07-08 | Osaka University | Radionuclide preparation system, storage medium readable by computer storing radionuclide preparation program, radionuclide preparation method, and terminal device |
| US11776705B1 (en) * | 2020-01-16 | 2023-10-03 | Innosense Llc | High temperature and high beam current compatible targets and methods thereof for generating noble gas/radiohalogen generators for medical isotopes |
| CN114249301B (zh) * | 2021-11-10 | 2023-06-16 | 砹尔法纽克莱(宁波)医疗科技有限公司 | 一种洗脱溶液及用于靶向核素药的放射性核素砹-211的制备方法 |
| CN118678997A (zh) * | 2021-12-14 | 2024-09-20 | 德克萨斯A&M大学系统 | 自动分离和回收砹的系统和方法 |
| WO2024094882A1 (en) | 2022-11-05 | 2024-05-10 | Atley Solutions Ab | Automatic scraper for radioactive substances |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681727A (en) * | 1984-04-10 | 1987-07-21 | The United States Of America As Represented By The United States Department Of Energy | Process for producing astatine-211 for radiopharmaceutical use |
| EP0203764B1 (en) | 1985-05-17 | 1993-03-24 | Neorx Corporation | Radiohalogenated small molecules for protein labeling |
| US4826672A (en) | 1985-06-07 | 1989-05-02 | President And Fellows Of Harvard College | Astatinated organic compounds |
| US5102651A (en) | 1989-12-29 | 1992-04-07 | Neorx Corporation | Process for isolation and radiolabeling of pharmaceuticals with isotopes of astatine |
| DE4239344A1 (en) * | 1991-12-20 | 1993-06-24 | Sulzer Ag | Robotic machining of workpieces using scraping process - involves manipulating workpiece so that features to be machined are drawn past scraper blade under controlled pressure |
| NO314537B1 (no) | 1999-12-06 | 2003-04-07 | Anticancer Therapeutic Inv Sa | Reseptorbindende konjugater |
| US6749830B2 (en) * | 2001-01-31 | 2004-06-15 | Centre For Addiction And Mental Health | Method for the synthesis of radiolabeled compounds |
| WO2003064678A2 (en) | 2002-01-31 | 2003-08-07 | Bioscan, Inc. | Apparatus for synthesis of radiolabeled compounds |
| DE602004015454D1 (de) | 2003-06-25 | 2008-09-11 | Peregrine Pharmaceuticals Inc | Verfahren und vorrichtung zur kontinuierlichen radioaktiven markierung von proteinen im grossen massstab |
| AU2003904201A0 (en) | 2003-08-11 | 2003-08-21 | Allen, Barry John Mr | Alpha-conjugate of C595 for therapy of pancreatic, prostate and other cancers |
| US8337810B2 (en) | 2005-12-22 | 2012-12-25 | Duke University | Stabilized compositions and methods for radiolabeling pharmaceuticals with alpha-particle emitters |
| WO2010021719A1 (en) | 2008-08-19 | 2010-02-25 | The Regents Of The University Of California | Modular radiochemistry synthesis system |
| US8435454B2 (en) * | 2009-07-09 | 2013-05-07 | Siemens Medical Solutions Usa, Inc. | Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure |
| US8273300B2 (en) | 2009-07-09 | 2012-09-25 | Siemens Medical Solutions Usa, Inc. | Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure |
-
2015
- 2015-06-17 ES ES15809093T patent/ES2843625T3/es active Active
- 2015-06-17 DK DK15809093.6T patent/DK3157577T3/da active
- 2015-06-17 WO PCT/SE2015/050714 patent/WO2015195042A1/en active Application Filing
- 2015-06-17 JP JP2017519443A patent/JP6830435B2/ja active Active
- 2015-06-17 CN CN201580032763.7A patent/CN107073141B/zh active Active
- 2015-06-17 PL PL15809093T patent/PL3157577T3/pl unknown
- 2015-06-17 US US15/530,265 patent/US10829423B2/en active Active
- 2015-06-17 EP EP15809093.6A patent/EP3157577B8/en active Active
-
2020
- 2020-10-01 US US17/060,810 patent/US11851383B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PL3157577T3 (pl) | 2021-04-19 |
| CN107073141B (zh) | 2021-06-29 |
| CN107073141A (zh) | 2017-08-18 |
| US10829423B2 (en) | 2020-11-10 |
| EP3157577A4 (en) | 2018-03-07 |
| EP3157577B8 (en) | 2020-12-23 |
| EP3157577B1 (en) | 2020-10-28 |
| US20210139389A1 (en) | 2021-05-13 |
| WO2015195042A1 (en) | 2015-12-23 |
| JP2017528512A (ja) | 2017-09-28 |
| JP6830435B2 (ja) | 2021-02-17 |
| US11851383B2 (en) | 2023-12-26 |
| EP3157577A1 (en) | 2017-04-26 |
| ES2843625T3 (es) | 2021-07-19 |
| US20180215680A1 (en) | 2018-08-02 |
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