DK3150627T3 - Antimikrobielle peptider baseret på cmap27 - Google Patents

Antimikrobielle peptider baseret på cmap27 Download PDF

Info

Publication number
DK3150627T3
DK3150627T3 DK16197733.5T DK16197733T DK3150627T3 DK 3150627 T3 DK3150627 T3 DK 3150627T3 DK 16197733 T DK16197733 T DK 16197733T DK 3150627 T3 DK3150627 T3 DK 3150627T3
Authority
DK
Denmark
Prior art keywords
cmap27
peptide
arg phe
arg
peptides
Prior art date
Application number
DK16197733.5T
Other languages
English (en)
Inventor
Floris Jacob Bikker
Dijk Albert Van
Rosalia Mars-Groenendijk
Edwin Johannes Adrianus Veldhuizen
Der Kleij Desiree Van
Hendrik Haagsman
Elisabeth Margaretha Molhoek
Original Assignee
Univ Utrecht Holding Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utrecht Holding Bv filed Critical Univ Utrecht Holding Bv
Application granted granted Critical
Publication of DK3150627T3 publication Critical patent/DK3150627T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides

Claims (14)

1. CMAP27-derivater, der består af den almene aminosyresekvens RX1GRX2LRKIRRX3X4, hvor Xi, X2 og X3 uafhængigt kan være F, F, W, eller Y og X4 kan være 0-9 aminosyrer, og hvor de yderligere derivater er C-terminalt amiderede.
2. CMAP27-derivat ifølge krav 1, hvor én af Xi, X2 og X3 er F.
3. CMAP27-derivat ifølge krav 1 eller 2, hvor to eller tre af Xi, X2 og X3 er F.
4. CMAP27-derivat ifølge et hvilket som helst af de foregående krav, hvor X4 er 0 aminosyrer.
5. CMAP27-derivat ifølge et hvilket som helst af kravene 1-3, hvor X4 er R.
6. CMAP27-derivat ifølge et hvilket som helst af kravene 1-3, hvor X4 er RX5K, RX5KVT eller RX5KVTITIQ, hvor X5 er P, G eller F.
7. CMAP27-derivat ifølge krav 6, hvor X5 er P.
8. CMAP27-derivat ifølge et hvilket som helst af kravene 1-7 til anvendelse som et lægemiddel.
9. CMAP27-derivat ifølge et hvilket som helst af kravene 1-7 til anvendelse som et antibiotikum.
10. Farmaceutisk sammensætning, der omfatter mindst ét CMAP27-derivat ifølge et hvilket som helst af kravene 1 til 7.
11. Anvendelse af et CMAP27-derivat ifølge et hvilket som helst af kravene 1-7 til fremstilling af et lægemiddel til behandling af bakterieinfektioner.
12. Anvendelse af et CMAP27-derivat ifølge et hvilket som helst af kravene 1-7 i fremstillingen af et antibiotikum.
13. Immunologisk sammensætning, fortrinsvis en vaccinesammensætning, der omfatter et CMAP27-peptid valgt fra gruppen af CMAP27-derivater ifølge krav 1.
14. Anvendelse af et CMAP27-peptid valgt fra gruppen af CMAP27-derivater ifølge krav 1 som adjuvans.
DK16197733.5T 2009-02-13 2010-02-12 Antimikrobielle peptider baseret på cmap27 DK3150627T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09152810 2009-02-13
EP10704016.4A EP2396345B1 (en) 2009-02-13 2010-02-12 Antimicrobial peptides based on cmap27

Publications (1)

Publication Number Publication Date
DK3150627T3 true DK3150627T3 (da) 2019-03-11

Family

ID=40671145

Family Applications (2)

Application Number Title Priority Date Filing Date
DK16197733.5T DK3150627T3 (da) 2009-02-13 2010-02-12 Antimikrobielle peptider baseret på cmap27
DK10704016.4T DK2396345T3 (da) 2009-02-13 2010-02-12 Antimikrobielle peptider baseret på cmap27

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10704016.4T DK2396345T3 (da) 2009-02-13 2010-02-12 Antimikrobielle peptider baseret på cmap27

Country Status (11)

Country Link
US (3) US9006174B2 (da)
EP (2) EP3150627B1 (da)
DK (2) DK3150627T3 (da)
ES (2) ES2710785T3 (da)
HR (1) HRP20190262T1 (da)
HU (2) HUE042310T2 (da)
PL (2) PL3150627T3 (da)
PT (2) PT3150627T (da)
SI (1) SI3150627T1 (da)
TR (1) TR201901717T4 (da)
WO (1) WO2010093245A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3207425A1 (en) 2014-05-09 2015-11-12 Universiteit Utrecht Holding B.V. New cath2 derivatives
CN107043428A (zh) * 2017-05-02 2017-08-15 东北农业大学 一种α螺旋结构的抗炎杂合抗菌肽及其制备方法和应用
CN110128544B (zh) * 2019-04-03 2020-12-01 中国农业大学 一种具有免疫调节和抗炎功能的杂合肽及其制备方法与应用
CN117120071A (zh) 2020-12-18 2023-11-24 乌得勒支大学控股有限公司 刺激先天免疫记忆的cath2衍生物
EP4288449A1 (en) 2021-02-05 2023-12-13 Universiteit Utrecht Holding B.V. Cath2 and derivatives for inhibiting streptococcus suis
WO2023015274A1 (en) * 2021-08-05 2023-02-09 Zoetis Services Llc Compositions and methods for treating mastitis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007064903A1 (en) * 2005-12-02 2007-06-07 The Board Of Regents For Oklahoma State University Fowlicidins and methods of their use

Also Published As

Publication number Publication date
WO2010093245A1 (en) 2010-08-19
PT3150627T (pt) 2019-02-18
US11186619B2 (en) 2021-11-30
PT2396345T (pt) 2017-02-10
PL2396345T3 (pl) 2017-06-30
US10301363B2 (en) 2019-05-28
EP3150627A1 (en) 2017-04-05
HUE042310T2 (hu) 2019-06-28
US20120093844A1 (en) 2012-04-19
HUE031681T2 (en) 2017-08-28
SI3150627T1 (sl) 2019-03-29
EP2396345A1 (en) 2011-12-21
TR201901717T4 (tr) 2019-03-21
EP2396345B1 (en) 2016-11-09
ES2613266T3 (es) 2017-05-23
EP3150627B1 (en) 2018-11-21
PL3150627T3 (pl) 2019-05-31
US9006174B2 (en) 2015-04-14
ES2710785T3 (es) 2019-04-26
HRP20190262T1 (hr) 2019-04-05
DK2396345T3 (da) 2017-02-13
US20150197547A1 (en) 2015-07-16
US20190233483A1 (en) 2019-08-01

Similar Documents

Publication Publication Date Title
US11186619B2 (en) Antimicrobial peptides based on CMAP27
EP2170928B1 (en) Antibiotic peptides
US11603391B2 (en) CATH2 derivatives
US6440690B1 (en) Peptides for the activation of the immune system in humans and animals
TWI577697B (zh) 耐高鹽及抗蛋白之抗菌胜肽及其製造方法
EP1814904B1 (en) Antibiotic drosocin derivatives
EP2575852A1 (en) Antimicrobial peptides and peptide derivatives derived from oncopeltus fasciatus