DK3046902T3 - Sammensætninger til behandling af hypertension og/eller fibrose - Google Patents

Sammensætninger til behandling af hypertension og/eller fibrose Download PDF

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DK3046902T3
DK3046902T3 DK14845828.4T DK14845828T DK3046902T3 DK 3046902 T3 DK3046902 T3 DK 3046902T3 DK 14845828 T DK14845828 T DK 14845828T DK 3046902 T3 DK3046902 T3 DK 3046902T3
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mmol
nmr
compound
pharmaceutically acceptable
dmso
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DK14845828.4T
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Karen Annette Duggan
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Vectus Biosystems Ltd
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Claims (14)

  1. SAMMENSÆTNINGER TIL BEHANDLING AF HYPERTENSION OG/ELLER FIBROSE
    1. Forbindelse med formlen
    hvor: A er valgt fra gruppen bestående af:
    Q uafhængigt af hinanden er valgt blandt halogen, alkyl, hydroxy, amino og substitueret amino; n er 0, 1,2, 3, 4 eller 5; Ri, R3 og R4 uafhængigt af hinanden er C, CH, CH2, O, N, NH eller S, og R2 er C, CH, CH2, N, NH, C-CF3, CH-CFs eller C=O, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, hvor Q, når n er 1, ikke kan være hydroxy, og
    hvor den substituerede amino har formlen -NHW, og hvor: W er valgt blandt -CN, -SO2(X)aY og -CO(X)aY, a er 0 eller 1, X er valgt blandt -NH- og -O-, og Y er valgt blandt -H, -CH3, -CH2CH3, -CH2OH og -CH2CH2OH.
  2. 2. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, ifølge krav 1, hvor Q er halogen, som er valgt fra gruppen bestående af F, Cl, Br og I.
  3. 3. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, ifølge krav 1, hvor Q er substitueret amino, som er valgt fra gruppen bestående af -NHSO2CH3, -NHCOH, -NHCONHCH3, -NHCONHCH2CH3, -NHSO2NHCH3, -NHSO2NHCH2CH3, -NHCOCH3, -NHCOOCH3, -NHCOOCH2CH2OH, -NHCONH2 og -NHCN.
  4. 4. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, ifølge krav 1, hvor Q er alkyl, som er valgt fra gruppen bestående af methyl, ethyl, propyl, butyl og pentyl.
  5. 5. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, ifølge krav 1, hvor A er valgt blandt:
  6. 6. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, ifølge krav 1, hvor forbindelsen er valgt fra gruppen bestående af:
  7. 7. Farmaceutisk sammensætning, der omfatter en forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, ifølge et hvilket som helst af kravene 1 til 6 og en farmaceutisk acceptabel excipiens.
  8. 8. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, ifølge et hvilket som helst af kravene 1 til 6 til anvendelse ved terapeutisk behandling af hypertension eller præhypertension.
  9. 9. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, ifølge et hvilket som helst af kravene 1 til 6 til anvendelse ved profylaktisk behandling af fibrose.
  10. 10. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, ifølge et hvilket som helst af kravene 1 til 6 til anvendelse ved terapeutisk behandling af fibrose.
  11. 11. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, ifølge et hvilket som helst af kravene 1 til 6 til anvendelse ved terapeutisk behandling af hypertension og fibrose.
  12. 12. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, ifølge et hvilket som helst af kravene 1 til 6 til anvendelse ved behandling af præhypertension og fibrose.
  13. 13. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, til anvendelse ifølge et hvilket som helst af kravene 9 til 12, hvor fibrosen er myokardiefibrose eller nyrefibrose.
  14. 14. Forbindelse, eller en stereoisomer eller et farmaceutisk acceptabelt salt deraf, til anvendelse ifølge et hvilket som helst af kravene 9 til 12, hvor fibrosen er myokardiefibrose og nyrefibrose.
DK14845828.4T 2013-09-17 2014-09-17 Sammensætninger til behandling af hypertension og/eller fibrose DK3046902T3 (da)

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