DK2992004T3 - Protransducin b en forstærker af genoverførsel - Google Patents
Protransducin b en forstærker af genoverførsel Download PDFInfo
- Publication number
- DK2992004T3 DK2992004T3 DK14724030.3T DK14724030T DK2992004T3 DK 2992004 T3 DK2992004 T3 DK 2992004T3 DK 14724030 T DK14724030 T DK 14724030T DK 2992004 T3 DK2992004 T3 DK 2992004T3
- Authority
- DK
- Denmark
- Prior art keywords
- peptide
- gin
- ile
- glu
- lys
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 241000700605 Viruses Species 0.000 claims 2
- 238000001415 gene therapy Methods 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims 1
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 claims 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (6)
1. Peptid med sekvensen X-Glu-Cys-Lys-lle-Lys-GIn-lle-lle-Asn-Met-Trp-GIn, hvor gruppen X-Glu er aminosyren pyroglutaminsyre.
2. Medikament der indeholder et peptid ifølge krav 1.
3. Peptidet ifølge krav 1 til anvendelse i genterapi ved behandling af sygdomme, der kan behandles med genterapi.
4. Fremgangsmåde til forstærkning af infektionen af en celle med et virus, hvilken fremgangsmåde omfatter følgende trin: - at tilvejebringe peptidet ifølge krav 1 opløst i et organisk opløsningsmiddel; - at tilsætte peptidet til en vandig opløsning under dannelse af uopløselige aggregater af peptidet; - at blande opløsningen fra det foregående trin og - at dyrke cellerne.
5. In vitro anvendelse af peptidet ifølge krav 1 til forstærkning af infektionen af en celle med en virus.
6. Kit der indeholder et peptid ifølge krav 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13166266 | 2013-05-02 | ||
| PCT/EP2014/058870 WO2014177635A1 (de) | 2013-05-02 | 2014-04-30 | Protransduzin b ein enhancer des gentransfers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2992004T3 true DK2992004T3 (da) | 2018-09-17 |
Family
ID=48227026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14724030.3T DK2992004T3 (da) | 2013-05-02 | 2014-04-30 | Protransducin b en forstærker af genoverførsel |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10125169B2 (da) |
| EP (2) | EP3412681B1 (da) |
| JP (1) | JP6667432B2 (da) |
| CN (2) | CN110172085A (da) |
| AU (2) | AU2014261381B2 (da) |
| CA (1) | CA2909744C (da) |
| CY (1) | CY1120511T1 (da) |
| DK (1) | DK2992004T3 (da) |
| ES (1) | ES2681424T3 (da) |
| HR (1) | HRP20181138T1 (da) |
| HU (1) | HUE040476T2 (da) |
| LT (1) | LT2992004T (da) |
| PL (1) | PL2992004T3 (da) |
| PT (1) | PT2992004T (da) |
| RS (1) | RS57506B1 (da) |
| SI (1) | SI2992004T1 (da) |
| SM (1) | SMT201800412T1 (da) |
| TR (1) | TR201809579T4 (da) |
| WO (1) | WO2014177635A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018087146A1 (de) | 2016-11-09 | 2018-05-17 | Pharis Biotec Gmbh | Protransduzin-c - ein enhancer des gentransfers |
| WO2019043037A1 (de) | 2017-08-29 | 2019-03-07 | Pharis Biotec Gmbh | Protransduzin-d - verbesserter enhancer des gentransfers |
| EP4067375A1 (en) | 2021-03-30 | 2022-10-05 | Universität Ulm | Fibril peptides |
| EP4636093A1 (en) | 2024-04-19 | 2025-10-22 | Paul-Ehrlich-Institut, Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel | Targeting mapk-erk pathway for enhancing nucleic acid delivery |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1293204A (zh) * | 1999-10-18 | 2001-05-02 | 上海博容基因开发有限公司 | 一种新的多肽－人溴基功能域蛋白72和编码这种多肽的多核苷酸 |
| GB0514071D0 (en) * | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
| US8557767B2 (en) * | 2007-08-28 | 2013-10-15 | Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
| WO2010022740A2 (en) * | 2008-08-28 | 2010-03-04 | Aarhus Universitet | Hiv-1 envelope polypeptides for hiv vaccine |
| US9163067B2 (en) * | 2008-10-06 | 2015-10-20 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | HIV-1 integrase derived stimulatory peptides interfering with integrase—Rev protein binding |
| WO2011034207A1 (en) * | 2009-09-16 | 2011-03-24 | Senju Pharmaceutical Co., Ltd. | Partial peptide of lacritin |
| EP2452947A1 (en) * | 2010-11-16 | 2012-05-16 | Münch, Jan | Viral infection enhancing peptide |
| EP2751291B1 (en) * | 2011-09-01 | 2018-08-15 | University of Southern California | Methods for preparing high throughput peptidomimetics, orally bioavailable drugs and compositions containing same |
-
2014
- 2014-04-30 PT PT14724030T patent/PT2992004T/pt unknown
- 2014-04-30 PL PL14724030T patent/PL2992004T3/pl unknown
- 2014-04-30 EP EP18175770.9A patent/EP3412681B1/de active Active
- 2014-04-30 LT LTEP14724030.3T patent/LT2992004T/lt unknown
- 2014-04-30 CN CN201910487826.8A patent/CN110172085A/zh active Pending
- 2014-04-30 HR HRP20181138TT patent/HRP20181138T1/hr unknown
- 2014-04-30 CA CA2909744A patent/CA2909744C/en active Active
- 2014-04-30 EP EP14724030.3A patent/EP2992004B1/de active Active
- 2014-04-30 US US14/787,160 patent/US10125169B2/en active Active
- 2014-04-30 JP JP2016511064A patent/JP6667432B2/ja not_active Expired - Fee Related
- 2014-04-30 ES ES14724030.3T patent/ES2681424T3/es active Active
- 2014-04-30 AU AU2014261381A patent/AU2014261381B2/en not_active Ceased
- 2014-04-30 TR TR2018/09579T patent/TR201809579T4/tr unknown
- 2014-04-30 SM SM20180412T patent/SMT201800412T1/it unknown
- 2014-04-30 HU HUE14724030A patent/HUE040476T2/hu unknown
- 2014-04-30 DK DK14724030.3T patent/DK2992004T3/da active
- 2014-04-30 RS RS20180896A patent/RS57506B1/sr unknown
- 2014-04-30 SI SI201430785T patent/SI2992004T1/en unknown
- 2014-04-30 WO PCT/EP2014/058870 patent/WO2014177635A1/de not_active Ceased
- 2014-04-30 CN CN201480023747.7A patent/CN105209480B/zh not_active Expired - Fee Related
-
2018
- 2018-04-16 AU AU2018202618A patent/AU2018202618A1/en not_active Abandoned
- 2018-07-31 CY CY20181100793T patent/CY1120511T1/el unknown
- 2018-10-15 US US16/159,900 patent/US20190100557A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014261381A1 (en) | 2015-11-12 |
| US10125169B2 (en) | 2018-11-13 |
| CY1120511T1 (el) | 2019-07-10 |
| HUE040476T2 (hu) | 2019-03-28 |
| JP6667432B2 (ja) | 2020-03-18 |
| CA2909744A1 (en) | 2014-11-06 |
| EP2992004B1 (de) | 2018-06-06 |
| EP3412681A1 (de) | 2018-12-12 |
| AU2018202618A1 (en) | 2018-05-10 |
| EP3412681C0 (de) | 2024-04-17 |
| CA2909744C (en) | 2021-06-15 |
| ES2681424T3 (es) | 2018-09-13 |
| CN105209480B (zh) | 2019-08-16 |
| SMT201800412T1 (it) | 2018-09-13 |
| EP2992004A1 (de) | 2016-03-09 |
| HRP20181138T1 (hr) | 2018-09-21 |
| CN105209480A (zh) | 2015-12-30 |
| CN110172085A (zh) | 2019-08-27 |
| EP3412681B1 (de) | 2024-04-17 |
| LT2992004T (lt) | 2018-08-10 |
| SI2992004T1 (en) | 2018-08-31 |
| JP2016524594A (ja) | 2016-08-18 |
| US20190100557A1 (en) | 2019-04-04 |
| US20160185820A1 (en) | 2016-06-30 |
| TR201809579T4 (tr) | 2018-07-23 |
| PL2992004T3 (pl) | 2018-10-31 |
| AU2014261381B2 (en) | 2018-01-18 |
| PT2992004T (pt) | 2018-10-19 |
| WO2014177635A1 (de) | 2014-11-06 |
| RS57506B1 (sr) | 2018-10-31 |
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