DK2972332T3 - Mikrofluid chip med aftætnet reagens - Google Patents

Mikrofluid chip med aftætnet reagens Download PDF

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Publication number
DK2972332T3
DK2972332T3 DK14773692.0T DK14773692T DK2972332T3 DK 2972332 T3 DK2972332 T3 DK 2972332T3 DK 14773692 T DK14773692 T DK 14773692T DK 2972332 T3 DK2972332 T3 DK 2972332T3
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DK
Denmark
Prior art keywords
cavity
bag
pouch
microfluidic chip
microfluidic
Prior art date
Application number
DK14773692.0T
Other languages
English (en)
Inventor
Dafeng Chen
James E Rasmussen
Manish Deshpande
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Siemens Healthcare Diagnostics Inc
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Publication of DK2972332T3 publication Critical patent/DK2972332T3/da

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/003—Valves for single use only
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/008—Multi-layer fabrications
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Claims (9)

1. Mikrofluid-produktposearrangement til brug i en mikrofluid chip, og som omfatter: en pose, som omgiver et indre kammer, og som har en del, der kan brydes itu, en indre membran, som er anbragt i det indre kammer og tjener til fastlæggelse af et første hulrum og et andet hulrum; et reagens i tør form, og som anbragt inden i det første hulrum; og en struktur, som kan brydes itu, som er således udformet, at den selektivt kan brække den del, som skal brydes itu, og hvor det andet hulrum rummer et fortyndingsmiddel, som - når nævnte indre membran gennemstikkes, gennemtrænges og/eller gennembrydes på tilnærmelsesvis samme tidspunkt eller på et tidspunkt kort efter, hvor man bryder den del af posen, der kan brydes itu - kan hydratisere det tørre reagens.
2. Mikrofluid produktpose ifølge krav 1, hvor en itubrydende struktur i posen er en nål, som har en skarp kant, der er således udformet, at den kan gennemtrænge den del, som skal brydes itu.
3. Mikrofluid produktpose ifølge krav 1, hvor den struktur, som kan bryde posen itu, er et stempel.
4. Mikrofluid produktpose ifølge krav 3, hvor stemplet omfatter en stang, som er forbundet med en kontaktdel, der har en i hovedsagen plan overflade.
5. Mikrofluid produktpose ifølge krav 4, hvor posen yderligere omfatter en deformerbar membran, og hvor en plan flade på stemplet er således udformet, at den kan tilvejebringe tryk på den deformerbare membran, så at posens itubryde-lige del brydes itu.
6. Mikrofluid produktpose ifølge krav 4, hvor stemplet har en første ende og en anden ende, hvor den første ende er udformet til formmæssigt at passe ind i det andet hulrum i det andet kammer.
7. Mikrofluid produktpose ifølge krav 1, hvor den struktur, som kan itubryde en lomme, omfatter en valse.
8. Mikrofluid produktpose ifølge krav 7, hvor det andet hulrum er et aflangt hulrum, som har en første ende og en anden ende, og hvor det første hulrum er anbragt ved den anden ende af hulrummet, og valsen er således udformet, at den kan bevæges fra den første ende til den anden ende af det aflange hulrum.
9. Mikrofluid chip, som omfatter: et hus; en prøvetilslutning, som bæres af huset, og som tjener til indføring af fluider i huset; en eller flere kanaler, som tilvejebringer fluidumforbindelse mellem prøve-portåbningen og et affølingskammer; og en eller flere produktpose-arrangementer ifølge krav 1, hvilke pose-arrangementer er anbragt ved siden af en eller flere kanaler, og hvor den del, som i posen kan brydes itu, er anbragt i fluidumforbindelse med de en eller flere reagenser og de en eller flere kanaler.
DK14773692.0T 2013-03-14 2014-03-13 Mikrofluid chip med aftætnet reagens DK2972332T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361783287P 2013-03-14 2013-03-14
PCT/US2014/025281 WO2014159834A1 (en) 2013-03-14 2014-03-13 Microfluidic chip with sealed on-board reagent

Publications (1)

Publication Number Publication Date
DK2972332T3 true DK2972332T3 (da) 2018-09-03

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ID=51625267

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Application Number Title Priority Date Filing Date
DK14773692.0T DK2972332T3 (da) 2013-03-14 2014-03-13 Mikrofluid chip med aftætnet reagens

Country Status (6)

Country Link
US (2) US10441951B2 (da)
EP (2) EP3431989B1 (da)
KR (1) KR101632886B1 (da)
CN (1) CN105026931B (da)
DK (1) DK2972332T3 (da)
WO (1) WO2014159834A1 (da)

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Also Published As

Publication number Publication date
KR20150125722A (ko) 2015-11-09
US20160038938A1 (en) 2016-02-11
CN105026931B (zh) 2020-03-03
EP3431989A1 (en) 2019-01-23
EP2972332B1 (en) 2018-05-30
EP2972332A1 (en) 2016-01-20
US11235321B2 (en) 2022-02-01
EP2972332A4 (en) 2017-04-05
US20200038855A1 (en) 2020-02-06
EP3431989B1 (en) 2019-10-09
CN105026931A (zh) 2015-11-04
WO2014159834A1 (en) 2014-10-02
US10441951B2 (en) 2019-10-15
KR101632886B1 (ko) 2016-06-23

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