DK2968479T3 - Terapeutiske sure ceramidasesammensætninger og fremgangsmåder til fremstilling og anvendelse heraf - Google Patents
Terapeutiske sure ceramidasesammensætninger og fremgangsmåder til fremstilling og anvendelse heraf Download PDFInfo
- Publication number
- DK2968479T3 DK2968479T3 DK14775400.6T DK14775400T DK2968479T3 DK 2968479 T3 DK2968479 T3 DK 2968479T3 DK 14775400 T DK14775400 T DK 14775400T DK 2968479 T3 DK2968479 T3 DK 2968479T3
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- Prior art keywords
- sure
- therapeutic
- preparing
- methods
- ceramidase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01023—Ceramidase (3.5.1.23)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Biotechnology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361784594P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/026481 WO2014160390A1 (en) | 2013-03-14 | 2014-03-13 | Therapeutic acid ceramidase compositions and methods of making and using them |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2968479T3 true DK2968479T3 (da) | 2019-08-12 |
Family
ID=51625420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14775400.6T DK2968479T3 (da) | 2013-03-14 | 2014-03-13 | Terapeutiske sure ceramidasesammensætninger og fremgangsmåder til fremstilling og anvendelse heraf |
Country Status (14)
Country | Link |
---|---|
US (3) | US9937246B2 (da) |
EP (2) | EP3659619A1 (da) |
JP (4) | JP6832158B2 (da) |
CA (1) | CA2905449A1 (da) |
DK (1) | DK2968479T3 (da) |
ES (1) | ES2739811T3 (da) |
HK (1) | HK1220399A1 (da) |
HR (1) | HRP20191361T1 (da) |
HU (1) | HUE046113T2 (da) |
IL (4) | IL241390B (da) |
MX (2) | MX2015012471A (da) |
PL (1) | PL2968479T3 (da) |
PT (1) | PT2968479T (da) |
WO (1) | WO2014160390A1 (da) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006007560A2 (en) | 2004-07-01 | 2006-01-19 | University Of Pennsylvania | Targeted protein replacement for the treatment of lysosomal storage disorders |
WO2013036875A1 (en) | 2011-09-07 | 2013-03-14 | Mount Sinai School Of Medicine | Ceramidase and cell differentiation |
PT2854910T (pt) | 2012-06-01 | 2020-05-06 | Yeda Res & Dev | Níveis de ceramida no tratamento e prevenção de infeções |
HUE046113T2 (hu) * | 2013-03-14 | 2020-02-28 | Icahn School Med Mount Sinai | Terápiás sav ceramidáz készítmények és azok elõállítási és felhasználási eljárásai |
US20190343936A1 (en) | 2017-01-13 | 2019-11-14 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating farber disease |
WO2019150192A1 (en) | 2018-02-02 | 2019-08-08 | Enzyvant Therapeutics Gmbh | Methods for treating farber disease |
IL311212A (en) * | 2018-03-27 | 2024-05-01 | Enzyvant Therapeutics Gmbh | Suburb disease markers and their uses |
WO2020005341A1 (en) * | 2018-06-29 | 2020-01-02 | Icahn School Of Medicine At Mount Sinai | Anc80 encoding sphingolipid-metabolizing proteins |
US20220088158A1 (en) | 2019-01-23 | 2022-03-24 | Aceragen, Inc. | Method of ameliorating a pro-inflammatory immunophenotype in farber disease subjects by repeated administration of a recombinant human acid ceramidase |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH585793A5 (da) | 1974-02-01 | 1977-03-15 | Nestle Sa | |
JPS5322158B2 (da) | 1974-05-02 | 1978-07-06 | ||
US4237224A (en) | 1974-11-04 | 1980-12-02 | Board Of Trustees Of The Leland Stanford Jr. University | Process for producing biologically functional molecular chimeras |
IT1130242B (it) | 1980-02-01 | 1986-06-11 | Anic Spa | Procedimento per la produzione dell'enzima alfa-galattosidasi e per l'idrolisi del raffinosio mediante l'impiego dell'enzima stesso |
US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
US5059421A (en) | 1985-07-26 | 1991-10-22 | The Liposome Company, Inc. | Preparation of targeted liposome systems of a defined size distribution |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
EP0463109A4 (en) | 1989-03-24 | 1992-11-19 | Research Corporation Technologies, Inc. | Recombinant alpha-galactosidase, a therapy for fabry disease |
US5382524A (en) | 1990-10-24 | 1995-01-17 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-n-acetylgalactosaminidase |
US5401650A (en) | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
US5773278A (en) | 1991-05-03 | 1998-06-30 | Mount Sinai Medical Center | Acid sphingomyelinase gene |
US5433946A (en) | 1991-10-11 | 1995-07-18 | Health Research Inc. | Synthesis and utilization of therapeutic agents for the treatment of lysosomal storage diseases |
US5631237A (en) | 1992-12-22 | 1997-05-20 | Dzau; Victor J. | Method for producing in vivo delivery of therapeutic agents via liposomes |
HUT72469A (en) | 1992-12-30 | 1996-04-29 | Revis | Anticaries compositions |
US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
JPH08512056A (ja) | 1993-06-30 | 1996-12-17 | ジェネンテク・インコーポレイテッド | リポソームの製造法 |
US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
US5817789A (en) | 1995-06-06 | 1998-10-06 | Transkaryotic Therapies, Inc. | Chimeric proteins for use in transport of a selected substance into cells |
US5643599A (en) | 1995-06-07 | 1997-07-01 | President And Fellows Of Harvard College | Intracellular delivery of macromolecules |
US6118045A (en) | 1995-08-02 | 2000-09-12 | Pharming B.V. | Lysosomal proteins produced in the milk of transgenic animals |
US6884435B1 (en) | 1997-01-30 | 2005-04-26 | Chiron Corporation | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
EP2147681A1 (en) | 1997-10-29 | 2010-01-27 | Genzyme Corporation | Compositions and methods for treating lysosomal storage disease |
US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
WO2000002996A2 (en) | 1998-07-10 | 2000-01-20 | Cornell Research Foundation, Inc. | Recombinant constructs and systems for secretion of proteins via type iii secretion systems |
US7018628B1 (en) | 1998-07-24 | 2006-03-28 | Aventis Pharma S.A. | Vectors derived from baculovirus and use for transferring nucleic acids into nerve cells of vertebrates |
US6258581B1 (en) | 1998-08-20 | 2001-07-10 | Takara Shuzo Co., Ltd. | Ceramidase gene |
GB9909064D0 (en) | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
US6730297B1 (en) | 1999-05-28 | 2004-05-04 | Chiron Corporation | Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders |
US7927587B2 (en) | 1999-08-05 | 2011-04-19 | Regents Of The University Of Minnesota | MAPC administration for the treatment of lysosomal storage disorders |
US6767741B1 (en) | 1999-08-27 | 2004-07-27 | Invitrogen Corporation | Metal binding compounds and their use in cell culture medium compositions |
US6642038B1 (en) | 1999-09-14 | 2003-11-04 | Genzyme Glycobiology Research Institute, Inc. | GlcNAc phosphotransferase of the lysosomal targeting pathway |
CA2387541A1 (en) | 1999-10-13 | 2001-04-19 | Yeda Research And Development Co. Ltd. | Short segments of dap-kinase |
US6350768B1 (en) | 1999-11-24 | 2002-02-26 | Aventis Pharma S.A. | Combination of riluzole and of gabapentin and its use as a medicament |
US7850984B2 (en) | 2000-02-15 | 2010-12-14 | The General Hospital Corporation | Protection of the female reproductive system from natural and artificial insults |
EP1272620A2 (en) | 2000-04-06 | 2003-01-08 | Cytoclonal Pharmaceutics, Inc. | Expression system for efficiently producing clinically effective glucocerebrosidase |
US20040204379A1 (en) | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
CA2432978C (en) | 2000-12-22 | 2012-08-28 | Medlyte, Inc. | Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor |
US20020142299A1 (en) | 2001-01-09 | 2002-10-03 | Davidson Beverly L. | PTD-modified proteins |
EP1234816B1 (de) | 2001-02-23 | 2004-06-30 | Biofrontera Pharmaceuticals GmbH | Scyphostatin-Analoga als SMase-Inhibitoren |
ES2300439T3 (es) | 2001-04-30 | 2008-06-16 | Zystor Therapeutics , Inc. | Reconocimiento subcelular de proteinas terapeuticas. |
US7232670B2 (en) | 2001-09-28 | 2007-06-19 | St. Jude Children's Research Hospital | Targeting proteins to cells expressing mannose receptors via expression in insect cells |
JP2005515777A (ja) | 2002-01-25 | 2005-06-02 | ジェンザイム・コーポレーション | 軟骨細胞のための無血清培地およびその使用法 |
AU2003224880A1 (en) | 2002-04-05 | 2003-10-27 | Genzyme Corporation | Methods of enhancing lysosomal storage disease therapy |
DE10239531A1 (de) | 2002-08-23 | 2004-03-04 | Gulbins, Erich, Prof. Dr. | Prophylaxe und Therapie von Infektionserkrankungen |
EP1431399A1 (en) | 2002-12-20 | 2004-06-23 | Clinigenetics | Methods and composition for identifying therapeutic agents of atherosclerotic plaque lesions |
ES2371913T3 (es) | 2003-01-22 | 2012-01-11 | Duke University | Constructos mejorados para expresar polipéptidos lisosomales. |
US20050026823A1 (en) | 2003-06-20 | 2005-02-03 | Biomarin Pharmaceutical Inc. | Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues |
ES2369667T3 (es) | 2003-07-17 | 2011-12-02 | Pacific Edge Limited | Marcadores para la detección del cáncer gástrico. |
US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
WO2006007560A2 (en) | 2004-07-01 | 2006-01-19 | University Of Pennsylvania | Targeted protein replacement for the treatment of lysosomal storage disorders |
US7273756B2 (en) | 2004-10-01 | 2007-09-25 | Isto Technologies, Inc. | Method for chondrocyte expansion with phenotype retention |
US8017394B2 (en) | 2004-10-01 | 2011-09-13 | Isto Technologies, Inc. | Method for chondrocyte expansion with phenotype retention |
CA2585645C (en) | 2004-10-29 | 2014-10-21 | Musc Foundation For Research Development | Ceramides and apoptosis-signaling ligand |
US7993868B2 (en) | 2005-04-19 | 2011-08-09 | Vermillion, Inc. | Saposin D and FAM3C are biomarkers for alzheimer's disease |
US20070162992A1 (en) | 2006-01-09 | 2007-07-12 | Mcgill University | Metabolomic determination in assisted reproductive technology |
EP1994408A4 (en) | 2006-01-27 | 2009-05-06 | Eastern Virginia Med School | PROTEOMIC FINGERPRINTS OF IVF-HUMAN EMBRYOS: IDENTIFICATION OF BIOMARKERS OF DEVELOPMENT POTENTIAL |
WO2007095688A1 (en) | 2006-02-23 | 2007-08-30 | The Australian National University | Methods for increasing the number of circulating cells |
JP2009538276A (ja) | 2006-04-24 | 2009-11-05 | アカデミッシュ メディシュ セントラム | 嚢胞性線維症の改良型治療 |
WO2007136635A1 (en) | 2006-05-16 | 2007-11-29 | Musc Foundation For Research Development | Enhancement of radiation therapy and/or chemotherapy with acid ceramidase modulators |
EP2030025A2 (en) | 2006-06-07 | 2009-03-04 | Tethys Bioscience, Inc. | Markers associated with arteriovascular events and methods of use thereof |
WO2007149328A1 (en) | 2006-06-20 | 2007-12-27 | Genzyme Corporation | Serum-free media and their uses for chondrocyte expansion |
EP2106443A4 (en) | 2007-01-05 | 2010-10-13 | Sinai School Medicine | ACIDIC CERAMIDASE AND SURVIVAL OF CELLS |
CA2682948C (en) | 2007-04-06 | 2016-05-31 | Genzyme Corporation | Methods of evaluating cells and cell cultures |
US8956825B2 (en) | 2007-05-24 | 2015-02-17 | The United States Of America As Represented By The Department Of Veterans Affairs | Intranuclear protein transduction through a nucleoside salvage pathway |
AU2008255565B2 (en) | 2007-05-31 | 2013-10-24 | Paradigm Biopharmaceuticals Ltd | Sulphated xylans for treatment or prophylaxis of respiratory diseases |
FR2924946B1 (fr) | 2007-12-18 | 2010-02-26 | Oreal | Utilisation cosmetique de proteines de type ceramidase acide |
DE102007063535A1 (de) | 2007-12-21 | 2009-06-25 | Cycnad Gmbh & Co. Kg | Pharmazeutische Zusammensetzung zur Prophylaxe und/oder symptomatischen Behandlung von zystischer Fibrose |
PL2318032T3 (pl) | 2008-06-26 | 2012-08-31 | Orphazyme Aps | Zastosowanie hsp70 jako regulatora aktywności enzymatycznej |
US20100068302A1 (en) | 2008-09-17 | 2010-03-18 | Traslational Cancer Drugs Pharma, S.L. | Methods and compositions for the treatment of cancer |
CN102368905B (zh) | 2008-11-06 | 2015-04-01 | 南卡罗来纳医科大学研究发展基金会 | 酸性神经酰胺酶的向溶酶体抑制剂 |
WO2010127355A1 (en) | 2009-05-01 | 2010-11-04 | Mount Sinai School Of Medicine | Method to determine embryo and oocyte quality based on ceramidase |
HRP20211992T1 (hr) | 2009-08-28 | 2022-04-01 | Icahn School Of Medicine At Mount Sinai | Zamjenska enzimska terapija povećanjem doze za liječenje nedostatka kiseline sfingomijelinaze |
HUE041971T2 (hu) | 2009-10-19 | 2019-06-28 | Amicus Therapeutics Inc | Új készítmények lizoszomális tárolási rendellenességek kezelésére és/vagy megelõzésére |
SI3133070T1 (sl) | 2009-11-27 | 2019-11-29 | Genzyme Corp | Eliglustat (GENZ 112638) kot inhibitor sintaze glukozilceramida za uporabo v postopku zdravljenja Fabrjyeve ali Gaucherjeve bolezni, kjer postopek obsega prilagajanje individualnega terapevtskega odmerka metabolizmu P-450 pacienta |
WO2012051415A2 (en) | 2010-10-13 | 2012-04-19 | Mount Sinai School Of Medicine | Inhibitors of acid ceramidase and uses thereof in cancer and other disease treatment therapies |
WO2013101276A2 (en) | 2011-04-01 | 2013-07-04 | Mount Sinai School Of Medicine | Diagnosis and detection of disease conditions modulated by activation of the sphingolipid pathway |
US9140635B2 (en) * | 2011-05-10 | 2015-09-22 | Advanced Liquid Logic, Inc. | Assay for measuring enzymatic modification of a substrate by a glycoprotein having enzymatic activity |
JP6175431B2 (ja) | 2011-06-20 | 2017-08-02 | アイカーン スクール オブ メディシン アット マウント サイナイ | ムコ多糖症およびその他のリソソーム障害に対する抗tnf療法 |
WO2013036875A1 (en) | 2011-09-07 | 2013-03-14 | Mount Sinai School Of Medicine | Ceramidase and cell differentiation |
PT2854910T (pt) | 2012-06-01 | 2020-05-06 | Yeda Res & Dev | Níveis de ceramida no tratamento e prevenção de infeções |
US9341787B2 (en) | 2013-01-02 | 2016-05-17 | Micron Technology, Inc. | Apparatus providing simplified alignment of optical fiber in photonic integrated circuits |
HUE046113T2 (hu) * | 2013-03-14 | 2020-02-28 | Icahn School Med Mount Sinai | Terápiás sav ceramidáz készítmények és azok elõállítási és felhasználási eljárásai |
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- 2014-03-13 US US14/776,442 patent/US9937246B2/en active Active
- 2014-03-13 DK DK14775400.6T patent/DK2968479T3/da active
- 2014-03-13 WO PCT/US2014/026481 patent/WO2014160390A1/en active Application Filing
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- 2014-03-13 JP JP2016502154A patent/JP6832158B2/ja active Active
- 2014-03-13 PL PL14775400T patent/PL2968479T3/pl unknown
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- 2014-03-13 ES ES14775400T patent/ES2739811T3/es active Active
- 2014-03-13 CA CA2905449A patent/CA2905449A1/en active Pending
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- 2018-03-01 US US15/909,609 patent/US10238721B2/en active Active
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Also Published As
Publication number | Publication date |
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US9937246B2 (en) | 2018-04-10 |
EP2968479A4 (en) | 2016-07-27 |
JP2016520519A (ja) | 2016-07-14 |
IL241390A0 (en) | 2015-11-30 |
JP6832158B2 (ja) | 2021-02-24 |
IL241390B (en) | 2020-03-31 |
HUE046113T2 (hu) | 2020-02-28 |
US10918702B2 (en) | 2021-02-16 |
MX2015012471A (es) | 2016-08-03 |
EP2968479B1 (en) | 2019-07-17 |
JP6832386B2 (ja) | 2021-02-24 |
IL288427A (en) | 2022-01-01 |
CA2905449A1 (en) | 2014-10-02 |
US10238721B2 (en) | 2019-03-26 |
US20190231857A1 (en) | 2019-08-01 |
US20180193436A1 (en) | 2018-07-12 |
JP2019150042A (ja) | 2019-09-12 |
JP2023015402A (ja) | 2023-01-31 |
MX2022003486A (es) | 2022-04-25 |
PT2968479T (pt) | 2019-08-07 |
PL2968479T3 (pl) | 2019-10-31 |
ES2739811T3 (es) | 2020-02-04 |
BR112015024538A2 (pt) | 2018-05-08 |
EP2968479A1 (en) | 2016-01-20 |
US20160038574A1 (en) | 2016-02-11 |
IL272214A (en) | 2020-03-31 |
EP3659619A1 (en) | 2020-06-03 |
HRP20191361T1 (hr) | 2019-11-01 |
IL272214B (en) | 2022-01-01 |
WO2014160390A1 (en) | 2014-10-02 |
HK1220399A1 (zh) | 2017-05-05 |
JP2021042227A (ja) | 2021-03-18 |
IL304629A (en) | 2023-09-01 |
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