DK2956176T3 - MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS - Google Patents

MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS Download PDF

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DK2956176T3
DK2956176T3 DK14751357.6T DK14751357T DK2956176T3 DK 2956176 T3 DK2956176 T3 DK 2956176T3 DK 14751357 T DK14751357 T DK 14751357T DK 2956176 T3 DK2956176 T3 DK 2956176T3
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apociii
certain embodiments
compound
modified oligonucleotide
modified
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DK14751357.6T
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Danish (da)
English (en)
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Veronica J Alexander
Nicholas J Viney
Joseph L Witztum
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Ionis Pharmaceuticals Inc
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/30—Chemical structure
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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DK14751357.6T 2013-02-14 2014-02-14 MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS DK2956176T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361764969P 2013-02-14 2013-02-14
US201361880779P 2013-09-20 2013-09-20
PCT/US2014/016546 WO2014127268A2 (en) 2013-02-14 2014-02-14 Modulation of apolipoprotein c-iii (apociii) expression in lipoprotein lipase deficient (lpld) populations

Publications (1)

Publication Number Publication Date
DK2956176T3 true DK2956176T3 (en) 2018-08-27

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DK14751357.6T DK2956176T3 (en) 2013-02-14 2014-02-14 MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS

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Country Link
US (4) US9593333B2 (https=)
EP (2) EP2956176B1 (https=)
JP (3) JP6313789B2 (https=)
KR (2) KR20200123263A (https=)
CN (2) CN104994884B (https=)
AU (3) AU2014216137B2 (https=)
BR (1) BR112015019515A8 (https=)
CA (2) CA2901119C (https=)
DK (1) DK2956176T3 (https=)
ES (2) ES2680599T3 (https=)
IL (2) IL240338B (https=)
MX (2) MX368155B (https=)
NZ (1) NZ631119A (https=)
RU (2) RU2661781C2 (https=)
WO (1) WO2014127268A2 (https=)
ZA (1) ZA201505628B (https=)

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US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
KR20200074975A (ko) 2017-10-31 2020-06-25 스태튼 바이오테크놀로지 비.브이. 항-ApoC3 항체 및 이의 사용 방법
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CN121271867A (zh) * 2022-08-05 2026-01-06 厦门甘宝利生物医药有限公司 一种抑制apoc3基因表达的rna抑制剂及其应用
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