DK2952523T3 - Trail-mutant, der er membran-penetrerende og peptid-lignende, fremgangsmåde til fremstilling af samme og anvendelse deraf - Google Patents

Trail-mutant, der er membran-penetrerende og peptid-lignende, fremgangsmåde til fremstilling af samme og anvendelse deraf

Info

Publication number
DK2952523T3
DK2952523T3 DK14877744.4T DK14877744T DK2952523T3 DK 2952523 T3 DK2952523 T3 DK 2952523T3 DK 14877744 T DK14877744 T DK 14877744T DK 2952523 T3 DK2952523 T3 DK 2952523T3
Authority
DK
Denmark
Prior art keywords
peptid
preparing
procedure
similar
same
Prior art date
Application number
DK14877744.4T
Other languages
English (en)
Inventor
Shouchun Chen
Juan Yan
Qi Xu
Haiyang Hu
Xianzhou Huang
Lijia Wei
Original Assignee
Chengdu Huachuang Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chengdu Huachuang Biotechnology Co Ltd filed Critical Chengdu Huachuang Biotechnology Co Ltd
Application granted granted Critical
Publication of DK2952523T3 publication Critical patent/DK2952523T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK14877744.4T 2013-10-14 2014-10-10 Trail-mutant, der er membran-penetrerende og peptid-lignende, fremgangsmåde til fremstilling af samme og anvendelse deraf DK2952523T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201310479275.3A CN103555729B (zh) 2013-10-14 2013-10-14 一种改造的trail基因序列、表达方法及应用
PCT/CN2014/088299 WO2015103894A1 (zh) 2013-10-14 2014-10-10 一种trail穿膜肽样突变体、制备方法及应用

Publications (1)

Publication Number Publication Date
DK2952523T3 true DK2952523T3 (da) 2017-11-06

Family

ID=50010080

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14877744.4T DK2952523T3 (da) 2013-10-14 2014-10-10 Trail-mutant, der er membran-penetrerende og peptid-lignende, fremgangsmåde til fremstilling af samme og anvendelse deraf

Country Status (9)

Country Link
US (1) US9499604B2 (da)
EP (1) EP2952523B1 (da)
JP (1) JP6300913B2 (da)
KR (1) KR101871219B1 (da)
CN (2) CN103555729B (da)
AU (1) AU2014377142B2 (da)
CA (1) CA2925700C (da)
DK (1) DK2952523T3 (da)
WO (1) WO2015103894A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103555729B (zh) * 2013-10-14 2016-08-24 成都华创生物技术有限公司 一种改造的trail基因序列、表达方法及应用
CN106132986B (zh) * 2015-03-02 2019-08-30 成都华创生物技术有限公司 TRAIL穿膜肽样突变体MuR5、制备方法及应用
WO2016138625A1 (zh) * 2015-03-02 2016-09-09 成都华创生物技术有限公司 TRAIL穿膜肽样突变体MuR6、制备方法及应用
EP3348578B1 (en) * 2015-10-22 2019-10-09 Chengdu Huachuang Biotechnology Co., Ltd Double-target mutein mur6s4tr of trail, and preparation method and use thereof
CN110551205B (zh) * 2018-06-01 2023-07-28 云南大学 可溶性人肿瘤坏死因子凋亡相关诱导配体的突变体及其制备方法和应用
CN109125709B (zh) * 2018-08-23 2021-10-22 成都华创生物技术有限公司 Trail突变体在制备治疗痤疮药物中的应用及一种制剂
CN115068590A (zh) * 2021-03-10 2022-09-20 四川大学华西医院 一种肿瘤坏死因子相关凋亡诱导配体突变体的新用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0835305T3 (da) * 1995-06-29 2006-02-13 Immunex Corp Cytokin som inducerer apoptose
CN1500808A (zh) * 2002-11-15 2004-06-02 宏 李 重组人可溶性trail蛋白、其制备方法及其应用
CN1958794B (zh) * 2005-11-03 2010-05-05 成都地奥九泓制药厂 人肿瘤坏死因子相关凋亡诱导配体突变体编码cDNA及制备方法和应用
GB0723059D0 (en) * 2007-11-23 2008-01-02 Nat Univ Ireland Improved cytokine design
GB0724532D0 (en) * 2007-12-17 2008-01-30 Nat Univ Ireland Trail variants for treating cancer
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
MX2011011960A (es) * 2009-05-20 2011-12-06 Toray Industries Peptidos penetradores de celulas.
US8461311B2 (en) * 2010-06-08 2013-06-11 Washington University TRAIL trimers, methods and uses therefor
CN102021173B (zh) * 2010-07-30 2012-11-07 湖北大学 可溶性截短的人trail活性蛋白的制备方法
PL394618A1 (pl) * 2011-04-19 2012-10-22 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe bialko fuzyjne
CN103555729B (zh) * 2013-10-14 2016-08-24 成都华创生物技术有限公司 一种改造的trail基因序列、表达方法及应用

Also Published As

Publication number Publication date
JP6300913B2 (ja) 2018-03-28
JP2016538834A (ja) 2016-12-15
CN105555799B (zh) 2020-04-17
AU2014377142A1 (en) 2016-04-21
EP2952523B1 (en) 2017-08-09
CN103555729A (zh) 2014-02-05
CN105555799A (zh) 2016-05-04
KR20160048936A (ko) 2016-05-04
KR101871219B1 (ko) 2018-06-27
CA2925700A1 (en) 2015-07-16
AU2014377142B2 (en) 2017-07-20
EP2952523A1 (en) 2015-12-09
US9499604B2 (en) 2016-11-22
US20160145317A1 (en) 2016-05-26
CN103555729B (zh) 2016-08-24
EP2952523A4 (en) 2016-06-01
WO2015103894A1 (zh) 2015-07-16
CA2925700C (en) 2019-07-16

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