DK2880155T3 - Anvendelse af den reduktive glycinvej til generering af formatotrofiske og autotrofiske mikroorganismer - Google Patents
Anvendelse af den reduktive glycinvej til generering af formatotrofiske og autotrofiske mikroorganismer Download PDFInfo
- Publication number
- DK2880155T3 DK2880155T3 DK13759023.8T DK13759023T DK2880155T3 DK 2880155 T3 DK2880155 T3 DK 2880155T3 DK 13759023 T DK13759023 T DK 13759023T DK 2880155 T3 DK2880155 T3 DK 2880155T3
- Authority
- DK
- Denmark
- Prior art keywords
- formatotrophic
- organisms
- glycine
- road
- generating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
- C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01002—Formate dehydrogenase (1.2.1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
- C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
- C12Y105/01005—Methylenetetrahydrofolate dehydrogenase (NADP+) (1.5.1.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
- C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
- C12Y105/01015—Methylenetetrahydrofolate dehydrogenase (NAD+) (1.5.1.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04009—Methenyltetrahydrofolate cyclohydrolase (3.5.4.9)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
- C12Y603/04003—Formate--tetrahydrofolate ligase (6.3.4.3)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261676962P | 2012-07-29 | 2012-07-29 | |
PCT/IL2013/050643 WO2014020599A1 (en) | 2012-07-29 | 2013-07-29 | Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2880155T3 true DK2880155T3 (da) | 2019-07-15 |
Family
ID=49117916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK13759023.8T DK2880155T3 (da) | 2012-07-29 | 2013-07-29 | Anvendelse af den reduktive glycinvej til generering af formatotrofiske og autotrofiske mikroorganismer |
Country Status (5)
Country | Link |
---|---|
US (2) | US10155933B2 (da) |
EP (2) | EP3594331A1 (da) |
DK (1) | DK2880155T3 (da) |
ES (1) | ES2730377T3 (da) |
WO (1) | WO2014020599A1 (da) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3594331A1 (en) | 2012-07-29 | 2020-01-15 | Yeda Research and Development Co. Ltd. | Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms |
US20150050708A1 (en) * | 2013-03-15 | 2015-02-19 | Genomatica, Inc. | Microorganisms and methods for producing butadiene and related compounds by formate assimilation |
ES2697757T3 (es) | 2013-12-10 | 2019-01-28 | Yeda Res & Dev | Uso de enzimas que catalizan la síntesis de piruvato a partir de formiato y acetil-CoA y bacterias que expresan la misma |
KR102000755B1 (ko) * | 2016-12-27 | 2019-07-17 | 한국과학기술원 | 외부 유전자가 도입된 재조합 미생물 및 상기 미생물을 이용하여 개미산과 이산화탄소로부터 유용물질을 제조하는 방법 |
WO2018124475A2 (ko) * | 2016-12-27 | 2018-07-05 | 한국과학기술원 | 외부 유전자가 도입된 재조합 미생물 및 상기 미생물을 이용하여 개미산과 이산화탄소로부터 유용물질을 제조하는 방법 |
WO2021084526A1 (en) | 2019-10-31 | 2021-05-06 | Yeda Research And Development Co. Ltd. | Engineered autotrophic bacteria for co2 conversion to organic materials |
EP4073238A1 (en) * | 2019-12-10 | 2022-10-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Novel genetically engineered microorganism capable of growing on formate, methanol, methane or co2 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
DE10047264B4 (de) | 2000-09-23 | 2006-05-04 | G.A.S. Energietechnologie Gmbh | Verfahren zur Nutzung von methanhaltigem Biogas |
MX2010005061A (es) * | 2007-11-10 | 2010-09-09 | Joule Unltd Inc | Organismos hiperfotosinteticos. |
US8349587B2 (en) * | 2011-10-31 | 2013-01-08 | Ginkgo Bioworks, Inc. | Methods and systems for chemoautotrophic production of organic compounds |
EP3594331A1 (en) | 2012-07-29 | 2020-01-15 | Yeda Research and Development Co. Ltd. | Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms |
US20150050708A1 (en) | 2013-03-15 | 2015-02-19 | Genomatica, Inc. | Microorganisms and methods for producing butadiene and related compounds by formate assimilation |
-
2013
- 2013-07-29 EP EP19163469.0A patent/EP3594331A1/en active Pending
- 2013-07-29 EP EP13759023.8A patent/EP2880155B1/en active Active
- 2013-07-29 ES ES13759023T patent/ES2730377T3/es active Active
- 2013-07-29 DK DK13759023.8T patent/DK2880155T3/da active
- 2013-07-29 US US14/417,559 patent/US10155933B2/en active Active
- 2013-07-29 WO PCT/IL2013/050643 patent/WO2014020599A1/en active Application Filing
-
2018
- 2018-10-17 US US16/162,427 patent/US10377994B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ES2730377T3 (es) | 2019-11-11 |
US20190032027A1 (en) | 2019-01-31 |
EP2880155B1 (en) | 2019-04-17 |
EP3594331A1 (en) | 2020-01-15 |
US10377994B2 (en) | 2019-08-13 |
WO2014020599A1 (en) | 2014-02-06 |
US10155933B2 (en) | 2018-12-18 |
EP2880155A1 (en) | 2015-06-10 |
US20150218528A1 (en) | 2015-08-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL244081A0 (en) | Preparations and methods for modulating RNA | |
MX2022000026A (es) | Anticuerpos para tau. | |
DK2935303T3 (da) | 4`-fluornukleosider, 4`-fluornukleotider og analoger dertil til behandling af HCV | |
DK2898061T3 (da) | Probiotiske sammensætninger til behandlingen af fedme og fedme-relaterede tilstande | |
DK3628161T3 (da) | Synergistiske bakterielle sammensætninger og fremgangsmåder til fremstilling og anvendelse deraf | |
MX2013011479A (es) | Anticuerpos anti-fgfr4 y metodos de uso. | |
DK2914627T3 (da) | Anti-cd40-antistoffer og fremgangsmåder til anvendelse | |
DK3594348T3 (da) | Kort c/ebp-alpha til aktivering af rna-sammensætninger og anvendelsesfremgangsmåder | |
PH12014502132A1 (en) | Anti-lgr5 antibodies and immunoconjugates | |
UY34721A (es) | Anticuerpos anti-hla-b*27 y usos de éstos. | |
DK2929031T5 (da) | Pcsk9-irna-sammensætninger og fremgangsmåder til anvendelse deraf | |
DK3252160T3 (da) | Systemer, fremgangsmåder og sammensætninger med crispr-cas-bestanddele til sekvensmanipulation | |
DK2914291T3 (da) | Anti-komplement-c1s-antistoffer og anvendelser deraf | |
EA201590993A1 (ru) | Гетеродимерные иммуноглобулины | |
EP2978300A4 (en) | COMPOSITIONS AND METHODS FOR INCREASING MICROBIAL STABILITY | |
DK2776567T3 (da) | Sammensætninger og fremgangsmåder til behandling af cytomegalovirus. | |
MX2014004022A (es) | Anticuerpos anti-htra1 y metodos de uso. | |
DK3381943T3 (da) | Anti-kit-antistoffer og anvendelser deraf | |
MX336001B (es) | Anticuerpos anti-axl y metodos de uso. | |
CL2015001266A1 (es) | Anticuerpos de antihemaglutinina y métodos de uso. | |
DK2815769T3 (da) | Fam19a5 til anvendelse i diagnosticering og behandling af skader på centralnervesystemet | |
MX2014002053A (es) | Anticuerpos anti -mcsp y metodos de uso. | |
DK2880155T3 (da) | Anvendelse af den reduktive glycinvej til generering af formatotrofiske og autotrofiske mikroorganismer | |
DK3089707T3 (da) | Vævtransplantater og fremgangsmåder til fremstilling og brug af samme | |
PH12014501605A1 (en) | Anti-lrp5 antibodies and methods of use |