DK2836294T3 - Væskeintegreret roterende kugleknuser - Google Patents

Væskeintegreret roterende kugleknuser Download PDF

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DK2836294T3
DK2836294T3 DK13720818.7T DK13720818T DK2836294T3 DK 2836294 T3 DK2836294 T3 DK 2836294T3 DK 13720818 T DK13720818 T DK 13720818T DK 2836294 T3 DK2836294 T3 DK 2836294T3
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closed chamber
sample
chamber
coupled
fluid
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DK13720818.7T
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Fabra Jordi Carrera
Cases Anna Comenges
Blanco Ricard Martin
Gibert Rafael Bru
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Stat-Diagnostica & Innovation S L
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/07—Stirrers characterised by their mounting on the shaft
    • B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
    • B01F27/0721—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis parallel with respect to the rotating axis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/09—Stirrers characterised by the mounting of the stirrers with respect to the receptacle
    • B01F27/092—Stirrers characterised by the mounting of the stirrers with respect to the receptacle occupying substantially the whole interior space of the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
    • B01F27/1121—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades pin-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
    • B01F27/1125—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/115—Stirrers characterised by the configuration of the stirrers comprising discs or disc-like elements essentially perpendicular to the stirrer shaft axis
    • B01F27/1155—Stirrers characterised by the configuration of the stirrers comprising discs or disc-like elements essentially perpendicular to the stirrer shaft axis with interconnected discs, forming open frameworks or cages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/23—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis
    • B01F27/231—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with a variable orientation during mixing operation, e.g. with tiltable rotor axis
    • B01F27/2311—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with a variable orientation during mixing operation, e.g. with tiltable rotor axis the orientation of the rotating shaft being adjustable in the interior of the receptacle, e.g. by tilting the stirrer shaft during the mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
    • B01F33/8305—Devices with one shaft, provided with mixing and milling tools, e.g. using balls or rollers as working tools; Devices with two or more tools rotating about the same axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/16—Mills in which a fixed container houses stirring means tumbling the charge
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C12N1/066—Lysis of microorganisms by physical methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
    • B01F33/8361—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
    • B01F33/83613—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by grinding or milling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/02—Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2866—Grinding or homogeneising
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S366/00—Agitating
    • Y10S366/605—Paint mixer

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  • Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Food Science & Technology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Accessories For Mixers (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Centrifugal Separators (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (26)

1. System til mindst én af homogenisering og lysering af en prøve, hvilket system omfatter: et engangstestpatronsystem, som er konfigureret til at være aftageligt koblet til en analysator og omfatter: et første reservoir (124B); et andet reservoir (116); én eller flere vægge, der danner et lukket kammer (502) med et indløb (132) og en flerhed af væskeforbindelser (203a-c), hvor mindst én af den ene eller de flere vægge i det lukkede kammer omfatter en termisk styret overflade; et første væskenetværk, som er koblet til mindst én af flerheden af væskeforbindelser (203a-c) og konfigureret til at indføre i det mindste prøven til det lukkede kammer (502) fra det mindst ene første reservoir (124B); et andet væskenetværk, som er koblet til mindst én af flerheden af væskeforbindelser (203a-c) og konfigureret til at udstøde i det mindste prøven fra det lukkede kammer (502) til det mindst ene andet reservoir (116); og et roterende element (136), som er anbragt inde i det lukkede kammer; og en aktuator (202), som er koblet til det roterende element (136) af engangstest-patronsystemet og konfigureret til at rotere det roterende element (136) omkring en akse, der strækker sig langs med en længde af det roterende element (136).
2. System ifølge krav 1, hvor den ene eller de flere vægge danner et i det væsentlige cylindrisk lukket kammer (502).
3. System ifølge krav 1, hvor den ene eller de flere vægge danner et lukket kammer (502) med et rektangulært tværsnit.
4. System ifølge krav 1, hvor indløbet (132) er konfigureret til at indføre faste, halvfaste eller flydende prøver fra et eksternt miljø.
5. System ifølge krav 1, hvor indløbet (132) er placeret øverst i det lukkede kammer (502).
6. System ifølge krav 1, hvor indløbet (132) er placeret på siden af det lukkede kammer (502).
7. System ifølge krav 1, der yderligere omfatter et låg (134), som er konfigureret til at passe over indløbet (132) og forhindre lækage.
8. System ifølge krav 1, hvor i det mindste en del af enten det første væskenetværk eller det andet væskenetværk er konfigureret til at sætte tryk på eller fjerne tryk fra det lukkede kammer (502).
9. System ifølge krav 1, der yderligere omfatter et tredje væskenetværk, som er koblet til det lukkede kammer (502) og konfigureret til at sætte tryk på eller fjerne tryk fra det lukkede kammer (502).
10. System ifølge krav 1, der yderligere omfatter et antal kugler (604), som er anbragt inde i det lukkede kammer.
11. System ifølge krav 10, hvor flerheden af kugler (604) omfatter materialer valgt fra gruppen, der er plast, glas, keramik og silika.
12. System ifølge krav 10, hvor flerheden af kugler (604) i diameter går fra 1 mikron til ca. 3000 mikron.
13. System ifølge krav 10, hvor det roterende element (136) er konfigureret til at excite-re flerheden af kugler (604).
14. System ifølge krav 1, hvor aktuatoren (202) er aftageligt koblet til det roterende element (136) via en koblingsmekanisme (302).
15. System ifølge krav 14, der yderligere omfatter en understøtning (140), som er anbragt i det væsentlige ved koblingsmekanismen (302) og konfigureret til at forhindre lækage.
16. System ifølge krav 1, der yderligere omfatter et hulrum (205), som er anbragt på en side af det lukkede kammer (502), således at en opvarmet overflade, der er anbragt op mod hulrummet (205), i det væsentlige hæver temperaturen inde i det lukkede kammer (502).
17. System ifølge krav 1, hvor engangstestpatronsystemet yderligere omfatter et bevægeligt centralt kammer (104), som er koblet til mindst ét af det første væskenetværk og det andet væskenetværk.
18. Fremgangsmåde til homogenisering afen prøve, hvilken fremgangsmåde omfatter: indføring af i det mindste prøven i et lukket kammer (502) via en væskeforbindelse (203a-c), som er koblet til et væskenetværk, der yderligere er koblet til ét eller flere andre kamre (116), hvor én eller flere vægge i det lukkede kammer (502) omfatter en termisk styret overflade, hvor det lukkede kammer (502), væskeforbindelsen (203a-c), væskenetværket og det ene eller de flere andre kamre (116) er anbragt inde i et engangstestpatronsystem; rotering af et roterende element (136), som er anbragt inde i det lukkede kammer, langs med en akse, som strækker sig langs med en længde af det roterende element (136); og homogenisering af prøven i det lukkede kammer (502) via bevægelsen af det roterende element (136).
19. Fremgangsmåde til lysering afen prøve, hvilken fremgangsmåde omfatter: indføring af i det mindste prøven i et lukket kammer (502) via en væskeforbindelse (203a-c), som er koblet til et væskenetværk, der yderligere er koblet til ét eller flere andre kamre (116), hvor én eller flere vægge i det lukkede kammer (502) omfatter en termisk styret overflade, hvor det lukkede kammer (502), væskeforbindelsen (203a-c), væskenetværket og det ene eller de flere andre kamre (116) er anbragt inde i et engangstestpatronsystem; rotering af et roterende element (136), som er anbragt inde i det lukkede kammer (502), langs med en akse, som strækker sig langs med en længde af det roterende element (136); og lysering af prøven i det lukkede kammer (502) via bevægelsen af det roterende element (136).
20. Fremgangsmåde ifølge et hvilket som helst af kravene 18 eller 19, der yderligere omfatter udstødelse af i det mindste prøven fra det lukkede kammer (502) via en anden væskeforbindelse (203a-c), som er koblet til væskenetværket.
21. Fremgangsmåde ifølge et hvilket som helst af kravene 18 eller 19, der yderligere omfatter, at der sættes tryk på eller fjernes tryk fra det lukkede kammer (502) via væskenetværket.
22. Fremgangsmåde ifølge et hvilket som helst af kravene 18 eller 19, der yderligere omfatter fastgørelse afen aktuator (202) til det roterende element (136) via en koblingsmekanisme (302).
23. Fremgangsmåde ifølge et hvilket som helst af kravene 18 eller 19, der yderligere omfatter indføring af i det mindste prøven i det lukkede kammer (502) via et indløb (132), som er konfigureret til at indføre prøver fra et eksternt miljø.
24. Fremgangsmåde ifølge krav 23, hvor indføring af i det mindste prøven via indløbet (132) omfatter indføring af faste, halvfaste eller flydende prøver.
25. Fremgangsmåde ifølge et hvilket som helst af kravene 18 eller 19, der yderligere omfatter opvarmning af prøven via et hulrum (205), som er anbragt på en side af det lukkede kammer (502).
26. Fremgangsmåde ifølge et hvilket som helst af kravene 18 eller 19, der yderligere omfatter excitation af en flerhed af kugler (604), som er anbragt inde i det lukkede kammer (502), ved bevægelse af det roterende element.
DK13720818.7T 2012-04-11 2013-04-11 Væskeintegreret roterende kugleknuser DK2836294T3 (da)

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US13/836,741 US9304066B2 (en) 2012-04-11 2013-03-15 Fluidically integrated rotary bead beader
PCT/EP2013/057625 WO2013153176A1 (en) 2012-04-11 2013-04-11 Fluidically integrated rotary bead beater

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EP (1) EP2836294B1 (da)
JP (2) JP5931275B2 (da)
KR (1) KR102251762B1 (da)
CN (1) CN104703683B (da)
AU (1) AU2013246867B2 (da)
BR (1) BR112014025389B1 (da)
CA (1) CA2870220C (da)
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ES (1) ES2647942T3 (da)
IN (1) IN2014KN02333A (da)
RU (1) RU2638854C2 (da)
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ZA (1) ZA201500087B (da)

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EP2836294B1 (en) 2017-09-20
ES2647942T3 (es) 2017-12-27
US20130280710A1 (en) 2013-10-24
RU2014141794A (ru) 2016-05-27
BR112014025389B1 (pt) 2021-06-01
AU2013246867A8 (en) 2014-12-11
JP2016075703A (ja) 2016-05-12
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EP2836294A1 (en) 2015-02-18
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CA2870220C (en) 2019-08-27
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CN104703683A (zh) 2015-06-10
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WO2013153176A1 (en) 2013-10-17
BR112014025389A2 (pt) 2018-04-10

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