DK2827860T3 - USE OF A pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease - Google Patents
USE OF A pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease Download PDFInfo
- Publication number
- DK2827860T3 DK2827860T3 DK13710851.0T DK13710851T DK2827860T3 DK 2827860 T3 DK2827860 T3 DK 2827860T3 DK 13710851 T DK13710851 T DK 13710851T DK 2827860 T3 DK2827860 T3 DK 2827860T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- obstructive pulmonary
- methylbenzamide
- cyclopropyl
- pulmonary disease
- Prior art date
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-M valerate Chemical class CCCCC([O-])=O NQPDZGIKBAWPEJ-UHFFFAOYSA-M 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613187P | 2012-03-20 | 2012-03-20 | |
| PCT/EP2013/055730 WO2013139809A1 (en) | 2012-03-20 | 2013-03-19 | Use of a pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2827860T3 true DK2827860T3 (en) | 2016-12-12 |
Family
ID=47901996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13710851.0T DK2827860T3 (en) | 2012-03-20 | 2013-03-19 | USE OF A pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US9339491B2 (enExample) |
| EP (1) | EP2827860B1 (enExample) |
| JP (1) | JP6091593B2 (enExample) |
| KR (1) | KR101793777B1 (enExample) |
| CN (1) | CN104203234B (enExample) |
| AU (1) | AU2013237503B2 (enExample) |
| BR (1) | BR112014023107B1 (enExample) |
| CA (1) | CA2866108C (enExample) |
| CL (1) | CL2014002471A1 (enExample) |
| CY (1) | CY1118327T1 (enExample) |
| DK (1) | DK2827860T3 (enExample) |
| ES (1) | ES2605942T3 (enExample) |
| HR (1) | HRP20161514T1 (enExample) |
| HU (1) | HUE032004T2 (enExample) |
| IL (1) | IL234537A (enExample) |
| LT (1) | LT2827860T (enExample) |
| MA (1) | MA37455B1 (enExample) |
| MX (1) | MX351996B (enExample) |
| NZ (1) | NZ628392A (enExample) |
| PH (1) | PH12014502107B1 (enExample) |
| PL (1) | PL2827860T3 (enExample) |
| PT (1) | PT2827860T (enExample) |
| RU (1) | RU2625762C2 (enExample) |
| SG (1) | SG11201404941WA (enExample) |
| SI (1) | SI2827860T1 (enExample) |
| TN (1) | TN2014000350A1 (enExample) |
| TW (1) | TWI583381B (enExample) |
| WO (1) | WO2013139809A1 (enExample) |
| ZA (1) | ZA201405871B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2600822C1 (ru) * | 2015-09-03 | 2016-10-27 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ (ФГБУ "РНЦРХТ" Минздрава России) | Способ лечения хронического обструктивного бронхита |
| RU2600833C1 (ru) * | 2015-09-03 | 2016-10-27 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ (ФГБУ "РНЦРХТ" Минздрава России) | Способ лечения хронической обструктивной болезни легких |
| CA3016488C (en) | 2016-03-08 | 2023-04-11 | Mereo Biopharma 1 Limited | Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease |
| KR20180119597A (ko) * | 2016-03-08 | 2018-11-02 | 메레오 바이오파마 1 리미티드 | 염증 상태의 급성 악화의 치료를 위한 투약법 |
| US10331542B2 (en) * | 2016-06-23 | 2019-06-25 | International Business Machines Corporation | System and method for detecting and alerting unexpected behavior of software applications |
| GB201612238D0 (en) * | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-Yl]-n-cyclopropyl-4-methylbenzamide |
| GB201612240D0 (en) | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| CN114748622B (zh) | 2017-10-05 | 2024-09-24 | 弗尔康医疗公司 | P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd |
| KR102899004B1 (ko) | 2017-12-11 | 2025-12-12 | 메레오 바이오파마 1 리미티드 | 만성 폐쇄성 폐 질환의 급성 악화의 치료에서의 3-[5-아미노-4-(3-시아노벤조일)-피라졸-1-일]-n-시클로프로필-4-메틸벤즈아미드의 용도 |
| AU2018381874B2 (en) | 2017-12-11 | 2024-08-15 | Mereo Biopharma 1 Limited | Use of 3-(5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide in the prevention or reduction of acute exacerbations of chronic obstructive pulmonary disease |
| CN114141383A (zh) * | 2021-12-17 | 2022-03-04 | 湖南大学 | 慢阻肺智能护理方法、装置及系统 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005009973A1 (en) * | 2003-06-26 | 2005-02-03 | Novartis Ag | 5-membered heterocycle-based p38 kinase inhibitors |
| GB0603684D0 (en) * | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
-
2013
- 2013-03-19 SG SG11201404941WA patent/SG11201404941WA/en unknown
- 2013-03-19 WO PCT/EP2013/055730 patent/WO2013139809A1/en not_active Ceased
- 2013-03-19 MX MX2014011291A patent/MX351996B/es active IP Right Grant
- 2013-03-19 AU AU2013237503A patent/AU2013237503B2/en active Active
- 2013-03-19 BR BR112014023107-9A patent/BR112014023107B1/pt active IP Right Grant
- 2013-03-19 CA CA2866108A patent/CA2866108C/en active Active
- 2013-03-19 DK DK13710851.0T patent/DK2827860T3/en active
- 2013-03-19 RU RU2014141893A patent/RU2625762C2/ru active
- 2013-03-19 CN CN201380015703.5A patent/CN104203234B/zh active Active
- 2013-03-19 ES ES13710851.0T patent/ES2605942T3/es active Active
- 2013-03-19 JP JP2015500892A patent/JP6091593B2/ja active Active
- 2013-03-19 KR KR1020147025904A patent/KR101793777B1/ko active Active
- 2013-03-19 TW TW102109739A patent/TWI583381B/zh active
- 2013-03-19 PL PL13710851T patent/PL2827860T3/pl unknown
- 2013-03-19 SI SI201330397A patent/SI2827860T1/sl unknown
- 2013-03-19 MA MA37455A patent/MA37455B1/fr unknown
- 2013-03-19 LT LTEP13710851.0T patent/LT2827860T/lt unknown
- 2013-03-19 NZ NZ628392A patent/NZ628392A/en unknown
- 2013-03-19 EP EP13710851.0A patent/EP2827860B1/en active Active
- 2013-03-19 HU HUE13710851A patent/HUE032004T2/en unknown
- 2013-03-19 US US14/386,174 patent/US9339491B2/en active Active
- 2013-03-19 HR HRP20161514TT patent/HRP20161514T1/hr unknown
- 2013-03-19 PT PT137108510T patent/PT2827860T/pt unknown
-
2014
- 2014-08-11 ZA ZA2014/05871A patent/ZA201405871B/en unknown
- 2014-08-11 TN TNP2014000350A patent/TN2014000350A1/fr unknown
- 2014-09-08 IL IL234537A patent/IL234537A/en active IP Right Grant
- 2014-09-17 CL CL2014002471A patent/CL2014002471A1/es unknown
- 2014-09-22 PH PH12014502107A patent/PH12014502107B1/en unknown
-
2016
- 2016-04-29 US US15/143,356 patent/US20160243081A1/en not_active Abandoned
- 2016-11-18 CY CY20161101194T patent/CY1118327T1/el unknown
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