DK2803366T3 - Sammensætninger til behandling eller forebyggelse af oxalat-relateret sygdom - Google Patents

Sammensætninger til behandling eller forebyggelse af oxalat-relateret sygdom Download PDF

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Publication number
DK2803366T3
DK2803366T3 DK14180734.7T DK14180734T DK2803366T3 DK 2803366 T3 DK2803366 T3 DK 2803366T3 DK 14180734 T DK14180734 T DK 14180734T DK 2803366 T3 DK2803366 T3 DK 2803366T3
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Denmark
Prior art keywords
oxalate
enzymes
compositions
reducing
bacteria
Prior art date
Application number
DK14180734.7T
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English (en)
Inventor
Harmeet Sidhu
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Oxthera Intellectual Property Ab
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Publication of DK2803366T3 publication Critical patent/DK2803366T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/03—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with oxygen as acceptor (1.2.3)
    • C12Y102/03004—Oxalate oxidase (1.2.3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
    • C12Y208/03—CoA-transferases (2.8.3)
    • C12Y208/03016—Formyl-CoA transferase (2.8.3.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01002—Oxalate decarboxylase (4.1.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01008—Oxalyl-CoA decarboxylase (4.1.1.8)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Claims (4)

1. Farmaceutisk sammensætning omfattende oxalat-decarboxylase, til anvendelse i den terapeutiske behandling afen oxalat-relateret sygdom ved at reducere en oxalat-koncentration hos et menneske, hvor sammensætningen administreres mere end én gang om dagen kontinuerligt hver dag i en periode på måneder eller år og hvor nævnte oxalat-relateret sygdom er valgt fra gruppen bestående af hyperoxaluri, primær hyperoxaluri, idiopatisk calcium-oxalat-nyrestenssygdom (urolithiasis) og enterisk hyperoxaluri.
2. Den farmaceutiske sammensætning til anvendelse ifølge krav 1, hvor sammensætningen omfatter en enterisk coating.
3. Den farmaceutiske sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-2, hvor det ene eller flere enzymer er til stede i en mængde på 5 til 5000 aktivitetsenheder af oxalat-reducerende enzymaktivitet.
4. Den farmaceutiske sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-3, hvor sammensætningen yderligere omfatter coenzymer og/eller co-faktorer.
DK14180734.7T 2004-06-15 2005-06-15 Sammensætninger til behandling eller forebyggelse af oxalat-relateret sygdom DK2803366T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/868,242 US8486389B2 (en) 1997-05-23 2004-06-15 Compositions and methods for treating or preventing oxalate-related disease
EP05786347.4A EP1771201B1 (en) 2004-06-15 2005-06-15 Compositions and methods for treating or preventing oxalate-related disease

Publications (1)

Publication Number Publication Date
DK2803366T3 true DK2803366T3 (da) 2018-11-05

Family

ID=35510266

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05786347.4T DK1771201T3 (da) 2004-06-15 2005-06-15 Sammensætninger og fremgangsmåder til behandling eller forebyggelse af oxalat-relateret sygdom
DK14180734.7T DK2803366T3 (da) 2004-06-15 2005-06-15 Sammensætninger til behandling eller forebyggelse af oxalat-relateret sygdom

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK05786347.4T DK1771201T3 (da) 2004-06-15 2005-06-15 Sammensætninger og fremgangsmåder til behandling eller forebyggelse af oxalat-relateret sygdom

Country Status (13)

Country Link
US (3) US8486389B2 (da)
EP (2) EP1771201B1 (da)
CN (2) CN104998253A (da)
CY (2) CY1115745T1 (da)
DK (2) DK1771201T3 (da)
ES (2) ES2692148T3 (da)
HK (2) HK1198922A1 (da)
LT (1) LT2803366T (da)
PL (2) PL1771201T3 (da)
PT (2) PT1771201E (da)
SI (2) SI2803366T1 (da)
TR (1) TR201815200T4 (da)
WO (1) WO2005123116A2 (da)

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Also Published As

Publication number Publication date
CN101166421A (zh) 2008-04-23
PL2803366T3 (pl) 2018-12-31
US10653726B2 (en) 2020-05-19
CY1120782T1 (el) 2019-12-11
US20190091268A1 (en) 2019-03-28
ES2692148T3 (es) 2018-11-30
EP2803366A3 (en) 2015-02-18
PT2803366T (pt) 2018-11-06
HK1198922A1 (en) 2015-06-19
US20140030324A1 (en) 2014-01-30
PL1771201T3 (pl) 2015-01-30
TR201815200T4 (tr) 2018-11-21
WO2005123116A3 (en) 2008-01-03
EP1771201A2 (en) 2007-04-11
ES2522898T3 (es) 2014-11-19
EP2803366A2 (en) 2014-11-19
US10149866B2 (en) 2018-12-11
CY1115745T1 (el) 2017-01-25
WO2005123116A2 (en) 2005-12-29
EP1771201A4 (en) 2011-01-19
HK1216080A1 (zh) 2016-10-14
US8486389B2 (en) 2013-07-16
DK1771201T3 (da) 2014-11-03
PT1771201E (pt) 2014-11-06
CN104998253A (zh) 2015-10-28
LT2803366T (lt) 2018-12-27
EP1771201B1 (en) 2014-08-13
SI1771201T1 (sl) 2014-12-31
EP2803366B1 (en) 2018-08-01
SI2803366T1 (sl) 2018-12-31
US20040234514A1 (en) 2004-11-25

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