DK2797921T3 - FUSED TETRA- OR PENTA-CYCLIC DIHYDRODIAZEPINOCARBAZOLONES AS PARB INHIBITORS - Google Patents

Info

Publication number

DK2797921T3

DK2797921T3 DK11878508.8T DK11878508T DK2797921T3 DK 2797921 T3 DK2797921 T3 DK 2797921T3 DK 11878508 T DK11878508 T DK 11878508T DK 2797921 T3 DK2797921 T3 DK 2797921T3

Authority

DK

Denmark

Prior art keywords

alkyl

aryl

cycloalkyl

heterocyclyl

heteroaryl

Prior art date

2011-12-31

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• 239000003112 inhibitor Substances 0.000 title description 12
• 125000000217 alkyl group Chemical group 0.000 claims description 174
• 125000003118 aryl group Chemical group 0.000 claims description 158
• 150000001875 compounds Chemical class 0.000 claims description 138
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 137
• 125000000623 heterocyclic group Chemical group 0.000 claims description 126
• 125000001072 heteroaryl group Chemical group 0.000 claims description 108
• 125000003342 alkenyl group Chemical group 0.000 claims description 92
• 125000000304 alkynyl group Chemical group 0.000 claims description 92
• 125000001424 substituent group Chemical group 0.000 claims description 92
• 239000001257 hydrogen Substances 0.000 claims description 85
• 229910052739 hydrogen Inorganic materials 0.000 claims description 85
• 150000003839 salts Chemical class 0.000 claims description 80
• 229920006395 saturated elastomer Polymers 0.000 claims description 48
• 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims description 46
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• 229910052736 halogen Inorganic materials 0.000 claims description 32
• 150000002367 halogens Chemical class 0.000 claims description 32
• 125000001188 haloalkyl group Chemical group 0.000 claims description 28
• 125000004429 atom Chemical group 0.000 claims description 27
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 20
• 201000011510 cancer Diseases 0.000 claims description 19
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 19
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
• 230000005764 inhibitory process Effects 0.000 claims description 15
• 229910052717 sulfur Inorganic materials 0.000 claims description 15
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
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• 229910052799 carbon Inorganic materials 0.000 claims description 10
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 10
• 101100134929 Gallus gallus COR9 gene Chemical group 0.000 claims description 8
• 239000003937 drug carrier Substances 0.000 claims description 5
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• 239000000203 mixture Substances 0.000 description 50
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