IN2014DN06169A - - Google Patents
Info
- Publication number
- IN2014DN06169A IN2014DN06169A IN6169DEN2014A IN2014DN06169A IN 2014DN06169 A IN2014DN06169 A IN 2014DN06169A IN 6169DEN2014 A IN6169DEN2014 A IN 6169DEN2014A IN 2014DN06169 A IN2014DN06169 A IN 2014DN06169A
- Authority
- IN
- India
- Prior art keywords
- salts
- compositions
- methods
- cyclic compounds
- certain fused
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Provided are certain fused tetra or penta cyclic compounds and salts thereof compositions thereof and methods of use thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2011/085148 WO2013097225A1 (en) | 2011-12-31 | 2011-12-31 | Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN06169A true IN2014DN06169A (en) | 2015-08-21 |
Family
ID=48696280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN6169DEN2014 IN2014DN06169A (en) | 2011-12-31 | 2011-12-31 |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US9260440B2 (en) |
| EP (2) | EP3315500B1 (en) |
| JP (1) | JP6034877B2 (en) |
| KR (1) | KR101716012B1 (en) |
| CN (2) | CN106220635B (en) |
| AU (1) | AU2011384858B2 (en) |
| BR (1) | BR112014012628B8 (en) |
| CA (1) | CA2856309C (en) |
| CY (1) | CY1119804T1 (en) |
| DK (1) | DK2797921T3 (en) |
| EA (1) | EA027533B1 (en) |
| ES (1) | ES2645814T3 (en) |
| HK (1) | HK1192233A1 (en) |
| HR (1) | HRP20171883T1 (en) |
| HU (1) | HUE035153T2 (en) |
| IL (1) | IL233365A (en) |
| IN (1) | IN2014DN06169A (en) |
| LT (1) | LT2797921T (en) |
| ME (1) | ME02855B (en) |
| MX (1) | MX353578B (en) |
| NO (1) | NO2797921T3 (en) |
| NZ (1) | NZ624063A (en) |
| PL (1) | PL2797921T3 (en) |
| PT (1) | PT2797921T (en) |
| RS (1) | RS56616B1 (en) |
| SG (1) | SG11201401726VA (en) |
| SI (1) | SI2797921T1 (en) |
| WO (1) | WO2013097225A1 (en) |
| ZA (1) | ZA201405560B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2797921T (en) | 2011-12-31 | 2017-11-14 | Beigene Ltd | Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors |
| AU2013229229B2 (en) | 2012-03-07 | 2017-10-19 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| NO3044221T3 (en) | 2013-09-11 | 2018-07-21 | ||
| KR20180041748A (en) * | 2015-08-25 | 2018-04-24 | 베이진 엘티디 | PARP inhibitors, processes for preparing crystalline forms and uses thereof |
| MX2018011419A (en) * | 2016-04-01 | 2019-06-06 | Zeno Royalties & Milestones Llc | Estrogen receptor modulators. |
| CN110087730B (en) * | 2016-09-27 | 2023-03-28 | 百济神州(苏州)生物科技有限公司 | Treatment of cancer using a combination comprising a PARP inhibitor |
| US10899763B2 (en) | 2017-02-28 | 2021-01-26 | Beigene, Ltd. | Crystalline forms of salts of fused penta-cyclic dihydrodiazepinocarbazolones, and uses thereof |
| CN106883232B (en) | 2017-03-31 | 2019-01-22 | 苏州康润医药有限公司 | A kind of derivative and the preparation method and application thereof of non-that alkene -3- ketone of azepine |
| EP3654985A4 (en) * | 2017-07-17 | 2021-04-07 | BeiGene, Ltd. | Treatment cancers using a combination comprising parp inhibitors, temozolomide and/or radiation therapy |
| US20210205323A1 (en) * | 2018-06-01 | 2021-07-08 | Beigene, Ltd. | Maintenance therapy of a parp inhibitor in treating gastric cancer |
| CN111171031B (en) * | 2019-05-10 | 2021-04-09 | 百济神州(苏州)生物科技有限公司 | Preparation method of sesquihydrate product containing PARP inhibitor |
| CN113402502B (en) * | 2019-05-16 | 2022-10-14 | 百济神州(苏州)生物科技有限公司 | Material combination system for preparing PARP inhibitor intermediate |
| JP2022534093A (en) | 2019-05-31 | 2022-07-27 | ベイジーン リミテッド | PARP inhibitor pellet formulation and its preparation method |
| EP3993787A4 (en) | 2019-08-06 | 2023-07-12 | Recurium IP Holdings, LLC | Estrogen receptor modulators for treating mutants |
| WO2021046014A1 (en) | 2019-09-03 | 2021-03-11 | Teva Czech Industries S.R.O | Solid state forms of pamiparib and process for preparation thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE445326B (en) | 1983-04-05 | 1986-06-16 | Malmstroem Anders E H | SET AND DEVICE FOR THE PREVENTION OF WALL TURNS |
| US6799298B2 (en) | 1998-03-11 | 2004-09-28 | Overture Services, Inc. | Technique for locating an item of interest within a stored representation of data |
| HU229875B1 (en) | 1999-01-11 | 2014-11-28 | Agouron Pharmaceuticals Inc La Jolla | Tricyclic inhibitors of poly(adp-ribose) polymerases |
| JP4323802B2 (en) | 2000-12-01 | 2009-09-02 | エムジーアイ・ジーピー・インコーポレーテッド | Compounds and uses thereof |
| US6423705B1 (en) | 2001-01-25 | 2002-07-23 | Pfizer Inc. | Combination therapy |
| US6906096B2 (en) | 2002-06-28 | 2005-06-14 | Irm Llc | 4,7-Disubstituted indoles and methods of making |
| ES2309484T3 (en) | 2003-01-09 | 2008-12-16 | Pfizer Inc. | DERIVATIVES OF DIAZEPINOINDOL AS QUINASA INHIBITORS. |
| MXPA05012812A (en) | 2003-05-28 | 2006-02-28 | Guilford Pharm Inc | Compounds, methods and pharmaceutical compositions for inhibiting parp. |
| CA2648371A1 (en) | 2006-04-04 | 2007-10-11 | Pfizer Products Inc. | Combination therapy of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4-yl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide |
| EP2004655A1 (en) | 2006-04-04 | 2008-12-24 | Pfizer Products Incorporated | Polymorphic forms of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4 l)-1-oxo-2,6-dihydro-1h-ý1,2¨diazepinoý4,5,6-cd¨indol-8-yl)acetamide |
| BRPI0820236A2 (en) | 2007-11-15 | 2015-06-16 | Angeletti P Ist Richerche Bio | Pyridazinone derivatives as parp inhibitors |
| BRPI0917119B1 (en) * | 2008-08-06 | 2021-07-13 | Medivation Technologies, Inc. | COMPOUND, PHARMACEUTICAL COMPOSITION, USE OF THE SAME AND ITS MANUFACTURING PROCESS |
| WO2011130661A1 (en) | 2010-04-16 | 2011-10-20 | Biomarin Pharmaceutical Inc. | Methods of using dihydropyridophthalazinone inhibitors of poly (adp-ribose)polymerase (parp) |
| PT2797921T (en) | 2011-12-31 | 2017-11-14 | Beigene Ltd | Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors |
| CN107011441B (en) | 2013-09-13 | 2020-12-01 | 百济神州(广州)生物科技有限公司 | anti-PD 1 antibodies and their use as therapeutic and diagnostic agents |
| KR102003754B1 (en) | 2014-07-03 | 2019-07-25 | 베이진 엘티디 | Anti-PD-L1 Antibodies and Their Use as Therapeutics and Diagnostics |
| US9637488B2 (en) | 2015-01-29 | 2017-05-02 | Fuqiang Ruan | Heterocyclic compounds as inhibitors of class I PI3KS |
| KR20180041748A (en) | 2015-08-25 | 2018-04-24 | 베이진 엘티디 | PARP inhibitors, processes for preparing crystalline forms and uses thereof |
| CN110087730B (en) | 2016-09-27 | 2023-03-28 | 百济神州(苏州)生物科技有限公司 | Treatment of cancer using a combination comprising a PARP inhibitor |
| US10899763B2 (en) | 2017-02-28 | 2021-01-26 | Beigene, Ltd. | Crystalline forms of salts of fused penta-cyclic dihydrodiazepinocarbazolones, and uses thereof |
| EP3654985A4 (en) | 2017-07-17 | 2021-04-07 | BeiGene, Ltd. | Treatment cancers using a combination comprising parp inhibitors, temozolomide and/or radiation therapy |
-
2011
- 2011-12-31 PT PT118785088T patent/PT2797921T/en unknown
- 2011-12-31 RS RS20171228A patent/RS56616B1/en unknown
- 2011-12-31 ES ES11878508.8T patent/ES2645814T3/en active Active
- 2011-12-31 LT LTEP11878508.8T patent/LT2797921T/en unknown
- 2011-12-31 ME MEP-2017-278A patent/ME02855B/en unknown
- 2011-12-31 WO PCT/CN2011/085148 patent/WO2013097225A1/en active Application Filing
- 2011-12-31 HU HUE11878508A patent/HUE035153T2/en unknown
- 2011-12-31 CA CA2856309A patent/CA2856309C/en active Active
- 2011-12-31 DK DK11878508.8T patent/DK2797921T3/en active
- 2011-12-31 MX MX2014007840A patent/MX353578B/en active IP Right Grant
- 2011-12-31 NZ NZ624063A patent/NZ624063A/en unknown
- 2011-12-31 SG SG11201401726VA patent/SG11201401726VA/en unknown
- 2011-12-31 US US14/369,374 patent/US9260440B2/en active Active
- 2011-12-31 JP JP2014549295A patent/JP6034877B2/en active Active
- 2011-12-31 EP EP17183473.2A patent/EP3315500B1/en active Active
- 2011-12-31 SI SI201131351T patent/SI2797921T1/en unknown
- 2011-12-31 CN CN201610603192.4A patent/CN106220635B/en active Active
- 2011-12-31 KR KR1020147018104A patent/KR101716012B1/en active IP Right Grant
- 2011-12-31 BR BR112014012628A patent/BR112014012628B8/en active IP Right Grant
- 2011-12-31 EP EP11878508.8A patent/EP2797921B1/en active Active
- 2011-12-31 AU AU2011384858A patent/AU2011384858B2/en active Active
- 2011-12-31 PL PL11878508T patent/PL2797921T3/en unknown
- 2011-12-31 CN CN201180072418.8A patent/CN103703004B/en active Active
- 2011-12-31 IN IN6169DEN2014 patent/IN2014DN06169A/en unknown
- 2011-12-31 NO NO11878508A patent/NO2797921T3/no unknown
- 2011-12-31 EA EA201491303A patent/EA027533B1/en not_active IP Right Cessation
-
2014
- 2014-06-12 HK HK14105542.6A patent/HK1192233A1/en unknown
- 2014-06-25 IL IL233365A patent/IL233365A/en active IP Right Grant
- 2014-07-28 ZA ZA2014/05560A patent/ZA201405560B/en unknown
-
2016
- 2016-01-05 US US14/988,484 patent/US9617273B2/en active Active
-
2017
- 2017-04-05 US US15/479,958 patent/US10112952B2/en active Active
- 2017-11-16 CY CY20171101198T patent/CY1119804T1/en unknown
- 2017-12-04 HR HRP20171883TT patent/HRP20171883T1/en unknown
-
2018
- 2018-09-19 US US16/135,512 patent/US10501467B2/en active Active
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