DK2793878T3 - COMBINATION OF (3S, 3S ') 4,4'-DISULFANDIYLBIS (3-AMINOBUTANE 1-SULPHONIC ACID) AND ANOTHER ANTI-HYPERTENSIVE AGENT - Google Patents

COMBINATION OF (3S, 3S ') 4,4'-DISULFANDIYLBIS (3-AMINOBUTANE 1-SULPHONIC ACID) AND ANOTHER ANTI-HYPERTENSIVE AGENT Download PDF

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Publication number
DK2793878T3
DK2793878T3 DK12812987.1T DK12812987T DK2793878T3 DK 2793878 T3 DK2793878 T3 DK 2793878T3 DK 12812987 T DK12812987 T DK 12812987T DK 2793878 T3 DK2793878 T3 DK 2793878T3
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Prior art keywords
angiotensin
pharmaceutical composition
aminobutane
enalapril
sulfonic acid
Prior art date
Application number
DK12812987.1T
Other languages
Danish (da)
English (en)
Inventor
Catherine Llorens-Cortes
Yannick Marc
Ji Gao-Desliens
Fabrice Balavoine
Lionel Segard
Original Assignee
Quantum Genomics
Inserm (Institut Nat De La Santé Et De La Rech Médicale)
Centre Nat Rech Scient
College France
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Application filed by Quantum Genomics, Inserm (Institut Nat De La Santé Et De La Rech Médicale), Centre Nat Rech Scient, College France filed Critical Quantum Genomics
Application granted granted Critical
Publication of DK2793878T3 publication Critical patent/DK2793878T3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401Proline; Derivatives thereof, e.g. captopril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/005Enzyme inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK12812987.1T 2011-12-21 2012-12-21 COMBINATION OF (3S, 3S ') 4,4'-DISULFANDIYLBIS (3-AMINOBUTANE 1-SULPHONIC ACID) AND ANOTHER ANTI-HYPERTENSIVE AGENT DK2793878T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11306735 2011-12-21
PCT/EP2012/076607 WO2013092984A1 (en) 2011-12-21 2012-12-21 Combination of (3s,3s') 4,4'-disulfanediylbis(3-aminobutane 1-sulfonic acid) and a second antihypertensive agent

Publications (1)

Publication Number Publication Date
DK2793878T3 true DK2793878T3 (en) 2017-03-27

Family

ID=47522577

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12812987.1T DK2793878T3 (en) 2011-12-21 2012-12-21 COMBINATION OF (3S, 3S ') 4,4'-DISULFANDIYLBIS (3-AMINOBUTANE 1-SULPHONIC ACID) AND ANOTHER ANTI-HYPERTENSIVE AGENT

Country Status (25)

Country Link
US (1) US10959938B2 (enExample)
EP (1) EP2793878B1 (enExample)
JP (2) JP6212500B2 (enExample)
KR (1) KR20140116879A (enExample)
CN (2) CN104220062B (enExample)
AU (1) AU2012356895B2 (enExample)
BR (1) BR112014015276B1 (enExample)
CA (1) CA2859704C (enExample)
CY (1) CY1118711T1 (enExample)
DK (1) DK2793878T3 (enExample)
EA (1) EA028718B1 (enExample)
ES (1) ES2619027T3 (enExample)
HR (1) HRP20170267T1 (enExample)
HU (1) HUE033403T2 (enExample)
IL (1) IL233156B (enExample)
IN (1) IN2014DN05787A (enExample)
LT (1) LT2793878T (enExample)
MX (1) MX345469B (enExample)
PL (1) PL2793878T3 (enExample)
PT (1) PT2793878T (enExample)
RS (1) RS55774B1 (enExample)
SI (1) SI2793878T1 (enExample)
SM (1) SMT201700156T1 (enExample)
WO (1) WO2013092984A1 (enExample)
ZA (1) ZA201405266B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE033403T2 (en) * 2011-12-21 2017-11-28 Quantum Genomics Combination with (3S, 3S ') - 4,4'-disulfandyl-bis (3-aminobutane-1-sulfonic acid) and a second antihypertensive agent
TW202207917A (zh) * 2020-05-06 2022-03-01 法商量子基因科技有限公司 包含腦胺肽酶抑制劑、利尿劑及全身性腎素-血管收縮素系統阻斷劑之醫藥組合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2773712B1 (fr) * 1998-01-16 2000-06-02 Inst Nat Sante Rech Med Composition pharmaceutique comprenant au moins un inhibiteur de l'aminopeptidase a
AU2003271811A1 (en) * 2002-07-16 2004-02-02 Institut National De La Sante Et De La Recherche Medicale (Inserm) Novel derivatives of 4,4'-dithiobis-(3-aminobutane-1-sulphonates) and compositions containing same
FR2858617A1 (fr) * 2003-08-06 2005-02-11 Inst Nat Sante Rech Med Derives de 4',4'-dithiobis-(3-aminobutane-1-sulfonate-1- sulfonates) nouveaux et compositions les contenant
US20080014187A1 (en) * 2006-07-15 2008-01-17 Bryant Villeponteau Compositions and Methods for Treating Hypertension and Inflammation
HUE033403T2 (en) * 2011-12-21 2017-11-28 Quantum Genomics Combination with (3S, 3S ') - 4,4'-disulfandyl-bis (3-aminobutane-1-sulfonic acid) and a second antihypertensive agent

Also Published As

Publication number Publication date
CN109464432A (zh) 2019-03-15
PT2793878T (pt) 2017-03-23
BR112014015276A8 (pt) 2017-06-13
MX2014007547A (es) 2014-08-01
CA2859704A1 (en) 2013-06-27
NZ627251A (en) 2015-08-28
BR112014015276B1 (pt) 2020-09-29
EA201400724A1 (ru) 2014-09-30
CY1118711T1 (el) 2017-07-12
US10959938B2 (en) 2021-03-30
JP6726138B2 (ja) 2020-07-22
HUE033403T2 (en) 2017-11-28
JP2017222696A (ja) 2017-12-21
ES2619027T3 (es) 2017-06-22
RS55774B1 (sr) 2017-07-31
LT2793878T (lt) 2017-05-25
MX345469B (es) 2017-02-01
PL2793878T3 (pl) 2017-08-31
AU2012356895A1 (en) 2014-07-31
HK1203051A1 (en) 2015-10-16
BR112014015276A2 (pt) 2017-06-13
CN104220062B (zh) 2018-06-15
SMT201700156T1 (it) 2017-05-08
IL233156A0 (en) 2014-07-31
JP6212500B2 (ja) 2017-10-11
WO2013092984A1 (en) 2013-06-27
EP2793878B1 (en) 2017-02-01
HRP20170267T1 (hr) 2017-05-19
ZA201405266B (en) 2016-06-29
AU2012356895B2 (en) 2017-05-25
JP2015506338A (ja) 2015-03-02
CA2859704C (en) 2020-04-28
KR20140116879A (ko) 2014-10-06
SI2793878T1 (sl) 2017-07-31
IN2014DN05787A (enExample) 2015-05-15
EA028718B1 (ru) 2017-12-29
IL233156B (en) 2018-05-31
US20150320703A1 (en) 2015-11-12
CN104220062A (zh) 2014-12-17
EP2793878A1 (en) 2014-10-29

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