DK2791138T3 - Substituted pyrazole [1,5-a] pyridines as tropomyosin receptor kinase (TRK) inhibitors. - Google Patents

Substituted pyrazole [1,5-a] pyridines as tropomyosin receptor kinase (TRK) inhibitors. Download PDF

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Publication number
DK2791138T3
DK2791138T3 DK12832784.8T DK12832784T DK2791138T3 DK 2791138 T3 DK2791138 T3 DK 2791138T3 DK 12832784 T DK12832784 T DK 12832784T DK 2791138 T3 DK2791138 T3 DK 2791138T3
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carboxamide
pyridine
pyrrolidin
pyrazole
difluorophenyl
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DK12832784.8T
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Danish (da)
English (en)
Inventor
Ashok Tehim
Pradip Kumar Sasmal
Shahadat Ahmed
Vidyadhar Paradkar
Prasanna M Dattatreya
Nanjegowda Jagadeesh Mavinahalli
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Dr Reddys Laboratories Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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DK12832784.8T 2011-12-12 2012-12-12 Substituted pyrazole [1,5-a] pyridines as tropomyosin receptor kinase (TRK) inhibitors. DK2791138T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4329CH2011 2011-12-12
PCT/IB2012/003012 WO2013088256A1 (en) 2011-12-12 2012-12-12 Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (trk) inhibitors

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DK2791138T3 true DK2791138T3 (en) 2018-09-17

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DK12832784.8T DK2791138T3 (en) 2011-12-12 2012-12-12 Substituted pyrazole [1,5-a] pyridines as tropomyosin receptor kinase (TRK) inhibitors.

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US (7) US9045478B2 (https=)
EP (2) EP2791139B1 (https=)
JP (1) JP5990595B2 (https=)
KR (2) KR20140105508A (https=)
CN (1) CN104114553B (https=)
AU (1) AU2012351748B2 (https=)
BR (1) BR112014014276A2 (https=)
CA (1) CA2858958C (https=)
CL (1) CL2014001529A1 (https=)
CO (1) CO7071124A2 (https=)
DK (1) DK2791138T3 (https=)
EA (1) EA025352B1 (https=)
ES (1) ES2686501T3 (https=)
IL (1) IL233067B (https=)
MX (1) MX356401B (https=)
WO (2) WO2013088256A1 (https=)

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WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
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CN113354649B (zh) 2014-11-16 2024-12-10 阵列生物制药公司 一种新的晶型
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FI3439662T3 (fi) 2016-04-04 2024-09-04 Loxo Oncology Inc (s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin nesteformulaatioita
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