DK2758061T3 - Kombination af antibiotika til behandling af en autoimmun lidelse - Google Patents

Kombination af antibiotika til behandling af en autoimmun lidelse Download PDF

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DK2758061T3
DK2758061T3 DK12834382.9T DK12834382T DK2758061T3 DK 2758061 T3 DK2758061 T3 DK 2758061T3 DK 12834382 T DK12834382 T DK 12834382T DK 2758061 T3 DK2758061 T3 DK 2758061T3
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mice
eae
disease
treatment
day
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Reza Fathi
Patrick Laughlin Mclean
Harry Jefferson Leighton
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Redhill Biopharma Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
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    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
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    • AHUMAN NECESSITIES
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5929,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Claims (6)

  1. KOMBINATION AF ANTIBIOTIKA TIL BEHANDLING AF EN AUTOIMMUN LIDELSE Patentkrav
    1. Kombination af tre antibiotika omfattende clarithromycin, rifabutin, og clofazimin til anvendelse i behandlingen af multipel sklerose.
  2. 2. Kombination af tre antibiotika ifølge krav 1 til anvendelse i behandlingen af relapserende-remitterende multipel sklerose.
  3. 3. Kombinationen af krav 1, yderligere omfattende vitamin D.
  4. 4. Kombinationen af krav 1, yderligere omfattende en anti-inflammatorisk agent.
  5. 5. Kombinationen af krav 1, yderligere omfattende en cyclin-afhængig kinaseinhibitor.
  6. 6. Kombinationen af krav 1, yderligere omfattende en aktiveret T-celle transkriptionsinhibitor.
DK12834382.9T 2011-09-20 2012-09-19 Kombination af antibiotika til behandling af en autoimmun lidelse DK2758061T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161536824P 2011-09-20 2011-09-20
US201161537229P 2011-09-21 2011-09-21
PCT/IB2012/002252 WO2013041963A2 (en) 2011-09-20 2012-09-19 A composition and method for treating an autoimmune disease

Publications (1)

Publication Number Publication Date
DK2758061T3 true DK2758061T3 (da) 2017-02-20

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US (1) US9901638B2 (da)
EP (1) EP2758061B1 (da)
JP (1) JP6035340B2 (da)
KR (1) KR101987512B1 (da)
CN (1) CN103813797B (da)
AU (1) AU2012311235B2 (da)
BR (1) BR112014006473A2 (da)
CA (1) CA2849255C (da)
CL (1) CL2014000671A1 (da)
DK (1) DK2758061T3 (da)
ES (1) ES2614923T3 (da)
HU (1) HUE032959T2 (da)
IL (1) IL231489A (da)
IN (1) IN2014CN02908A (da)
MX (1) MX347660B (da)
PL (1) PL2758061T3 (da)
PT (1) PT2758061T (da)
RU (1) RU2621129C2 (da)
SG (1) SG11201400386RA (da)
TW (1) TWI573590B (da)
WO (1) WO2013041963A2 (da)
ZA (1) ZA201401954B (da)

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Publication number Priority date Publication date Assignee Title
US20160089363A1 (en) * 2013-04-30 2016-03-31 Thomas Julius Borody Compositions and methods for treating microbiota-related psychotropic conditions and diseases
CA2953110C (en) 2014-05-22 2018-10-30 John Todd Kuenstner Treatment of diseases caused by mycobacterium avium using a combination of ultraviolet blood irradiation and antibiotics
AU2016336133B2 (en) * 2015-10-06 2021-02-25 Redhill Biopharma Ltd. Combination therapies for treating cancer
WO2017191560A1 (en) 2016-05-02 2017-11-09 Prothena Biosciences Limited Antibodies recognizing tau
CN111148531A (zh) 2017-09-08 2020-05-12 伊夫罗生物科学公司 细菌胞外囊泡
JP2023533472A (ja) * 2020-06-30 2023-08-03 レッド ヒル バイオファーマ リミテッド 肺非結核性真菌感染症を治療するための三重抗生物質固定用量コンビネーション製品、投与レジメン、方法及びキット
WO2023182288A1 (ja) * 2022-03-22 2023-09-28 国立大学法人京都大学 シャルコー・マリー・ツース病の治療または予防薬

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043667A1 (en) * 1997-04-01 1998-10-08 Borody Thomas J Methods and compositions for treating inflammatory bowel disease
US7488580B1 (en) 2005-03-10 2009-02-10 University Of Central Florida Research Foundation, Inc. Protocol for detection of Mycobacterium avium subspecies paratuberculosis in blood
US20090054380A1 (en) * 2005-12-20 2009-02-26 Greenstein Robert J Methods for diagnosing and treating a mycobacterium avium subspecies paratuberculosis infection
US20080275063A1 (en) 2007-04-24 2008-11-06 Heike Schauerte Inhibitors of protein kinases
WO2009042114A2 (en) * 2007-09-21 2009-04-02 The Johns Hopkins University Phenazine derivatives and uses thereof
SI2247291T1 (sl) * 2008-02-08 2019-03-29 Red Hill Biopharma Ltd. Metode in sestavki za obravnavo kronične vnetne črevesne bolezni
WO2011011706A2 (en) * 2009-07-24 2011-01-27 The Johns Hopkins University Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents

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CN103813797B (zh) 2017-07-11
WO2013041963A2 (en) 2013-03-28
EP2758061A2 (en) 2014-07-30
US9901638B2 (en) 2018-02-27
CA2849255A1 (en) 2013-03-28
JP6035340B2 (ja) 2016-11-30
CL2014000671A1 (es) 2014-10-03
MX2014003430A (es) 2014-07-28
IL231489A0 (en) 2014-04-30
WO2013041963A3 (en) 2013-06-06
AU2012311235B2 (en) 2017-02-02
JP2014526548A (ja) 2014-10-06
EP2758061A4 (en) 2015-02-25
ZA201401954B (en) 2016-06-29
PL2758061T3 (pl) 2017-08-31
KR101987512B1 (ko) 2019-06-10
EP2758061B1 (en) 2016-11-16
KR20140082982A (ko) 2014-07-03
RU2014115807A (ru) 2015-10-27
IN2014CN02908A (da) 2015-07-03
SG11201400386RA (en) 2014-09-26
PT2758061T (pt) 2017-02-14
TWI573590B (zh) 2017-03-11
AU2012311235A1 (en) 2014-03-20
MX347660B (es) 2017-05-08
RU2621129C2 (ru) 2017-05-31
TW201320999A (zh) 2013-06-01
BR112014006473A2 (pt) 2017-03-28
CA2849255C (en) 2019-06-04
US20140228307A1 (en) 2014-08-14
IL231489A (en) 2017-01-31
ES2614923T3 (es) 2017-06-02
HUE032959T2 (hu) 2017-11-28
CN103813797A (zh) 2014-05-21

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