DK2720698T3 - Fremgangsmåde til administration af 4-((1r,3s)-6-chlor-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazin og saltene deraf i behandlingen af skizofreni - Google Patents

Fremgangsmåde til administration af 4-((1r,3s)-6-chlor-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazin og saltene deraf i behandlingen af skizofreni Download PDF

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DK2720698T3
DK2720698T3 DK12729555.8T DK12729555T DK2720698T3 DK 2720698 T3 DK2720698 T3 DK 2720698T3 DK 12729555 T DK12729555 T DK 12729555T DK 2720698 T3 DK2720698 T3 DK 2720698T3
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compound
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weekly
disorder
treatment
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René Holm
Lone Bruun
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H Lundbeck As
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

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  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (9)

1. Forbindelse (I)
til anvendelse i behandlingen afen sygdom i det centrale nervesystem, kendetegnet ved, at forbindelse (I) administreres halvugentligt eller ugentligt i en formulering med øjeblikkelig frigivelse (IR-formulering), en formulering med forlænget, kontrolleret eller forsinket frigivelse, til oral administration i en dosis svarende til mellem 20 mg/uge og 50 mg/uge, beregnet som den frie base af forbindelse (I)
2. Forbindelse (I)
ifølge krav 1 til anvendelse ifølge krav 1, hvor forbindelse (I) administreres ugentligt i en dosis, beregnet som den frie base af forbindelse (I), mellem 20 mg/dosis og 50 mg/dosis.
3. Forbindelse (I)
ifølge krav 1 eller 2 til anvendelse ifølge krav 1, hvor forbindelse (I) administreres
ugentligt i en dosis, beregnet som den frie base af forbindelse (I), mellem omkring 30 mg/dosis og omkring 45 mg/dosis.
4. Forbindelse (I)
ifølge krav 1, 2 eller 3 til anvendelse ifølge krav 1, hvor forbindelse (I) administreres ugentligt i en dosis, beregnet som den frie base af forbindelse (I), på omkring 30 mg/dosis. Forbindelse (I)
5. Forbindelse (I)
ifølge krav 1, 2 eller 3 til anvendelse ifølge krav 1, hvor forbindelse (I) administreres ugentligt i en dosis, beregnet som den frie base af forbindelse (I), på omkring 45 mg/dosis.
6. Forbindelse (I)
til anvendelse i behandlingen ifølge krav 1, hvor sygdommen er valgt fra gruppen af sygdomme bestående af psykose, i særdeleshed skizofreni eller andre sygdomme der involverer psykotiske symptomer, såsom eksempelvis skizofreni, Skizofreniform lidelse, skizoaffektiv lidelse, paranoid psykose, kortvarig psykotisk
lidelse, delt psykotisk lidelse, samt andre psykotiske lidelser eller sygdomme der forekommer med psykotiske symptomer, eksempelvis bipolar lidelse, såsom mani i bipolar lidelse, og til behandling af psykose i Parkinsons sygdom.
7. Forbindelse (I)
ifølge krav 1 til anvendelse ifølge krav 1 og en yderligere forbindelse valgt fra gruppen bestående af sertindol, olanzapin, risperidon, quetiapin, aripiprazol, haloperidol, clozapin, ziprasidon og osanetant til anvendelse i behandlingen af psykose, i særdeleshed skizofreni eller andre sygdomme der involverer psykotiske symptomer, såsom eksempelvis skizofreniform lidelse, skizoaffektiv lidelse, paranoid psykose, kortvarig psykotisk lidelse, delt psykotisk lidelse, samt andre psykotiske lidelser eller sygdomme der forekommer med psykotiske symptomer, eksempelvis bipolar lidelse, såsom mani i bipolar lidelse, og til behandling af psykose i Parkinsons sygdom, hvor forbindelse (I) administreres halvugentligt eller ugentligt i en formulering med øjeblikkelig frigivelse (IR-formulering), en formulering med forlænget, kontrolleret eller forsinket frigivelse, til oral administration i en dosis svarende til mellem 20 mg/uge og 50 mg/uge beregnet som den frie base af forbindelse (I).
8. Farmaceutisk sammensætning omfattende Forbindelse (I)
eller et salt af forbindelse (I) og en eller flere farmaceutisk acceptable bærere,
fortyndingsmidler og excipienser til anvendelse i behandlingen afen sygdom i det centrale nervesystem, i særdeleshed psykose, såsom skizofreni, kendetegnet ved, at den farmaceutiske sammensætning omfattende forbindelse (I) administreres halvugentligt eller ugentligt i en formulering med øjeblikkelig frigivelse (IR-formulering), en formulering med forlænget, kontrolleret eller forsinket frigivelse til oral administration.
9. Den farmaceutiske sammensætning ifølge krav 8 til anvendelse ifølge krav 8 yderligere omfattende et eller flere neuroleptiske midler valgt fra sertindol, olanzapin, risperidon, quetiapin, aripiprazol, haloperidol, clozapin, ziprasidon og osanetant.
DK12729555.8T 2011-06-20 2012-06-20 Fremgangsmåde til administration af 4-((1r,3s)-6-chlor-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazin og saltene deraf i behandlingen af skizofreni DK2720698T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161498653P 2011-06-20 2011-06-20
DKPA201100465 2011-06-20
PCT/EP2012/061779 WO2012175531A1 (en) 2011-06-20 2012-06-20 Method of administration of 4-((1r,3s)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and the salts thereof in the treatment of schizophrenia

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DK2720698T3 true DK2720698T3 (da) 2018-11-26

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US (1) US9610287B2 (da)
EP (1) EP2720698B1 (da)
JP (1) JP6140151B2 (da)
KR (1) KR101900989B1 (da)
CN (1) CN103608015A (da)
AU (1) AU2012274150B2 (da)
BR (1) BR112013032178A2 (da)
CA (1) CA2838055C (da)
DK (1) DK2720698T3 (da)
ES (1) ES2694298T3 (da)
HR (1) HRP20181684T1 (da)
IL (1) IL230060A (da)
JO (1) JO3421B1 (da)
LT (1) LT2720698T (da)
MX (1) MX349754B (da)
PL (1) PL2720698T3 (da)
RS (1) RS57944B1 (da)
RU (1) RU2613177C2 (da)
SI (1) SI2720698T1 (da)
TW (1) TWI552751B (da)
WO (1) WO2012175531A1 (da)
ZA (1) ZA201309617B (da)

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