DK2627386T3 - Næsesprayindretning - Google Patents
Næsesprayindretning Download PDFInfo
- Publication number
- DK2627386T3 DK2627386T3 DK11779089.9T DK11779089T DK2627386T3 DK 2627386 T3 DK2627386 T3 DK 2627386T3 DK 11779089 T DK11779089 T DK 11779089T DK 2627386 T3 DK2627386 T3 DK 2627386T3
- Authority
- DK
- Denmark
- Prior art keywords
- nasal spray
- discharge orifice
- spray device
- pharmaceutical formulation
- transfer channel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/44—Valves specially adapted therefor; Regulating devices
- B65D83/52—Valves specially adapted therefor; Regulating devices for metering
- B65D83/54—Metering valves ; Metering valve assemblies
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Massaging Devices (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Claims (10)
1. Næsesprayindretning (1) til levering afen farmaceutisk formulering til næsehulen i afmålte doser, indretningen omfattende: en tryksat aerosolbeholder (3) som inkluderer en ampul (4) indeholdende en farmaceutisk formulering omfattende en aktiv ingrediens, et drivmiddel og, eventuelt, et cosolvent, aerosolbeholderen (3) endvidere inkluderende en kalibreringsventil (6) som har en ventilspindel (8); og en aktuator (2) til aerosolbeholderen (3), aktuatoren (2) inkluderende en spindelblok (11) som har en beholder i hvilken ventilspindlen (8) af kalibreringsventilen (6) af aerosolbeholderen (3) er modtaget og aksialt placeret og som kan forskydes i forhold til ampullen (4) af aerosolbeholderen (3) for at aktivere kalibreringsventilen (6) af aerosolbeholderen (3), et bundkar (15) som strækker sig under beholderen, spindelblokken (11) definerer endvidere en udledningsmunding (19) til den farmaceutiske formulering og en overførselskanal (13) igennem hvilken en dispenseret dosis af den farmaceutiske formulering er i stand til at passere fra bundkarret (15) til udledningsmundingen (19), hvor aktuatoren (2) endvidere omfatter et leveringsudløb (12) til en aerosolsky, hvor udledningsmundingen (19) er anbragt til at rette aerosolskyen igennem leveringsudløbet (12), kendetegnet ved at indretningen (1) er indrettet til at producere en aerosolsky for en dispenseret dosis som har en spray kraftværd i ikke større end 40 mN målt ved en afstand på 30 mm fra udledningsmundingen (19), hvor udledningsmundingen (19) haren diameter fra 0,15 til 0,65 mm og en længde fra 0,5 til 1,0 mm, og overførselskanalen (13) har en længde på 3 til 20 mm.
2. Næsesprayindretning ifølge krav 1, hvor en maksimal transversal dimension af overførselskanalen (13) er større end en diameter af udledningsmundingen (19).
3. Næsesprayindretning ifølge krav 1, hvor en maksimal tværgående dimension af overførselskanalen (13) er fra 1,0 til 3,0 mm.
4. Næsesprayindretning ifølge krav 1, hvor overførselskanalen (13) haret cirkulært tværsnit.
5. Næsesprayindretning ifølge krav 1, hvor overførselskanalen (13) har en tværgående dimension som tilspidser ned mod en ende af udledningsmundingen (19).
6. Næsesprayindretning ifølge krav 1, hvor overførselskanalen (13) har en første del i fluid forbindelse med bundkarret (15) af spindelblokken (11) og en anden del i fluid forbindelse med udledningsmundingen (19), hvor den anden del og udledningsmundingen (19) er defineret af en separat indsats modtaget i en åbning formet i spindelblokken (11) af aktuatoren (2).
7. Næsesprayindretning ifølge krav 1, hvor cosolventet er til stede i 0,5 til 20 vægtprocent, baseret på en samlet vægt af den farmaceutiske formulering.
8. Næsesprayindretning ifølge krav 1, hvor den aktive ingrediens er beclometason dipropionat, drivmidlet er valgt fra P134a, P227 eller blandinger deraf, eller andre tryksatte gasser, og cosolventet er til stede og er vandfrit ethanol.
9. Næsesprayindretning ifølge krav 1, hvor den farmaceutiske formulering er en opløsningsformulering.
10. Næsesprayindretning ifølge krav 1, hvor den farmaceutiske formulering er en suspensionsformulering.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39222310P | 2010-10-12 | 2010-10-12 | |
| PCT/EP2011/005118 WO2012048867A1 (en) | 2010-10-12 | 2011-10-12 | Nasal spray device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2627386T3 true DK2627386T3 (da) | 2015-05-26 |
Family
ID=44907783
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15164095.0T DK2926855T3 (da) | 2010-10-12 | 2011-10-12 | Næsesprayanordning |
| DK11779089.9T DK2627386T3 (da) | 2010-10-12 | 2011-10-12 | Næsesprayindretning |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15164095.0T DK2926855T3 (da) | 2010-10-12 | 2011-10-12 | Næsesprayanordning |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US20120085345A1 (da) |
| EP (2) | EP2627386B1 (da) |
| JP (2) | JP6050236B2 (da) |
| KR (1) | KR101559639B1 (da) |
| CN (3) | CN106178205A (da) |
| AU (1) | AU2011316124B2 (da) |
| BR (1) | BR112013008824A2 (da) |
| CA (1) | CA2814212C (da) |
| CL (1) | CL2013000958A1 (da) |
| CY (1) | CY1121719T1 (da) |
| DK (2) | DK2926855T3 (da) |
| EA (1) | EA023795B1 (da) |
| ES (2) | ES2536969T3 (da) |
| HK (1) | HK1214990A1 (da) |
| HR (2) | HRP20150452T1 (da) |
| HU (1) | HUE043276T2 (da) |
| IL (1) | IL225712A (da) |
| LT (1) | LT2926855T (da) |
| MX (1) | MX336164B (da) |
| NZ (1) | NZ608218A (da) |
| PE (1) | PE20131492A1 (da) |
| PL (2) | PL2926855T3 (da) |
| PT (2) | PT2627386E (da) |
| RS (2) | RS58574B1 (da) |
| SG (1) | SG189892A1 (da) |
| SI (2) | SI2926855T1 (da) |
| SM (1) | SMT201500114B (da) |
| TR (1) | TR201902415T4 (da) |
| WO (1) | WO2012048867A1 (da) |
| ZA (1) | ZA201301938B (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201121812D0 (en) * | 2011-12-07 | 2012-02-01 | Teva Branded Pharmaceutical Prod R & D Inc | NAsal formulation |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| EP2890437B1 (en) * | 2012-08-29 | 2019-12-18 | Chiesi Farmaceutici S.p.A. | Aerosol inhalation device |
| GB201308679D0 (en) * | 2013-05-14 | 2013-06-26 | 3M Innovative Properties Co | Actuator for an inhaler |
| CN103550058B (zh) * | 2013-11-21 | 2015-08-19 | 江门大诚医疗器械有限公司 | 一种加氧清创器 |
| GB201322677D0 (en) * | 2013-12-20 | 2014-02-05 | 3M Innovative Properties Co | Actuator for an inhaler |
| GB201408229D0 (en) * | 2014-05-09 | 2014-06-25 | Norton Waterford Ltd | Aerosol device |
| US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
| WO2017008127A1 (en) * | 2015-07-16 | 2017-01-19 | Gd Pharma Pty Ltd | Spray device and dosage cartridge |
| CN106376976B (zh) * | 2016-10-13 | 2023-05-12 | 深圳市新宜康科技股份有限公司 | 一种单侧气道油气分离电子烟雾化器 |
| US20190240427A1 (en) * | 2016-11-06 | 2019-08-08 | Microbase Technology Corp. | Microstructured nozzle |
| US10556072B2 (en) * | 2017-01-31 | 2020-02-11 | Dunan Microstaq, Inc. | Metering device for a metered dose inhaler |
| KR102140739B1 (ko) | 2018-04-23 | 2020-08-04 | 충남대학교산학협력단 | 상기도 분무 장치 |
| KR20200098188A (ko) | 2019-02-12 | 2020-08-20 | 조민수 | 다기능 상기도 분무 장치 |
| CN210123827U (zh) * | 2019-05-31 | 2020-03-03 | 庆虹电子(苏州)有限公司 | 电连接器 |
| WO2021247283A1 (en) * | 2020-06-04 | 2021-12-09 | Amcyte Pharma, Inc. | Delivery of aerosolized micromolar composition concentrations |
| FR3120534B1 (fr) * | 2021-03-09 | 2023-06-30 | Aptar France Sas | Tête de distribution nasale de produit fluide et dispositif comportant une telle tête |
| WO2024079676A1 (en) * | 2022-10-12 | 2024-04-18 | Glenmark Specialty S.A. | Novel nasal spray assembling process |
| CN116688331B (zh) * | 2023-05-29 | 2024-02-20 | 山东京卫制药有限公司 | 一种鼻气雾剂给药器及其方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3361306A (en) * | 1966-03-31 | 1968-01-02 | Merck & Co Inc | Aerosol unit dispensing uniform amounts of a medically active ingredient |
| SE8704767L (sv) * | 1987-11-30 | 1989-05-31 | Sigmund Johannes Loefstedt | Ny metod foer administrering av laekemedel |
| JP2922935B2 (ja) * | 1989-08-11 | 1999-07-26 | 東興薬品工業株式会社 | 粘稠液用鼻孔内噴霧容器の使捨てアダプタ |
| ES2064160T3 (es) | 1990-10-18 | 1995-01-16 | Minnesota Mining & Mfg | Formulacion de aerosol que comprende 17,21-dipropionato de beclometasona. |
| GB9705657D0 (en) * | 1997-03-19 | 1997-05-07 | Bacon Raymond J | Dispenser |
| GB9805938D0 (en) | 1998-03-19 | 1998-05-13 | Glaxo Group Ltd | Valve for aerosol container |
| GB0121568D0 (en) * | 2001-09-06 | 2001-10-24 | Optinose As | Nasal delivery device |
| US6315985B1 (en) * | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
| GB0002798D0 (en) * | 2000-02-09 | 2000-03-29 | Glaxo Group Ltd | Actuator nozzle for metered dose inhaler |
| JP4472105B2 (ja) * | 2000-04-20 | 2010-06-02 | 株式会社ダイゾー | 噴霧製品 |
| GB2367011A (en) * | 2000-08-26 | 2002-03-27 | Glaxo Group Ltd | Metered dose inhaler for salmeterol |
| US20030178022A1 (en) * | 2001-12-21 | 2003-09-25 | Chiesi Farmaceutici S.P.A. | Pressurized metered dose inhaler (PMDI) actuators and medicinal aerosol solution formulation products comprising therse actuators |
| GB0226020D0 (en) | 2002-11-07 | 2002-12-18 | Glaxo Group Ltd | A holder |
| US7448385B2 (en) * | 2004-06-07 | 2008-11-11 | Purepharm Inc. | Nasal adaptation of an oral inhaler device |
| US7055541B2 (en) | 2004-09-07 | 2006-06-06 | Ramot At Tel-Aviv University Ltd. | Method and mechanism for producing suction and periodic excitation flow |
| FR2881119B1 (fr) * | 2005-01-25 | 2010-07-30 | Valois Sas | Dispositif de distribution de produit fluide. |
| EP1792660A1 (en) * | 2005-12-02 | 2007-06-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device |
| CN101528290A (zh) * | 2006-08-22 | 2009-09-09 | 葛兰素集团有限公司 | 用于吸入器的致动器 |
| WO2008023015A1 (en) * | 2006-08-22 | 2008-02-28 | Glaxo Group Limited | Actuator for an inhaler |
| MX2009009061A (es) * | 2007-02-28 | 2009-11-12 | Abbott Respiratory Llc | Sistema de atomizacion a base de boquilla. |
| EP2011534A1 (en) | 2007-07-03 | 2009-01-07 | CHIESI FARMACEUTICI S.p.A. | Metered dose inhaler actuator |
| DE102007063213B3 (de) * | 2007-12-20 | 2009-06-18 | Ing. Erich Pfeiffer Gmbh | Austragsvorrichtung zur nasalen Anwendung |
-
2011
- 2011-10-12 KR KR1020137012194A patent/KR101559639B1/ko active IP Right Grant
- 2011-10-12 EP EP11779089.9A patent/EP2627386B1/en active Active
- 2011-10-12 PT PT117790899T patent/PT2627386E/pt unknown
- 2011-10-12 NZ NZ608218A patent/NZ608218A/en unknown
- 2011-10-12 PE PE2013000844A patent/PE20131492A1/es active IP Right Grant
- 2011-10-12 SI SI201131681T patent/SI2926855T1/sl unknown
- 2011-10-12 JP JP2013533127A patent/JP6050236B2/ja active Active
- 2011-10-12 ES ES11779089.9T patent/ES2536969T3/es active Active
- 2011-10-12 PL PL15164095T patent/PL2926855T3/pl unknown
- 2011-10-12 RS RS20190258A patent/RS58574B1/sr unknown
- 2011-10-12 DK DK15164095.0T patent/DK2926855T3/da active
- 2011-10-12 MX MX2013003840A patent/MX336164B/es unknown
- 2011-10-12 BR BR112013008824A patent/BR112013008824A2/pt not_active Application Discontinuation
- 2011-10-12 HU HUE15164095A patent/HUE043276T2/hu unknown
- 2011-10-12 SI SI201130496T patent/SI2627386T1/sl unknown
- 2011-10-12 CN CN201610527858.2A patent/CN106178205A/zh active Pending
- 2011-10-12 US US13/271,940 patent/US20120085345A1/en not_active Abandoned
- 2011-10-12 EP EP15164095.0A patent/EP2926855B1/en active Active
- 2011-10-12 SG SG2013027925A patent/SG189892A1/en unknown
- 2011-10-12 TR TR2019/02415T patent/TR201902415T4/tr unknown
- 2011-10-12 CN CN201180049278.2A patent/CN103282070B/zh active Active
- 2011-10-12 PL PL11779089T patent/PL2627386T3/pl unknown
- 2011-10-12 ES ES15164095T patent/ES2712996T3/es active Active
- 2011-10-12 CN CN201610529254.1A patent/CN106178206A/zh active Pending
- 2011-10-12 WO PCT/EP2011/005118 patent/WO2012048867A1/en active Application Filing
- 2011-10-12 AU AU2011316124A patent/AU2011316124B2/en active Active
- 2011-10-12 LT LTEP15164095.0T patent/LT2926855T/lt unknown
- 2011-10-12 RS RS20150283A patent/RS54037B1/en unknown
- 2011-10-12 CA CA2814212A patent/CA2814212C/en active Active
- 2011-10-12 EA EA201390490A patent/EA023795B1/ru not_active IP Right Cessation
- 2011-10-12 DK DK11779089.9T patent/DK2627386T3/da active
- 2011-10-12 PT PT15164095T patent/PT2926855T/pt unknown
-
2013
- 2013-03-14 ZA ZA2013/01938A patent/ZA201301938B/en unknown
- 2013-04-10 CL CL2013000958A patent/CL2013000958A1/es unknown
- 2013-04-11 IL IL225712A patent/IL225712A/en active IP Right Grant
-
2015
- 2015-03-27 JP JP2015065534A patent/JP6023247B2/ja active Active
- 2015-04-27 HR HRP20150452TT patent/HRP20150452T1/hr unknown
- 2015-05-15 SM SM201500114T patent/SMT201500114B/xx unknown
- 2015-09-25 US US14/865,823 patent/US10188811B2/en active Active
-
2016
- 2016-03-15 HK HK16102992.6A patent/HK1214990A1/zh unknown
-
2019
- 2019-02-21 HR HRP20190337TT patent/HRP20190337T1/hr unknown
- 2019-02-26 CY CY20191100236T patent/CY1121719T1/el unknown
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