DK2593463T3 - Formuleringer af rifaximin og anvendelser deraf - Google Patents
Formuleringer af rifaximin og anvendelser deraf Download PDFInfo
- Publication number
- DK2593463T3 DK2593463T3 DK11807418.6T DK11807418T DK2593463T3 DK 2593463 T3 DK2593463 T3 DK 2593463T3 DK 11807418 T DK11807418 T DK 11807418T DK 2593463 T3 DK2593463 T3 DK 2593463T3
- Authority
- DK
- Denmark
- Prior art keywords
- rifaximin formulations
- rifaximin
- formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36360910P | 2010-07-12 | 2010-07-12 | |
US41905610P | 2010-12-02 | 2010-12-02 | |
PCT/US2011/043769 WO2012009388A1 (en) | 2010-07-12 | 2011-07-12 | Formulations of rifaximin and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2593463T3 true DK2593463T3 (da) | 2020-08-10 |
Family
ID=45469785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11807418.6T DK2593463T3 (da) | 2010-07-12 | 2011-07-12 | Formuleringer af rifaximin og anvendelser deraf |
Country Status (26)
Country | Link |
---|---|
US (4) | US20120077835A1 (da) |
EP (2) | EP3750526A1 (da) |
JP (1) | JP5943915B2 (da) |
KR (1) | KR101887004B1 (da) |
CN (1) | CN103228662B (da) |
AU (1) | AU2011279261B2 (da) |
BR (1) | BR112013000802B1 (da) |
CA (1) | CA2804635C (da) |
CR (1) | CR20130033A (da) |
DK (1) | DK2593463T3 (da) |
EA (1) | EA033370B1 (da) |
ES (1) | ES2801678T3 (da) |
GE (1) | GEP20227342B (da) |
HU (1) | HUE049986T2 (da) |
IL (1) | IL223725B (da) |
LT (1) | LT2593463T (da) |
MX (1) | MX345697B (da) |
MY (1) | MY165086A (da) |
NZ (1) | NZ605232A (da) |
PL (1) | PL2593463T3 (da) |
PT (1) | PT2593463T (da) |
SG (2) | SG186981A1 (da) |
SI (1) | SI2593463T1 (da) |
TN (1) | TN2012000611A1 (da) |
WO (2) | WO2012009388A1 (da) |
ZA (1) | ZA201300193B (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1698630T3 (da) | 2005-03-03 | 2014-12-08 | Alfa Wassermann Spa | Nye polymorfe former af rifaximin, fremgangsmåde for deres fremstilling og anvendelse deraf i de medicinske præparater |
ITBO20050123A1 (it) | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
US9018684B2 (en) | 2009-11-23 | 2015-04-28 | California Institute Of Technology | Chemical sensing and/or measuring devices and methods |
IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
ITBO20110461A1 (it) | 2011-07-29 | 2013-01-30 | Alfa Wassermann Spa | Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali. |
AU2012332211B2 (en) * | 2011-11-02 | 2016-11-24 | Salix Pharmaceuticals, Ltd. | Methods for treating irritable bowel syndrome (IBS) and infections |
AU2013212008A1 (en) | 2012-01-25 | 2014-07-10 | Alfa Wassermann S.P.A. | Rifaximin derivative and uses thereof |
ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
EP2757135B1 (en) | 2013-01-18 | 2017-11-29 | 3M Innovative Properties Company | Method of bonding parts to a vehicle by an acrylic foam tape |
EP3065788A1 (en) * | 2013-11-08 | 2016-09-14 | Tyrx, Inc. | Antimicrobial compositions and methods for preventing infection in surgical incision sites |
CA2947962C (en) | 2014-05-04 | 2024-01-16 | Salix Pharmaceuticals, Inc. | Ibs microbiota and uses thereof |
ES2742106T3 (es) | 2014-05-12 | 2020-02-13 | Alfasigma Spa | Nueva forma de cristal solvatado de rifaximina, producción, composiciones y usos de la misma |
JP7024248B2 (ja) * | 2016-09-01 | 2022-02-24 | 大正製薬株式会社 | 固形製剤 |
WO2018064472A1 (en) * | 2016-09-30 | 2018-04-05 | Salix Pharmaceuticals, Ltd. | Solid dispersion forms of rifaximin |
CN110621305A (zh) * | 2017-07-24 | 2019-12-27 | 爱科思华制药研发有限责任公司 | 高载药量药物组合物 |
CN109453165B (zh) * | 2018-10-16 | 2021-02-05 | 丹诺医药(苏州)有限公司 | 一种利福霉素-硝基咪唑偶联分子的固体分散体及其应用 |
CN109453166B (zh) * | 2018-10-16 | 2021-03-12 | 丹诺医药(苏州)有限公司 | 一种利福霉素-喹嗪酮偶联分子的固体分散体及其应用 |
WO2020198136A1 (en) * | 2019-03-22 | 2020-10-01 | New York Medical College | Use of rifaximin on circulating aged neutrophils in sickle cell disease |
US20220378758A1 (en) | 2019-09-24 | 2022-12-01 | Bausch Health Ireland Limited | Rifaximin liquid formulations |
US20230141118A1 (en) * | 2020-04-13 | 2023-05-11 | Bausch Health Ireland Limited | Methods of using solid dispersions of rifaximin for the treatment of sickle cell disease |
CA3184054A1 (en) | 2020-06-26 | 2021-12-30 | Jacob Cole | Targeted release rifaximin compositions |
WO2022090490A1 (en) | 2020-10-29 | 2022-05-05 | Bausch Health Ireland Limited | Rifaximin liquid formulations for use in the treatment of sickle cell disease |
CN114366717B (zh) * | 2022-01-11 | 2023-06-09 | 四川农业大学 | 一种基于egcg纳米粒的肠溶固体分散体颗粒、制备方法及其应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1154655B (it) | 1980-05-22 | 1987-01-21 | Alfa Farmaceutici Spa | Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica |
IT1199374B (it) | 1984-05-15 | 1988-12-30 | Alfa Farmaceutici Spa | Processo per la preparazione di pirido-imidazo-rifamicine |
IT1320176B1 (it) | 2000-12-22 | 2003-11-26 | Nicox Sa | Dispersioni solide di principi attivi nitrati. |
BR0210520A (pt) * | 2001-06-22 | 2004-06-22 | Pfizer Prod Inc | Composições farmacêuticas de dispersões de fármacos amorfos misturados com polìmeros |
ITMI20032144A1 (it) | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
BRPI0418330A (pt) * | 2003-12-31 | 2007-05-02 | Pfizer Prod Inc | composições sólidas de drogas de solubilidade baixa e poloxámeros |
MY191349A (en) | 2004-08-27 | 2022-06-17 | Bayer Pharmaceuticals Corp | New pharmaceutical compositions for the treatment of hyper-proliferative disorders |
DK1698630T3 (da) | 2005-03-03 | 2014-12-08 | Alfa Wassermann Spa | Nye polymorfe former af rifaximin, fremgangsmåde for deres fremstilling og anvendelse deraf i de medicinske præparater |
ITBO20050123A1 (it) * | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
US20080095754A1 (en) * | 2006-10-18 | 2008-04-24 | Burke Susan E | Ophthalmic compositions comprising diglycine |
AU2008273699A1 (en) * | 2007-07-06 | 2009-01-15 | Lupin Limited | Pharmaceutical compositions of rifaximin |
DK2011486T3 (da) * | 2007-07-06 | 2012-09-03 | Lupin Ltd | Farmaceutiske sammensætninger af rifaximin |
KR100903618B1 (ko) * | 2007-10-30 | 2009-06-18 | 삼성에스디아이 주식회사 | 플라즈마 디스플레이 패널 |
CN102015725B (zh) * | 2008-02-25 | 2014-10-22 | 萨利克斯药品有限公司 | 利福昔明的多种形式及其用途 |
US8486956B2 (en) * | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
PL2252148T3 (pl) * | 2008-02-26 | 2019-09-30 | Salix Pharmaceuticals, Ltd. | Sposoby leczenia zespołu jelita drażliwego |
EP2105130A1 (de) * | 2008-03-25 | 2009-09-30 | Ratiopharm GmbH | Pharmazeutische Formulierung und Verfahren zu deren Herstellung |
JP5756020B2 (ja) * | 2008-12-10 | 2015-07-29 | シプラ・リミテッド | リファキシミン複合体 |
KR20200100215A (ko) | 2009-10-27 | 2020-08-25 | 루핀 리미티드 | 리팍시민의 고형 분산물 |
WO2011061748A1 (en) * | 2009-11-19 | 2011-05-26 | Strides Arcolab Limited | Rifaximin premix |
JP5717768B2 (ja) * | 2010-03-10 | 2015-05-13 | アッヴィ・バハマズ・リミテッド | 固体組成物 |
-
2011
- 2011-07-12 CN CN201180043828.XA patent/CN103228662B/zh active Active
- 2011-07-12 JP JP2013519780A patent/JP5943915B2/ja active Active
- 2011-07-12 GE GEAP201112996A patent/GEP20227342B/en unknown
- 2011-07-12 EP EP20172999.3A patent/EP3750526A1/en not_active Withdrawn
- 2011-07-12 PL PL11807418T patent/PL2593463T3/pl unknown
- 2011-07-12 PT PT118074186T patent/PT2593463T/pt unknown
- 2011-07-12 SG SG2013001458A patent/SG186981A1/en unknown
- 2011-07-12 EP EP11807418.6A patent/EP2593463B1/en active Active
- 2011-07-12 NZ NZ605232A patent/NZ605232A/en unknown
- 2011-07-12 WO PCT/US2011/043769 patent/WO2012009388A1/en active Application Filing
- 2011-07-12 KR KR1020137003493A patent/KR101887004B1/ko active IP Right Grant
- 2011-07-12 SG SG10201505484RA patent/SG10201505484RA/en unknown
- 2011-07-12 AU AU2011279261A patent/AU2011279261B2/en active Active
- 2011-07-12 SI SI201131898T patent/SI2593463T1/sl unknown
- 2011-07-12 LT LTEP11807418.6T patent/LT2593463T/lt unknown
- 2011-07-12 BR BR112013000802-4A patent/BR112013000802B1/pt active IP Right Grant
- 2011-07-12 WO PCT/US2011/043767 patent/WO2012009387A1/en active Application Filing
- 2011-07-12 DK DK11807418.6T patent/DK2593463T3/da active
- 2011-07-12 MX MX2013000522A patent/MX345697B/es active IP Right Grant
- 2011-07-12 MY MYPI2012005580A patent/MY165086A/en unknown
- 2011-07-12 HU HUE11807418A patent/HUE049986T2/hu unknown
- 2011-07-12 EA EA201370018A patent/EA033370B1/ru not_active IP Right Cessation
- 2011-07-12 US US13/181,481 patent/US20120077835A1/en not_active Abandoned
- 2011-07-12 ES ES11807418T patent/ES2801678T3/es active Active
- 2011-07-12 CA CA2804635A patent/CA2804635C/en active Active
-
2012
- 2012-12-18 IL IL223725A patent/IL223725B/en active IP Right Grant
- 2012-12-19 TN TNP2012000611A patent/TN2012000611A1/en unknown
-
2013
- 2013-01-08 ZA ZA2013/00193A patent/ZA201300193B/en unknown
- 2013-01-23 CR CR20130033A patent/CR20130033A/es unknown
-
2014
- 2014-04-10 US US14/250,293 patent/US9737610B2/en active Active
-
2017
- 2017-06-06 US US15/615,121 patent/US20170333562A1/en not_active Abandoned
-
2020
- 2020-06-30 US US16/916,421 patent/US20200397904A1/en not_active Abandoned
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