DK254488A - Azaindol- og indolizinderivater - Google Patents

Azaindol- og indolizinderivater

Info

Publication number
DK254488A
DK254488A DK254488A DK254488A DK254488A DK 254488 A DK254488 A DK 254488A DK 254488 A DK254488 A DK 254488A DK 254488 A DK254488 A DK 254488A DK 254488 A DK254488 A DK 254488A
Authority
DK
Denmark
Prior art keywords
azaindol
indolizin
derivatives
indolizin derivatives
Prior art date
Application number
DK254488A
Other languages
Danish (da)
English (en)
Other versions
DK254488D0 (da
Inventor
Paul Leroy Anderson
Faizulla Gulamhusein Kathawala
Nicholas Andrew Paolella
Sompong Wattanasin
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/945,750 external-priority patent/US4751235A/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK254488D0 publication Critical patent/DK254488D0/da
Publication of DK254488A publication Critical patent/DK254488A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK254488A 1986-09-10 1988-05-09 Azaindol- og indolizinderivater DK254488A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90589786A 1986-09-10 1986-09-10
US06/945,750 US4751235A (en) 1986-12-23 1986-12-23 Anti-atherosclerotic indolizine derivatives
PCT/EP1987/000511 WO1988001997A2 (en) 1986-09-10 1987-09-09 Azaindole and indolizine derivatives, processes for their production and their use as pharmaceuticals

Publications (2)

Publication Number Publication Date
DK254488D0 DK254488D0 (da) 1988-05-09
DK254488A true DK254488A (da) 1988-06-24

Family

ID=27129444

Family Applications (1)

Application Number Title Priority Date Filing Date
DK254488A DK254488A (da) 1986-09-10 1988-05-09 Azaindol- og indolizinderivater

Country Status (12)

Country Link
EP (1) EP0265640A3 (fi)
JP (1) JPH01500834A (fi)
KR (1) KR880701719A (fi)
AU (1) AU606621B2 (fi)
DK (1) DK254488A (fi)
FI (1) FI882160A (fi)
HU (1) HU200769B (fi)
IL (1) IL83821A0 (fi)
NZ (1) NZ221717A (fi)
PL (1) PL267646A1 (fi)
PT (1) PT85662B (fi)
WO (1) WO1988001997A2 (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0352575A3 (de) * 1988-07-28 1991-08-21 Bayer Ag Substituierte anellierte Pyrrole
JP2853227B2 (ja) * 1988-10-13 1999-02-03 ノバルテイス・アクチエンゲゼルシヤフト ７置換‐ヘプト‐６‐エン酸、ヘプタン酸及び誘導体並びにそれらの中間体の製法
JPH04270285A (ja) * 1988-11-14 1992-09-25 Nissan Chem Ind Ltd ピラゾロピリミジン系メバロノラクトン類
US5025000A (en) * 1990-03-02 1991-06-18 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitor compounds
US5124453A (en) * 1990-03-02 1992-06-23 E. R. Squibb & Sons, Inc. Process for preparing certain 5,6,7,8-tetrahydroindolizinyl (ethyl or ethynyl)-hydroxy or methoxy-phosphinyl-3-hydroxy-butanoates and derivatives thereof
WO1992019240A1 (en) * 1991-05-01 1992-11-12 University Of New Mexico Treatment of aberrant cellular states with biomodulators
WO1992019239A1 (en) * 1991-05-01 1992-11-12 University Of New Mexico Treatment of aberrant cellular states with biomodulators
FR2687402B1 (fr) * 1992-02-14 1995-06-30 Lipha Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
WO2004007495A1 (ja) 2002-07-11 2004-01-22 Takeda Pharmaceutical Company Limited ピロロピリジン誘導体およびその用途
NZ584499A (en) 2004-03-30 2011-08-26 Vertex Pharma Azaindoles Useful as Inhibitors of Jak and Other Protein Kinases
KR101235103B1 (ko) 2006-01-17 2013-02-21 버텍스 파마슈티칼스 인코포레이티드 야누스 키나제의 억제제로서 유용한 아자인돌
WO2008079346A1 (en) 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
TWI574963B (zh) 2009-06-17 2017-03-21 維泰克斯製藥公司 流感病毒複製之抑制劑
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
PL3068776T3 (pl) 2013-11-13 2019-10-31 Vertex Pharma Inhibitory replikacji wirusów grypy
HUE038820T2 (hu) 2013-11-13 2018-11-28 Vertex Pharma Eljárás influenzavírusok replikációjának inhibitorai elõállítására
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI61030C (fi) * 1976-02-19 1982-05-10 Sanofi Sa Foerfarande foer framstaellning av terapeutiskt verkande 2-substituerade-1- eller 3-benzoyl-indolizinderivat
JPS5559180A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent
US4474971A (en) * 1982-09-29 1984-10-02 Sandoz, Inc. (Tetrahydropyran-2-yl)-aldehydes
WO1984002131A1 (en) * 1982-11-22 1984-06-07 Sandoz Ag Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
IE840153L (en) * 1983-01-24 1984-07-24 Sandoz Ltd Mevalonolactone analogues and related hydroxy acids for¹control of blood cholesterol levels.
US4571428A (en) * 1983-07-08 1986-02-18 Sandoz, Inc. 6-Substituted-4-hydroxy-tetrahydropyran-2-ones
WO1986000307A2 (en) * 1984-06-22 1986-01-16 Sandoz Ag Pyrazole analogs of mevalonolactone and derivatives thereof, processes for their production and their use
US4677211A (en) * 1984-06-29 1987-06-30 Sandoz Pharmaceuticals Corp. Preparation of lactones
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs

Also Published As

Publication number Publication date
PL267646A1 (en) 1988-07-21
AU8022187A (en) 1988-04-07
IL83821A0 (en) 1988-02-29
HU200769B (en) 1990-08-28
AU606621B2 (en) 1991-02-14
HUT46914A (en) 1988-12-28
PT85662B (pt) 1990-06-29
FI882160A0 (fi) 1988-05-09
EP0265640A2 (en) 1988-05-04
PT85662A (en) 1987-10-01
DK254488D0 (da) 1988-05-09
KR880701719A (ko) 1988-11-04
WO1988001997A2 (en) 1988-03-24
WO1988001997A3 (en) 1988-04-07
FI882160A (fi) 1988-05-09
NZ221717A (en) 1990-08-28
JPH01500834A (ja) 1989-03-23
EP0265640A3 (en) 1988-05-18

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment