DK2493493T3 - Nye bacitracinantibiotika - Google Patents
Nye bacitracinantibiotika Download PDFInfo
- Publication number
- DK2493493T3 DK2493493T3 DK10765613.4T DK10765613T DK2493493T3 DK 2493493 T3 DK2493493 T3 DK 2493493T3 DK 10765613 T DK10765613 T DK 10765613T DK 2493493 T3 DK2493493 T3 DK 2493493T3
- Authority
- DK
- Denmark
- Prior art keywords
- bacitracin
- mlz
- methylene
- bacitracins
- lsoleucine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- C07K7/58—Bacitracins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (14)
1. Forbindelse repræsenteret ved formlen
hvor mindst én af Ri, R2 og R3 er -CH=CH2, og hvor Ri, R2 og R3 uafhængigt er -H, -CH3 eller -CH=CH2, og salte og hydrater deraf.
2. Forbindelse ifølge krav 1, hvor en af Ri, R2 og R3 er -CH3.
3. Forbindelse ifølge krav 1, hvor to af Ri, R2 og R3 er -CH3.
4. Forbindelse ifølge krav 1, hvor Ri er -CFRCFb.
5. Forbindelse ifølge krav 1, hvor R2 er -CFRCFb.
6. Forbindelse ifølge krav 1, hvor R3 er -CH=CFF.
7. Forbindelse ifølge krav 1, hvor Ri og R2 er -CFRCFb.
8. Forbindelse ifølge krav 1, hvor R2 og R3 er -CH=CH2.
9. Forbindelse ifølge krav 1, hvor Ri og R3 er -CFNCFb.
10. Forbindelse ifølge krav 1, hvor Ri og R2 og R3 er -CH=CH2.
11. Sammensætning, der omfatter forbindelsen ifølge krav 1.
12. Farmaceutisk sammensætning, der omfatter forbindelsen ifølge krav 1.
13. Anvendelse af forbindelsen ifølge krav 1 til fremstilling af et medikament til behandling af bakterielle infektioner.
14. Fremgangsmåde til fremstilling af forbindelser ifølge krav 1 ved substituering af isoleucin eller valin med 5-methylen-isoleucin under bacitracinsyntese in vitro.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25551709P | 2009-10-28 | 2009-10-28 | |
| PCT/EP2010/064523 WO2011051073A1 (en) | 2009-10-28 | 2010-09-30 | New bacitracin antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2493493T3 true DK2493493T3 (da) | 2016-09-05 |
Family
ID=43417043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10765613.4T DK2493493T3 (da) | 2009-10-28 | 2010-09-30 | Nye bacitracinantibiotika |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8410044B2 (da) |
| EP (1) | EP2493493B1 (da) |
| JP (1) | JP5763082B2 (da) |
| KR (1) | KR20120097379A (da) |
| CN (1) | CN102596218B (da) |
| AU (1) | AU2010311762B2 (da) |
| BR (1) | BR112012009943A2 (da) |
| CA (1) | CA2774590A1 (da) |
| CY (1) | CY1118233T1 (da) |
| DK (1) | DK2493493T3 (da) |
| ES (1) | ES2588205T3 (da) |
| HR (1) | HRP20161020T1 (da) |
| HU (1) | HUE029412T2 (da) |
| IL (1) | IL219183A (da) |
| IN (1) | IN2012DN01971A (da) |
| LT (1) | LT2493493T (da) |
| PL (1) | PL2493493T3 (da) |
| PT (1) | PT2493493T (da) |
| RU (1) | RU2536588C2 (da) |
| SI (1) | SI2493493T1 (da) |
| WO (1) | WO2011051073A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2493843B1 (en) | 2009-10-28 | 2015-11-11 | Xellia Pharmaceuticals ApS | 2-amino-3-methyl-hex-5-enoic acid and its use in the production of peptides such as bacitracins |
| CN109444318B (zh) * | 2018-12-03 | 2021-04-27 | 上海市食品药品检验研究院 | 一种用于分析杆菌肽组分的高效液相色谱方法 |
| CN111057131A (zh) * | 2019-12-13 | 2020-04-24 | 上海市食品药品检验所 | 一种杆菌肽及其组分的分析方法 |
| CN111678996A (zh) * | 2020-04-26 | 2020-09-18 | 上海市食品药品检验所 | 杆菌肽氧化组分及其分析方法和双键磺酸化半胱氨酸氧化组分的碎裂模式 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5300491A (en) | 1991-10-31 | 1994-04-05 | Apothekernes Laboratorium A.S. | Treatment of protozoal infection |
| AU3301997A (en) | 1996-06-10 | 1998-01-07 | Board Of Trustees Of The Leland Stanford Junior University | Total synthesis of bacitracin polypetides |
-
2010
- 2010-09-30 AU AU2010311762A patent/AU2010311762B2/en not_active Ceased
- 2010-09-30 PT PT107656134T patent/PT2493493T/pt unknown
- 2010-09-30 PL PL10765613T patent/PL2493493T3/pl unknown
- 2010-09-30 DK DK10765613.4T patent/DK2493493T3/da active
- 2010-09-30 WO PCT/EP2010/064523 patent/WO2011051073A1/en active Application Filing
- 2010-09-30 IN IN1971DEN2012 patent/IN2012DN01971A/en unknown
- 2010-09-30 ES ES10765613.4T patent/ES2588205T3/es active Active
- 2010-09-30 LT LTEP10765613.4T patent/LT2493493T/lt unknown
- 2010-09-30 RU RU2012120614/04A patent/RU2536588C2/ru not_active IP Right Cessation
- 2010-09-30 US US13/502,142 patent/US8410044B2/en active Active
- 2010-09-30 BR BR112012009943A patent/BR112012009943A2/pt not_active IP Right Cessation
- 2010-09-30 KR KR1020127013675A patent/KR20120097379A/ko active IP Right Grant
- 2010-09-30 JP JP2012535720A patent/JP5763082B2/ja not_active Expired - Fee Related
- 2010-09-30 SI SI201031258A patent/SI2493493T1/sl unknown
- 2010-09-30 CA CA2774590A patent/CA2774590A1/en not_active Abandoned
- 2010-09-30 HU HUE10765613A patent/HUE029412T2/en unknown
- 2010-09-30 EP EP10765613.4A patent/EP2493493B1/en active Active
- 2010-09-30 CN CN201080048962.4A patent/CN102596218B/zh not_active Expired - Fee Related
-
2012
- 2012-04-15 IL IL219183A patent/IL219183A/en not_active IP Right Cessation
-
2016
- 2016-08-16 HR HRP20161020TT patent/HRP20161020T1/hr unknown
- 2016-08-25 CY CY20161100841T patent/CY1118233T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120097379A (ko) | 2012-09-03 |
| EP2493493A1 (en) | 2012-09-05 |
| CN102596218B (zh) | 2014-10-22 |
| IL219183A (en) | 2015-04-30 |
| CY1118233T1 (el) | 2017-06-28 |
| EP2493493B1 (en) | 2016-07-06 |
| IN2012DN01971A (da) | 2015-08-21 |
| US8410044B2 (en) | 2013-04-02 |
| CA2774590A1 (en) | 2011-05-05 |
| US20120202737A1 (en) | 2012-08-09 |
| JP2013509367A (ja) | 2013-03-14 |
| AU2010311762B2 (en) | 2015-09-24 |
| WO2011051073A1 (en) | 2011-05-05 |
| PL2493493T3 (pl) | 2017-01-31 |
| HUE029412T2 (en) | 2017-02-28 |
| PT2493493T (pt) | 2016-08-31 |
| CN102596218A (zh) | 2012-07-18 |
| LT2493493T (lt) | 2016-09-26 |
| HRP20161020T1 (hr) | 2016-10-21 |
| IL219183A0 (en) | 2012-06-28 |
| AU2010311762A1 (en) | 2012-03-29 |
| SI2493493T1 (sl) | 2016-10-28 |
| JP5763082B2 (ja) | 2015-08-12 |
| BR112012009943A2 (pt) | 2019-09-24 |
| ES2588205T3 (es) | 2016-10-31 |
| RU2536588C2 (ru) | 2014-12-27 |
| RU2012120614A (ru) | 2013-12-10 |
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