DK248484A - Isoquinolinderivater - Google Patents
Isoquinolinderivater Download PDFInfo
- Publication number
- DK248484A DK248484A DK248484A DK248484A DK248484A DK 248484 A DK248484 A DK 248484A DK 248484 A DK248484 A DK 248484A DK 248484 A DK248484 A DK 248484A DK 248484 A DK248484 A DK 248484A
- Authority
- DK
- Denmark
- Prior art keywords
- image
- formula
- isoquinoline
- alkoxyphenyl
- halophenyl
- Prior art date
Links
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 2
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 150000002537 isoquinolines Chemical class 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/496,327 US4544657A (en) | 1983-05-19 | 1983-05-19 | Substituted isoquinolines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK248484D0 DK248484D0 (da) | 1984-05-17 |
| DK248484A true DK248484A (da) | 1984-11-20 |
Family
ID=23972146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK248484A DK248484A (da) | 1983-05-19 | 1984-05-17 | Isoquinolinderivater |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4544657A (en:Method) |
| EP (1) | EP0126480B1 (en:Method) |
| JP (1) | JPS59222478A (en:Method) |
| KR (1) | KR840009102A (en:Method) |
| AT (1) | ATE32072T1 (en:Method) |
| AU (1) | AU570044B2 (en:Method) |
| CA (1) | CA1243028A (en:Method) |
| DE (1) | DE3468875D1 (en:Method) |
| DK (1) | DK248484A (en:Method) |
| ES (1) | ES8601141A1 (en:Method) |
| FI (1) | FI81795C (en:Method) |
| GR (1) | GR82015B (en:Method) |
| HU (1) | HU192555B (en:Method) |
| IL (1) | IL71860A (en:Method) |
| MC (1) | MC1597A1 (en:Method) |
| NO (1) | NO159271C (en:Method) |
| NZ (1) | NZ208186A (en:Method) |
| PH (1) | PH19670A (en:Method) |
| PT (1) | PT78618A (en:Method) |
| ZA (1) | ZA843748B (en:Method) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681954A (en) * | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
| RU2124511C1 (ru) * | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| NZ295546A (en) * | 1994-10-05 | 1999-01-28 | Glaxo Wellcome Inc | Parenteral medicament containing n-{4-[2-1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-phenyl}- 9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide, surfactant, and buffer |
| FR2840896B1 (fr) * | 2002-06-18 | 2005-04-08 | Sanofi Synthelabo | Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| MX2008001292A (es) | 2005-07-29 | 2008-03-25 | Hoffmann La Roche | Nuevos derivados de indol-3-il-carbonil-piperidina y piperazina. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE759443A (fr) * | 1970-09-15 | 1971-04-30 | I F L O Istituto Farmacologico | Nouveau derive papaverolinique et procede de preparation relatif |
| DE2818423A1 (de) * | 1978-04-27 | 1979-11-08 | Hoechst Ag | Neue isochinolinderivate und verfahren zu ihrer herstellung |
| IN154317B (en:Method) * | 1979-07-19 | 1984-10-13 | Andre Buzas | |
| DE3034001A1 (de) * | 1980-09-10 | 1982-04-22 | Hoechst Ag, 6000 Frankfurt | Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung |
-
1983
- 1983-05-19 US US06/496,327 patent/US4544657A/en not_active Expired - Fee Related
-
1984
- 1984-05-17 FI FI841992A patent/FI81795C/fi not_active IP Right Cessation
- 1984-05-17 CA CA000454531A patent/CA1243028A/en not_active Expired
- 1984-05-17 IL IL71860A patent/IL71860A/xx unknown
- 1984-05-17 GR GR74757A patent/GR82015B/el unknown
- 1984-05-17 NZ NZ208186A patent/NZ208186A/en unknown
- 1984-05-17 ZA ZA843748A patent/ZA843748B/xx unknown
- 1984-05-17 DK DK248484A patent/DK248484A/da not_active Application Discontinuation
- 1984-05-17 MC MC841707A patent/MC1597A1/fr unknown
- 1984-05-18 NO NO842003A patent/NO159271C/no unknown
- 1984-05-18 HU HU841916A patent/HU192555B/hu not_active IP Right Cessation
- 1984-05-18 AU AU28356/84A patent/AU570044B2/en not_active Ceased
- 1984-05-18 ES ES532603A patent/ES8601141A1/es not_active Expired
- 1984-05-18 PH PH30693A patent/PH19670A/en unknown
- 1984-05-18 KR KR1019840002721A patent/KR840009102A/ko not_active Ceased
- 1984-05-18 JP JP59098863A patent/JPS59222478A/ja active Pending
- 1984-05-18 PT PT78618A patent/PT78618A/pt not_active IP Right Cessation
- 1984-05-21 DE DE8484105777T patent/DE3468875D1/de not_active Expired
- 1984-05-21 EP EP84105777A patent/EP0126480B1/de not_active Expired
- 1984-05-21 AT AT84105777T patent/ATE32072T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI841992A7 (fi) | 1984-11-20 |
| ES532603A0 (es) | 1985-11-01 |
| ATE32072T1 (de) | 1988-02-15 |
| PT78618A (en) | 1984-06-01 |
| NO159271C (no) | 1988-12-14 |
| FI81795B (fi) | 1990-08-31 |
| HU192555B (en) | 1987-06-29 |
| ES8601141A1 (es) | 1985-11-01 |
| NO842003L (no) | 1984-11-20 |
| HUT34185A (en) | 1985-02-28 |
| FI81795C (fi) | 1990-12-10 |
| FI841992A0 (fi) | 1984-05-17 |
| ZA843748B (en) | 1985-01-30 |
| MC1597A1 (fr) | 1985-05-09 |
| CA1243028A (en) | 1988-10-11 |
| AU570044B2 (en) | 1988-03-03 |
| US4544657A (en) | 1985-10-01 |
| IL71860A (en) | 1987-10-30 |
| KR840009102A (ko) | 1984-12-24 |
| AU2835684A (en) | 1984-11-22 |
| EP0126480B1 (de) | 1988-01-20 |
| JPS59222478A (ja) | 1984-12-14 |
| IL71860A0 (en) | 1984-09-30 |
| NZ208186A (en) | 1987-06-30 |
| EP0126480A1 (de) | 1984-11-28 |
| DK248484D0 (da) | 1984-05-17 |
| DE3468875D1 (en) | 1988-02-25 |
| GR82015B (en:Method) | 1984-12-12 |
| NO159271B (no) | 1988-09-05 |
| PH19670A (en) | 1986-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |