DK2441777T3 - Polypeptider og antistoffer, som stammer fra kronisk lymfatisk leukæmi-celler, og anvendelser deraf - Google Patents

Polypeptider og antistoffer, som stammer fra kronisk lymfatisk leukæmi-celler, og anvendelser deraf Download PDF

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Publication number
DK2441777T3
DK2441777T3 DK11009020.6T DK11009020T DK2441777T3 DK 2441777 T3 DK2441777 T3 DK 2441777T3 DK 11009020 T DK11009020 T DK 11009020T DK 2441777 T3 DK2441777 T3 DK 2441777T3
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DK11009020.6T
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Katherine S Bowdish
Anke Kretz-Rommel
Toshiaki Maruyama
John Mcwhirter
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Alexion Pharma Inc
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Priority claimed from US10/894,672 external-priority patent/US9249229B2/en
Priority claimed from US10/996,316 external-priority patent/US7408041B2/en
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Publication of DK2441777T3 publication Critical patent/DK2441777T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Claims (10)

1. Isoleret humaniseret anti-CD200-antistof eller CD200- bindende fragment deraf, som omfatter: en letkæde-CDRl med sekvensen ifølge resterne 26-36 ifølge SEQ ID NO: 209; en letkæde-CDR2 med sekvensen ifølge resterne 52-58 ifølge SEQ ID NO: 209; en letkæde-CDR3 med sekvensen ifølge resterne 91-99 ifølge SEQ ID NO: 209; en tungkæde-CDRl med sekvensen ifølge SEQ ID NO: 149; en tungkæde-CDR2 med sekvensen ifølge SEQ ID NO: 174; og en tungkæde-CDR3 med sekvensen ifølge SEQ ID NO: 195.
2. Isoleret humaniseret anti-CD200-antistof eller CD200- bindende fragment deraf, som omfatter: en letkæde-CDRl med sekvensen ifølge resterne 26-36 ifølge SEQ ID NO: 208; en letkæde-CDR2 med sekvensen ifølge resterne 52-58 ifølge SEQ ID NO: 208; en letkæde-CDR3 med sekvensen ifølge resterne 91-99 ifølge SEQ ID NO: 208; en tungkæde-CDRl med sekvensen ifølge SEQ ID NO: 114; en tungkæde-CDR2 med sekvensen ifølge SEQ ID NO: 165; og en tungkæde-CDR3 med sekvensen ifølge SEQ ID NO: 189.
3. Isoleret humaniseret anti-CD200-antistof eller CD200- bindende fragment deraf, som omfatter: en letkæde-CDRl med sekvensen ifølge resterne 26-35 ifølge SEQ ID NO: 207; en letkæde-CDR2 med sekvensen ifølge resterne 51-57 ifølge SEQ ID NO: 207; en letkæde-CDR3 med sekvensen ifølge resterne 90-98 ifølge SEQ ID NO: 207; en tungkæde-CDRl med sekvensen ifølge SEQ ID NO: 111; en tungkæde-CDR2 med sekvensen ifølge SEQ ID NO: 118; og en tungkæde-CDR3 med sekvensen ifølge resterne 100-112 ifølge SEQ ID NO: 201.
4. Isoleret antistof eller CD200-bindende fragment deraf ifølge et hvilket som helst af kravene 1-3, hvor det CD200-bindende fragment er valgt fra gruppen bestående af et Fv-, scFv-, Fab'- eller F(ab')2-fragment.
5. Farmaceutisk sammensætning, som omfatter en farmaceutisk acceptabel bærer og det isolerede antistof eller CD200-bindende fragment ifølge et hvilket som helst af kravene 1-4.
6. Isoleret antistof eller CD200-bindende fragment ifølge et hvilket som helst af kravene 1-4 til anvendelse til behandling af en cancer hos et individ.
7. Isoleret antistof eller CD200-bindende fragment deraf til anvendelse ifølge krav 6, hvor canceren omfatter cancerceller, der overudtrykker CD200.
8. Isoleret antistof eller CD200-bindende fragment deraf til anvendelse ifølge krav 6 eller 7, hvor canceren er kronisk lymfatisk leukæmi.
9. Isoleret antistof eller CD200-bindende fragment deraf til anvendelse ifølge krav 8, hvor den kroniske lymfatiske leukæmi er kronisk lymfatisk B-celleleukæmi.
10. Farmaceutisk sammensætning ifølge krav 5 til anvendelse til behandling af cancer.
DK11009020.6T 2004-07-20 2005-07-19 Polypeptider og antistoffer, som stammer fra kronisk lymfatisk leukæmi-celler, og anvendelser deraf DK2441777T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/894,672 US9249229B2 (en) 2000-12-08 2004-07-20 Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
US10/996,316 US7408041B2 (en) 2000-12-08 2004-11-23 Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
US11/171,567 US20060057651A1 (en) 2000-12-08 2005-06-30 Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
EP05774630A EP1786464A4 (en) 2004-07-20 2005-07-19 POLYPEPTIDES AND ANTIBODIES FROM CHRONIC LYMPHOCYTIC LEUKEMIC CELLS AND USES THEREOF

Publications (1)

Publication Number Publication Date
DK2441777T3 true DK2441777T3 (da) 2016-05-17

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DK11009020.6T DK2441777T3 (da) 2004-07-20 2005-07-19 Polypeptider og antistoffer, som stammer fra kronisk lymfatisk leukæmi-celler, og anvendelser deraf

Country Status (8)

Country Link
US (4) US20060057651A1 (da)
EP (2) EP1786464A4 (da)
JP (2) JP2008513354A (da)
AU (1) AU2005274785B2 (da)
CA (1) CA2574488C (da)
DK (1) DK2441777T3 (da)
ES (1) ES2569240T3 (da)
WO (1) WO2006020266A2 (da)

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US7915000B2 (en) 2011-03-29
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