DK2405748T3 - Administration af intravenøs ibuprofen - Google Patents
Administration af intravenøs ibuprofen Download PDFInfo
- Publication number
- DK2405748T3 DK2405748T3 DK10751461.4T DK10751461T DK2405748T3 DK 2405748 T3 DK2405748 T3 DK 2405748T3 DK 10751461 T DK10751461 T DK 10751461T DK 2405748 T3 DK2405748 T3 DK 2405748T3
- Authority
- DK
- Denmark
- Prior art keywords
- ibuprofen
- pain
- patients
- hours
- morphine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (6)
1. Intravenøs ibuprofenformulering til anvendelse i en fremgangsmåde til reducering af smerter hos humane patienter, der gennemgår abdominal- eller ortopædkirurgi, som omfatter (i) intravenøs administrering af formuleringen præoperativt til patienterne i en mængde på 800 mg ibuprofen; og (ii) administrering af et opioidt analgetikum til patienterne postoperativt til behandling af smerter; til reducering af postoperative smerter hos patienterne.
2. Formulering til anvendelse ifølge krav 1, der yderligere omfatter administrering af formuleringen hver sjette time postoperativt til patienten i mindst 24 timer postoperativt.
3. Formulering til anvendelse ifølge krav 2, der yderligere omfatter administrering af én dosis af ibuprofen over et tidsrum på 30 minutter hver 6. time i 8 doser og herefter hver 6. time efter behov for smerter.
4. Formulering til anvendelse ifølge krav 1, der yderligere omfatter intravenøs administrering af 800 mg ibuprofen administreret hver 6. time startende ved indledning af anæstesi.
5. Formulering til anvendelse ifølge krav 1 til reducering af tiden til mobilisering postoperativt hos humane patienter, der gennemgår ortopædkirurgiske procedurer, hvor ibuprofen administreres intravenøst hver 6. time startende ved indledning af intravenøs anæstesi indtil mindst 24 timer efter operation.
6. Formulering til anvendelse ifølge krav 1 eller 2 i en fremgangsmåde til reducering af smerter hos humane patienter, der gennemgår abdominal- eller ortopædkirurgi, som omfatter (i) intravenøs administrering af formuleringen præoperativt til patienten i en mængde på 800 mg ibuprofen; (ii) administrering af et opioidt analgetikum til patienten postoperativt til behandling af smerter; og (iii) intravenøs administrering af en yderligere dosis af 800 mg ibuprofen hver sjette time postoperativt til patienten indtil mindst 24 timer efter operationen; til derved reducering af postoperative smerter hos patienterne.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15958509P | 2009-03-12 | 2009-03-12 | |
PCT/US2010/027096 WO2010105129A1 (en) | 2009-03-12 | 2010-03-12 | Administration of intravenous ibuprofen |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2405748T3 true DK2405748T3 (da) | 2018-12-03 |
Family
ID=42728808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10751461.4T DK2405748T3 (da) | 2009-03-12 | 2010-03-12 | Administration af intravenøs ibuprofen |
Country Status (12)
Country | Link |
---|---|
US (3) | US9012508B2 (da) |
EP (2) | EP3417708B1 (da) |
JP (1) | JP2012523377A (da) |
KR (3) | KR20140014350A (da) |
CN (1) | CN102413687A (da) |
AU (1) | AU2010224063B2 (da) |
BR (1) | BRPI1006222A2 (da) |
CA (1) | CA2754922C (da) |
DK (1) | DK2405748T3 (da) |
ES (2) | ES2823249T3 (da) |
PT (2) | PT3417708T (da) |
WO (1) | WO2010105129A1 (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2823249T3 (es) | 2009-03-12 | 2021-05-06 | Cumberland Pharmaceuticals Inc | Administración de ibuprofeno por vía intravenosa |
CA2814057C (en) * | 2010-11-04 | 2022-02-01 | Aft Pharmaceuticals Limited | Intravenous composition comprising paracetamol and ibuprofen |
US20130190403A1 (en) * | 2012-01-23 | 2013-07-25 | Cumberland Pharmaceuticals Inc. | Administration of intravenous ibuprofen to trauma patients |
US9072661B2 (en) | 2012-03-16 | 2015-07-07 | Cumberland Pharmaceuticals Inc. | Injectable ibuprofen formulation |
US9072710B2 (en) | 2012-03-16 | 2015-07-07 | Cumberland Pharmaceuticals Inc. | Injectable ibuprofen formulation |
CN106999454A (zh) * | 2014-10-06 | 2017-08-01 | 坎伯兰医药品股份有限公司 | 共同施用静脉内布洛芬和对乙酰氨基酚以治疗疼痛 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1497044A (en) | 1974-03-07 | 1978-01-05 | Prodotti Antibiotici Spa | Salts of phenyl-alkanoic acids |
DE2914788A1 (de) | 1979-04-11 | 1980-10-16 | Nattermann A & Cie | Parenteral applizierbare, stabile arzneimittelloesungen mit entzuendungshemmender wirkung |
US4587252A (en) | 1984-12-18 | 1986-05-06 | Brighton Pharmaceutical, Inc. | Hydrocodone/ibuprofen pharmaceutical compositions and method |
CH664085A5 (de) | 1985-02-08 | 1988-02-15 | Ciba Geigy Ag | Pharmazeutische praeparate mit analgetischer wirksamkeit, sowie deren herstellung. |
US4569937A (en) | 1985-02-11 | 1986-02-11 | E. I. Du Pont De Nemours And Company | Analgesic mixture of oxycodone and ibuprofen |
GB8521350D0 (en) | 1985-08-28 | 1985-10-02 | Euro Celtique Sa | Analgesic composition |
US4859704A (en) | 1987-10-15 | 1989-08-22 | Oratech Pharmaceutical Development Corporation | Water soluble ibuprofen compositions and methods of making them |
US4861797A (en) | 1987-10-15 | 1989-08-29 | Oratech Pharmaceutical Development Corporation | Liquid ibuprofen compositions and methods of making them |
US5200558A (en) | 1989-10-17 | 1993-04-06 | Merck & Co., Inc. | S(+)-ibuprofen-L-amino acid and S(+)-ibuprofen-D-amino acid as onset-hastened enhanced analgesics |
TW225536B (da) | 1990-08-23 | 1994-06-21 | Ciba Geigy Ag | |
IT1264857B1 (it) | 1993-06-21 | 1996-10-17 | Zambon Spa | Composizione farmaceutica liquida per uso orale contenente acido 2-(4-isobutilfenil) propionico |
IT1266583B1 (it) | 1993-07-30 | 1997-01-09 | Zambon Spa | Processo per la preparazione di sali dell'acido 2-(4-isobutilfenil)- propionico |
US5840731A (en) * | 1995-08-02 | 1998-11-24 | Virginia Commonwealth University | Pain-alleviating drug composition and method for alleviating pain |
DE19912436A1 (de) * | 1999-03-19 | 2000-09-21 | Merckle Gmbh | Ibuprofen-Lösung |
US6423746B1 (en) * | 1999-07-03 | 2002-07-23 | The William M. Yarbrough Foundation | Urushiol induced contact dermatitis and method of use |
US6342530B1 (en) * | 2000-11-14 | 2002-01-29 | Farmacon-Il, Llc | Composition and method for parenteral administration of ibuprofen d,l- or l-lysine salt |
ES2253326T3 (es) | 2001-11-02 | 2006-06-01 | Cumberland Pharmaceuticals Inc. | Composicion farmaceutica de acido 2-(4-isobutilfenilo)propionico. |
US20040132823A1 (en) * | 2001-11-02 | 2004-07-08 | Leo Pavliv | Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid |
US6727286B2 (en) | 2001-11-02 | 2004-04-27 | Cumberland Pharmaceuticals Inc. | Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid |
WO2004050025A2 (en) * | 2002-11-29 | 2004-06-17 | Forest Laboratories, Inc. | Combination of ibuprofen and oxycodone for acute pain relief |
CA2516454A1 (en) | 2003-02-19 | 2004-09-02 | Rinat Neuroscience Corp. | Methods for treating pain by administering a nerve growth factor antagonist and an nsaid and compositions containing the same |
ZA200506509B (en) | 2003-02-19 | 2006-12-27 | Rinat Neuroscience Corp | Methods for treating pain by administering a nerve growth factor antagonist and an nsaid and compositions containing the same |
US7151084B2 (en) * | 2004-12-27 | 2006-12-19 | Miller Landon C G | Compound and method of treating neurogenic conditions using non-steroidal anti-inflammatory drug complexes |
MX2007014862A (es) | 2005-05-27 | 2008-02-21 | Panacea Biotec Ltd | Composiciones inyectables y procedimiento para la preparacion de dichas composiciones. |
TW200745106A (en) * | 2005-10-03 | 2007-12-16 | Astrazeneca Ab | Chemical compounds |
US7544676B2 (en) * | 2005-11-10 | 2009-06-09 | Adolor Corporation | Sulfamoyl benzamides and methods of their use |
PL2190418T3 (pl) * | 2007-08-15 | 2014-03-31 | Mcneil Ppc Inc | Sposób dawkowania ibuprofenu o natychmiastowym i długotrwałym uwalnianiu |
US8652525B2 (en) * | 2008-07-10 | 2014-02-18 | Tyrx, Inc. | NSAID delivery from polyarylates |
ES2823249T3 (es) | 2009-03-12 | 2021-05-06 | Cumberland Pharmaceuticals Inc | Administración de ibuprofeno por vía intravenosa |
US8871810B2 (en) * | 2009-07-15 | 2014-10-28 | Cumberland Pharmaceuticals Inc. | Treating critically ill patients with intravenous ibuprofen |
US8735452B2 (en) * | 2009-07-15 | 2014-05-27 | Cumberland Pharmaceuticals Inc. | Treating patients with intravenous ibuprofen |
WO2011014208A1 (en) * | 2009-07-31 | 2011-02-03 | Leo Pavliv | Treating critically ill patients with intravenous ibuprofen |
-
2010
- 2010-03-12 ES ES18183929T patent/ES2823249T3/es active Active
- 2010-03-12 CN CN2010800184058A patent/CN102413687A/zh active Pending
- 2010-03-12 BR BRPI1006222A patent/BRPI1006222A2/pt not_active Application Discontinuation
- 2010-03-12 KR KR1020117023915A patent/KR20140014350A/ko active Search and Examination
- 2010-03-12 KR KR1020187014956A patent/KR101971412B1/ko active IP Right Grant
- 2010-03-12 ES ES10751461.4T patent/ES2694506T3/es active Active
- 2010-03-12 EP EP18183929.1A patent/EP3417708B1/en active Active
- 2010-03-12 JP JP2011554226A patent/JP2012523377A/ja active Pending
- 2010-03-12 PT PT181839291T patent/PT3417708T/pt unknown
- 2010-03-12 CA CA2754922A patent/CA2754922C/en active Active
- 2010-03-12 DK DK10751461.4T patent/DK2405748T3/da active
- 2010-03-12 KR KR1020177021434A patent/KR101864559B1/ko active IP Right Grant
- 2010-03-12 PT PT10751461T patent/PT2405748T/pt unknown
- 2010-03-12 US US12/722,682 patent/US9012508B2/en active Active
- 2010-03-12 WO PCT/US2010/027096 patent/WO2010105129A1/en active Application Filing
- 2010-03-12 EP EP10751461.4A patent/EP2405748B1/en not_active Not-in-force
- 2010-03-12 AU AU2010224063A patent/AU2010224063B2/en active Active
-
2015
- 2015-04-02 US US14/677,691 patent/US20150209315A1/en not_active Abandoned
-
2017
- 2017-06-20 US US15/628,213 patent/US20170281534A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2694506T3 (es) | 2018-12-21 |
CA2754922A1 (en) | 2010-09-16 |
KR101971412B1 (ko) | 2019-04-22 |
US20100234465A1 (en) | 2010-09-16 |
KR20180063901A (ko) | 2018-06-12 |
ES2823249T3 (es) | 2021-05-06 |
JP2012523377A (ja) | 2012-10-04 |
KR20140014350A (ko) | 2014-02-06 |
CA2754922C (en) | 2016-10-18 |
KR101864559B1 (ko) | 2018-06-04 |
EP2405748A1 (en) | 2012-01-18 |
US9012508B2 (en) | 2015-04-21 |
PT3417708T (pt) | 2020-10-12 |
KR20170091775A (ko) | 2017-08-09 |
AU2010224063B2 (en) | 2015-04-16 |
BRPI1006222A2 (pt) | 2016-08-02 |
EP3417708B1 (en) | 2020-06-17 |
EP2405748A4 (en) | 2012-08-08 |
US20170281534A1 (en) | 2017-10-05 |
AU2010224063A1 (en) | 2011-09-29 |
US20150209315A1 (en) | 2015-07-30 |
WO2010105129A1 (en) | 2010-09-16 |
EP3417708A1 (en) | 2018-12-26 |
CN102413687A (zh) | 2012-04-11 |
PT2405748T (pt) | 2018-11-23 |
EP2405748B1 (en) | 2018-08-15 |
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