DK2364185T3 - Disubstituerede phthalazin-hedgehog-pathway-antagonister - Google Patents

Disubstituerede phthalazin-hedgehog-pathway-antagonister

Info

Publication number
DK2364185T3
DK2364185T3 DK09740613.6T DK09740613T DK2364185T3 DK 2364185 T3 DK2364185 T3 DK 2364185T3 DK 09740613 T DK09740613 T DK 09740613T DK 2364185 T3 DK2364185 T3 DK 2364185T3
Authority
DK
Denmark
Prior art keywords
hedgehog pathway
pathway antagonists
disubstituted phthalazine
phthalazine
disubstituted
Prior art date
Application number
DK09740613.6T
Other languages
Danish (da)
English (en)
Inventor
Jolie Anne Bastian
Philip Arthur Hipskind
Daniel Jon Sall
Takako Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2364185(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK2364185T3 publication Critical patent/DK2364185T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK09740613.6T 2008-11-03 2009-10-22 Disubstituerede phthalazin-hedgehog-pathway-antagonister DK2364185T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11070308P 2008-11-03 2008-11-03
PCT/US2009/061573 WO2010062507A1 (en) 2008-11-03 2009-10-22 Disubstituted phthalazine hedgehog pathway antagonists

Publications (1)

Publication Number Publication Date
DK2364185T3 true DK2364185T3 (da) 2013-06-03

Family

ID=41566219

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09740613.6T DK2364185T3 (da) 2008-11-03 2009-10-22 Disubstituerede phthalazin-hedgehog-pathway-antagonister

Country Status (29)

Country Link
US (1) US8404687B2 (https=)
EP (1) EP2364185B1 (https=)
JP (1) JP2012507535A (https=)
KR (1) KR101335746B1 (https=)
CN (1) CN102202737B (https=)
AU (1) AU2009320251C1 (https=)
BR (1) BRPI0921437A2 (https=)
CA (1) CA2742539C (https=)
CL (1) CL2011000979A1 (https=)
CO (1) CO6382123A2 (https=)
CR (1) CR20110202A (https=)
CY (1) CY1114023T1 (https=)
DK (1) DK2364185T3 (https=)
EA (1) EA018931B1 (https=)
EC (1) ECSP11011021A (https=)
ES (1) ES2418479T3 (https=)
HR (1) HRP20130527T1 (https=)
IL (1) IL211841A0 (https=)
MA (1) MA32726B1 (https=)
MX (1) MX2011004683A (https=)
NZ (1) NZ591945A (https=)
PE (1) PE20110433A1 (https=)
PL (1) PL2364185T3 (https=)
PT (1) PT2364185E (https=)
SI (1) SI2364185T1 (https=)
TN (1) TN2011000166A1 (https=)
UA (1) UA102115C2 (https=)
WO (1) WO2010062507A1 (https=)
ZA (1) ZA201102448B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2681162C (en) * 2007-03-15 2015-11-24 Novartis Ag Benzyl and pyridine derivatives as modulators of hedgehog pathway
UA102250C2 (ru) 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
KR101342184B1 (ko) 2008-11-17 2013-12-19 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
BRPI0921777A2 (pt) 2008-11-17 2016-01-12 Lilly Co Eli antagonistas da via hedgehog de piridazina tetrassubstituída
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
JP2023546536A (ja) 2020-10-13 2023-11-02 エンデバー バイオメディシンズ， インコーポレイテッド 線維症を処置する方法
US12605377B2 (en) 2020-10-13 2026-04-21 Endeavor Biomedicines, Inc. Methods of treating fibrosis
IL319619A (en) * 2022-09-23 2025-05-01 Merck Sharp & Dohme Llc Phthalazine derivatives used as NOD-LIKE PROTEIN 3 receptor inhibitors
WO2025188802A1 (en) 2024-03-05 2025-09-12 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
MY117098A (en) * 1996-01-15 2004-05-31 Janssen Pharmaceutica Nv Angiogenesis inhibiting pyridazinamines
EP0882717B1 (en) * 1996-10-01 2010-09-08 Kyowa Hakko Kirin Co., Ltd. Nitrogenous heterocyclic compounds
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
JP5067986B2 (ja) 1998-04-09 2012-11-07 ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用
ATE283700T1 (de) 1999-06-08 2004-12-15 Lorantis Ltd Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges
EP1496905B1 (en) 2002-04-22 2008-08-13 Johns Hopkins University School of Medicine Modulators of hedgehog signaling pathways, compositions and uses related thereto
WO2004020599A2 (en) 2002-08-29 2004-03-11 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
WO2006004589A2 (en) 2004-05-08 2006-01-12 Neurogen Corporation 3-aryl-5,6-disubstituted pyridazines
ES2377430T3 (es) * 2004-09-02 2012-03-27 Genentech, Inc. Inhibidores piridílicos de la señalización de hedgehog
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
CA2681162C (en) * 2007-03-15 2015-11-24 Novartis Ag Benzyl and pyridine derivatives as modulators of hedgehog pathway
US8153633B2 (en) * 2007-06-25 2012-04-10 Amgen Inc. Phthalazine compounds, compositions and methods of use
US8222251B2 (en) 2007-09-07 2012-07-17 Amgen Inc. Pyridopyridazine compounds, compositions and methods of use
UA102250C2 (ru) * 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
BRPI0921777A2 (pt) 2008-11-17 2016-01-12 Lilly Co Eli antagonistas da via hedgehog de piridazina tetrassubstituída
KR101342184B1 (ko) 2008-11-17 2013-12-19 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
CA2742539A1 (en) 2010-06-03
NZ591945A (en) 2012-10-26
TN2011000166A1 (en) 2012-12-17
CL2011000979A1 (es) 2011-10-07
ECSP11011021A (es) 2011-06-30
CN102202737A (zh) 2011-09-28
CR20110202A (es) 2011-06-09
EA018931B1 (ru) 2013-11-29
WO2010062507A1 (en) 2010-06-03
EP2364185B1 (en) 2013-05-22
CA2742539C (en) 2014-05-06
CO6382123A2 (es) 2012-02-15
CN102202737B (zh) 2014-03-26
KR101335746B1 (ko) 2013-12-12
HK1159010A1 (en) 2012-07-27
KR20110066212A (ko) 2011-06-16
ES2418479T3 (es) 2013-08-14
BRPI0921437A2 (pt) 2018-10-30
US8404687B2 (en) 2013-03-26
MA32726B1 (fr) 2011-10-02
IL211841A0 (en) 2011-06-30
JP2012507535A (ja) 2012-03-29
HRP20130527T1 (en) 2013-07-31
EP2364185A1 (en) 2011-09-14
US20110190304A1 (en) 2011-08-04
PE20110433A1 (es) 2011-07-09
EA201170640A1 (ru) 2011-12-30
PT2364185E (pt) 2013-07-24
AU2009320251B2 (en) 2013-01-24
UA102115C2 (ru) 2013-06-10
ZA201102448B (en) 2012-09-26
CY1114023T1 (el) 2016-07-27
SI2364185T1 (sl) 2013-07-31
PL2364185T3 (pl) 2013-10-31
AU2009320251C1 (en) 2013-08-15
AU2009320251A1 (en) 2010-06-03
MX2011004683A (es) 2011-06-20

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