DK2361091T3 - Galdesyre og biguanider som proteasehæmmere til bevarelse af peptiders integritet i tarmen - Google Patents
Galdesyre og biguanider som proteasehæmmere til bevarelse af peptiders integritet i tarmen Download PDFInfo
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- DK2361091T3 DK2361091T3 DK09817101T DK09817101T DK2361091T3 DK 2361091 T3 DK2361091 T3 DK 2361091T3 DK 09817101 T DK09817101 T DK 09817101T DK 09817101 T DK09817101 T DK 09817101T DK 2361091 T3 DK2361091 T3 DK 2361091T3
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- peptide
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- 239000002753 trypsin inhibitor Substances 0.000 description 1
- GHCZAUBVMUEKKP-UHFFFAOYSA-N ursodeoxycholic acid glycine-conjugate Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCC(O)=O)C)C1(C)CC2 GHCZAUBVMUEKKP-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (6)
1. Forbindelse til anvendelse i en fremgangsmåde til behandling af en sygdom i en menneskeeller dyrekrop ved terapi, i hvilken fremgangsmåde (i) menneske- eller dyrekroppen behandles ved administration af et eller flere terapeutiske peptider til tarmen, og (ii) forbindelsen administreres til tarmen for at hæmme nedbrydning af det ene eller flere peptider ved én eller flere serinproteaser, hvor forbindelsen er en galdesyre eller et biguanid, eller et farmaceutisk acceptabelt salt af galdesyren eller biguanidet, hvor galdesyren er udvalgt fra chenodesoxycholsyre, ursodesoxycholsyre, glycochenodesoxycholsyre og glycodesoxycholsyre, og hvor biguanidet er metformin eller phenformin, hvor det ene eller flere terapeutiske peptider er udvalgt fra insulin, calcitonin, væksthormon, væksthormonfrigivende faktorer, galanin, parathyroideahormon, peptid YY, oxyntomodulin, erythropoeitiner, kolonistimulerende faktorer, blodpladeafledte vækstfaktorer, epidermale vækstfaktorer, fibroblastvækstfaktorer, transformerende vækstfaktorer, GLP-1, GLP-2, exendin, leptin, neurotrofe faktorer, insulin-lignende vækstfaktorer, brusk-inducerende faktorer, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, interferon-gamma, interferon-la, alpha-interferoner og konjugater af et/en hvilket/hvilken som helst af ovenstående.
2. Forbindelse ifølge krav 1 til en anvendelse som defineret i krav 1, hvor forbindelsen er udvalgt fra chenodesoxycholsyre, ursodesoxycholsyre, glycochenodesoxycholsyre, glycodesoxycholsyre eller et farmaceutisk acceptabelt salt af disse forbindelser.
3. Forbindelse ifølge krav 1 til en anvendelse som defineret i krav 1, hvor forbindelsen er chenodesoxycholsyre eller et farmaceutisk acceptabelt salt deraf.
4. Forbindelse ifølge krav 1 til en anvendelse som defineret i krav 1, hvor forbindelsen er metformin eller phenformin eller et farmaceutisk acceptabelt salt af metformin eller phenformin.
5. Forbindelse ifølge krav 1 til en anvendelse som defineret i krav 1, hvor forbindelsen er metformin eller et farmaceutisk acceptabelt salt deraf.
6. Produkt eller farmaceutisk sammensætning indeholdende: (a) en forbindelse som defineret i et hvilket som helst af kravene 1 til 5, og (b) et peptid eller polypeptid, hvor (a) og (b) er fremstillet til samtidig, separat eller sekventiel indgivelse til et individ, hvor peptidet eller polypeptidet er beregnet til placering i tarmen til anvendelse i behandlingen ved terapi af en sygdom eller tilstand, der rammer individet, eller til anvendelse i forebyggelse af en sygdom eller tilstand, der rammer individet, og hvor forbindelsen er beregnet til anvendelse som en hæmmer af nedbrydningen af peptidet eller polypeptidet ved én eller flere serinproteaser, og hvor peptidet eller polypeptidet er udvalgt fra peptiderne defineret i krav 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0817969.9A GB0817969D0 (en) | 2008-10-01 | 2008-10-01 | Pharmaceutical composition |
| PCT/AU2009/001305 WO2010037173A1 (en) | 2008-10-01 | 2009-10-01 | Bile acids and biguanides as protease inhibitors for preserving the integrity of peptides in the gut |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2361091T3 true DK2361091T3 (da) | 2015-04-20 |
Family
ID=40019875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09817101T DK2361091T3 (da) | 2008-10-01 | 2009-10-01 | Galdesyre og biguanider som proteasehæmmere til bevarelse af peptiders integritet i tarmen |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9913850B2 (da) |
| EP (2) | EP2873420A1 (da) |
| KR (1) | KR101731656B1 (da) |
| CN (1) | CN102307582B (da) |
| AU (1) | AU2009299112B2 (da) |
| CA (1) | CA2740477C (da) |
| DK (1) | DK2361091T3 (da) |
| ES (1) | ES2535260T3 (da) |
| GB (1) | GB0817969D0 (da) |
| HK (1) | HK1209643A1 (da) |
| IL (1) | IL212050A (da) |
| PL (1) | PL2361091T3 (da) |
| PT (1) | PT2361091E (da) |
| RU (1) | RU2525290C2 (da) |
| SI (1) | SI2361091T1 (da) |
| WO (1) | WO2010037173A1 (da) |
| ZA (1) | ZA201102401B (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101724431B1 (ko) | 2015-08-19 | 2017-04-18 | 대우조선해양 주식회사 | 선박용 스러스터의 설치방법 및 이를 위한 얼라인먼트 결정용 지그 |
| CA3168207A1 (en) * | 2020-01-23 | 2021-07-29 | Axcess (Uk) Ltd. | Cellular uptake |
| EP4281062A1 (en) * | 2021-01-22 | 2023-11-29 | AXCESS (UK) Ltd. | Edta and egta for use in preserving the integrity of therapeutic compounds |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68769A (en) * | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
| US6156731A (en) * | 1989-05-10 | 2000-12-05 | G. D. Searle & Co. | Polypeptide composition for oral administration |
| US5085864A (en) * | 1989-10-30 | 1992-02-04 | Abbott Laboratories | Injectable formulation for lipophilic drugs |
| GB9013448D0 (en) | 1990-06-15 | 1990-08-08 | Sandoz Ltd | Pharmaceutical resorption-improved somatostatin compositions,their preparation and use |
| DK36392D0 (da) * | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Anvendelse af kemisk forbindelse |
| DK0640344T3 (da) * | 1993-08-30 | 1999-07-05 | Medichemie Ag | Ursodesoxycholsyreholdigt lægemiddel i flydende administreringsform |
| GB9417524D0 (en) * | 1994-08-31 | 1994-10-19 | Cortecs Ltd | Pharmaceutical compositions |
| AU1808897A (en) | 1995-12-13 | 1997-07-03 | Dullatur Limited | A calcitonin preparation |
| DE19845403B4 (de) * | 1998-10-02 | 2005-02-10 | Aventis Pharma Deutschland Gmbh | Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| GB2355009A (en) | 1999-07-30 | 2001-04-11 | Univ Glasgow | Peptides conjugated to bile acids/salts |
| US7524515B2 (en) * | 2003-01-10 | 2009-04-28 | Mutual Pharmaceuticals, Inc. | Pharmaceutical safety dosage forms |
| US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
| GB0308734D0 (en) * | 2003-04-15 | 2003-05-21 | Axcess Ltd | Uptake of macromolecules |
| US20070265187A1 (en) * | 2004-04-29 | 2007-11-15 | Slobodan Vukicevic | Oral Formulations Comprising Bone Morphogenetic Proteins For Treating Metabolic Bone Diseases |
| CA2573856A1 (en) | 2004-08-03 | 2006-02-16 | Emisphere Technologies, Inc. | Antidiabetic oral insulin-biguanide combination |
| TW200716679A (en) | 2005-05-26 | 2007-05-01 | Bristol Myers Squibb Co | N-terminally modified GLP-1 receptor modulators |
| AU2006288703B2 (en) * | 2005-09-06 | 2011-09-22 | Oramed Pharmaceuticals, Inc. | Methods and compositions for oral administration of proteins |
| JP2009508847A (ja) | 2005-09-16 | 2009-03-05 | イッサム リサーチ ディヴェロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム | 栄養状態、認知および生存を改善するための化合物 |
| GB0603252D0 (en) * | 2006-02-17 | 2006-03-29 | Axcess Ltd | Dissolution aids for oral peptide delivery |
| US8242294B2 (en) * | 2007-06-19 | 2012-08-14 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
-
2008
- 2008-10-01 GB GBGB0817969.9A patent/GB0817969D0/en not_active Ceased
-
2009
- 2009-10-01 US US13/122,241 patent/US9913850B2/en active Active
- 2009-10-01 ES ES09817101.0T patent/ES2535260T3/es active Active
- 2009-10-01 EP EP20140197777 patent/EP2873420A1/en not_active Withdrawn
- 2009-10-01 PT PT98171010T patent/PT2361091E/pt unknown
- 2009-10-01 PL PL09817101T patent/PL2361091T3/pl unknown
- 2009-10-01 SI SI200931174T patent/SI2361091T1/sl unknown
- 2009-10-01 CN CN200980146495.6A patent/CN102307582B/zh active Active
- 2009-10-01 CA CA2740477A patent/CA2740477C/en active Active
- 2009-10-01 KR KR1020117009813A patent/KR101731656B1/ko not_active Expired - Fee Related
- 2009-10-01 RU RU2011117267/04A patent/RU2525290C2/ru active
- 2009-10-01 AU AU2009299112A patent/AU2009299112B2/en not_active Ceased
- 2009-10-01 WO PCT/AU2009/001305 patent/WO2010037173A1/en not_active Ceased
- 2009-10-01 EP EP09817101.0A patent/EP2361091B1/en active Active
- 2009-10-01 DK DK09817101T patent/DK2361091T3/da active
-
2011
- 2011-03-31 IL IL212050A patent/IL212050A/en not_active IP Right Cessation
- 2011-03-31 ZA ZA2011/02401A patent/ZA201102401B/en unknown
-
2015
- 2015-10-27 HK HK15110575.5A patent/HK1209643A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009299112A1 (en) | 2010-04-08 |
| EP2361091A1 (en) | 2011-08-31 |
| US9913850B2 (en) | 2018-03-13 |
| CA2740477C (en) | 2017-06-27 |
| EP2361091B1 (en) | 2015-01-21 |
| HK1155376A1 (en) | 2012-05-18 |
| IL212050A (en) | 2016-08-31 |
| PT2361091E (pt) | 2015-05-20 |
| CN102307582A (zh) | 2012-01-04 |
| HK1209643A1 (en) | 2016-04-08 |
| SI2361091T1 (sl) | 2015-07-31 |
| ES2535260T3 (es) | 2015-05-07 |
| EP2361091A4 (en) | 2012-05-23 |
| AU2009299112B2 (en) | 2013-09-26 |
| KR101731656B1 (ko) | 2017-04-28 |
| ZA201102401B (en) | 2011-11-30 |
| IL212050A0 (en) | 2011-06-30 |
| RU2011117267A (ru) | 2012-11-10 |
| CA2740477A1 (en) | 2010-04-08 |
| CN102307582B (zh) | 2015-10-07 |
| KR20110128782A (ko) | 2011-11-30 |
| US20120035116A1 (en) | 2012-02-09 |
| GB0817969D0 (en) | 2008-11-05 |
| WO2010037173A1 (en) | 2010-04-08 |
| EP2873420A1 (en) | 2015-05-20 |
| PL2361091T3 (pl) | 2015-08-31 |
| RU2525290C2 (ru) | 2014-08-10 |
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