DK2300077T3 - Modullær hudklæbbart system til medicinsk fluidindgivelse - Google Patents

Modullær hudklæbbart system til medicinsk fluidindgivelse Download PDF

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DK2300077T3
DK2300077T3 DK09730599.9T DK09730599T DK2300077T3 DK 2300077 T3 DK2300077 T3 DK 2300077T3 DK 09730599 T DK09730599 T DK 09730599T DK 2300077 T3 DK2300077 T3 DK 2300077T3
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fluid
piston rod
reservoir
disposable
housing
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DK09730599.9T
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English (en)
Inventor
Yair Dan
Avraham Neta
Ofer Yodfat
Ofer Arnold
Yossi Shalev
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Hoffmann La Roche
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1413—Modular systems comprising interconnecting elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features
    • A61M2005/1402—Priming
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M2005/14573—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for quick connection/disconnection with a driving system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/314—Flat shaped barrel forms, e.g. credit card shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A61M2205/186—General characteristics of the apparatus with alarm the sound being acoustically amplified, e.g. by resonance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3365—Rotational speed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A61M2205/3389—Continuous level detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3569—Range sublocal, e.g. between console and disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/04—Tools for specific apparatus
    • A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/1684—Monitoring, detecting, signalling or eliminating infusion flow anomalies by detecting the amount of infusate remaining, e.g. signalling end of infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels

Claims (13)

1. Bærbar terapeutisk fluidindgivelsesanordning (10), der omfatter: en genanvendelig del (100), der omfatter et hus (102) til en genanvendelig del, der indbefatter mindst en styreenhed (130), og en første del af en drivmekanisme (120), der indbefatter en motor (184); og en del til engangsbrug (200), der omfatter et hus (202) til en del til engangsbrug, der indbefatter mindst en beholder (220) til opbevaring af terapeutisk fluid, en udgangsåbning (210), hvortil det terapeutiske fluid afgives, en fluidkanal (230), der etablerer fluidforbindelse mellem beholderen (220) og udgangsåbningen (210), og en anden del af drivmekanismen (120), hvilken anden del af drivmekanismen omfatter et stempel (110) og en stempelstang (112); hvor mindst en del af huset (202) til delen til engangsbrug definerer mindst en del af beholderen (220); og hvor den anden del af drivmekanismen (120) mekanisk kan kobles til den første del af drivmekanismen (120) efter tilkobling af delen til engangsbrug (200) til den genanvendelige del (100); kendetegnet ved, at: den første del af drivmekanismen (120) endvidere omfatter et drivhylster (186); stempelstangen (112) er mekanisk koblet ved en første ende af stempelstangen (112) til stemplet (110); stempelstangen (112) er med gevind; den anden del af drivmekanismen (120) endvidere omfatter en drivspids (288) mekanisk koblet til stempelstangen (112) ved en anden ende af stempelstangen (112), drivspidsen (288) er udformet til at interagere mekanisk med drivhylsteret (186) efter tilkobling af den genanvendelige del (100) og delen til engangsbrug (200): og den anden del af drivmekanismen (120) endvidere omfatter et indgrebselement (2861) koblet til og udformet til gevindindgreb med stempelstangen (112), hvor indgrebselementet (2861) endvidere er udformet til at selektivt at muliggøre styret forskydning af stempelstangen (112) og i alt væsentligt ubegrænset forskydning af stempelstangen (112) inde i mindst beholderen (220) af delen til engangsbrug (200), hvilket indgrebselement (2861) omfatter: en første åbning (2891) og en anden åbning (2901), hvor den første åbning (2891) er forbundet med den anden åbning (2901), og hvor mindst en del af den anden åbning (2901) er med gevind; og en forlængelsesstykke (2910), der strækker sig fra indgrebselementet, der, når det er aktiveret, bevirker, at indgrebselementet bevæger sig fra en første position, hvori genvindstempelstangen (112) er placeret i den første åbning (2891), hvorved der muliggøres i alt væsentligt ubegrænset lineær bevægelse af genvindstempelstangen (112) til en anden position, hvori genvindstempelstangen (112) er placeret i den anden åbning (2901), hvorved der kun muliggøres lineær bevægelse af genvindstempelstangen (112) efter rotation af genvindstempelstangen.
2. Fluidindgivelsesanordning (10) ifølge krav 1, hvor huset (202) til delen til engangsbrug omfatter en hudklæbbar base (25) udformet til at modtage den genanvendelige dels hus (102).
3. Fluidindgivelsesanordning (10) ifølge krav 1, hvor mindst én af den genanvendelige del (100) og delen til engangsbrug (200) omfatter: mindst ét chassis (181) udformet til at blive modtaget i den tilsvarende af den genanvendelige dels hus (102) og huset (202) til delen til engangsbrug og endvidere udformet til at yde strukturel støtte for én eller flere komponenter af den tilsvarende af genanvendelige del og delen til engangsbrug.
4. Fluidindgivelsesanordning (10) ifølge krav 1, hvor med det ene eller flere tandhjul (182) omfatter en del af et planetdrevsystem, hvilket planetdrevsystem endvidere omfatter et hus (182b) med et indre, der mindst delvis er med gevind, til at rumme det ene eller flere tandhjul.
5. Fluidindgivelsesanordning (10) ifølge krav 1, hvor drivhylsteret (186) omfatter en hul cylinder, hvor mindst en del af den hyle cylinder har en flerhed af tænder defineret langs en ydre periferi af mindst delen af den hyle cylinder, hvor flerheden af tænder er udformet til at interagere mekanisk med det ene eller flere tandhjul af den første del af drivmekanismen.
6. Fluidindgivelsesanordning (10) ifølge krav 1, hvor drivspidsen (288) indbefatter en flerhed af ribber placeret med afstand fra hinanden langs periferien af spidsen, hvor drivspidsen (288) kan modtages inde i et drivhylster (186) af den første del af drivmekanismen (120) mekanisk koblet til en motor (184) ved hjælp af ét eller flere tandhjul (182).
7. Fluidindgivelsesanordning (10) ifølge krav 6, hvor drivhylsteret (186) indbefatter en flerhed af riller inde i hylsteret, hvilke riller er placeret med afstand fra hinanden for at svare til afstanden af flerheden af drivspidsens (288) ribber.
8. Fluidindgivelsesanordning (10) ifølge krav 7, hvor rillerne inde i drivhylsteret (186) i alt væsentligt er parallelle med drivhylsterets længdeakse.
9. Fluidindgivelsesanordning (10) ifølge krav 1, hvor forlængelsesstykket (2910) aktiveres af en aktuator efter tilkobling af den genanvendelige del (100) og delen til engangsbrug (200).
10. Fluidindgivelsesanordning (10) ifølge krav 1, hvor den første del af drivmekanismen endvidere omfatter ét eller flere tandhjul (182) aktiveret af motoren (184), med drivhylsteret (186) i mekanisk forbindelse med det ene eller flere tandhjul (182), således at rotationskraft overført af med det ene eller flere tandhjul (182) bevirker rotationsbevægelse af drivhylsteret (186).
11. Fluidindgivelsesanordning (10) ifølge krav 6, hvor drivspidsen (288) omfatter en konveks profil for at lette modtagelsen af drivspidsen inde i drivhylsteret (186).
12. Fluidindgivelsessystem (1000), der omfatter: den bærbare fluidindgivelsesanordning (10) ifølge krav 1; en fjernstyringsenhed (900) til at styre funktionen af mindst den bærbare fluidindgivelsesanordning (10); og en hudklæbbar holder (20), der kan forbindes med fluidindgivelsesanordningen (10), således at fluidindgivelsesanordningen aftageligt kan forbindes med den hudklæbbare holder.
13. Fluidindgivelsessystem (1000) ifølge krav 13, hvor fjemstyringsenheden (900) endvidere omfatter: en åbning (908) til at modtage en teststrimmel (907), der indeholder en blodprøve fra en bruger; og en analysandsensor udformet til at bestemme analysandkoncentrationsniveauer i brugerens blod.
DK09730599.9T 2008-04-09 2009-04-07 Modullær hudklæbbart system til medicinsk fluidindgivelse DK2300077T3 (da)

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US12350908P 2008-04-09 2008-04-09
PCT/IL2009/000388 WO2009125398A2 (en) 2008-04-09 2009-04-07 Systems, devices and methods for fluid delivery

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DK2300077T3 true DK2300077T3 (da) 2017-08-28

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DK17174680.3T DK3260145T3 (da) 2008-04-09 2009-04-07 Fluidniveausensor til et modulopbygget, hudklæbbart system til medicinsk fluidlevering

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US (2) US8568361B2 (da)
EP (3) EP3260145B1 (da)
JP (1) JP5506780B2 (da)
CN (2) CN102083483B (da)
AU (1) AU2009235064A1 (da)
DK (2) DK2300077T3 (da)
ES (1) ES2772756T3 (da)
HK (1) HK1186134A1 (da)
WO (1) WO2009125398A2 (da)

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HK1186134A1 (en) 2014-03-07
AU2009235064A1 (en) 2009-10-15
ES2772756T3 (es) 2020-07-08
US20110160652A1 (en) 2011-06-30
JP2011516196A (ja) 2011-05-26
EP3260145A1 (en) 2017-12-27
JP5506780B2 (ja) 2014-05-28
EP2300077B1 (en) 2017-07-19
CN102083483A (zh) 2011-06-01
CN103127573A (zh) 2013-06-05
CN103127573B (zh) 2015-03-25
US9486574B2 (en) 2016-11-08
CN102083483B (zh) 2013-07-24
EP3639869A1 (en) 2020-04-22
US20140052055A1 (en) 2014-02-20
WO2009125398A2 (en) 2009-10-15
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EP2300077A2 (en) 2011-03-30
WO2009125398A3 (en) 2010-02-18

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