DK2296581T3 - Biomateriale - Google Patents

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DK2296581T3
DK2296581T3 DK09766306.6T DK09766306T DK2296581T3 DK 2296581 T3 DK2296581 T3 DK 2296581T3 DK 09766306 T DK09766306 T DK 09766306T DK 2296581 T3 DK2296581 T3 DK 2296581T3
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independently
oxide
viscoelastic
bio
carbamate
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DK09766306.6T
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Niall Behan
Ashutosh Kumar
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Coloplast As
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C08G77/458—Block-or graft-polymers containing polysiloxane sequences containing polyurethane sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/50—Polyethers having heteroatoms other than oxygen
    • C08G18/5096—Polyethers having heteroatoms other than oxygen containing silicon
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/61—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
    • C08G18/6505—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen the low-molecular compounds being compounds of group C08G18/32 or polyamines of C08G18/38
    • C08G18/6523—Compounds of group C08G18/3225 or C08G18/3271 or polyamines of C08G18/38
    • C08G18/6535—Compounds of group C08G18/3271
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/38—Polysiloxanes modified by chemical after-treatment
    • C08G77/382—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon
    • C08G77/388—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C08G77/445—Block-or graft-polymers containing polysiloxane sequences containing polyester sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C08G77/445—Block-or graft-polymers containing polysiloxane sequences containing polyester sequences
    • C08G77/448—Block-or graft-polymers containing polysiloxane sequences containing polyester sequences containing polycarbonate sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C08G77/46—Block-or graft-polymers containing polysiloxane sequences containing polyether sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/10—Block- or graft-copolymers containing polysiloxane sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/044—Oesophagi or esophagi or gullets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/045—Stomach, intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2110/00—Foam properties
    • C08G2110/0008—Foam properties flexible
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2110/00—Foam properties
    • C08G2110/0083—Foam properties prepared using water as the sole blowing agent

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)

Claims (12)

  1. BIOMATERIALE Patent krav I. Viskoelastisk biostabilt skum, der omfatter en triblok-copolymer af forme!rest i; hvor:
    hver I er et btndingspunkt til en urethan·* eller ureakobling; hver af X og Y uafhængigt er en ether, en ester, en carhonat eller et iluorearbonhydrid eller en blanding deraf; hver af R1, R3, Ry R4, R3 og R” uafhængigt er valgt blandt en eller liere af R, OR, ~CO:;R, en fluoreret earbonhydrkl, en polvether, en polyester eller en fluorpolymer; hver R uafhængigt er hydrogen, en eventuelt substitueret Cwealifatisk gruppe eller en eventuelt substitueret gruppe valgt blandt phenyl, en 8-1 O-leddet bi cyklisk ary i, en 4-8-leddet monocyklisk mættet eller delvist umættet heteroeyklisk ring, der har I -2 heteroatomer, der er valgt uafhængigt blandt nitrogen, oxygen eller svovl, eller en S-6-leddet monocyklisk eller 8-1.0-leddet bicyklisk heteroarylgruppe, der har 1-4 heteroatomer, der er valgt uafhængigt blandt nitrogen, oxygen eller svovl; hver af m, n og p uafhængigt er 2 til 100; og hver af L1 og I2 uafhængigt er en bivalent Cnsocarbonhydridkæde, hvor 3-4 methylenenheder i carbonhydridkæden eventuelt og uafhængigt er substitueret med -O-, -S-, -N(R>, -C(O)-, -C(0)N(R)~, -N(R)C(0>-, -SOa-, -SOzNfR)-, -X(R)S02-, -OC(O)-, -C(0)0~ eller en bivalent cycloalkylen, arylen, heierocyelen eller heteroarylen, forudsat at hverken Id eller L2 omfatter en urea- eller ur ethandel, hvor det viskoelastiske biostabile skum: har en densitet på 0,1 til 1,5 g/em3; oplager mindre end >0 vægt-% vand ved ligevægt; har en forlængelseskapacitet på 200 % til 1200 %; og har en træks tyrke på 0,1 til 1,0 MPa,
  2. 2. Viskoelastisk biostabilt skum ifølge krav 1, hvor tribiok-eopolymerresten er valgt blandt:
  3. 3. Viskoeiastisk biostabilt skum ifølge krav 1, hvor mindst én al (a), (b), (c) eller (d) gælder: (a) skummet er stabilt over for gastrisk fluid i mindst 3 måneder, i mindst 4 måneder, i mindst 5 måneder, i mindst 6 måneder, i mindst 7 måneder, i mindst 8 måneder, i mindst 9 måneder, i mindst 10 måneder, i mindst 11 måneder eller i mindst 1. år, (b) skammet har en densitet på 0,3 til 1,2 g/cm3, (c) skummet har en densitet på 0,8 til 0,9 g/eur, eller (d) skummet har en densitet på 0,5 til 0,6 g/cra3,
  4. 4. Viskoelastisk biostabilt skum ifølge krav 1 og 3, hvor X er valgt blandt ethylenoxid, difluormethylethylenoxid, trifluormethylethylenoxid, propylenoxid, difluorrøethyipropylenoxtd, tri fl u o nn e t h y 1 prop y len ox i d, butylenoxid, tetramethylenetherglyeol, tetrahydrofuran, oxymefhylen, etherketon, etheretherketoii, dimethyl siioxan, diethylsiloxan, methylphenylsiloxan, diphenylsiloxan, methyldiiluorethylsiloxan, methyltrifluorethylsiloxan, phenyldiOnorethyistloxan, phe ny I tri 11 u oret h y i si lo x a n, ethylenterephthalat, ethylenterephthalationomer, ethylennaphthalat, methylennaplifhalat, butylenterephthalat, butylennaphthalat eller polycarbonat
  5. 5. Viskoelastisk biostabilt skum ifølge krav 4, hvor Y er valgt blandt ethylenoxid, diflu orme thy 1 et h vie n ox i d, iri il u orm et h y 1 e ί h y! e no x i d. propyienoxid, diiluormethy lpropyl en ox id, ir ifl uormethy Ipropy! en ox id, buty i enoxi d, tetramethylenetherglycol, tetrahydrøfuran, oxymethylen, etherketon, ethereiherketon, diraethylsiloxan, diethylsiloxan, 'mcthylphenyl.sil.ox.au, diphenykiloxan. methyldifluorethylsiloxan, methyltrifluorethylsiloxan, phenyldifluorethylsiioxan, phenyltriflitorethylsiloxan, ethylentercphthalat, eihylenterephthalaikmomer, ethylennaphthalat. methylennaphthalai, buty lenterepb tha i at, butyiennapbthalat eller poiyea.rbonat
  6. 6. Viskoelastisk biostabilt skura ifølge krav 5, hvor X og Y er ens og valgt blandt ethylenoxid, difluormethylethylenoxid, mfliiomiethylethylenoxid, propyienoxid, difluormethylpropylenoxid, triflnormethyipropylenoxid, butylenoxid, tetramethylenetherglycoi, tetrahydrofuran, oxymethylen, etherketon, etheretherketon, dimethylsiloxan, diethyl siloxan, methylphenylsi loxan, diphenylsiloxan, methyMifluorethylsiloxan, methyltrifluorethylsi loxan, pheny Idifluorethylsi loxan, phenyltrifiuorethylsiloxan, ethylenterephthalat, ethylenterephthalationomer, ethylennaphthalat, methylennaphthalai, buiyieoterephthaiat, butylennaphthalat eller polycarbonat.
  7. 7» Viskoelastisk. biostabilt skum ifølge krav 1 eller et. hvilket som helst af kravene 3 til 6, hvor X og Y er ens.
  8. 8. Viskoelastisk biostabilt skum ifølge krav 1 eller et hvilket som helst af kravene 3 til 7, hvor X og Y begge er en ether.
  9. 9. Viskoelastisk biostabilt skura ifølge krav 1 eller et hvilket som helst af kravene 3 til 7, hvor X og Y begge er propyienoxid.
  10. 10. Viskoelastisk biostabilt skum ifølge krav 1 eller et hvilket som helst af kravene 2 til 9, hvor (a) m og p hver før sig er mellem 2 og 50, og n er mellem 2 og 20, (b) m og p hver for sig er mellem 2 og 30, og n er mellem 2 og 20, eller (c) hver af m, n og p er 8-16.
  11. 11. Vi skoel as ti sk biostabilt skum Ifølge krav 1 eller et hvilket som helst af kravene 2 til 10, hvor (a) en eller flere af R1, Ro R'\ K4, R' og R6 uafhængigt er en eventuelt substitueret Ci -salkyl, (b) hver af R1, R2, R'\ R4, R5 og R.6 uafhængigt er methyl, ethyl, propyl. Isopropyl, cyclopropyl, butyl, isobutyl eller cyclobutyl, (c) hver af R% R2, R3, R4, R5 og R6 uafhængigt er mono-, di-, tri- eller periluoreret methyl, ethyl, propyl, butyl eller phenyl, eller (d) hver af Rf, R2, R\ R4, R' og Rd uafhængigt er methyl, ethyl, propyl, trifluormethyb trifluorethyl eller tri fluorprop yL
  12. 12..Viskoelastisk biostabilt skum ifølge krav 1 eller et hvilket som helst af kravene 2 til 11, hvor mindst én af (a), (b), (c), (d), (e) eller (f) gælder; (a) hver af Lf og L2 er uafhængigt en bivalent Ci-coalkylenkæde, (b) hver af Lf og L2 er uafhængigt en bivalent C utoalky lenkæde, (e) hver af L* og L2 er uafhængigt en bivalent methylen-, ethylen-, propyten- eller buty lenkæde, (d) hver af L! og L2 er uafhængigt -OCHa-, -OCH?CKh-, -OCHaCHaCHa- eller -OCH2CH2CH2CH2-, (e) hver af Ll og L2 er uafhængigt en bivalent Cj-salkylenkæde, hvor mindst én methylenenbed af kæden er substitueret med -O-, og mindst én methylenhed af kæden er substitueret med en bivalent arylen, eller (f) hver af L! og L2 er uafhængigt ~OC.H2-phenyle.n-, -OCHzCib-phenylen-, -OCH2CH a-phenylen-CHa- ef fer -OCHaCHrCHiCHs-phenylen-.
DK09766306.6T 2008-06-20 2009-06-19 Biomateriale DK2296581T3 (da)

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US7440008P 2008-06-20 2008-06-20
US18104309P 2009-05-26 2009-05-26
PCT/IE2009/000038 WO2009153769A1 (en) 2008-06-20 2009-06-19 A biomaterial

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JP (1) JP5694926B2 (da)
AU (1) AU2009261578B2 (da)
CA (1) CA2726744C (da)
DK (1) DK2296581T3 (da)
ES (1) ES2659081T3 (da)
HU (1) HUE038155T2 (da)
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KR20090015591A (ko) * 2007-08-09 2009-02-12 삼성전자주식회사 폴리우레탄 발포 복합체 조성물, 이로부터 제조된폴리우레탄 발포 복합체 및 그 제조방법
DE102009045365A1 (de) * 2009-10-06 2011-04-07 Wacker Chemie Ag Verfahren zum Entlüften von Flüssigkeiten
US20110153027A1 (en) * 2009-12-18 2011-06-23 Vysera Biomedical Limited Drug Delivery System
DK2513200T3 (da) * 2009-12-18 2018-06-14 Coloplast As Et biomateriale
IE20100789A1 (en) 2009-12-18 2011-08-03 Vysera Biomedical Ltd A medical device
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
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US20160184075A1 (en) 2016-06-30
US20100120934A1 (en) 2010-05-13

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