DK2235017T3 - Spiroindolinonderivater som anticancermidler - Google Patents
Spiroindolinonderivater som anticancermidlerInfo
- Publication number
- DK2235017T3 DK2235017T3 DK08863724.4T DK08863724T DK2235017T3 DK 2235017 T3 DK2235017 T3 DK 2235017T3 DK 08863724 T DK08863724 T DK 08863724T DK 2235017 T3 DK2235017 T3 DK 2235017T3
- Authority
- DK
- Denmark
- Prior art keywords
- anticancer agents
- spiroindolinone derivatives
- spiroindolinone
- derivatives
- agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1488807P | 2007-12-19 | 2007-12-19 | |
US10738108P | 2008-10-22 | 2008-10-22 | |
PCT/EP2008/067061 WO2009080488A1 (fr) | 2007-12-19 | 2008-12-09 | Dérivés de spiroindolinone en tant qu'agents anticancéreux |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2235017T3 true DK2235017T3 (da) | 2011-10-24 |
Family
ID=40351961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08863724.4T DK2235017T3 (da) | 2007-12-19 | 2008-12-09 | Spiroindolinonderivater som anticancermidler |
Country Status (16)
Country | Link |
---|---|
US (1) | US7776875B2 (fr) |
EP (1) | EP2235017B1 (fr) |
JP (1) | JP2011506524A (fr) |
KR (1) | KR20100076075A (fr) |
CN (1) | CN101903388A (fr) |
AT (1) | ATE524470T1 (fr) |
AU (1) | AU2008340473A1 (fr) |
BR (1) | BRPI0820699A2 (fr) |
CA (1) | CA2708312A1 (fr) |
DK (1) | DK2235017T3 (fr) |
ES (1) | ES2372903T3 (fr) |
IL (1) | IL205506A0 (fr) |
MX (1) | MX2010006332A (fr) |
PL (1) | PL2235017T3 (fr) |
PT (1) | PT2235017E (fr) |
WO (1) | WO2009080488A1 (fr) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100190814A1 (en) * | 2009-01-26 | 2010-07-29 | Li Chen | Spiroindolinone derivative prodrugs |
US8217051B2 (en) | 2009-02-17 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
US8076482B2 (en) * | 2009-04-23 | 2011-12-13 | Hoffmann-La Roche Inc. | 3,3′-spiroindolinone derivatives |
KR20120099462A (ko) | 2009-11-12 | 2012-09-10 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | 스피로-옥신돌 mdm2 길항제 |
US8088815B2 (en) | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
US8288431B2 (en) | 2010-02-17 | 2012-10-16 | Hoffmann-La Roche Inc. | Substituted spiroindolinones |
US8217044B2 (en) | 2010-04-28 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone pyrrolidines |
JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
SG190230A1 (en) | 2010-11-12 | 2013-06-28 | Univ Michigan | Spiro-oxindole mdm2 antagonists |
US8629133B2 (en) | 2011-03-10 | 2014-01-14 | Daiichi Sankyo Company, Limited | Dispiropyrrolidine derivatives |
SG194873A1 (en) | 2011-05-11 | 2013-12-30 | Sanofi Sa | Spiro-oxindole mdm2 antagonists |
US9376425B2 (en) | 2011-09-27 | 2016-06-28 | Amgen, Inc. | Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer |
WO2013102145A1 (fr) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Composés d'aldéhydes hétéroaryles substitués et leurs procédés d'utilisation dans l'accroissement de l'oxygénation tissulaire |
ES2963218T3 (es) | 2011-12-28 | 2024-03-25 | Global Blood Therapeutics Inc | Productos intermedios para obtener compuestos de benzaldehído sustituidos y métodos para su uso en el aumento de la oxigenación tisular |
CN102838610B (zh) * | 2012-08-28 | 2014-09-10 | 吕叶叶 | 双吲哚二氧杂双环辛二酮 |
TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
WO2014134201A1 (fr) | 2013-02-28 | 2014-09-04 | Amgen Inc. | Inhibiteur mdm2 dérivé de l'acide benzoïque pour le traitement du cancer |
CA2906538C (fr) | 2013-03-14 | 2021-02-02 | Ana Gonzalez Buenrostro | Composes morpholinone d'acide heteroaryle utilises comme inhibiteurs de mdm2 pour le traitement du cancer |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
CA2902711C (fr) | 2013-03-15 | 2021-07-06 | Global Blood Therapeutics, Inc. | Derives de pyridinyl-6-methoxy-2-hydroxybenzaldehyde substitues et compositions pharmaceutiques de ceux-ci pour utilisation dans la modulation de l'hemoglobine |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
WO2014145040A1 (fr) * | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Composés aldéhydes substitués et leurs procédés d'utilisation pour accroître l'oxygénation tissulaire |
CN111454200A (zh) | 2013-03-15 | 2020-07-28 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
US20160083343A1 (en) | 2013-03-15 | 2016-03-24 | Global Blood Therapeutics, Inc | Compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
CA2916564C (fr) | 2014-02-07 | 2023-02-28 | Global Blood Therapeutics, Inc. | Polymorphes cristallins de la base libre de 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
WO2016001376A1 (fr) | 2014-07-03 | 2016-01-07 | Boehringer Ingelheim International Gmbh | Nouveaux composés et dérivés spiro [3h-indole-3,2'-pyrrolidine]-2(1h)-one en tant qu'inhibiteurs de mdm2-p53 |
TWI711452B (zh) | 2015-02-20 | 2020-12-01 | 日商第一三共股份有限公司 | 癌症的倂用治療法 |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
EP3284466A4 (fr) | 2015-04-13 | 2018-12-05 | Daiichi Sankyo Company, Limited | Procédé de traitement combinant un inhibiteur de mdm2 et un inhibiteur de btk |
PE20181205A1 (es) | 2015-10-09 | 2018-07-23 | Boehringer Ingelheim Int | Nuevos compuestos de espiro[3h-indol-3,2'-pirrolidin]-2(1h)-ona y derivados como inhibidores de mdm2-p53 |
SG10201912511WA (en) | 2015-12-04 | 2020-02-27 | Global Blood Therapeutics Inc | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
PL3458101T3 (pl) | 2016-05-20 | 2021-05-31 | F. Hoffmann-La Roche Ag | Koniugaty PROTAC-przeciwciało i sposoby ich stosowania |
TWI778983B (zh) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
JPWO2018074387A1 (ja) | 2016-10-17 | 2019-08-08 | 第一三共株式会社 | Mdm2阻害剤とdnaメチルトランスフェラーゼ阻害剤との併用治療法 |
EP3511334A1 (fr) * | 2018-01-16 | 2019-07-17 | Adamed sp. z o.o. | Composés de 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole] -2,3'-dione comme agents thérapeutiques activant le tp53 |
US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
WO2023056069A1 (fr) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Conjugués agent de dégradation-anticorps et leurs procédés d'utilisation |
CN117069647A (zh) * | 2023-07-27 | 2023-11-17 | 兰州大学 | 一种双官能团螺环催化剂及其合成方法和应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ516452A (en) * | 1999-07-21 | 2004-06-25 | Astrazeneca Ab | Spirooxindole Derivatives |
CN101160314B (zh) * | 2005-02-22 | 2012-05-23 | 密执安州立大学董事会 | Mdm2的小分子抑制剂以及其应用 |
JPWO2007013691A1 (ja) * | 2005-07-29 | 2009-02-12 | 武田薬品工業株式会社 | スピロ環化合物 |
US20070213341A1 (en) * | 2006-03-13 | 2007-09-13 | Li Chen | Spiroindolinone derivatives |
US7495007B2 (en) | 2006-03-13 | 2009-02-24 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
JP2009530236A (ja) * | 2006-03-13 | 2009-08-27 | エフ.ホフマン−ラ ロシュ アーゲー | スピロインドリノン誘導体 |
US7784589B2 (en) * | 2006-07-10 | 2010-08-31 | Inventio Ag | Elevator lift cage load measuring assembly |
US7638548B2 (en) | 2006-11-09 | 2009-12-29 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
US7834179B2 (en) * | 2007-05-23 | 2010-11-16 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
US8134001B2 (en) * | 2007-12-14 | 2012-03-13 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
-
2008
- 2008-11-18 US US12/273,035 patent/US7776875B2/en not_active Expired - Fee Related
- 2008-12-09 EP EP08863724A patent/EP2235017B1/fr not_active Not-in-force
- 2008-12-09 WO PCT/EP2008/067061 patent/WO2009080488A1/fr active Application Filing
- 2008-12-09 AT AT08863724T patent/ATE524470T1/de active
- 2008-12-09 PT PT08863724T patent/PT2235017E/pt unknown
- 2008-12-09 AU AU2008340473A patent/AU2008340473A1/en not_active Abandoned
- 2008-12-09 KR KR1020107013353A patent/KR20100076075A/ko active IP Right Grant
- 2008-12-09 MX MX2010006332A patent/MX2010006332A/es active IP Right Grant
- 2008-12-09 CA CA2708312A patent/CA2708312A1/fr not_active Abandoned
- 2008-12-09 JP JP2010538565A patent/JP2011506524A/ja active Pending
- 2008-12-09 DK DK08863724.4T patent/DK2235017T3/da active
- 2008-12-09 BR BRPI0820699A patent/BRPI0820699A2/pt not_active IP Right Cessation
- 2008-12-09 PL PL08863724T patent/PL2235017T3/pl unknown
- 2008-12-09 CN CN2008801217831A patent/CN101903388A/zh active Pending
- 2008-12-09 ES ES08863724T patent/ES2372903T3/es active Active
-
2010
- 2010-05-03 IL IL205506A patent/IL205506A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20090163512A1 (en) | 2009-06-25 |
ATE524470T1 (de) | 2011-09-15 |
EP2235017B1 (fr) | 2011-09-14 |
KR20100076075A (ko) | 2010-07-05 |
PT2235017E (pt) | 2011-10-13 |
IL205506A0 (en) | 2010-12-30 |
BRPI0820699A2 (pt) | 2019-09-24 |
ES2372903T3 (es) | 2012-01-27 |
EP2235017A1 (fr) | 2010-10-06 |
JP2011506524A (ja) | 2011-03-03 |
WO2009080488A1 (fr) | 2009-07-02 |
AU2008340473A1 (en) | 2009-07-02 |
CN101903388A (zh) | 2010-12-01 |
CA2708312A1 (fr) | 2009-07-02 |
MX2010006332A (es) | 2010-07-05 |
PL2235017T3 (pl) | 2012-02-29 |
US7776875B2 (en) | 2010-08-17 |
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