DK2215058T3 - Substituerede N-phenylbipyrrolidinureaer og terapeutisk anvendelse deraf - Google Patents
Substituerede N-phenylbipyrrolidinureaer og terapeutisk anvendelse derafInfo
- Publication number
- DK2215058T3 DK2215058T3 DK08838702.2T DK08838702T DK2215058T3 DK 2215058 T3 DK2215058 T3 DK 2215058T3 DK 08838702 T DK08838702 T DK 08838702T DK 2215058 T3 DK2215058 T3 DK 2215058T3
- Authority
- DK
- Denmark
- Prior art keywords
- substituted
- ureas
- phenylbipyrrolidine
- therapeutic use
- phenyl
- Prior art date
Links
- 235000013877 carbamide Nutrition 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
- 102000004384 Histamine H3 receptors Human genes 0.000 abstract 2
- 108090000981 Histamine H3 receptors Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98060607P | 2007-10-17 | 2007-10-17 | |
| PCT/US2008/079763 WO2009052068A1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2215058T3 true DK2215058T3 (da) | 2012-03-12 |
Family
ID=40248052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08838702.2T DK2215058T3 (da) | 2007-10-17 | 2008-10-14 | Substituerede N-phenylbipyrrolidinureaer og terapeutisk anvendelse deraf |
Country Status (24)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2212283T3 (pl) * | 2007-10-17 | 2012-01-31 | Sanofi Sa | Podstawione karboksyamidy N-fenylobipirolidyny i ich zastosowanie terapeutyczne |
| MX2010004003A (es) | 2007-10-17 | 2010-04-30 | Sanofi Aventis | N-fenil-pirrolidinilmetlipirrolidin amidas sustituidas y uso terapeutico de las mismas. |
| DK2212282T3 (da) * | 2007-10-17 | 2012-01-23 | Sanofi Sa | Substituerede N-phenylbipyrrolidincarboxamider og terapeutisk anvendelse deraf |
| KR20090129927A (ko) | 2008-06-13 | 2009-12-17 | 주식회사 엘지화학 | 발열체 및 이의 제조방법 |
| US10412788B2 (en) | 2008-06-13 | 2019-09-10 | Lg Chem, Ltd. | Heating element and manufacturing method thereof |
| WO2009151203A1 (ko) * | 2008-06-13 | 2009-12-17 | 주식회사 엘지화학 | 발열체 및 이의 제조방법 |
| WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| AR081383A1 (es) * | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
| JP2013529198A (ja) * | 2010-05-11 | 2013-07-18 | サノフイ | 置換されたｎ−ヘテロシクロアルキルビピロリジニルフェニルアミド誘導体、その製造及び治療上の使用 |
| AR081034A1 (es) | 2010-05-11 | 2012-05-30 | Sanofi Aventis | Derivados de n-heteroaril tetrahidro-isoquinolina sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central |
| AR081384A1 (es) * | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N- fenil espirolactama bipirrolidinas sustituidas, preparacion y uso terapeutico de las mismas |
| TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
| JP5766278B2 (ja) | 2010-05-11 | 2015-08-19 | サノフイ | 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用 |
| JP6117104B2 (ja) * | 2010-11-15 | 2017-04-19 | アッヴィ・インコーポレイテッド | Ｎａｍｐｔおよびｒｏｃｋ阻害薬 |
| HUE025163T2 (en) * | 2011-02-23 | 2016-02-29 | Suven Life Sciences Ltd | New compounds that are histamine H3 receptor ligands |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| AU2003287206A1 (en) * | 2002-10-23 | 2004-05-13 | Janssen Pharmaceutica, N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| ATE450503T1 (de) | 2005-03-17 | 2009-12-15 | Lilly Co Eli | Pyrrolidinderivate als histamin-h3- rezeptorantagonisten |
| JP5072827B2 (ja) * | 2005-04-01 | 2012-11-14 | イーライ リリー アンド カンパニー | ヒスタミンｈ３受容体薬剤、製剤及び治療的使用 |
| EP2322506A1 (en) * | 2005-07-01 | 2011-05-18 | Eli Lilly and Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| CA2627234A1 (en) * | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| PL2212283T3 (pl) | 2007-10-17 | 2012-01-31 | Sanofi Sa | Podstawione karboksyamidy N-fenylobipirolidyny i ich zastosowanie terapeutyczne |
| MX2010004003A (es) | 2007-10-17 | 2010-04-30 | Sanofi Aventis | N-fenil-pirrolidinilmetlipirrolidin amidas sustituidas y uso terapeutico de las mismas. |
| DK2212282T3 (da) | 2007-10-17 | 2012-01-23 | Sanofi Sa | Substituerede N-phenylbipyrrolidincarboxamider og terapeutisk anvendelse deraf |
-
2008
- 2008-10-14 CA CA2702933A patent/CA2702933C/en not_active Expired - Fee Related
- 2008-10-14 SI SI200830552T patent/SI2215058T1/sl unknown
- 2008-10-14 RU RU2010119554/04A patent/RU2478094C2/ru not_active IP Right Cessation
- 2008-10-14 NZ NZ584692A patent/NZ584692A/en not_active IP Right Cessation
- 2008-10-14 ES ES08838702T patent/ES2378011T3/es active Active
- 2008-10-14 EP EP08838702A patent/EP2215058B1/en active Active
- 2008-10-14 WO PCT/US2008/079763 patent/WO2009052068A1/en not_active Ceased
- 2008-10-14 AT AT08838702T patent/ATE534625T1/de active
- 2008-10-14 KR KR1020107010481A patent/KR20100082349A/ko not_active Ceased
- 2008-10-14 HR HR20120166T patent/HRP20120166T1/hr unknown
- 2008-10-14 PL PL08838702T patent/PL2215058T3/pl unknown
- 2008-10-14 PT PT08838702T patent/PT2215058E/pt unknown
- 2008-10-14 MX MX2010003948A patent/MX2010003948A/es active IP Right Grant
- 2008-10-14 JP JP2010530054A patent/JP5380455B2/ja not_active Expired - Fee Related
- 2008-10-14 AU AU2008312641A patent/AU2008312641A1/en not_active Abandoned
- 2008-10-14 MY MYPI2010001300A patent/MY148807A/en unknown
- 2008-10-14 DK DK08838702.2T patent/DK2215058T3/da active
- 2008-10-14 CN CN2008801212096A patent/CN101903341B/zh not_active Expired - Fee Related
- 2008-10-14 RS RS20120067A patent/RS52221B/sr unknown
-
2010
- 2010-03-15 US US12/724,045 patent/US8222290B2/en not_active Expired - Fee Related
- 2010-03-25 ZA ZA2010/02114A patent/ZA201002114B/en unknown
- 2010-04-11 IL IL205002A patent/IL205002A0/en unknown
- 2010-05-17 MA MA32842A patent/MA31889B1/fr unknown
-
2012
- 2012-02-23 CY CY20121100185T patent/CY1112391T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201002114B (en) | 2010-12-29 |
| MY148807A (en) | 2013-05-31 |
| HRP20120166T1 (hr) | 2012-03-31 |
| KR20100082349A (ko) | 2010-07-16 |
| RS52221B (sr) | 2012-10-31 |
| ES2378011T3 (es) | 2012-04-04 |
| US20100173908A1 (en) | 2010-07-08 |
| NZ584692A (en) | 2011-12-22 |
| IL205002A0 (en) | 2010-11-30 |
| CA2702933C (en) | 2012-12-18 |
| AU2008312641A1 (en) | 2009-04-23 |
| JP5380455B2 (ja) | 2014-01-08 |
| ATE534625T1 (de) | 2011-12-15 |
| CN101903341B (zh) | 2012-10-03 |
| PT2215058E (pt) | 2012-03-06 |
| HK1146056A1 (en) | 2011-05-13 |
| EP2215058A1 (en) | 2010-08-11 |
| JP2011500697A (ja) | 2011-01-06 |
| MX2010003948A (es) | 2010-04-30 |
| CN101903341A (zh) | 2010-12-01 |
| RU2478094C2 (ru) | 2013-03-27 |
| CY1112391T1 (el) | 2015-12-09 |
| WO2009052068A1 (en) | 2009-04-23 |
| RU2010119554A (ru) | 2011-11-27 |
| PL2215058T3 (pl) | 2012-04-30 |
| MA31889B1 (fr) | 2010-12-01 |
| SI2215058T1 (sl) | 2012-03-30 |
| EP2215058B1 (en) | 2011-11-23 |
| US8222290B2 (en) | 2012-07-17 |
| CA2702933A1 (en) | 2009-04-23 |
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