DK2201099T3 - Fremgangsmåde til chondrocytopformering med fænotypebevaring - Google Patents

Fremgangsmåde til chondrocytopformering med fænotypebevaring Download PDF

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Publication number
DK2201099T3
DK2201099T3 DK08831789.6T DK08831789T DK2201099T3 DK 2201099 T3 DK2201099 T3 DK 2201099T3 DK 08831789 T DK08831789 T DK 08831789T DK 2201099 T3 DK2201099 T3 DK 2201099T3
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Denmark
Prior art keywords
phenotypic
conservation
chondrocyte proliferation
chondrocyte
proliferation
Prior art date
Application number
DK08831789.6T
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English (en)
Inventor
Iv H Davis Adkisson
Curt L Milliman
Neil Kizer
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Isto Technologies Inc
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Application granted granted Critical
Publication of DK2201099T3 publication Critical patent/DK2201099T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/80—Hyaluronan

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK08831789.6T 2007-09-21 2008-09-22 Fremgangsmåde til chondrocytopformering med fænotypebevaring DK2201099T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/859,524 US8017394B2 (en) 2004-10-01 2007-09-21 Method for chondrocyte expansion with phenotype retention
PCT/US2008/077161 WO2009039469A1 (en) 2007-09-21 2008-09-22 Method for chondrocyte expansion with phenotype retention

Publications (1)

Publication Number Publication Date
DK2201099T3 true DK2201099T3 (da) 2015-02-23

Family

ID=40469879

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08831789.6T DK2201099T3 (da) 2007-09-21 2008-09-22 Fremgangsmåde til chondrocytopformering med fænotypebevaring

Country Status (7)

Country Link
US (1) US8017394B2 (da)
EP (1) EP2201099B1 (da)
JP (1) JP2010539905A (da)
AU (1) AU2008302088B2 (da)
DK (1) DK2201099T3 (da)
ES (1) ES2530757T3 (da)
WO (1) WO2009039469A1 (da)

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US8889127B2 (en) 2004-07-01 2014-11-18 Icahn School Of Medicine At Mount Sinai Targeted protein replacement for the treatment of lysosomal storage disorders
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EP1764117A1 (en) * 2005-09-20 2007-03-21 Zimmer GmbH Implant for the repair of a cartilage defect and method for manufacturing the implant
US20080154233A1 (en) * 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Apparatus for delivering a biocompatible material to a surgical site and method of using same
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
US8426196B2 (en) * 2008-06-05 2013-04-23 Lynn L. H. Huang Method for regulating proliferation of cells
US20100041149A1 (en) * 2008-08-15 2010-02-18 Mark Weidenbecher Bioreactor and method for generating cartilage tissue constructs
US11248211B2 (en) * 2008-11-25 2022-02-15 Kolon Tissuegene, Inc. Primed cell therapy
JP5721319B2 (ja) * 2009-08-17 2015-05-20 国立大学法人北海道大学 軟骨細胞培養基材及び培養方法
JP5544635B2 (ja) * 2009-09-30 2014-07-09 国立大学法人北海道大学 軟骨細胞再分化誘導用基材およびこれを用いた軟骨細胞の製造方法
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
GB201010422D0 (en) * 2010-06-22 2010-08-04 Univ Cardiff Cartilage repair
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
ES2803499T3 (es) 2011-06-29 2021-01-27 Biorestorative Therapies Inc Composiciones y métodos de células grasas marrones
WO2013036875A1 (en) 2011-09-07 2013-03-14 Mount Sinai School Of Medicine Ceramidase and cell differentiation
CA2874146C (en) 2012-06-01 2023-03-21 Icahn School Of Medicine At Mount Sinai Ceramide levels in the treatment and prevention of infections
EP2875125B1 (en) 2012-07-20 2018-10-24 Alfred C. Kuo Methods for producing cartilage and bone
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
WO2014160390A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Therapeutic acid ceramidase compositions and methods of making and using them
EP2986714B1 (en) 2013-04-19 2021-01-06 Biorestorative Therapies, Inc. Human brown adipose derived stem cells and uses
JP6481611B2 (ja) * 2013-06-07 2019-03-13 日産化学株式会社 生体物質の付着抑制能を有するイオンコンプレックス材料及びその製造方法
CA2956359C (en) * 2014-08-01 2023-09-19 Isto Technologies, Inc. Cartilage compositions and methods for modifying proteoglycan content
WO2016019168A1 (en) * 2014-08-01 2016-02-04 Isto Technologies, Inc. Cell expansion methods and systems
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Also Published As

Publication number Publication date
EP2201099B1 (en) 2014-11-19
EP2201099A4 (en) 2011-06-01
AU2008302088B2 (en) 2014-02-20
ES2530757T3 (es) 2015-03-05
JP2010539905A (ja) 2010-12-24
EP2201099A1 (en) 2010-06-30
US20080081369A1 (en) 2008-04-03
WO2009039469A1 (en) 2009-03-26
AU2008302088A1 (en) 2009-03-26
US8017394B2 (en) 2011-09-13

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