DK2167169T4 - Tokammerkarpule med tilbehør - Google Patents

Tokammerkarpule med tilbehør Download PDF

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Publication number
DK2167169T4
DK2167169T4 DK08758924.8T DK08758924T DK2167169T4 DK 2167169 T4 DK2167169 T4 DK 2167169T4 DK 08758924 T DK08758924 T DK 08758924T DK 2167169 T4 DK2167169 T4 DK 2167169T4
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DK
Denmark
Prior art keywords
exendin
asp28
des pro36
cylinder
lys
Prior art date
Application number
DK08758924.8T
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English (en)
Other versions
DK2167169T3 (da
Inventor
Werner Seiferlein
Jörn Möckel
Original Assignee
Sanofi Aventis Deutschland
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38621207&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2167169(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of DK2167169T3 publication Critical patent/DK2167169T3/da
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
    • A61M2005/31506—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit formed as a single piece, e.g. moulded
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture

Claims (10)

1. Tokammerkarpule bestående af a) en cylinder indeholdende en endeprop, som er placeret på den proksimale ende af cylinderen, valgfrit et stop (13) på den proksimale ende (9), en midterprop (6), en bypass (3) , en distal ende (8) til forbindelse med tilbehør, og b) tilbehøret bestående af en lukkeanordning med en distal åbning, som er egnet til at stikke en applikationsnål igennem, og valgfrit en nåleholder, et eller flere tætningselementer til tætning af den distale ende på lukkeanordningen og/eller til tætning af forbindelsen mellem lukkeanordning og cylinder, kendetegnet ved, at lukninganordningen er udført i to eller tre stykker, og en proksimal ende på tilbehøret er enden af et hoved, som i samlet tilstand er forbundet med den distale ende på cylinderen, idet der er tilvejebragt en aksial not (11) på den proksimale ende af hovedet eller på den distale ende på cylinderen på indersiden af den optagende del.
2. Tokammerkarpule ifølge krav 1, idet tilbehøret består af hovedet (2) og en lukkekappe (5) med distal åbning, som er egnet til at stikke en applikationsnål igennem, og valgfrit en nåleholder, et tætningselement til tætning af forbindelsen mellem hoved (2) og lukkekappe (5) og valgfrit et yderligere tætningselement (7) til tætning af forbindelsen mellem hoved (2) og cylinder (1) .
3. Tokammerkarpule ifølge krav 1, idet udstyret består af hovedet (2), en hovedholder (19) og en lukkekappe (5) med distal åbning, som er egnet til at stikke en applikationsnål igennem, og valgfrit en nåleholder, et tætningselement til tætning af forbindelsen mellem hoved (2) og lukkekappe (5) og valgfrit et yderligere tætningselement (7) til tætning af forbindelsen mellem hoved (2) og cylinder (1).
4. Tokammerkarpule ifølge et af kravene 1 til 3, idet den proksimale ende på cylinderen (1) har et stop (13).
5. Tokammerkarpule ifølge et af kravene 1 til 4, idet tokammerkarpulen har et medikament, som skal administreres, og idet det medikament, der skal administreres, er et peptid til behandling af diabetes mellitus eller komplikationer i forbindelse med diabetes mellitus.
6. Tokammerkarpule ifølge krav 5, idet peptidet er exendin-4(1-39) eller et peptid udvalgt af gruppen H-(Lys)4-des Pro36, des Pro37 exendin-4 (1-39) -NH2, H-(Lys)5-des Pro36, des Pro37 exendin-4 (1-39) -NH2, des Pro36 [Asp28] exendin-4 (1-39) , des Pro36 [IsoAsp28] exendin-4 (1-39) , des Pro36 [Met (O)14, Asp28] exendin-4 (1-39) , des Pro36 [Met (O)14, IsoAsp28] exendin-4 (1-39) , des Pro36 [Trp(02) 25, Asp28] exendin-4 (1-39) , des Pro36 [Trp(C>2)25, IsoAsp28] exendin-4 (1-39) , des Pro36 [Met (0) 14 Trp(02) 25, Asp28] exendin-4 (1-39) , des Pro36 [Met (0) 14 Trp(02) 25, IsoAsp28] exendin-4 (1-39) , H-(Lys)6_des Pro36 [Asp28] exendin-4 (1-39)-Lys6-NH2, des Asp28 Pro36, Pro37, Pro38exendin-4 (1-39)-NH2, H-(Lys)6_des Pro36, Pro38 [Asp28] exendin-4 (1-39) -NH2, H-Asn- (Glu) 5des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39) -NH2, des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39) - (Lys) 6_NH2, H-(Lys)6_des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39) - (Lys) e~ NH2, H-Asn-(Glu) 5-des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39)-(Lys) 6-NH2, H-(Lys)6_des Pro36 [Trp(C>2)25, Asp28] exendin-4 (1-39) -Lys6-NH2, H-des Asp28 Pro36, Pro37, Pro38 [Trp(C>2)25] exendin-4 (1-39) -NH2, H-(Lys)6_des Pro36, Pro37, Pro38 [Trp(C>2)25, Asp28] exendin-4 (1-39) -NH2, H-Asn-(Glu) 5-des Pro36, Pro37, Pro38 [Trp(C>2)25, Asp28] exendin-4 (1-39) -NH2, des Pro36, Pro37, Pro38 [Trp(C>2)25, Asp28] exendin-4 (1-39) - (Lys) e~ NH2, H-(Lys)6_des Pro36, Pro37, Pro38 [Trp(02) 25, Asp28] exendin-4(1-39) - (Lys) 6-NH2, H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Trp(02) 25, Asp28] exendin-4 (1-39) - (Lys) 6-NH2, H-(Lys)6_des Pro36 [Met(O)14, Asp28] exendin-4 (1-39)-Lys6-NH2, des Met (0) 14 Asp28 Pro36, Pro37, Pro38 exendin-4 (1-39) -NH2, H-(Lys) 6_desPro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1-39)-NH2, H-Asn-(Glu) 5-des Pro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1-39) -NH2, des Pro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1-39) - (Lys) e~ NH2, H-(Lys)6_des Pro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1- 39) - (Lys) 6-NH2, H-Asn-(Glu) s des Pro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1-39) - (Lys) 6-NH2, H-Lys6-des Pro36 [Met(O)14, Trp(02) 25, Asp28] exendin-4 (1-39) - Lys6-NH2, H-des Asp28 Pro36, Pro37, Pro38 [Met(O)14, Trp(02) 25] exendin-4 (1-
39) -NH2, H-(Lys)6_des Pro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1-
39) -NH2, H-Asn-(Glu) 5-des Pro36, Pro37, Pro38 [Met(O)14, Trp(02) 25, Asp28] exendin-4 (1-39) -NH2, des Pro36, Pro37, Pro38 [Met(O)14, Trp(02) 25, Asp28] exendin-4 (1- 39) - (Lys) 6-NH2, H-(LyS)6_des Pro36, Pro37, Pro38 [Met(O)14, Trp(02) 25, Asp28] exendin-4 (S1 — 39) - (Lys) 6_NH2, H-Asn-(Glu) 5-des Pro36, Pro37, Pro38 [Met(O)14, Trp(02) 25, Asp28] exendin-4(1-39)-(Lys) 6_NH2; eller des Pro36 [Asp28] exendin-4 (1-39) , des Pro36 [IsoAsp28] exendin-4 (1-39) , des Pro36 [Met(O)14, Asp28] exendin-4 (1-39) , des Pro36 [Met(O)14, IsoAsp28] exendin-4 (1-39) , des Pro36 [Trp(02) 25, Asp28] exendin-4 (1-39) , des Pro36 [Trp(02) 25, IsoAsp28] exendin-4 (1-39) , des Pro36 [Met (0) 14 Trp(C>2)2s, Asp28] exendin-4 (1-39) , des Pro36 [Met (0) 14 Trp(C>2)25, IsoAsp28] exendin-4 (1-39) , idet gruppen -Lys6-NH2 er knyttet sammen med C-terminus på exendin-4-derivatet; eller et farmaceutisk acceptabelt salt eller solvat heraf.
7. Applikationsapparat indeholdende en tokammerkarpule ifølge et af kravene 1 til 6.
8. Fremgangsmåde til fremstilling og påfyldning af en tokammerkarpule ifølge et af kravene 1 til 6, kendetegnet ved, at a) en cylinder indeholdende en bypass forsynes med et midterprop mellem bypass og den proksimale ende; b) kammeret mellem midterprop og den proksimale ende påfyldes med en flydende bestanddel; c) det kammer, der indeholder den flydende bestanddel, lukkes med en endeprop; d) en flydende eller fortrinsvis fast bestanddel fyldes i kammeret mellem midterproppen og den distale ende på cylinderen; og e) den distale ende på cylinderen lukkes med tilbehøret.
DK08758924.8T 2007-06-14 2008-05-31 Tokammerkarpule med tilbehør DK2167169T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07011687 2007-06-14
PCT/EP2008/004355 WO2008151736A1 (de) 2007-06-14 2008-05-31 Zweikammerkarpule mit aufsatz

Publications (2)

Publication Number Publication Date
DK2167169T3 DK2167169T3 (da) 2012-09-03
DK2167169T4 true DK2167169T4 (da) 2016-05-30

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DK08758924.8T DK2167169T4 (da) 2007-06-14 2008-05-31 Tokammerkarpule med tilbehør

Country Status (9)

Country Link
US (2) US8092422B2 (da)
EP (1) EP2167169B2 (da)
JP (1) JP2010528791A (da)
CN (1) CN101678175A (da)
AR (1) AR066986A1 (da)
DK (1) DK2167169T4 (da)
ES (1) ES2386166T5 (da)
TW (1) TW200916140A (da)
WO (1) WO2008151736A1 (da)

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Also Published As

Publication number Publication date
US20120078171A1 (en) 2012-03-29
EP2167169B2 (de) 2016-03-09
WO2008151736A1 (de) 2008-12-18
US20100274186A1 (en) 2010-10-28
AR066986A1 (es) 2009-09-23
DK2167169T3 (da) 2012-09-03
JP2010528791A (ja) 2010-08-26
EP2167169B1 (de) 2012-05-23
ES2386166T3 (es) 2012-08-10
CN101678175A (zh) 2010-03-24
ES2386166T5 (es) 2016-06-21
EP2167169A1 (de) 2010-03-31
TW200916140A (en) 2009-04-16
US8092422B2 (en) 2012-01-10

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