DK2140275T3 - Piezo Dispensing of a Diagnostic Fluid in Microfluidic Devices - Google Patents
Piezo Dispensing of a Diagnostic Fluid in Microfluidic Devices Download PDFInfo
- Publication number
- DK2140275T3 DK2140275T3 DK08732211.1T DK08732211T DK2140275T3 DK 2140275 T3 DK2140275 T3 DK 2140275T3 DK 08732211 T DK08732211 T DK 08732211T DK 2140275 T3 DK2140275 T3 DK 2140275T3
- Authority
- DK
- Denmark
- Prior art keywords
- sample
- liquid
- reagent
- capillary
- dispensing
- Prior art date
Links
- 239000012530 fluid Substances 0.000 title description 6
- 239000007788 liquid Substances 0.000 claims abstract description 94
- 239000013060 biological fluid Substances 0.000 claims abstract description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 84
- 238000000034 method Methods 0.000 claims description 27
- 239000012491 analyte Substances 0.000 claims description 19
- 239000012472 biological sample Substances 0.000 abstract description 21
- 238000003556 assay Methods 0.000 abstract description 12
- 239000000523 sample Substances 0.000 description 48
- 239000000758 substrate Substances 0.000 description 31
- 238000006243 chemical reaction Methods 0.000 description 21
- 238000000151 deposition Methods 0.000 description 17
- 230000004044 response Effects 0.000 description 13
- 230000002209 hydrophobic effect Effects 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000003287 optical effect Effects 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 230000008021 deposition Effects 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 239000004816 latex Substances 0.000 description 5
- 229920000126 latex Polymers 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000003085 diluting agent Substances 0.000 description 4
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 239000000020 Nitrocellulose Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000007598 dipping method Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 229920001220 nitrocellulos Polymers 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 238000002562 urinalysis Methods 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 235000017276 Salvia Nutrition 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004976 chemiluminescence spectroscopy Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 238000000157 electrochemical-induced impedance spectroscopy Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- -1 for example urine Substances 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000007641 inkjet printing Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 238000004735 phosphorescence spectroscopy Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
- Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91545007P | 2007-05-02 | 2007-05-02 | |
| PCT/US2008/056983 WO2008137212A1 (en) | 2007-05-02 | 2008-03-14 | Piezo dispensing of a diagnostic liquid into microfluidic devices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2140275T3 true DK2140275T3 (en) | 2018-04-09 |
Family
ID=39943878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08732211.1T DK2140275T3 (en) | 2007-05-02 | 2008-03-14 | Piezo Dispensing of a Diagnostic Fluid in Microfluidic Devices |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8361782B2 (enExample) |
| EP (1) | EP2140275B1 (enExample) |
| JP (1) | JP5296054B2 (enExample) |
| CN (1) | CN101688875B (enExample) |
| DK (1) | DK2140275T3 (enExample) |
| WO (1) | WO2008137212A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100968524B1 (ko) * | 2008-04-11 | 2010-07-08 | 인싸이토 주식회사 | 생체 시료 분석용 마이크로-나노 플루이딕 바이오칩 |
| KR100961874B1 (ko) * | 2010-04-05 | 2010-06-09 | 주식회사 나노엔텍 | 외부동력 없이 유체가 이동하는 유체분석용 칩 |
| KR101208303B1 (ko) | 2010-12-10 | 2012-12-05 | 삼성전기주식회사 | 미세 토출기 및 이의 제조방법 |
| WO2013163549A1 (en) * | 2012-04-26 | 2013-10-31 | The University Of Akron | Flexible tactile sensors and method of making |
| JP6632525B2 (ja) * | 2013-11-06 | 2020-01-22 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | マイクロ流体デバイスならびにその製造方法および使用方法 |
| BR112016010721B1 (pt) | 2013-11-13 | 2021-06-01 | Becton, Dickinson And Company | Método e sistema de análise de uma amostra para um analito |
| CA3001954A1 (en) | 2015-10-16 | 2017-04-20 | Oxford University Innovation Limited | Microfluidic arrangements |
| GB201614150D0 (en) | 2016-08-18 | 2016-10-05 | Univ Oxford Innovation Ltd | Microfluidic arrangements |
| GB201802819D0 (en) | 2018-02-21 | 2018-04-04 | Univ Oxford Innovation Ltd | Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement |
| EP3569716A1 (en) * | 2018-05-14 | 2019-11-20 | Consejo Superior De Investigaciones Científicas (CSIC) | A method for controlling timing of events in a microfluidic device and a timer microfluidic device |
| CN111057150B (zh) * | 2019-12-30 | 2021-10-29 | 深圳开立生物医疗科技股份有限公司 | 一种乳胶微球及其应用以及糖化血红蛋白检测试剂盒 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0207532B1 (en) | 1982-11-20 | 1990-05-16 | The University Of Birmingham | Recording apparatus |
| US4849340A (en) | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
| US5209904A (en) | 1987-12-23 | 1993-05-11 | Abbott Laboratories | Agglutination reaction device utilizing selectively impregnated porous material |
| EP0353591B1 (en) | 1988-08-02 | 1996-04-17 | Abbott Laboratories | Biological sample analyzer |
| JPH02269058A (ja) | 1989-03-14 | 1990-11-02 | Seiko Epson Corp | レーリーモード弾性表面波による液滴ジェット装置 |
| JPH06507496A (ja) | 1991-06-13 | 1994-08-25 | アボツト・ラボラトリーズ | 位置決め及び細胞カウントのための光学像形成 |
| US5518179A (en) | 1991-12-04 | 1996-05-21 | The Technology Partnership Limited | Fluid droplets production apparatus and method |
| CA2389358C (en) | 1996-12-31 | 2008-07-15 | Genometrix Incorporated | Multiplexed molecular analysis apparatus and method |
| GB9808182D0 (en) | 1998-04-17 | 1998-06-17 | The Technology Partnership Plc | Liquid projection apparatus |
| EP1004870A1 (en) | 1998-11-09 | 2000-05-31 | Aurora Biosciences Corporation | Liquid barriers for assays |
| NL1010833C2 (nl) | 1998-12-17 | 2000-06-20 | Univ Delft Tech | Werkwijze voor het gedoseerd aanbrengen van een vloeistof op een oppervlak. |
| US6245297B1 (en) | 1999-04-16 | 2001-06-12 | Pe Corporation (Ny) | Apparatus and method for transferring small volumes of substances |
| US6656432B1 (en) | 1999-10-22 | 2003-12-02 | Ngk Insulators, Ltd. | Micropipette and dividedly injectable apparatus |
| US7004184B2 (en) | 2000-07-24 | 2006-02-28 | The Reagents Of The University Of Michigan | Compositions and methods for liquid metering in microchannels |
| WO2002012895A1 (en) | 2000-08-10 | 2002-02-14 | Biomerieux B.V. | Moving droplet diagnostic assay |
| US6833111B2 (en) | 2001-04-13 | 2004-12-21 | Varian, Inc. | Multiple analyte assaying device with a multiple sample introduction system |
| US6485918B1 (en) | 2001-07-02 | 2002-11-26 | Packard Bioscience Corporation | Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate |
| US20040147034A1 (en) | 2001-08-14 | 2004-07-29 | Gore Jay Prabhakar | Method and apparatus for measuring a substance in a biological sample |
| US7189580B2 (en) | 2001-10-19 | 2007-03-13 | Wisconsin Alumni Research Foundation | Method of pumping fluid through a microfluidic device |
| WO2003052381A2 (en) * | 2001-12-18 | 2003-06-26 | Lynx Therapeutics, Inc. | METHOD FOR APPLYING A pH GRADIENT TO A MICROCHANNEL DEVICE |
| DE60303504T2 (de) | 2002-02-22 | 2006-10-12 | Biodot, Inc., Irvine | Verfahren und vorrichtung zur kontaktlosen tröpfchenabgabe unterhalb einer fluidischen oberfläche |
| US7459127B2 (en) * | 2002-02-26 | 2008-12-02 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
| US7125711B2 (en) * | 2002-12-19 | 2006-10-24 | Bayer Healthcare Llc | Method and apparatus for splitting of specimens into multiple channels of a microfluidic device |
| EP1578533A2 (en) * | 2002-12-24 | 2005-09-28 | Tecan Trading AG | Microfluidics devices and methods for diluting samples and reagents |
| US20040265172A1 (en) | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method and apparatus for entry and storage of specimens into a microfluidic device |
| JP4844124B2 (ja) | 2003-10-03 | 2011-12-28 | 和光純薬工業株式会社 | 微量のサンプル又は試液の微小液滴を供給する装置 |
| EP1799348A2 (en) | 2004-08-04 | 2007-06-27 | Spinx, Inc. | Devices and methods for interfacing microfluidic devices with fluid handling devices |
| EP1787129A1 (en) * | 2004-08-21 | 2007-05-23 | LG Life Sciences, Ltd. | Microfluidic device, and diagnostic and analytical apparatus using the same |
| WO2006042838A1 (de) | 2004-10-15 | 2006-04-27 | Siemens Aktiengesellschaft | Anordnung zur integrierten und automatisierten dna- oder protein-analyse in einer einmal verwendbaren cartridge, herstellungsverfahren für eine solche cartridge und betriebsverfahren der dna- oder protein-analyse unter verwendung einer solchen cartridge |
| US8263414B2 (en) | 2005-05-23 | 2012-09-11 | Siemens Healthcare Diagnostics Inc. | Dispensing of a diagnostic liquid onto a diagnostic reagent |
| WO2007054689A1 (en) * | 2005-11-08 | 2007-05-18 | Smart Holograms Limited | Novel boronate complex and its use in a glucose sensor |
-
2008
- 2008-03-14 DK DK08732211.1T patent/DK2140275T3/en active
- 2008-03-14 US US12/598,141 patent/US8361782B2/en not_active Expired - Fee Related
- 2008-03-14 CN CN200880014433.5A patent/CN101688875B/zh not_active Expired - Fee Related
- 2008-03-14 WO PCT/US2008/056983 patent/WO2008137212A1/en not_active Ceased
- 2008-03-14 EP EP08732211.1A patent/EP2140275B1/en active Active
- 2008-03-14 JP JP2010506358A patent/JP5296054B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2140275A4 (en) | 2014-11-26 |
| EP2140275A1 (en) | 2010-01-06 |
| JP2010526293A (ja) | 2010-07-29 |
| CN101688875B (zh) | 2014-07-23 |
| WO2008137212A1 (en) | 2008-11-13 |
| CN101688875A (zh) | 2010-03-31 |
| US8361782B2 (en) | 2013-01-29 |
| JP5296054B2 (ja) | 2013-09-25 |
| EP2140275B1 (en) | 2017-12-20 |
| US20100093109A1 (en) | 2010-04-15 |
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