DK2140275T3 - Piezo Dispensing of a Diagnostic Fluid in Microfluidic Devices - Google Patents
Piezo Dispensing of a Diagnostic Fluid in Microfluidic Devices Download PDFInfo
- Publication number
- DK2140275T3 DK2140275T3 DK08732211.1T DK08732211T DK2140275T3 DK 2140275 T3 DK2140275 T3 DK 2140275T3 DK 08732211 T DK08732211 T DK 08732211T DK 2140275 T3 DK2140275 T3 DK 2140275T3
- Authority
- DK
- Denmark
- Prior art keywords
- sample
- liquid
- reagent
- capillary
- dispensing
- Prior art date
Links
- 239000012530 fluid Substances 0.000 title description 6
- 239000007788 liquid Substances 0.000 claims abstract description 94
- 239000013060 biological fluid Substances 0.000 claims abstract description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 84
- 238000000034 method Methods 0.000 claims description 27
- 239000012491 analyte Substances 0.000 claims description 19
- 239000012472 biological sample Substances 0.000 abstract description 21
- 238000003556 assay Methods 0.000 abstract description 12
- 239000000523 sample Substances 0.000 description 48
- 239000000758 substrate Substances 0.000 description 31
- 238000006243 chemical reaction Methods 0.000 description 21
- 238000000151 deposition Methods 0.000 description 17
- 230000004044 response Effects 0.000 description 13
- 230000002209 hydrophobic effect Effects 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000003287 optical effect Effects 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 230000008021 deposition Effects 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 239000004816 latex Substances 0.000 description 5
- 229920000126 latex Polymers 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000003085 diluting agent Substances 0.000 description 4
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 239000000020 Nitrocellulose Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000007598 dipping method Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 229920001220 nitrocellulos Polymers 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 238000002562 urinalysis Methods 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 235000017276 Salvia Nutrition 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004976 chemiluminescence spectroscopy Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 238000000157 electrochemical-induced impedance spectroscopy Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- -1 for example urine Substances 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000007641 inkjet printing Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 238000004735 phosphorescence spectroscopy Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
- Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91545007P | 2007-05-02 | 2007-05-02 | |
| PCT/US2008/056983 WO2008137212A1 (en) | 2007-05-02 | 2008-03-14 | Piezo dispensing of a diagnostic liquid into microfluidic devices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2140275T3 true DK2140275T3 (en) | 2018-04-09 |
Family
ID=39943878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08732211.1T DK2140275T3 (en) | 2007-05-02 | 2008-03-14 | Piezo Dispensing of a Diagnostic Fluid in Microfluidic Devices |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8361782B2 (enExample) |
| EP (1) | EP2140275B1 (enExample) |
| JP (1) | JP5296054B2 (enExample) |
| CN (1) | CN101688875B (enExample) |
| DK (1) | DK2140275T3 (enExample) |
| WO (1) | WO2008137212A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100968524B1 (ko) * | 2008-04-11 | 2010-07-08 | 인싸이토 주식회사 | 생체 시료 분석용 마이크로-나노 플루이딕 바이오칩 |
| KR100961874B1 (ko) | 2010-04-05 | 2010-06-09 | 주식회사 나노엔텍 | 외부동력 없이 유체가 이동하는 유체분석용 칩 |
| KR101208303B1 (ko) | 2010-12-10 | 2012-12-05 | 삼성전기주식회사 | 미세 토출기 및 이의 제조방법 |
| US9664717B2 (en) | 2012-04-26 | 2017-05-30 | The University Of Akron | Flexible tactile sensors and method of making |
| WO2015069789A1 (en) * | 2013-11-06 | 2015-05-14 | Becton, Dickinson And Company | Microfluidic devices, and methods of making and using the same |
| US10018640B2 (en) | 2013-11-13 | 2018-07-10 | Becton, Dickinson And Company | Optical imaging system and methods for using the same |
| GB201614150D0 (en) | 2016-08-18 | 2016-10-05 | Univ Oxford Innovation Ltd | Microfluidic arrangements |
| CA3001954A1 (en) | 2015-10-16 | 2017-04-20 | Oxford University Innovation Limited | Microfluidic arrangements |
| GB201802819D0 (en) | 2018-02-21 | 2018-04-04 | Univ Oxford Innovation Ltd | Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement |
| EP3569716A1 (en) * | 2018-05-14 | 2019-11-20 | Consejo Superior De Investigaciones Científicas (CSIC) | A method for controlling timing of events in a microfluidic device and a timer microfluidic device |
| CN111057150B (zh) * | 2019-12-30 | 2021-10-29 | 深圳开立生物医疗科技股份有限公司 | 一种乳胶微球及其应用以及糖化血红蛋白检测试剂盒 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3381570D1 (de) * | 1982-11-20 | 1990-06-21 | Univ Birmingham | Vorrichtung zum registrieren von reaktionen. |
| US4849340A (en) * | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
| US5209904A (en) * | 1987-12-23 | 1993-05-11 | Abbott Laboratories | Agglutination reaction device utilizing selectively impregnated porous material |
| DE68926273T2 (de) | 1988-08-02 | 1996-12-19 | Abbott Lab | Vorrichtung zur Analyse biologischer Proben |
| JPH02269058A (ja) * | 1989-03-14 | 1990-11-02 | Seiko Epson Corp | レーリーモード弾性表面波による液滴ジェット装置 |
| CA2109943A1 (en) | 1991-06-13 | 1992-12-23 | Herbert S. Chow | Automated specimen analyzing apparatus and method |
| EP0615470B1 (en) * | 1991-12-04 | 1995-12-13 | The Technology Partnership Public Limited Company | Fluid droplet production apparatus and method |
| EP0990142A4 (en) * | 1996-12-31 | 2000-09-27 | Genometrix Genomics Inc | MULTIPLEXED MOLECULAR ANALYSIS METHOD AND DEVICE |
| GB9808182D0 (en) * | 1998-04-17 | 1998-06-17 | The Technology Partnership Plc | Liquid projection apparatus |
| CA2289174A1 (en) | 1998-11-09 | 2000-05-09 | Andrew A. Pham | Liquid barriers for assays |
| NL1010833C2 (nl) | 1998-12-17 | 2000-06-20 | Univ Delft Tech | Werkwijze voor het gedoseerd aanbrengen van een vloeistof op een oppervlak. |
| US6245297B1 (en) * | 1999-04-16 | 2001-06-12 | Pe Corporation (Ny) | Apparatus and method for transferring small volumes of substances |
| US6656432B1 (en) * | 1999-10-22 | 2003-12-02 | Ngk Insulators, Ltd. | Micropipette and dividedly injectable apparatus |
| US7004184B2 (en) | 2000-07-24 | 2006-02-28 | The Reagents Of The University Of Michigan | Compositions and methods for liquid metering in microchannels |
| ATE433574T1 (de) * | 2000-08-10 | 2009-06-15 | Biomerieux Bv | Diagnostischer test auf basis von bewegenden tropfen |
| US6833111B2 (en) * | 2001-04-13 | 2004-12-21 | Varian, Inc. | Multiple analyte assaying device with a multiple sample introduction system |
| US6485918B1 (en) * | 2001-07-02 | 2002-11-26 | Packard Bioscience Corporation | Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate |
| US20040147034A1 (en) * | 2001-08-14 | 2004-07-29 | Gore Jay Prabhakar | Method and apparatus for measuring a substance in a biological sample |
| US7189580B2 (en) * | 2001-10-19 | 2007-03-13 | Wisconsin Alumni Research Foundation | Method of pumping fluid through a microfluidic device |
| WO2003052381A2 (en) * | 2001-12-18 | 2003-06-26 | Lynx Therapeutics, Inc. | METHOD FOR APPLYING A pH GRADIENT TO A MICROCHANNEL DEVICE |
| DE60303504T2 (de) | 2002-02-22 | 2006-10-12 | Biodot, Inc., Irvine | Verfahren und vorrichtung zur kontaktlosen tröpfchenabgabe unterhalb einer fluidischen oberfläche |
| US7459127B2 (en) * | 2002-02-26 | 2008-12-02 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
| US7125711B2 (en) * | 2002-12-19 | 2006-10-24 | Bayer Healthcare Llc | Method and apparatus for splitting of specimens into multiple channels of a microfluidic device |
| US7476361B2 (en) * | 2002-12-24 | 2009-01-13 | Tecan Trading Ag | Microfluidics devices and methods of diluting samples and reagents |
| US20040265172A1 (en) * | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method and apparatus for entry and storage of specimens into a microfluidic device |
| WO2005033713A1 (ja) | 2003-10-03 | 2005-04-14 | Wako Pure Chemical Industries, Ltd. | 微量のサンプル又は試液の微小液滴を供給する装置 |
| EP1799348A2 (en) | 2004-08-04 | 2007-06-27 | Spinx, Inc. | Devices and methods for interfacing microfluidic devices with fluid handling devices |
| JP2007523355A (ja) * | 2004-08-21 | 2007-08-16 | エルジー・ライフ・サイエンシズ・リミテッド | 微細流体素子及びそれを備えた診断及び分析装置 |
| CN100534619C (zh) | 2004-10-15 | 2009-09-02 | 西门子公司 | 对可通过导管进入测量室中的液态测量样品进行电化学测量的方法和相应的布置 |
| US8263414B2 (en) | 2005-05-23 | 2012-09-11 | Siemens Healthcare Diagnostics Inc. | Dispensing of a diagnostic liquid onto a diagnostic reagent |
| EP1949083A1 (en) * | 2005-11-08 | 2008-07-30 | Smart Holograms Limited | Novel boronate complex and its use in a glucose sensor |
-
2008
- 2008-03-14 JP JP2010506358A patent/JP5296054B2/ja not_active Expired - Fee Related
- 2008-03-14 CN CN200880014433.5A patent/CN101688875B/zh active Active
- 2008-03-14 DK DK08732211.1T patent/DK2140275T3/en active
- 2008-03-14 EP EP08732211.1A patent/EP2140275B1/en active Active
- 2008-03-14 US US12/598,141 patent/US8361782B2/en not_active Expired - Fee Related
- 2008-03-14 WO PCT/US2008/056983 patent/WO2008137212A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2140275B1 (en) | 2017-12-20 |
| CN101688875B (zh) | 2014-07-23 |
| US8361782B2 (en) | 2013-01-29 |
| JP2010526293A (ja) | 2010-07-29 |
| US20100093109A1 (en) | 2010-04-15 |
| CN101688875A (zh) | 2010-03-31 |
| EP2140275A1 (en) | 2010-01-06 |
| EP2140275A4 (en) | 2014-11-26 |
| WO2008137212A1 (en) | 2008-11-13 |
| JP5296054B2 (ja) | 2013-09-25 |
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