CN101688875B - 在微流体装置中测定生物流体中分析物的量的方法 - Google Patents

在微流体装置中测定生物流体中分析物的量的方法 Download PDF

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Publication number
CN101688875B
CN101688875B CN200880014433.5A CN200880014433A CN101688875B CN 101688875 B CN101688875 B CN 101688875B CN 200880014433 A CN200880014433 A CN 200880014433A CN 101688875 B CN101688875 B CN 101688875B
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China
Prior art keywords
sample
liquid
droplets
reagent
inlet
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CN200880014433.5A
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English (en)
Chinese (zh)
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CN101688875A (zh
Inventor
M·J·普日亚
J·A·普罗菲特
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Siemens Healthcare Diagnostics Inc
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Siemens Healthcare Diagnostics Inc
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Publication of CN101688875A publication Critical patent/CN101688875A/zh
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN200880014433.5A 2007-05-02 2008-03-14 在微流体装置中测定生物流体中分析物的量的方法 Active CN101688875B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91545007P 2007-05-02 2007-05-02
US60/915,450 2007-05-02
PCT/US2008/056983 WO2008137212A1 (en) 2007-05-02 2008-03-14 Piezo dispensing of a diagnostic liquid into microfluidic devices

Publications (2)

Publication Number Publication Date
CN101688875A CN101688875A (zh) 2010-03-31
CN101688875B true CN101688875B (zh) 2014-07-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880014433.5A Active CN101688875B (zh) 2007-05-02 2008-03-14 在微流体装置中测定生物流体中分析物的量的方法

Country Status (6)

Country Link
US (1) US8361782B2 (enExample)
EP (1) EP2140275B1 (enExample)
JP (1) JP5296054B2 (enExample)
CN (1) CN101688875B (enExample)
DK (1) DK2140275T3 (enExample)
WO (1) WO2008137212A1 (enExample)

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KR100968524B1 (ko) * 2008-04-11 2010-07-08 인싸이토 주식회사 생체 시료 분석용 마이크로-나노 플루이딕 바이오칩
KR100961874B1 (ko) 2010-04-05 2010-06-09 주식회사 나노엔텍 외부동력 없이 유체가 이동하는 유체분석용 칩
KR101208303B1 (ko) 2010-12-10 2012-12-05 삼성전기주식회사 미세 토출기 및 이의 제조방법
US9664717B2 (en) 2012-04-26 2017-05-30 The University Of Akron Flexible tactile sensors and method of making
WO2015069789A1 (en) * 2013-11-06 2015-05-14 Becton, Dickinson And Company Microfluidic devices, and methods of making and using the same
US10018640B2 (en) 2013-11-13 2018-07-10 Becton, Dickinson And Company Optical imaging system and methods for using the same
GB201614150D0 (en) 2016-08-18 2016-10-05 Univ Oxford Innovation Ltd Microfluidic arrangements
CA3001954A1 (en) 2015-10-16 2017-04-20 Oxford University Innovation Limited Microfluidic arrangements
GB201802819D0 (en) 2018-02-21 2018-04-04 Univ Oxford Innovation Ltd Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
EP3569716A1 (en) * 2018-05-14 2019-11-20 Consejo Superior De Investigaciones Científicas (CSIC) A method for controlling timing of events in a microfluidic device and a timer microfluidic device
CN111057150B (zh) * 2019-12-30 2021-10-29 深圳开立生物医疗科技股份有限公司 一种乳胶微球及其应用以及糖化血红蛋白检测试剂盒

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Also Published As

Publication number Publication date
EP2140275B1 (en) 2017-12-20
US8361782B2 (en) 2013-01-29
JP2010526293A (ja) 2010-07-29
US20100093109A1 (en) 2010-04-15
CN101688875A (zh) 2010-03-31
DK2140275T3 (en) 2018-04-09
EP2140275A1 (en) 2010-01-06
EP2140275A4 (en) 2014-11-26
WO2008137212A1 (en) 2008-11-13
JP5296054B2 (ja) 2013-09-25

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