DK2139457T3 - Lægemiddelafgivelsesindretning til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade - Google Patents
Lægemiddelafgivelsesindretning til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade Download PDFInfo
- Publication number
- DK2139457T3 DK2139457T3 DK08719893.3T DK08719893T DK2139457T3 DK 2139457 T3 DK2139457 T3 DK 2139457T3 DK 08719893 T DK08719893 T DK 08719893T DK 2139457 T3 DK2139457 T3 DK 2139457T3
- Authority
- DK
- Denmark
- Prior art keywords
- collagen
- local
- analgesia
- bupivacaine
- drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (14)
1. Lægemiddelafgivelsesindretning egnet til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade ved et sted i et menneske eller dyr med behov derfor, indretningen omfatter en fibrillær kollagenmatriks; og mindst ét lægemiddelstof, det mindst ene lægemiddelstof er i det væsentlige homogent fordelt i kollagenmatriksen, og det mindst ene lægemiddelstofertil stede i en mængde tilstrækkelig til at tilvejebringe en varighed af lokal analgesi, lokal anæstesi eller nerveblokade der varer mindst én dag efter administration hvor lægemiddelindretningen omfatter en flerhed af kollagensvampe, hvert kollagensvamp har 3,6 til 8 mg/cm3 type I kollagen, og 2,0 til 6,0 mg/cm3 bupivacain-hydrochlorid.
2. Lægemiddelafgivelsesindretningen ifølge krav 1, hvor det mindst ene lægemiddelstof er til stede i en mængde der er tilstrækkelig til at tilvejebringe en varighed af lokal analgesi, lokal anæstesi eller nerveblokade der varer mindst to dage efter administration.
3. Lægemiddelafgivelsesindretningen ifølge krav 1 eller 2, hvor det mindst ene lægemiddelstof er til stede i en mængde der er tilstrækkelig til at tilvejebringe en varighed af lokal analgesi, lokal anæstesi eller nerveblokade der varer mindst tre dage efter administration.
4. Indretningen ifølge kravene 1-3, hvor analgesi er tilvejebragt uden bivirkninger forbundet med toksicitet fra bupivacain-kollagensvampen.
5. Indretningen ifølge kravene 1-4, hvor indretningen reducerer patientens behov for systemisk analgesi.
6. Anvendelse afen lægemiddelafgivelsesindretning omfattende en fibrillær kollagenmatriks; og mindst ét lægemiddelstof, det mindst ene lægemiddelstof er i det væsentlige homogent fordelt i kollagenmatriksen, og det mindst ene lægemiddelstof er til stede i en mængde tilstrækkelig til at tilvejebringe en varighed af lokal analgesi, lokal anæstesi eller nerveblokade der varer mindst én dag efter administration til fremstillingen af et medikament til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade i mennesket eller dyr med behov derfor, analgesien, anæstesi eller nerveblokade omfatter administrering af medikamentet ved det sted hos et menneske eller dyr med behov derfor, hvor lægemiddelindretningen omfatter en flerhed af kollagensvampe, hvert kollagensvamp har 3,6 til 8mg/cm3 type I kollagen, og 2,0 til 6,0 mg/cm3 bupivacain-hydrochlorid.
7. Anvendelsen ifølge krav 6, hvor mindst én svamp er anbragt tilgrænsende det kirurgiske sted, mindst én svamp er anbragt på tværs af indsnittet i legemeskaviteten og mindst ét kompres er anbragt mellem kappen og huden rundt om indsnittet.
8. Anvendelsen ifølge krav 7, hvor anvendelsen er til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade hos et menneske efter laparotomi.
9. Anvendelsen ifølge kravene 7-8, hvor anvendelsen er til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade i et menneske efterortopædisk, abdominal, gynækologisk eller bryst-kirurgiske procedurer.
10. Anvendelsen ifølge krav 9, hvor anvendelsen er til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade i et menneske efter af benign abdominal eller bryst-kirurgiske procedurer.
11. Anvendelsen ifølge krav 10, hvor anvendelsen is til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade i et menneske efter abdominal hysterektomier, myomektomy og adnexal kirurgi.
12. Indretningen ifølge kravene 1-5 eller anvendelsen ifølge kravene 6-11, hvor svampen har en dybde på 0,5 cm.
13. Anvendelsen ifølge kravene 6-11, hvor analgesi er tilvejebragt uden bivirkninger forbundet med toksicitet fra kollagensvampen.
14. Anvendelsen ifølge kravene 6-11, hvor indretningen reducerer patientens behov for systemisk analgesi.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IE2007/0220A IE85880B1 (en) | 2007-03-28 | A drug delivery device for providing local analgesia, local anesthesia or nerve blockade | |
US11/692,337 US20080241243A1 (en) | 2007-03-28 | 2007-03-28 | Drug delivery device for providing local analgesia, local anesthesia or nerve blockade |
PCT/IE2008/000035 WO2008117268A2 (en) | 2007-03-28 | 2008-03-28 | A drug delivery device for providing local analgesia, local anesthesia or nerve blockade |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2139457T3 true DK2139457T3 (da) | 2016-07-25 |
Family
ID=39540798
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08719893.3T DK2139457T3 (da) | 2007-03-28 | 2008-03-28 | Lægemiddelafgivelsesindretning til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade |
DK16154811.0T DK3085363T3 (da) | 2007-03-28 | 2008-03-28 | Lægemiddelindgivelsesindretning til at tilvejebringe lokalanalgesi, lokalanæstesi eller nerveblokade |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16154811.0T DK3085363T3 (da) | 2007-03-28 | 2008-03-28 | Lægemiddelindgivelsesindretning til at tilvejebringe lokalanalgesi, lokalanæstesi eller nerveblokade |
Country Status (15)
Country | Link |
---|---|
EP (2) | EP3085363B1 (da) |
JP (1) | JP5372905B2 (da) |
CY (2) | CY1117814T1 (da) |
DE (1) | DE202008018583U1 (da) |
DK (2) | DK2139457T3 (da) |
ES (2) | ES2582368T3 (da) |
HR (2) | HRP20160743T1 (da) |
HU (2) | HUE027803T2 (da) |
IE (1) | IES20080229A2 (da) |
LT (1) | LT3085363T (da) |
PL (2) | PL2139457T3 (da) |
PT (2) | PT3085363T (da) |
SI (2) | SI2139457T1 (da) |
TR (1) | TR201905174T4 (da) |
WO (1) | WO2008117268A2 (da) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE47826E1 (en) | 2007-03-28 | 2020-01-28 | Innocoll Pharmaceuticals Limited | Drug delivery device for providing local analgesia, local anesthesia or nerve blockage |
WO2010052694A2 (en) * | 2008-11-06 | 2010-05-14 | Innocoll Technologies Limited | Drug delivery implants and processes for their preparation |
US20100278895A1 (en) | 2009-04-30 | 2010-11-04 | Medtronic, Inc. | Antioxidants and antimicrobial accessories including antioxidants |
US8911427B2 (en) | 2010-12-28 | 2014-12-16 | Medtronic, Inc. | Therapeutic agent reservoir delivery system |
WO2013086015A1 (en) | 2011-12-05 | 2013-06-13 | Incept, Llc | Medical organogel processes and compositions |
LT2802624T (lt) * | 2012-01-09 | 2017-12-27 | Innocoll Pharmaceuticals Limited | Modifikuotas kolagenas |
AU2014223993B2 (en) | 2013-02-28 | 2016-09-08 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid formulations and its compostions |
US10220093B2 (en) | 2013-02-28 | 2019-03-05 | Mira Pharma Corporation | Long-acting semi-solid lipid formulations |
RU2561301C1 (ru) * | 2014-10-06 | 2015-08-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Омский государственный аграрный университет имени П.А. Столыпина" | Способ трансфеморальной блокады нервов мочевого пузыря у мелких животных |
US10561606B2 (en) | 2017-12-06 | 2020-02-18 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid gel formulations |
US11426418B2 (en) | 2017-12-06 | 2022-08-30 | Mira Pharma Corporation | Injectable long-acting semi-solid gel formulations |
AU2022213016A1 (en) * | 2021-02-01 | 2023-08-24 | Massey University | Post-operative pain management |
WO2022219179A1 (en) * | 2021-04-15 | 2022-10-20 | Innocoll Pharmaceuticals Limited | Drug-release implant for soft tissue surgery |
IL310517A (en) * | 2021-07-28 | 2024-03-01 | Innocoll Pharm Ltd | Bupivacaine-collagen drug delivery implant and methods for its preparation and use |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4125400C2 (de) * | 1991-07-31 | 2000-08-17 | Edwin Klaus | Verwendung von unlöslichem Kollagen zur Behandlung von degenerativen, nicht entzündlichen Gelenkprozessen |
JPH08143449A (ja) * | 1994-11-17 | 1996-06-04 | Lederle Japan Ltd | 徐放性局所麻酔用注射剤 |
US7119062B1 (en) * | 2001-02-23 | 2006-10-10 | Neucoll, Inc. | Methods and compositions for improved articular surgery using collagen |
WO2006002365A2 (en) * | 2004-06-24 | 2006-01-05 | Angiotech International Ag | Microparticles with high loadings of a bioactive agent |
PL1809329T3 (pl) * | 2004-09-17 | 2012-08-31 | Durect Corp | Kompozycja znieczulająca zawierająca saib o przedłużonym uwalnianiu do stosowania miejscowego |
EP1793872B1 (en) * | 2004-09-30 | 2016-05-11 | Covalon Technologies Inc. | Non-adhesive elastic gelatin matrices |
-
2008
- 2008-03-28 ES ES08719893.3T patent/ES2582368T3/es active Active
- 2008-03-28 DE DE202008018583.1U patent/DE202008018583U1/de not_active Expired - Lifetime
- 2008-03-28 HU HUE08719893A patent/HUE027803T2/en unknown
- 2008-03-28 HU HUE16154811A patent/HUE043185T2/hu unknown
- 2008-03-28 PT PT16154811T patent/PT3085363T/pt unknown
- 2008-03-28 SI SI200831641A patent/SI2139457T1/sl unknown
- 2008-03-28 EP EP16154811.0A patent/EP3085363B1/en active Active
- 2008-03-28 PT PT87198933T patent/PT2139457T/pt unknown
- 2008-03-28 SI SI200832058T patent/SI3085363T1/sl unknown
- 2008-03-28 LT LTEP16154811.0T patent/LT3085363T/lt unknown
- 2008-03-28 JP JP2010500426A patent/JP5372905B2/ja active Active
- 2008-03-28 IE IE20080229A patent/IES20080229A2/en not_active IP Right Cessation
- 2008-03-28 PL PL08719893.3T patent/PL2139457T3/pl unknown
- 2008-03-28 EP EP08719893.3A patent/EP2139457B1/en active Active
- 2008-03-28 PL PL16154811T patent/PL3085363T3/pl unknown
- 2008-03-28 ES ES16154811T patent/ES2718542T3/es active Active
- 2008-03-28 WO PCT/IE2008/000035 patent/WO2008117268A2/en active Application Filing
- 2008-03-28 TR TR2019/05174T patent/TR201905174T4/tr unknown
- 2008-03-28 DK DK08719893.3T patent/DK2139457T3/da active
- 2008-03-28 DK DK16154811.0T patent/DK3085363T3/da active
-
2016
- 2016-06-27 HR HRP20160743TT patent/HRP20160743T1/hr unknown
- 2016-07-14 CY CY20161100677T patent/CY1117814T1/el unknown
-
2019
- 2019-04-12 CY CY20191100409T patent/CY1121568T1/el unknown
- 2019-04-15 HR HRP20190699TT patent/HRP20190699T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
EP3085363B1 (en) | 2019-03-20 |
JP2010522738A (ja) | 2010-07-08 |
HUE027803T2 (en) | 2016-10-28 |
EP2139457B1 (en) | 2016-05-04 |
PT3085363T (pt) | 2019-05-16 |
WO2008117268A2 (en) | 2008-10-02 |
CY1117814T1 (el) | 2017-05-17 |
HRP20160743T1 (hr) | 2016-09-23 |
JP5372905B2 (ja) | 2013-12-18 |
PL3085363T3 (pl) | 2019-08-30 |
HUE043185T2 (hu) | 2019-08-28 |
EP2139457A2 (en) | 2010-01-06 |
CY1121568T1 (el) | 2020-05-29 |
TR201905174T4 (tr) | 2019-05-21 |
PT2139457T (pt) | 2016-07-26 |
PL2139457T3 (pl) | 2016-11-30 |
ES2718542T3 (es) | 2019-07-02 |
DE202008018583U1 (de) | 2016-03-14 |
DK3085363T3 (da) | 2019-04-29 |
HRP20190699T1 (hr) | 2019-07-12 |
SI2139457T1 (sl) | 2016-09-30 |
WO2008117268A3 (en) | 2009-03-26 |
IES20080229A2 (en) | 2008-12-24 |
EP3085363A1 (en) | 2016-10-26 |
SI3085363T1 (sl) | 2019-07-31 |
LT3085363T (lt) | 2019-06-25 |
ES2582368T3 (es) | 2016-09-12 |
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