DK2136653T3 - Indlejrede flydende smøremidler til tablettering - Google Patents
Indlejrede flydende smøremidler til tablettering Download PDFInfo
- Publication number
- DK2136653T3 DK2136653T3 DK08745723.0T DK08745723T DK2136653T3 DK 2136653 T3 DK2136653 T3 DK 2136653T3 DK 08745723 T DK08745723 T DK 08745723T DK 2136653 T3 DK2136653 T3 DK 2136653T3
- Authority
- DK
- Denmark
- Prior art keywords
- matrix
- composition
- multivitamin
- vitamin
- mineral
- Prior art date
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Landscapes
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- General Preparation And Processing Of Foods (AREA)
Claims (10)
1. Multivitamin- og mineralsammensætning til tablettering, omfattende 0,1 % til 1,5 % v/v af en matrix med indlejret smøring, hvor matrixen med indlejret smøring omfatter 50 vægt-% af en olieagtig væske, der er fint dispergeret i et olieuopløseligt materiale, og hvor sammensætningen omfatter mindre end 0,01 vægtprocent stearat; hvor den olieagtige væske er udvalgt fra gruppen bestående af vitamin E, animalsk olie, syntetisk olie, mineralolie, polyethy-lenglycol, siliconolie og kombinationer deraf; og hvor multivitamin- og mineralsammensætningen omfatter en væsentlig del af abrasive mineraler.
2. Multivitamin- og mineralsammensætning ifølge krav 1, hvor den olieagtige væske er vitamin E-acetat.
3. Multivitamin- og mineralsammensætning ifølge krav 1 eller krav 2, hvor det olieuopløselige materiale er udvalgt fra gruppen bestående af stivelse, dextrin, mikrokrystallinsk cellulose, ethylcellulose, gelatine, sukkerarter, glucose, maltose, fructose, sorbitol, sucrose, mannitol, sorbitol, lactose, methylcellulo-se, hydroxypropylmethylcellulose, maltodextrin, siliciumdioxid, vandfri dical-ciumphosphat og kombinationer deraf.
4. Multivitamin- og mineralsammensætning ifølge et hvilket som helst af kravene 1 til 3, hvor sammensætningen yderligere omfatter mindst et næringsmiddel.
5. Multivitamin- og mineralsammensætning ifølge krav 4, hvor det mindst ene næringsmiddel er udvalgt fra gruppen bestående af carotenoider, fiber, phy-tosteroler, glucosider, polyphenoler, B-komplex-relaterede forbindelser, ome-ga-3-fedtsyrer, probiotika, glucosamin, urter, aminosyrer, peptider og kombinationer deraf.
6. Multivitamin- og mineralsammensætning ifølge et hvilket som helst af kravene 1 til 5, hvor sammensætningen er en direkte komprimeringsammensætning.
7. Multivitamin- og mineralsammensætning ifølge et hvilket som helst af kravene 1 til 5, hvor sammensætningen omfatter en granulering.
8. Multivitamin- og mineralsammensætning ifølge krav 1 eller krav 2, hvor sammensætningen er en sammensætning til rulle-sammenpresning.
9. Multivitamin- og mineralsammensætning ifølge et hvilket som helst af de foregående krav, hvor de abrasive mineraler omfatter metalsalte.
10. Tablet fremstillet ved tablettering af en sammensætning ifølge et af kravene 1 til 9.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/787,381 US20080254119A1 (en) | 2007-04-16 | 2007-04-16 | Imbedded liquid lubricants for tableting |
| PCT/US2008/060188 WO2008130883A1 (en) | 2007-04-16 | 2008-04-14 | Embedded liquid lubricants for tableting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2136653T3 true DK2136653T3 (da) | 2018-01-22 |
Family
ID=39683787
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13154734.1T DK2599394T3 (da) | 2007-04-16 | 2008-04-14 | Indlejrede flydende smøremidler til tablettering |
| DK08745723.0T DK2136653T3 (da) | 2007-04-16 | 2008-04-14 | Indlejrede flydende smøremidler til tablettering |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13154734.1T DK2599394T3 (da) | 2007-04-16 | 2008-04-14 | Indlejrede flydende smøremidler til tablettering |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20080254119A1 (da) |
| EP (2) | EP2136653B1 (da) |
| JP (2) | JP5615170B2 (da) |
| KR (2) | KR20100016514A (da) |
| CN (2) | CN101657109A (da) |
| AU (1) | AU2008242256B2 (da) |
| BR (1) | BRPI0810017A2 (da) |
| CA (1) | CA2682551C (da) |
| CO (1) | CO6220919A2 (da) |
| DK (2) | DK2599394T3 (da) |
| EC (1) | ECSP099676A (da) |
| ES (2) | ES2676820T3 (da) |
| HK (1) | HK1216227A1 (da) |
| HU (2) | HUE035179T2 (da) |
| IL (1) | IL201495A (da) |
| MX (1) | MX340643B (da) |
| MY (1) | MY146906A (da) |
| NO (1) | NO2136653T3 (da) |
| NZ (1) | NZ580136A (da) |
| PH (1) | PH12009501979A1 (da) |
| PL (2) | PL2599394T3 (da) |
| PT (2) | PT2599394T (da) |
| RU (2) | RU2473243C2 (da) |
| TW (1) | TWI433652B (da) |
| WO (1) | WO2008130883A1 (da) |
| ZA (1) | ZA200907217B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201909238T4 (tr) * | 2004-03-29 | 2019-07-22 | Wyeth Llc | Multi-vitamin ve mineral besin takviyeleri. |
| US20080254119A1 (en) * | 2007-04-16 | 2008-10-16 | Wyeth | Imbedded liquid lubricants for tableting |
| CN103261404B (zh) * | 2010-12-16 | 2017-06-09 | 默克专利有限公司 | 干的颗粒状细胞培养基 |
| DE102011010437A1 (de) * | 2011-02-04 | 2012-08-09 | J. Rettenmaier & Söhne Gmbh + Co. Kg | Tablettierhilfsmittel |
| KR102284453B1 (ko) * | 2014-01-29 | 2021-08-02 | 삼성전자 주식회사 | 셀룰러 이동 통신 시스템에서 상향링크 제어 정보 전송 방법 및 장치 |
| SG11201705092TA (en) * | 2015-01-14 | 2017-07-28 | Pfizer | Oral delivery product |
| US11419350B2 (en) | 2016-07-01 | 2022-08-23 | Corbion Biotech, Inc. | Feed ingredients comprising lysed microbial cells |
| JP2019521697A (ja) | 2016-07-28 | 2019-08-08 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 水溶液中の成分の溶解挙動を改善するためのプロセス |
| US11019838B2 (en) * | 2017-02-21 | 2021-06-01 | Jarrow Formulas, Inc. | Probiotic dietary supplement formulation |
| EP3657966A1 (en) * | 2017-07-26 | 2020-06-03 | Abbott Laboratories | Nutritional tablets and methods of making the same |
| AU2020324553A1 (en) | 2019-08-08 | 2022-03-24 | Evonik Operations Gmbh | Method of preparing a solid dosage form and a lubricant |
| EP3937983A4 (en) * | 2019-12-17 | 2022-12-14 | 9286-3620 Québec Inc. | ORAL DELIVERY SYSTEMS BASED ON THE IN SITU FORMATION OF PROTEIN/POLYSACCHARIDE COACERVATES |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3518343A (en) * | 1967-10-02 | 1970-06-30 | Miles Lab | Effervescent tablet and process for making same |
| US3577490A (en) * | 1967-10-02 | 1971-05-04 | Miles Lab | Effervescent tablet and process for making same |
| US3518344A (en) * | 1967-10-02 | 1970-06-30 | Miles Lab | Tableting lubricant |
| US3577492A (en) * | 1967-10-02 | 1971-05-04 | Miles Lab | Tableting lubricant |
| US3518345A (en) * | 1967-10-05 | 1970-06-30 | Miles Lab | Tableting lubricant |
| US3619292A (en) * | 1968-07-15 | 1971-11-09 | Penick & Ford Ltd | Tablets and method of forming |
| US3655852A (en) * | 1969-08-01 | 1972-04-11 | Hoffmann La Roche | Method of forming a stable vitamin e-c granulation |
| US3619462A (en) * | 1969-12-29 | 1971-11-09 | Miles Lab | Tableting lubricant |
| CH586568A5 (da) * | 1972-04-10 | 1977-04-15 | Hoffmann La Roche | |
| JPS51148066A (en) * | 1975-05-26 | 1976-12-18 | Furointo Sangiyou Kk | Method of producing tablet confection |
| JPS5266615A (en) * | 1975-11-29 | 1977-06-02 | Sawai Seiyaku Kk | Manufacturing of solidified oily liquid substance |
| US4385422A (en) * | 1981-03-18 | 1983-05-31 | Duzitall Equipment Corporation | Crayfish peeler |
| US4395422A (en) * | 1981-04-06 | 1983-07-26 | Basf Wyandotte Corporation | Spray dried vitamin E powder |
| US4603143A (en) * | 1983-05-02 | 1986-07-29 | Basf Corporation | Free-flowing, high density, fat soluble vitamin powders with improved stability |
| ZA845180B (en) * | 1983-07-07 | 1986-02-26 | American Home Prod | Pharmaceutical composition containing a liquid lubricant |
| US4684534A (en) * | 1985-02-19 | 1987-08-04 | Dynagram Corporation Of America | Quick-liquifying, chewable tablet |
| EP0491754A4 (en) * | 1989-09-15 | 1992-08-12 | Cima Labs, Inc. | Magnesium carbonate and oil tableting aid |
| US5922351A (en) * | 1991-03-27 | 1999-07-13 | Bayer Corporation | Lubricants for use in tabletting |
| WO1995005808A1 (en) * | 1993-08-24 | 1995-03-02 | Abbott Laboratories | Oil-based tableting method |
| SI0931543T1 (en) * | 1997-12-19 | 2002-10-31 | Merck Patent Gmbh | Multilayered tablet comprising probiotic microorganisms such as lactobacilli or bifidobacteria |
| JPH11178895A (ja) * | 1997-12-22 | 1999-07-06 | Nippon Kayaku Co Ltd | 錠剤製造における打錠障害の防止方法及び錠剤の製造方法 |
| EP0966889B1 (en) * | 1998-06-24 | 2007-05-02 | DSM IP Assets B.V. | Vitamin powders for beverage applications |
| JP2000178206A (ja) * | 1998-12-18 | 2000-06-27 | Fancl Corp | 植物性油脂を含む滑沢剤 |
| US6914073B2 (en) * | 1999-03-18 | 2005-07-05 | Bristol Myers Squibb Company | Vitamin formulation for cardiovascular health |
| DK1066761T3 (da) * | 1999-07-06 | 2005-01-03 | Dsm Ip Assets Bv | Præparater indeholdende fedtoplöselige stoffer i en carbohydratmatrix |
| DE60019239T3 (de) * | 1999-12-09 | 2017-03-02 | Dsm Ip Assets B.V. | Fettlösliche Vitamine enthaltende Zusammensetzungen |
| US6375982B1 (en) * | 2000-07-05 | 2002-04-23 | Capricorn Pharma, Inc. | Rapid-melt semi-solid compositions, methods of making same and method of using same |
| JP2002188095A (ja) * | 2000-12-21 | 2002-07-05 | Fancl Corp | 植物性油脂粉末及び該粉末を含む食品組成物 |
| US6638557B2 (en) * | 2001-08-14 | 2003-10-28 | Cerestar Holding B.V. | Dry, edible oil and starch composition |
| US20060135446A1 (en) * | 2004-12-22 | 2006-06-22 | Toyo Shinyaku Co., Ltd. | Composition for improving blood fluidity |
| US20080254119A1 (en) * | 2007-04-16 | 2008-10-16 | Wyeth | Imbedded liquid lubricants for tableting |
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2007
- 2007-04-16 US US11/787,381 patent/US20080254119A1/en not_active Abandoned
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2008
- 2008-04-14 PL PL13154734T patent/PL2599394T3/pl unknown
- 2008-04-14 AU AU2008242256A patent/AU2008242256B2/en active Active
- 2008-04-14 NZ NZ580136A patent/NZ580136A/en unknown
- 2008-04-14 PT PT131547341T patent/PT2599394T/pt unknown
- 2008-04-14 DK DK13154734.1T patent/DK2599394T3/da active
- 2008-04-14 PL PL08745723T patent/PL2136653T3/pl unknown
- 2008-04-14 MX MX2009011058A patent/MX340643B/es active IP Right Grant
- 2008-04-14 CA CA2682551A patent/CA2682551C/en active Active
- 2008-04-14 DK DK08745723.0T patent/DK2136653T3/da active
- 2008-04-14 JP JP2010504175A patent/JP5615170B2/ja active Active
- 2008-04-14 WO PCT/US2008/060188 patent/WO2008130883A1/en active Application Filing
- 2008-04-14 PT PT87457230T patent/PT2136653T/pt unknown
- 2008-04-14 CN CN200880012059A patent/CN101657109A/zh active Pending
- 2008-04-14 MY MYPI20094240A patent/MY146906A/en unknown
- 2008-04-14 HU HUE08745723A patent/HUE035179T2/hu unknown
- 2008-04-14 CN CN201510953380.5A patent/CN105360879B/zh active Active
- 2008-04-14 ES ES13154734.1T patent/ES2676820T3/es active Active
- 2008-04-14 EP EP08745723.0A patent/EP2136653B1/en active Active
- 2008-04-14 ES ES08745723.0T patent/ES2655552T3/es active Active
- 2008-04-14 KR KR1020097023699A patent/KR20100016514A/ko active Search and Examination
- 2008-04-14 HU HUE13154734A patent/HUE038703T2/hu unknown
- 2008-04-14 NO NO08745723A patent/NO2136653T3/no unknown
- 2008-04-14 BR BRPI0810017-9A patent/BRPI0810017A2/pt not_active Application Discontinuation
- 2008-04-14 RU RU2009136554/13A patent/RU2473243C2/ru active
- 2008-04-14 KR KR1020157014285A patent/KR101867139B1/ko active IP Right Grant
- 2008-04-14 EP EP13154734.1A patent/EP2599394B1/en active Active
- 2008-04-14 RU RU2012138912A patent/RU2615823C9/ru active
- 2008-04-14 PH PH12009501979A patent/PH12009501979A1/en unknown
- 2008-04-16 TW TW097113859A patent/TWI433652B/zh active
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2009
- 2009-10-02 EC EC2009009676A patent/ECSP099676A/es unknown
- 2009-10-13 IL IL201495A patent/IL201495A/en active IP Right Grant
- 2009-10-14 CO CO09114325A patent/CO6220919A2/es not_active Application Discontinuation
- 2009-10-15 ZA ZA2009/07217A patent/ZA200907217B/en unknown
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2014
- 2014-06-02 JP JP2014113770A patent/JP2014195459A/ja active Pending
- 2014-08-01 US US14/449,335 patent/US20140342047A1/en not_active Abandoned
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2016
- 2016-04-13 HK HK16104223.3A patent/HK1216227A1/zh unknown
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2017
- 2017-05-22 US US15/601,114 patent/US11013251B2/en active Active
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