DK2120921T3 - Anvendelse af aminolevulinsyre og afledninger deraf - Google Patents
Anvendelse af aminolevulinsyre og afledninger deraf Download PDFInfo
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- DK2120921T3 DK2120921T3 DK08701770.3T DK08701770T DK2120921T3 DK 2120921 T3 DK2120921 T3 DK 2120921T3 DK 08701770 T DK08701770 T DK 08701770T DK 2120921 T3 DK2120921 T3 DK 2120921T3
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- composition
- photoactivation
- treatment
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Claims (18)
1. En sammensætning omfattende methyl-5-ALA-ester, eller et farmaceutisk acceptabelt salt deraf til anvendelse i fotodynamisk terapi (PDT) på et dyr til behandling af acne, hvor nævnte PDT omfatter: (a) indgivelse af sammensætningen til dyret; og (b) fotoaktivering nævnte methyl-5-ALA-ester, og hvor bivirkninger af nævnte PDT forebygges eller reduceres ved (i) at sammensætningen omfatter methyl-5-ALA-ester i en koncentration på mindre end 10 vægt-%, og (ii) at sammensætningen indgives i mindre end 2 timer før nævnte fotoaktivering.
2. Sammensætning til anvendelse i PDT ifølge krav 1, hvor bivirkningerne er smerter og/eller erytem.
3. Sammensætning til anvendelse i PDT ifølge krav 1 eller krav 2, hvor sammensætningen omfatter methyl-5-ALA ester i en koncentration på 0,5 til 8 vægt-%.
4. Sammensætning til anvendelse i PDT ifølge krav 3, hvor sammensætningen omfatter methyl-5-ALA-ester i en koncentration på 4 til 8 vægt-%.
5. Sammensætning til anvendelse i PDT ifølge ethvert af kravene 1 til 4, hvor sammensætningen indgives i 5 minutter til 90 minutter inden nævnte fotoaktivering.
6. Sammensætning til anvendelse i PDT ifølge ethvert af kravene 1 til 4, hvor sammensætningen indgives i 30 minutter til 90 minutter inden nævnte fotoaktivering.
7. Sammensætning til anvendelse i PDT ifølge ethvert af de foregående krav, hvor nævnte fotoaktivering udføres ved at anvende en lysdosis på 10-100 J / cm2.
8. Sammensætning til anvendelse i PDT ifølge ethvert af de foregående krav, hvor nævnte fotoaktivering udføres ved at anvende en lysdosis på 37 J / cm2.
9. Sammensætning til anvendelse i PDT ifølge ethvert af kravene 1 til 8, hvor nævnte fotoaktivering udføres ved anvendelse af en LED-lampe.
10. Sammensætning til anvendelse i PDT ifølge ethvert af kravene 1 til 9, hvor nævnte fotoaktivering udføres med lys med en bølgelængde på 400 til 700 nm.
11. Sammensætning til anvendelse i PDT ifølge ethvert af kravene 1 til 8, hvor nævnte fotoaktivering udføres med sollys .
12. Sammensætning til anvendelse i PDT ifølge krav 11, hvor fotoaktivering med sollys udføres umiddelbart efter indgivelsen af sammensætningen.
13. Sammensætning til anvendelse i PDT ifølge krav 11 eller krav 12, hvor den lette dosis modtaget af dyret med sollys overvåges ved hjælp af et bærbart fotometer.
14. Sammensætning til anvendelse i PDT ifølge ethvert af de foregående krav, hvor sammensætningen er i form af en creme.
15. Sammensætning til anvendelse i PDT ifølge ethvert af de foregående krav, hvor den nævnte PDT har i det væsentlige den samme terapeutiske virkning som den tilsvarende standard PDT behandling.
16. Sammensætning til anvendelse i PDT ifølge ethvert af de foregående krav, hvor dyret er et menneske.
17. Anvendelse af methyl-5-ALA-ester, eller et farmaceutisk acceptabelt salt deraf, til fremstilling af en sammensætning til fotodynamisk terapi (PDT) på et dyr ifølge krav 1.
18. Anvendelse ifølge krav 17, hvor dyret er et menneske.
Applications Claiming Priority (2)
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| GBGB0700580.4A GB0700580D0 (en) | 2007-01-11 | 2007-01-11 | Use |
| PCT/GB2008/000086 WO2008084241A2 (en) | 2007-01-11 | 2008-01-11 | Use of aminolevulinic acid and derivatives thereof |
Publications (1)
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| DK2120921T3 true DK2120921T3 (da) | 2015-08-24 |
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| EP (3) | EP2120921B1 (da) |
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| US20110224598A1 (en) * | 2010-03-12 | 2011-09-15 | Daniel Barolet | Radiant near infrared light emitting diode exposure as skin preparation |
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| ES2821831T3 (es) * | 2009-06-11 | 2021-04-27 | Photocure Asa | Composiciones y productos farmacéuticos semisólidos que comprenden ésteres de ácido 5-aminolevulínico |
| WO2011107478A1 (en) * | 2010-03-01 | 2011-09-09 | Photocure Asa | Cosmetic compositions |
| WO2012086802A1 (ja) | 2010-12-24 | 2012-06-28 | アークレイ株式会社 | 癌細胞の検出方法 |
| CN102617378B (zh) * | 2011-01-26 | 2016-04-27 | 上海泺安医药技术有限公司 | 一种2-(3’-氨基-2’-氧-丙基)丙二酸酯盐及制备 |
| KR101254752B1 (ko) * | 2011-02-28 | 2013-04-15 | 부산대학교 산학협력단 | 광역동치료의 광증감제로 사용하기 위한 구연산을 이용한 아미노레불리닉산 트라이머 |
| KR101254758B1 (ko) * | 2011-02-28 | 2013-04-15 | 부산대학교병원 | 광역동치료의 광증감제로 사용하기 위한 이디티에이를 이용한 아미노레불리닉산 테트라머 |
| CN102179010B (zh) * | 2011-05-27 | 2013-01-09 | 吉林大学 | 脑胶质瘤光动力直接照射治疗装置 |
| BR112014014847B1 (pt) | 2011-12-19 | 2022-08-16 | Photocure Asa | Aparelho de aplicação de luz portátil, autônomo, para tratamento fotodinâmico da vulva, e kit |
| WO2013111719A1 (ja) * | 2012-01-26 | 2013-08-01 | Ｓｂｉファーマ株式会社 | 光線力学的診断剤、及び、フォトブリーチング防止剤 |
| US20140067024A1 (en) | 2012-08-30 | 2014-03-06 | Photocure Asa | Dual panel photodynamic therapy lamp |
| GB201306369D0 (en) | 2013-04-09 | 2013-05-22 | Photocure As | Irradiation device |
| KR20150004092A (ko) * | 2013-07-02 | 2015-01-12 | 제너럴바이오(주) | 칼란코에 추출물이 포함된 항산화 액상 조성물 |
| US10716855B2 (en) * | 2013-12-20 | 2020-07-21 | Galderma Research & Development | Pulse photodynamic treatment of photodamaged skin |
| PL229756B1 (pl) | 2014-11-12 | 2018-08-31 | Tarchominskie Zaklady Farmaceutyczne Polfa Spólka Akcyjna | Krem do stosowania w diagnostyce i terapii z zastosowaniem metody fotodynamicznej |
| WO2016080096A1 (ja) * | 2014-11-19 | 2016-05-26 | シャープ株式会社 | 光線力学治療装置 |
| US10603508B2 (en) | 2015-10-15 | 2020-03-31 | Dusa Pharmaceuticals, Inc. | Adjustable illuminators and methods for photodynamic therapy and diagnosis |
| WO2017066270A1 (en) | 2015-10-15 | 2017-04-20 | Dusa Pharmaceuticals, Inc. | Adjustable illuminator for photodynamic therapy and diagnosis |
| CN108697800A (zh) | 2015-12-17 | 2018-10-23 | 光治疗Asa公司 | 用于膀胱癌的光动力疗法（pdt）的方法 |
| US10632324B2 (en) | 2017-04-27 | 2020-04-28 | 9127-4910 Quebec Inc. | Method for the treatment of skin tissues |
| IL301904A (en) * | 2017-07-17 | 2023-06-01 | Dusa Pharmaceuticals Inc | Photodynamic therapy method for skin problems |
| US10357567B1 (en) | 2018-01-12 | 2019-07-23 | Dusa Pharmaceuticals, Inc. | Methods for photodynamic therapy |
| CN112584864A (zh) * | 2018-08-23 | 2021-03-30 | 生物前沿生物科学有限公司 | 包括两种不同波长的曝光的光动力疗法 |
| EP3960241A4 (en) | 2019-04-26 | 2023-06-07 | Neopharma Japan Co., Ltd. | THERAPEUTIC AGENT FOR FLAVIVIRUS INFECTION |
| JP2022540769A (ja) | 2019-06-25 | 2022-09-20 | デューサ ファーマシューティカルズ インコーポレイテッド | 光線性角化症の光線力学的治療の間の痛みを低減する方法 |
| CN115916178A (zh) * | 2020-07-15 | 2023-04-04 | 日本纽翱医药股份有限公司 | 非洲猪瘟(African Swine Fever:ASF)的治疗剂和/或预防剂 |
| CN113620828A (zh) * | 2021-08-17 | 2021-11-09 | 湖南复瑞生物医药技术有限责任公司 | 一种5-氨基酮戊酸酯化物、用途和农药组合物 |
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| US5955490A (en) | 1989-07-28 | 1999-09-21 | Queen's University At Kingston | Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins |
| US5079262A (en) | 1989-07-28 | 1992-01-07 | Queen's University At Kingston | Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid |
| US5422093A (en) | 1989-07-28 | 1995-06-06 | Queen's University | Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof |
| US6034267A (en) | 1995-03-10 | 2000-03-07 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US7530461B2 (en) * | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| GB9700396D0 (en) * | 1997-01-10 | 1997-02-26 | Photocure As | Photochemotherapeutic compositions |
| AUPQ044499A0 (en) | 1999-05-19 | 1999-06-10 | Commonwealth Scientific And Industrial Research Organisation | Control of wool growth |
| GB0018528D0 (en) * | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| GB0018527D0 (en) * | 2000-07-27 | 2000-09-13 | Photocure Asa | Composition |
| EP1313448B1 (en) * | 2000-08-16 | 2010-04-07 | The General Hospital Corporation doing business as Massachusetts General Hospital | Topical aminolevulinic acid-photodynamic therapy for acne vulgaris |
| US6723750B2 (en) * | 2002-03-15 | 2004-04-20 | Allergan, Inc. | Photodynamic therapy for pre-melanomas |
| AU2003230808A1 (en) | 2002-04-05 | 2003-10-27 | Candela Corporation | High fluence rate activation of photosensitizers for dermatological applications |
| US20040048842A1 (en) | 2002-09-10 | 2004-03-11 | Mcmillan Kathleen | Method of treating skin disorders |
| AU2003301267A1 (en) | 2002-10-18 | 2004-05-04 | The Regents Of The University Of California | Photodynamic therapy for ocular neovascularization |
| US20050209331A1 (en) | 2004-03-22 | 2005-09-22 | Syneron Medical Ltd. | Method of treatment of skin |
| US20050209330A1 (en) | 2004-03-22 | 2005-09-22 | Syneron Medical Ltd. | Method of treatment of skin |
| GB0406917D0 (en) * | 2004-03-26 | 2004-04-28 | Photocure Asa | Compounds |
| GB0424833D0 (en) * | 2004-11-10 | 2004-12-15 | Photocure Asa | Method |
| GB0609809D0 (en) * | 2006-05-17 | 2006-06-28 | Photocure Asa | Product |
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2007
- 2007-01-11 GB GBGB0700580.4A patent/GB0700580D0/en not_active Ceased
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2008
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- 2008-01-11 SI SI200831500T patent/SI2120921T1/sl unknown
- 2008-01-11 CN CN200880002124A patent/CN101631541A/zh active Pending
- 2008-01-11 JP JP2009545231A patent/JP5814508B2/ja not_active Expired - Fee Related
- 2008-01-11 KR KR1020147014684A patent/KR20140076641A/ko active Search and Examination
- 2008-01-11 PL PL08701770T patent/PL2120921T3/pl unknown
- 2008-01-11 EP EP14163782.7A patent/EP2754439B1/en active Active
- 2008-01-11 EP EP13173602.7A patent/EP2659888A1/en not_active Withdrawn
- 2008-01-11 CA CA2675334A patent/CA2675334C/en active Active
- 2008-01-11 KR KR1020097016703A patent/KR20090118925A/ko not_active Application Discontinuation
- 2008-01-11 ES ES14163782T patent/ES2900528T3/es active Active
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- 2008-01-11 WO PCT/GB2008/000086 patent/WO2008084241A2/en active Application Filing
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2012
- 2012-10-10 US US13/648,946 patent/US20130090592A1/en not_active Abandoned
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2014
- 2014-01-22 JP JP2014009382A patent/JP5827702B2/ja active Active
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2015
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- 2015-10-02 US US14/873,566 patent/US10543272B2/en not_active Expired - Fee Related
Also Published As
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|---|---|
| JP2010515714A (ja) | 2010-05-13 |
| CA2675334A1 (en) | 2008-07-17 |
| EP2120921B1 (en) | 2015-06-17 |
| KR20140076641A (ko) | 2014-06-20 |
| US20150150972A1 (en) | 2015-06-04 |
| JP5814508B2 (ja) | 2015-11-17 |
| JP5827702B2 (ja) | 2015-12-02 |
| US20130090592A1 (en) | 2013-04-11 |
| PL2120921T3 (pl) | 2015-12-31 |
| GB0700580D0 (en) | 2007-02-21 |
| US20100137439A1 (en) | 2010-06-03 |
| US20160030565A1 (en) | 2016-02-04 |
| ES2900528T3 (es) | 2022-03-17 |
| JP2014094963A (ja) | 2014-05-22 |
| CA2675334C (en) | 2014-02-25 |
| EP2754439A2 (en) | 2014-07-16 |
| EP2659888A1 (en) | 2013-11-06 |
| CN101631541A (zh) | 2010-01-20 |
| EP2120921A2 (en) | 2009-11-25 |
| ES2546381T3 (es) | 2015-09-23 |
| EP2754439A3 (en) | 2014-10-01 |
| PT2120921E (pt) | 2015-09-30 |
| EP2754439B1 (en) | 2021-10-13 |
| US8759396B2 (en) | 2014-06-24 |
| CN104069493A (zh) | 2014-10-01 |
| SI2120921T1 (sl) | 2015-10-30 |
| CA2784250C (en) | 2016-03-15 |
| WO2008084241A3 (en) | 2008-09-18 |
| KR20090118925A (ko) | 2009-11-18 |
| CA2784250A1 (en) | 2008-07-17 |
| US10543272B2 (en) | 2020-01-28 |
| WO2008084241A2 (en) | 2008-07-17 |
| CN104524576A (zh) | 2015-04-22 |
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