DK2061810T3 - Fremgangsmåder og præparater til behandling af antistofmedierede neuropatier - Google Patents
Fremgangsmåder og præparater til behandling af antistofmedierede neuropatier Download PDFInfo
- Publication number
- DK2061810T3 DK2061810T3 DK07837788.4T DK07837788T DK2061810T3 DK 2061810 T3 DK2061810 T3 DK 2061810T3 DK 07837788 T DK07837788 T DK 07837788T DK 2061810 T3 DK2061810 T3 DK 2061810T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibody
- antibodies
- complement
- eculizumab
- nhs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Mycology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (7)
1. Antistof til anvendelse til behandling af Guillain-Barrés syndrom hos et pattedyr, hvor antistoffet binder til: (i) komplement-bestanddel C5 og hæmmer spaltningen af C5 til fragmenterne C5a og C5b; eller (ii) C5b, hvor antistoffet hæmmer dannelsen af membranangrebskomplekset.
2. Antistof til anvendelse ifølge krav 1, hvor pattedyret har Miller-Fisher-varianten af Guillain-Barrés syndrom.
3. Antistof til anvendelse ifølge krav 1 eller 2, hvor antistoffet er et helt antistof eller et antistoffragment.
4. Antistof til anvendelse ifølge krav 3, hvor det hele antistof eller antistoffragmentet er udvalgt fra gruppen, der består af: et polyklonalt antistof, et monoklonalt antistof eller antistoffragment, et diabody, et kimeriseret eller kimært antistof eller antistoffragment, et humaniseret antistof eller antistoffragment, et deimmuniseret humant antistof eller antistoffragment, et fuldt humant antistof eller antistoffragment, et enketlkædet antistof, et Fv-antistoffragment, et Fab-antistoffragment, et Fab' - antistoffragment og et F (ab')2-antistoffragment.
5. Antistof til anvendelse ifølge krav 1 eller 2, hvor antistoffet er eculizumab.
6. Antistof til anvendelse ifølge krav 1 eller 2, hvor antistoffet er pexelizumab.
7. Antistof til anvendelse ifølge et hvilket som helst af kravene 1 til 6, hvor pattedyret er et menneske.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84229606P | 2006-09-05 | 2006-09-05 | |
PCT/US2007/019416 WO2008030505A2 (en) | 2006-09-05 | 2007-09-05 | Methods and compositions for the treatment of antibody mediated neuropathies |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2061810T3 true DK2061810T3 (da) | 2015-02-16 |
Family
ID=39157834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07837788.4T DK2061810T3 (da) | 2006-09-05 | 2007-09-05 | Fremgangsmåder og præparater til behandling af antistofmedierede neuropatier |
Country Status (17)
Country | Link |
---|---|
US (1) | US9388235B2 (da) |
EP (4) | EP2061810B1 (da) |
JP (2) | JP5695317B2 (da) |
KR (1) | KR101503540B1 (da) |
AU (1) | AU2007293013B2 (da) |
BR (1) | BRPI0715869A2 (da) |
CA (1) | CA2662480C (da) |
DK (1) | DK2061810T3 (da) |
ES (2) | ES2530428T3 (da) |
HK (1) | HK1126793A1 (da) |
IL (1) | IL197148A (da) |
MX (1) | MX2009002426A (da) |
NZ (1) | NZ575018A (da) |
PL (1) | PL2061810T3 (da) |
PT (1) | PT2061810E (da) |
SI (1) | SI2061810T1 (da) |
WO (1) | WO2008030505A2 (da) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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BR122017024057B8 (pt) | 2006-03-15 | 2021-05-25 | Alexion Pharma Inc | anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável |
GB0617734D0 (en) * | 2006-09-08 | 2006-10-18 | Evolutec Ltd | Method of treating peripheral nerve disorders |
AU2009307661B2 (en) * | 2008-10-21 | 2014-11-20 | Thomas M. Donndelinger | Methods and compositions for preventing artifacts in tissue samples |
PT2817329T (pt) | 2012-02-20 | 2019-04-01 | Swedish Orphan Biovitrum Ab Publ | Polipeptioos que se ligam ao complemento humano c5 |
WO2014066744A2 (en) | 2012-10-25 | 2014-05-01 | True North Therapeutics, Inc. | Anti-complement c1s antibodies and uses thereof |
US8945562B2 (en) | 2012-11-02 | 2015-02-03 | True North Therapeutics, Inc. | Anti-complement C1s antibodies |
EP2997045A4 (en) * | 2013-05-15 | 2016-11-23 | Annexon Inc | ANTI-FACTOR C1S ANTIBODIES OF THE COMPLEMENT AND USES THEREOF |
MY175896A (en) | 2013-07-09 | 2020-07-14 | Annexon Inc | Anti-complement factor c1q antibodies and uses thereof |
KR20160132034A (ko) | 2014-03-13 | 2016-11-16 | 우니페르시테트 바젤 | 미엘린-관련 당단백질에 대한 IgM 항체와 결합하는 탄수화물 리간드 |
BR112017009297B1 (pt) | 2014-11-05 | 2024-02-15 | Annexon, Inc | Anticorpos antifator de complemento c1q humanizados, composição farmacêutica e kit compreendendo os mesmos, uso terapêutico destes,polinucleotídeo isolado, célula hospedeira isolada, bem como métodos in vitro para detectar sinapses |
KR20230137502A (ko) * | 2014-12-19 | 2023-10-04 | 레제네상스 비.브이. | 인간 c6에 결합하는 항체 및 이의 용도 |
LT3280440T (lt) | 2015-04-06 | 2023-02-27 | Bioverativ Usa Inc. | Humanizuoti antikūnai prieš c1s ir jų panaudojimo būdai |
US11091591B2 (en) | 2015-09-16 | 2021-08-17 | Universität Basel | Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids |
EP3380518A4 (en) | 2015-11-24 | 2019-07-31 | Annexon, Inc. | ANTI-COMPLEMENT FACTOR C1Q FAB FRAGMENTS AND USES THEREOF |
MA45235A (fr) | 2016-06-14 | 2019-04-17 | Regeneron Pharma | Anticorps anti-c5 et leurs utilisations |
EP3724226A1 (en) | 2017-12-13 | 2020-10-21 | Regeneron Pharmaceuticals, Inc. | Anti-c5 antibody combinations and uses thereof |
BR112021007083A2 (pt) * | 2018-10-22 | 2021-08-03 | Ra Pharmaceuticals, Inc | tratamento de doença neurológica com zilucoplan |
GB2584105B (en) * | 2019-05-21 | 2023-08-02 | Argenx Bvba | Methods of treating neuropathy |
TW202404632A (zh) * | 2022-04-04 | 2024-02-01 | 瑞士商赫孚孟拉羅股份公司 | 用於藉由使用抗c5抗體克羅伐單抗治療或預防格林-巴利症候群之劑量及投予方案 |
Family Cites Families (38)
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GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
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DE69534347T2 (de) | 1994-01-31 | 2006-05-24 | Trustees Of Boston University, Boston | Bibliotheken aus Polyklonalen Antikörpern |
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ITMI20021527A1 (it) * | 2002-07-11 | 2004-01-12 | Consiglio Nazionale Ricerche | Anticorpi anti componente c5 del complemento e loro uso |
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-
2007
- 2007-09-05 KR KR1020097004369A patent/KR101503540B1/ko active IP Right Grant
- 2007-09-05 ES ES07837788T patent/ES2530428T3/es active Active
- 2007-09-05 WO PCT/US2007/019416 patent/WO2008030505A2/en active Application Filing
- 2007-09-05 US US12/439,070 patent/US9388235B2/en active Active
- 2007-09-05 AU AU2007293013A patent/AU2007293013B2/en active Active
- 2007-09-05 CA CA2662480A patent/CA2662480C/en active Active
- 2007-09-05 ES ES11005615.7T patent/ES2616204T3/es active Active
- 2007-09-05 EP EP07837788.4A patent/EP2061810B1/en active Active
- 2007-09-05 PT PT78377884T patent/PT2061810E/pt unknown
- 2007-09-05 NZ NZ575018A patent/NZ575018A/en not_active IP Right Cessation
- 2007-09-05 MX MX2009002426A patent/MX2009002426A/es active IP Right Grant
- 2007-09-05 JP JP2009527404A patent/JP5695317B2/ja not_active Expired - Fee Related
- 2007-09-05 DK DK07837788.4T patent/DK2061810T3/da active
- 2007-09-05 EP EP14192554.5A patent/EP2913342A1/en not_active Withdrawn
- 2007-09-05 EP EP16201244.7A patent/EP3199549A1/en not_active Withdrawn
- 2007-09-05 PL PL07837788T patent/PL2061810T3/pl unknown
- 2007-09-05 SI SI200731601T patent/SI2061810T1/sl unknown
- 2007-09-05 BR BRPI0715869-6A2A patent/BRPI0715869A2/pt not_active Application Discontinuation
- 2007-09-05 EP EP11005615.7A patent/EP2380907B1/en active Active
-
2009
- 2009-02-19 IL IL197148A patent/IL197148A/en active IP Right Grant
- 2009-06-23 HK HK09105652.9A patent/HK1126793A1/xx not_active IP Right Cessation
-
2014
- 2014-09-26 JP JP2014196133A patent/JP2014240438A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR101503540B1 (ko) | 2015-03-17 |
EP2380907B1 (en) | 2016-11-30 |
EP2061810A2 (en) | 2009-05-27 |
MX2009002426A (es) | 2009-03-20 |
NZ575018A (en) | 2012-04-27 |
KR20090051063A (ko) | 2009-05-20 |
AU2007293013B2 (en) | 2013-06-27 |
BRPI0715869A2 (pt) | 2013-07-30 |
WO2008030505A3 (en) | 2008-06-19 |
CA2662480A1 (en) | 2008-03-13 |
IL197148A (en) | 2016-06-30 |
US9388235B2 (en) | 2016-07-12 |
EP3199549A1 (en) | 2017-08-02 |
JP2014240438A (ja) | 2014-12-25 |
JP2010502708A (ja) | 2010-01-28 |
ES2616204T3 (es) | 2017-06-09 |
WO2008030505A8 (en) | 2009-03-05 |
EP2380907A1 (en) | 2011-10-26 |
EP2913342A1 (en) | 2015-09-02 |
WO2008030505A2 (en) | 2008-03-13 |
ES2530428T3 (es) | 2015-03-02 |
SI2061810T1 (sl) | 2015-04-30 |
IL197148A0 (en) | 2011-08-01 |
AU2007293013A1 (en) | 2008-03-13 |
PT2061810E (pt) | 2015-02-05 |
PL2061810T3 (pl) | 2015-05-29 |
JP5695317B2 (ja) | 2015-04-01 |
CA2662480C (en) | 2016-11-08 |
HK1126793A1 (en) | 2009-09-11 |
US20100143343A1 (en) | 2010-06-10 |
EP2061810B1 (en) | 2014-11-12 |
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