DK2059532T3 - Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus H5N1, og anvendelser deraf - Google Patents

Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus H5N1, og anvendelser deraf

Info

Publication number
DK2059532T3
DK2059532T3 DK07803310.7T DK07803310T DK2059532T3 DK 2059532 T3 DK2059532 T3 DK 2059532T3 DK 07803310 T DK07803310 T DK 07803310T DK 2059532 T3 DK2059532 T3 DK 2059532T3
Authority
DK
Denmark
Prior art keywords
influenza virus
binding molecules
molecules capable
human binding
neutralizing influenza
Prior art date
Application number
DK07803310.7T
Other languages
English (en)
Inventor
Den Brink Edward Norbert Van
Kruif Cornelis Adriaan De
Mark Throsby
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Priority claimed from PCT/EP2007/059356 external-priority patent/WO2008028946A2/en
Application granted granted Critical
Publication of DK2059532T3 publication Critical patent/DK2059532T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK07803310.7T 2006-09-07 2007-09-06 Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus H5N1, og anvendelser deraf DK2059532T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US84293006P 2006-09-07 2006-09-07
EP06120316 2006-09-07
EP06120644 2006-09-14
EP06125107 2006-11-30
EP07111235 2007-06-28
PCT/EP2007/059356 WO2008028946A2 (en) 2006-09-07 2007-09-06 Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof

Publications (1)

Publication Number Publication Date
DK2059532T3 true DK2059532T3 (da) 2013-03-18

Family

ID=45468077

Family Applications (5)

Application Number Title Priority Date Filing Date
DK12153016.6T DK2455399T3 (da) 2006-09-07 2007-09-06 Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus h5n1, og anvendelser deraf
DK12153015.8T DK2455398T3 (da) 2006-09-07 2007-09-06 Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus h5n1, og anvendelser deraf
DK07803310.7T DK2059532T3 (da) 2006-09-07 2007-09-06 Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus H5N1, og anvendelser deraf
DK12153012.5T DK2450378T3 (da) 2006-09-07 2007-09-06 Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus h5n1, og anvendelser deraf
DK12153013.3T DK2450379T3 (da) 2006-09-07 2007-09-06 Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus h5n1, og anvendelser deraf

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK12153016.6T DK2455399T3 (da) 2006-09-07 2007-09-06 Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus h5n1, og anvendelser deraf
DK12153015.8T DK2455398T3 (da) 2006-09-07 2007-09-06 Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus h5n1, og anvendelser deraf

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK12153012.5T DK2450378T3 (da) 2006-09-07 2007-09-06 Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus h5n1, og anvendelser deraf
DK12153013.3T DK2450379T3 (da) 2006-09-07 2007-09-06 Humane bindingsmolekyler, der er i stand til at neutralisere influenzavirus h5n1, og anvendelser deraf

Country Status (11)

Country Link
EP (5) EP2450378B1 (da)
BR (1) BRPI0716983B8 (da)
DK (5) DK2455399T3 (da)
ES (1) ES2402217T3 (da)
MX (1) MX343198B (da)
MY (1) MY165458A (da)
NZ (1) NZ574581A (da)
PT (1) PT2059532E (da)
RS (1) RS52688B (da)
SG (2) SG10201607410TA (da)
SI (1) SI2059532T1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110028578B (zh) * 2019-03-12 2021-05-11 中国科学院武汉病毒研究所 广谱抗h7流感病毒的中和性人源单克隆抗体及其应用
CN118126168B (zh) * 2024-05-10 2024-07-19 北京纳百生物科技有限公司 一种禽流感np蛋白单克隆抗体及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625015A (en) * 1982-08-23 1986-11-25 Scripps Clinic & Research Foundation Broad spectrum influenza antisera
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
NL9101953A (nl) 1991-11-21 1993-06-16 Seed Capital Investments Testinrichting omvattende een plaat met een veelvoud van putjes met een bijbehorende doseerinrichting, alsmede een kit die deze inrichtingen omvat en toepassing van de inrichtingen.
US5589174A (en) * 1992-09-17 1996-12-31 Takara Shuzo Co., Ltd. Anti-human influenza virus antibody
US5624949A (en) 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US6265150B1 (en) 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
JP2001512560A (ja) 1996-10-08 2001-08-21 ユー―ビスイス ベスローテン フェンノートシャップ 標的に対し特異的な親和性を有するペプチドおよびタンパク質の選択のための方法および手段
PT1161548E (pt) 1999-04-15 2005-06-30 Crucell Holland Bv Producao de proteinas recombinantes numa celula humana utilizando sequencias codificando a proteina e1 de adenovirus
US7521220B2 (en) 1999-11-26 2009-04-21 Crucell Holland B.V. Production of vaccines
CA2449071C (en) 2001-06-15 2008-12-16 Crucell Holland B.V. Chimaeric phages

Also Published As

Publication number Publication date
RS52688B (en) 2013-08-30
BRPI0716983B8 (pt) 2021-05-25
EP2450378A1 (en) 2012-05-09
EP2455399A2 (en) 2012-05-23
MX343198B (es) 2016-10-11
BRPI0716983B1 (pt) 2019-03-26
EP2455398A3 (en) 2012-05-30
EP2455399B1 (en) 2015-11-04
EP2450376A2 (en) 2012-05-09
EP2450378B1 (en) 2015-11-04
PT2059532E (pt) 2013-03-07
DK2455398T3 (da) 2016-02-08
EP2450379A1 (en) 2012-05-09
DK2450379T3 (da) 2016-02-08
ES2402217T3 (es) 2013-04-29
EP2450376B1 (en) 2018-02-28
SI2059532T1 (sl) 2013-04-30
SG174773A1 (en) 2011-10-28
SG10201607410TA (en) 2016-10-28
EP2455399A3 (en) 2012-05-30
EP2450376A3 (en) 2012-08-01
MY165458A (en) 2018-03-22
EP2455398A2 (en) 2012-05-23
BRPI0716983A2 (pt) 2013-10-15
EP2450379B1 (en) 2015-11-04
NZ574581A (en) 2012-02-24
EP2455398B1 (en) 2015-11-18
DK2455399T3 (da) 2016-01-25
DK2450378T3 (da) 2016-02-01

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