SG10201607410TA - Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof - Google Patents

Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof

Info

Publication number
SG10201607410TA
SG10201607410TA SG10201607410TA SG10201607410TA SG10201607410TA SG 10201607410T A SG10201607410T A SG 10201607410TA SG 10201607410T A SG10201607410T A SG 10201607410TA SG 10201607410T A SG10201607410T A SG 10201607410TA SG 10201607410T A SG10201607410T A SG 10201607410TA
Authority
SG
Singapore
Prior art keywords
influenza virus
binding molecules
molecules capable
human binding
neutralizing influenza
Prior art date
Application number
SG10201607410TA
Other languages
English (en)
Inventor
Den Brink Edward Norbert Van
Kruif Cornelis Adriaan De
Mark Throsby
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Publication of SG10201607410TA publication Critical patent/SG10201607410TA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG10201607410TA 2006-09-07 2007-09-06 Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof SG10201607410TA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US84293006P 2006-09-07 2006-09-07
EP06120316 2006-09-07
EP06120644 2006-09-14
EP06125107 2006-11-30
EP07111235 2007-06-28

Publications (1)

Publication Number Publication Date
SG10201607410TA true SG10201607410TA (en) 2016-10-28

Family

ID=45468077

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2011063955A SG174773A1 (en) 2006-09-07 2007-09-06 Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof
SG10201607410TA SG10201607410TA (en) 2006-09-07 2007-09-06 Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2011063955A SG174773A1 (en) 2006-09-07 2007-09-06 Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof

Country Status (11)

Country Link
EP (5) EP2450376B1 (da)
BR (1) BRPI0716983B8 (da)
DK (5) DK2455398T3 (da)
ES (1) ES2402217T3 (da)
MX (1) MX343198B (da)
MY (1) MY165458A (da)
NZ (1) NZ574581A (da)
PT (1) PT2059532E (da)
RS (1) RS52688B (da)
SG (2) SG174773A1 (da)
SI (1) SI2059532T1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110028578B (zh) * 2019-03-12 2021-05-11 中国科学院武汉病毒研究所 广谱抗h7流感病毒的中和性人源单克隆抗体及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625015A (en) * 1982-08-23 1986-11-25 Scripps Clinic & Research Foundation Broad spectrum influenza antisera
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
NL9101953A (nl) 1991-11-21 1993-06-16 Seed Capital Investments Testinrichting omvattende een plaat met een veelvoud van putjes met een bijbehorende doseerinrichting, alsmede een kit die deze inrichtingen omvat en toepassing van de inrichtingen.
US5589174A (en) * 1992-09-17 1996-12-31 Takara Shuzo Co., Ltd. Anti-human influenza virus antibody
US5624949A (en) 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US6265150B1 (en) 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
JP2001512560A (ja) 1996-10-08 2001-08-21 ユー―ビスイス ベスローテン フェンノートシャップ 標的に対し特異的な親和性を有するペプチドおよびタンパク質の選択のための方法および手段
ATE536417T1 (de) 1999-04-15 2011-12-15 Crucell Holland Bv Herstellung von rekombinanten proteinen in einer menschlichen zelle mit mindestens einem e1 adenovirus protein
US7521220B2 (en) 1999-11-26 2009-04-21 Crucell Holland B.V. Production of vaccines
CA2449071C (en) 2001-06-15 2008-12-16 Crucell Holland B.V. Chimaeric phages

Also Published As

Publication number Publication date
EP2455398A3 (en) 2012-05-30
EP2450376B1 (en) 2018-02-28
EP2450378B1 (en) 2015-11-04
DK2455399T3 (da) 2016-01-25
SG174773A1 (en) 2011-10-28
EP2455399B1 (en) 2015-11-04
DK2455398T3 (da) 2016-02-08
BRPI0716983B8 (pt) 2021-05-25
EP2450376A3 (en) 2012-08-01
NZ574581A (en) 2012-02-24
DK2450379T3 (da) 2016-02-08
BRPI0716983A2 (pt) 2013-10-15
EP2450376A2 (en) 2012-05-09
EP2455398A2 (en) 2012-05-23
MY165458A (en) 2018-03-22
EP2450379B1 (en) 2015-11-04
DK2059532T3 (da) 2013-03-18
SI2059532T1 (sl) 2013-04-30
EP2450378A1 (en) 2012-05-09
BRPI0716983B1 (pt) 2019-03-26
EP2455398B1 (en) 2015-11-18
PT2059532E (pt) 2013-03-07
EP2455399A2 (en) 2012-05-23
ES2402217T3 (es) 2013-04-29
RS52688B (en) 2013-08-30
EP2455399A3 (en) 2012-05-30
EP2450379A1 (en) 2012-05-09
DK2450378T3 (da) 2016-02-01
MX343198B (es) 2016-10-11

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