DK2049112T3 - Behandling af infektioner og følgesygdomme deraf med kombinerede, dissocierede glucocorticoid-receptor-agonister og anti-infektionsmidler - Google Patents

Behandling af infektioner og følgesygdomme deraf med kombinerede, dissocierede glucocorticoid-receptor-agonister og anti-infektionsmidler

Info

Publication number
DK2049112T3
DK2049112T3 DK07813634.8T DK07813634T DK2049112T3 DK 2049112 T3 DK2049112 T3 DK 2049112T3 DK 07813634 T DK07813634 T DK 07813634T DK 2049112 T3 DK2049112 T3 DK 2049112T3
Authority
DK
Denmark
Prior art keywords
infections
glucocorticoid receptor
sequelae
treatment
combined
Prior art date
Application number
DK07813634.8T
Other languages
Danish (da)
English (en)
Inventor
Keith Wayne Ward
Gary Phillips
Raili Kerppola
Zhenze Hu
Original Assignee
Bausch & Lomb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch & Lomb filed Critical Bausch & Lomb
Application granted granted Critical
Publication of DK2049112T3 publication Critical patent/DK2049112T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04Amoebicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK07813634.8T 2006-08-07 2007-08-01 Behandling af infektioner og følgesygdomme deraf med kombinerede, dissocierede glucocorticoid-receptor-agonister og anti-infektionsmidler DK2049112T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83611006P 2006-08-07 2006-08-07
PCT/US2007/074936 WO2008021728A2 (en) 2006-08-07 2007-08-01 Treating infections and sequelae thereof with combined dissociated' glucocorticoid receptor agonists and anti-infective agents

Publications (1)

Publication Number Publication Date
DK2049112T3 true DK2049112T3 (da) 2012-04-23

Family

ID=38823623

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07813634.8T DK2049112T3 (da) 2006-08-07 2007-08-01 Behandling af infektioner og følgesygdomme deraf med kombinerede, dissocierede glucocorticoid-receptor-agonister og anti-infektionsmidler

Country Status (20)

Country Link
US (1) US20080033008A1 (ko)
EP (2) EP2049112B1 (ko)
JP (1) JP2010500363A (ko)
KR (1) KR20090040369A (ko)
CN (1) CN101522196A (ko)
AT (1) ATE549022T1 (ko)
AU (1) AU2007284175A1 (ko)
BR (1) BRPI0714815A2 (ko)
CA (1) CA2660151C (ko)
CY (1) CY1113007T1 (ko)
DK (1) DK2049112T3 (ko)
ES (2) ES2403512T3 (ko)
HK (1) HK1131046A1 (ko)
MX (1) MX2009001334A (ko)
PL (1) PL2049112T3 (ko)
PT (1) PT2049112E (ko)
SG (1) SG174031A1 (ko)
SI (1) SI2049112T1 (ko)
TW (1) TWI343918B (ko)
WO (1) WO2008021728A2 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090042936A1 (en) * 2007-08-10 2009-02-12 Ward Keith W Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
BRPI0912985A2 (pt) * 2008-05-19 2015-10-13 Alcon Res Ltd composições farmacêuticas com polímero de carboxivinila e polímero de povidona
WO2010006306A1 (en) * 2008-07-10 2010-01-14 Inspire Pharmaceuticals, Inc. Method of treating blepharitis
US20100190734A1 (en) * 2009-01-23 2010-07-29 Romulus Kimbro Brazzell Method of treating dry eye disease with azithromycin
US20100247606A1 (en) * 2009-03-25 2010-09-30 Allergan, Inc. Intraocular sustained release drug delivery systems and methods for treating ocular conditions
US20110077270A1 (en) * 2009-04-21 2011-03-31 Pfeffer Bruce A Compositions and Methods for Treating Ocular Inflammation with Lower Risk of Increased Intraocular Pressure
GR1008168B (el) * 2013-03-14 2014-04-08 "Φαρματεν Α.Β.Ε.Ε.", Παρεντερικο σκευασμα αντιβακτηριακου παραγοντα φθοριοκινολονης και μεθοδος για την παρασκευη αυτου
SG11202107075RA (en) 2019-01-22 2021-08-30 Akribes Biomedical Gmbh Selective glucocorticoid receptor modifiers for treating impaired skin wound healing
CN111686239B (zh) * 2019-03-11 2021-12-24 中国科学院微生物研究所 抗真菌化合物的应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US6051576A (en) 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
ES2079320B1 (es) * 1994-05-17 1996-10-16 Cusi Lab Disolucion oftalmica a base de un diclofenaco y tobramicina y sus aplicaciones.
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5902598A (en) * 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6242196B1 (en) * 1997-12-11 2001-06-05 Dana-Farber Cancer Institute Methods and pharmaceutical compositions for inhibiting tumor cell growth
AU4713499A (en) 1998-06-27 2000-01-17 Photogenesis, Inc. Ophthalmic uses of ppargamma agonists and ppargamma antagonists
US6716830B2 (en) * 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
AR031135A1 (es) * 2000-10-10 2003-09-10 Upjohn Co Composiciones de antibiotico topico para el tratamiento de infecciones oculares
CA2443937A1 (en) * 2001-04-23 2002-10-31 Randall D. Glickman Prostanoids augment ocular drug penetration
US7216711B2 (en) * 2002-01-08 2007-05-15 Halliburton Eenrgy Services, Inc. Methods of coating resin and blending resin-coated proppant
US6960581B2 (en) * 2002-01-14 2005-11-01 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
PT1490062E (pt) * 2002-03-26 2008-01-30 Boehringer Ingelheim Pharma Miméticos de glucocorticóides, métodos para a sua preparação, composições farmacêuticas e suas utilizações
CA2477764A1 (en) 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US6897224B2 (en) * 2002-04-02 2005-05-24 Schering Ag Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
US7074806B2 (en) * 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JP4503436B2 (ja) * 2002-07-08 2010-07-14 ファイザー・プロダクツ・インク 糖質コルチコイド受容体のモジュレーター
CA2512257A1 (en) * 2003-01-03 2004-07-29 Boehringer Ingelheim Pharmaceuticals, Inc. 1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
US20040224992A1 (en) * 2003-02-27 2004-11-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JP2006525011A (ja) 2003-04-30 2006-11-09 ファイザー・プロダクツ・インク 白内障形成リスクに関するスクリーニング法
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7605264B2 (en) * 2004-01-16 2009-10-20 Bristol-Myers Squibb Company Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
WO2005095401A1 (en) * 2004-03-22 2005-10-13 Boehringer Ingelheim Pharmaceuticals, Inc. Alpha-trifluoromethyl alcohols or amines as glucocorticoid mimetics
US7417056B2 (en) 2004-11-12 2008-08-26 Schering Ag 5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents
DE102004055633A1 (de) * 2004-11-12 2006-05-18 Schering Ag 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
EP1836166B1 (en) * 2004-12-27 2009-06-17 Boehringer Ingelheim Pharmaceuticals Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CN101484187B (zh) * 2006-07-07 2012-12-26 博士伦公司 包含解离的糖皮质激素受体激动剂和免疫抑制剂的用于治疗干眼症的组合物

Also Published As

Publication number Publication date
US20080033008A1 (en) 2008-02-07
WO2008021728A3 (en) 2008-10-09
TWI343918B (en) 2011-06-21
MX2009001334A (es) 2009-02-13
SG174031A1 (en) 2011-09-29
WO2008021728A2 (en) 2008-02-21
CA2660151C (en) 2012-04-17
EP2364707A2 (en) 2011-09-14
CA2660151A1 (en) 2008-02-21
TW200815410A (en) 2008-04-01
PT2049112E (pt) 2012-06-05
SI2049112T1 (sl) 2012-05-31
KR20090040369A (ko) 2009-04-23
ES2381045T3 (es) 2012-05-22
EP2049112A2 (en) 2009-04-22
EP2364707B1 (en) 2013-04-03
JP2010500363A (ja) 2010-01-07
BRPI0714815A2 (pt) 2013-05-21
EP2364707A3 (en) 2011-12-28
CY1113007T1 (el) 2016-04-13
ES2403512T3 (es) 2013-05-20
CN101522196A (zh) 2009-09-02
HK1131046A1 (en) 2010-01-15
AU2007284175A1 (en) 2008-02-21
PL2049112T3 (pl) 2012-07-31
ATE549022T1 (de) 2012-03-15
EP2049112B1 (en) 2012-03-14

Similar Documents

Publication Publication Date Title
DK2049112T3 (da) Behandling af infektioner og følgesygdomme deraf med kombinerede, dissocierede glucocorticoid-receptor-agonister og anti-infektionsmidler
AR051322A1 (es) Composiciones de amitraz
HK1140968A1 (ko)
MX2016000649A (es) Un metodo para tratar la infeccion, sepsis y lesion.
EA200802166A1 (ru) Стабильная фармацевтическая композиция с защитным действием от раздражения (варианты), способ ее получения и способ лечения кальций-миметиком с ее помощью
TW200734344A (en) Antibacterial agents
ECSP11011412A (es) Atropisómeros de derivados de 2-purinil-3-tolil-quinazolinona y métodos de uso
BRPI0813450B8 (pt) composto, formulação farmacêutica, e, usos do composto
CL2008002273A1 (es) Uso de un compuesto capaz de aumentar el flujo de iones a traves de los canales de potasio kcnq, util para reducir los sintomas de, o para tratar trastornos en los cuales el sistema dopaminergico esta perturbado, como esquizofrenia y otros estados psicoticos.
JO2855B1 (en) Quinoline derivatives acting as antibacterial agents
TW200718689A (en) 2-Amino-quinazolin-5-ones
EA200800501A1 (ru) Производные хинолина в качестве антибактериальных средств
IL198073A0 (en) Substituted tetrahydropyrrolopyrazine compounds having affinity with the kcnq2/3 k+ channel and use thereof in medicaments
GEP20135983B (en) 1-benzyl-3-hydroxymethylindazole derivatives and usage therein treatment of diseases based on mcp-1, cx3cr1 and p40 expression
DE602006020279D1 (de) Antimikrobielle materialien
TW200630367A (en) Substituted adenines and the uses thereof
NO20091955L (no) Antivirale sammensetninger, og fremgangsmater for anvendelse
WO2008005686A3 (en) Compositions comprising a dissociated glucocorticoid receptor agonist and an immunosuppressive agent for treating dry eye
HK1141249A1 (en) Compositions comprising a dissociated glucocorticoid receptor agonist for treating or controlling anterior-segment inflammation
CL2008003602A1 (es) Compuestos derivados de triazolotriazinas y triazolopirazinas sustituidas; composicion farmaceutica; y su uso en el tratamiento y/o profilaxis de trastornos hematologicos.
WO2008144347A8 (en) Combinations comprising a fluoroquinolone for treating, reducing, ameliorating, or preventing infections
EA201100645A1 (ru) Композиции для местного применения, содержащие активные агенты с покрытием
IL182055A0 (en) Agent for prophylaxis or treatment of metabolic syndrome
CL2004001007A1 (es) Compuestos derivados de macrolitos de 14 o 15 miembros, sustituidos en posicion 4"; procedimiento para su preparacion; composicion farmaceutica que lo comprende; y su uso para el tratamiento o profilaxis de infecciones microbianas sistemicas o topica
DE602006016817D1 (de) 2-hydroxy-propionsäure-derivate und 3-hydroxy-benzofuran-2-on-derivate mit affinität für den gaba-b-rezeptor