CY1113007T1 - Θεραπευτικη αγωγη λοιμωξεων και επιπλοκων αυτων με συνδυασμο διαχωρισμενων αγωνιστων υποδοχεα γλυκοκορτικοειδους και αντιλοιμωδων παραγοντων - Google Patents

Θεραπευτικη αγωγη λοιμωξεων και επιπλοκων αυτων με συνδυασμο διαχωρισμενων αγωνιστων υποδοχεα γλυκοκορτικοειδους και αντιλοιμωδων παραγοντων

Info

Publication number
CY1113007T1
CY1113007T1 CY20121100476T CY121100476T CY1113007T1 CY 1113007 T1 CY1113007 T1 CY 1113007T1 CY 20121100476 T CY20121100476 T CY 20121100476T CY 121100476 T CY121100476 T CY 121100476T CY 1113007 T1 CY1113007 T1 CY 1113007T1
Authority
CY
Cyprus
Prior art keywords
combination
infections
treatment
gluccordic
complications
Prior art date
Application number
CY20121100476T
Other languages
English (en)
Inventor
Zhenze Hu
Keith Wayne Ward
Gary Phillips
Raili Kerppola
Original Assignee
Bausch & Lomb Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch & Lomb Incorporated filed Critical Bausch & Lomb Incorporated
Publication of CY1113007T1 publication Critical patent/CY1113007T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Σύνθεση για θεραπευτική αγωγή, έλεγχο, μείωση, βελτίωση, ή ανακούφιση λοιμώξεων και των φλεγμονωδών επιπλοκών τους περιλαμβάνει διαχωρισμένο αγωνιστή υποδοχέα γλυκοκορτικοειδούς ("DIGRA": dissociated glucocorticoid receptor agonist) και αντιλοιμώδη παράγοντα, όπως αντιβακτηριακό, αντι-ιικό, αντιμυκητιακό, αντιπρωτοζωικό παράγοντα, ή συνδυασμό αυτών. Η σύνθεση μπορεί να τυποποιηθεί για τοπική χορήγηση, ένεση, ή εμφύτευση.
CY20121100476T 2006-08-07 2012-05-25 Θεραπευτικη αγωγη λοιμωξεων και επιπλοκων αυτων με συνδυασμο διαχωρισμενων αγωνιστων υποδοχεα γλυκοκορτικοειδους και αντιλοιμωδων παραγοντων CY1113007T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83611006P 2006-08-07 2006-08-07
EP07813634A EP2049112B1 (en) 2006-08-07 2007-08-01 Treating infections and sequelae thereof with combined dissociated glucocorticoid receptor agonists and anti-infective agents

Publications (1)

Publication Number Publication Date
CY1113007T1 true CY1113007T1 (el) 2016-04-13

Family

ID=38823623

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100476T CY1113007T1 (el) 2006-08-07 2012-05-25 Θεραπευτικη αγωγη λοιμωξεων και επιπλοκων αυτων με συνδυασμο διαχωρισμενων αγωνιστων υποδοχεα γλυκοκορτικοειδους και αντιλοιμωδων παραγοντων

Country Status (20)

Country Link
US (1) US20080033008A1 (el)
EP (2) EP2364707B1 (el)
JP (1) JP2010500363A (el)
KR (1) KR20090040369A (el)
CN (1) CN101522196A (el)
AT (1) ATE549022T1 (el)
AU (1) AU2007284175A1 (el)
BR (1) BRPI0714815A2 (el)
CA (1) CA2660151C (el)
CY (1) CY1113007T1 (el)
DK (1) DK2049112T3 (el)
ES (2) ES2403512T3 (el)
HK (1) HK1131046A1 (el)
MX (1) MX2009001334A (el)
PL (1) PL2049112T3 (el)
PT (1) PT2049112E (el)
SG (1) SG174031A1 (el)
SI (1) SI2049112T1 (el)
TW (1) TWI343918B (el)
WO (1) WO2008021728A2 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090042936A1 (en) * 2007-08-10 2009-02-12 Ward Keith W Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
CN102026665A (zh) * 2008-05-19 2011-04-20 爱尔康研究有限公司 含有羧基乙烯基聚合物和聚维酮聚合物的药物组合物
CA2730120A1 (en) * 2008-07-10 2010-01-14 Inspire Pharmaceuticals, Inc. Method of treating blepharitis
EP2393355A4 (en) * 2009-01-23 2012-07-25 Inspire Pharmaceuticals Inc METHOD FOR TREATING A DRY EYE WITH AZITHROMYCIN
US20100247606A1 (en) * 2009-03-25 2010-09-30 Allergan, Inc. Intraocular sustained release drug delivery systems and methods for treating ocular conditions
US20110077270A1 (en) * 2009-04-21 2011-03-31 Pfeffer Bruce A Compositions and Methods for Treating Ocular Inflammation with Lower Risk of Increased Intraocular Pressure
GR1008168B (el) * 2013-03-14 2014-04-08 "Φαρματεν Α.Β.Ε.Ε.", Παρεντερικο σκευασμα αντιβακτηριακου παραγοντα φθοριοκινολονης και μεθοδος για την παρασκευη αυτου
WO2020152193A1 (en) 2019-01-22 2020-07-30 Akribes Biomedical Gmbh Selective glucocorticoid receptor modifiers for treating impaired skin wound healing
CN111686239B (zh) * 2019-03-11 2021-12-24 中国科学院微生物研究所 抗真菌化合物的应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US6051576A (en) * 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
ES2079320B1 (es) * 1994-05-17 1996-10-16 Cusi Lab Disolucion oftalmica a base de un diclofenaco y tobramicina y sus aplicaciones.
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5902598A (en) * 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6242196B1 (en) * 1997-12-11 2001-06-05 Dana-Farber Cancer Institute Methods and pharmaceutical compositions for inhibiting tumor cell growth
AU4713499A (en) * 1998-06-27 2000-01-17 Photogenesis, Inc. Ophthalmic uses of ppargamma agonists and ppargamma antagonists
US6716830B2 (en) * 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
AR031135A1 (es) * 2000-10-10 2003-09-10 Upjohn Co Composiciones de antibiotico topico para el tratamiento de infecciones oculares
CA2443937A1 (en) * 2001-04-23 2002-10-31 Randall D. Glickman Prostanoids augment ocular drug penetration
US7216711B2 (en) * 2002-01-08 2007-05-15 Halliburton Eenrgy Services, Inc. Methods of coating resin and blending resin-coated proppant
ES2276038T3 (es) * 2002-01-14 2007-06-16 Boehringer Ingelheim Pharmaceuticals Inc. Mimeticos de glucocorticoides, metodos para su obtencion, formulaciones farmaceuticas que los contienen y usos de los mismos.
AU2003230700A1 (en) 2002-03-26 2003-10-13 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US6903215B2 (en) 2002-03-26 2005-06-07 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US6897224B2 (en) 2002-04-02 2005-05-24 Schering Ag Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JP4503436B2 (ja) * 2002-07-08 2010-07-14 ファイザー・プロダクツ・インク 糖質コルチコイド受容体のモジュレーター
CA2512257A1 (en) 2003-01-03 2004-07-29 Boehringer Ingelheim Pharmaceuticals, Inc. 1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
US20040224992A1 (en) * 2003-02-27 2004-11-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JP2006525011A (ja) * 2003-04-30 2006-11-09 ファイザー・プロダクツ・インク 白内障形成リスクに関するスクリーニング法
UY28526A1 (es) * 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7605264B2 (en) * 2004-01-16 2009-10-20 Bristol-Myers Squibb Company Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
US20050234091A1 (en) 2004-03-22 2005-10-20 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
US7417056B2 (en) * 2004-11-12 2008-08-26 Schering Ag 5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents
DE102004055633A1 (de) * 2004-11-12 2006-05-18 Schering Ag 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
US7635711B2 (en) 2004-12-27 2009-12-22 Boehringer-Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
BRPI0714155A2 (pt) * 2006-07-07 2012-12-25 Bausch & Lomb composiÇço, e, uso de um agonista do receptor de glucocorticàide dissociado (digra), uma prà-droga do mesmo, ou um sal farmaceuticamente aceitÁvel do mesmo

Also Published As

Publication number Publication date
SI2049112T1 (sl) 2012-05-31
EP2049112A2 (en) 2009-04-22
BRPI0714815A2 (pt) 2013-05-21
ES2381045T3 (es) 2012-05-22
PT2049112E (pt) 2012-06-05
TW200815410A (en) 2008-04-01
MX2009001334A (es) 2009-02-13
WO2008021728A2 (en) 2008-02-21
CA2660151C (en) 2012-04-17
EP2364707A3 (en) 2011-12-28
EP2364707A2 (en) 2011-09-14
EP2364707B1 (en) 2013-04-03
JP2010500363A (ja) 2010-01-07
PL2049112T3 (pl) 2012-07-31
DK2049112T3 (da) 2012-04-23
US20080033008A1 (en) 2008-02-07
WO2008021728A3 (en) 2008-10-09
AU2007284175A1 (en) 2008-02-21
SG174031A1 (en) 2011-09-29
CN101522196A (zh) 2009-09-02
KR20090040369A (ko) 2009-04-23
HK1131046A1 (en) 2010-01-15
ES2403512T3 (es) 2013-05-20
CA2660151A1 (en) 2008-02-21
EP2049112B1 (en) 2012-03-14
TWI343918B (en) 2011-06-21
ATE549022T1 (de) 2012-03-15

Similar Documents

Publication Publication Date Title
CY1113007T1 (el) Θεραπευτικη αγωγη λοιμωξεων και επιπλοκων αυτων με συνδυασμο διαχωρισμενων αγωνιστων υποδοχεα γλυκοκορτικοειδους και αντιλοιμωδων παραγοντων
AR051322A1 (es) Composiciones de amitraz
CL2008002042A1 (es) Compuestos derivados de heterociclos nitrogenados enlazados; y su uso en el tratamiento de la diabetes y desordenes metabolicos.
TW200739819A (en) Semiconductor device, and method for manufacturing the same
BRPI0307550B8 (pt) composição farmacêutica em gel tópica, de adapaleno 0,3%
BRPI0414082A (pt) formas de dosagem de liberação sustentada de ziprasidona
BR112015021392A2 (pt) uso de agonistas do receptor de peptídeo formil 2 para tratar doenças dermatológicas
MY146388A (en) Thiazole pyrazolopyrimidines as crfi receptor antagonists
IL198073A0 (en) Substituted tetrahydropyrrolopyrazine compounds having affinity with the kcnq2/3 k+ channel and use thereof in medicaments
NO20023473L (no) Sammensetninger for levering av en kortisol antagonist
TW200742086A (en) Structure and method for MOSFET gate electrode landing pad
DE502006002777D1 (de) Längenausgleich für eine einstellvorrichtung einer injektionsvorrichtung
WO2008021729A3 (en) Compositions and methods for treating, reducing, ameliorating, or alleviating posterior-segment ophthalmic diseases
CL2007003825A1 (es) Composicion farmaceutica que comprende un anticuerpo monoclonal humanizado anti-antigeno de diferenciacion leucocitario humano cd6; y su uso para el diagnostico y tratamiento de la leucemia linfocitaria cronica b.
WO2008005686A3 (en) Compositions comprising a dissociated glucocorticoid receptor agonist and an immunosuppressive agent for treating dry eye
DE602005007926D1 (de) Organischer Feldeffekttransistor und dessen Herstellung
HK1141249A1 (en) Compositions comprising a dissociated glucocorticoid receptor agonist for treating or controlling anterior-segment inflammation
PL2061444T3 (pl) Kompozycje i sposoby leczenia, traktowania, kontrolowania, redukowania, łagodzenia lub zapobiegania alergii
ATE372772T1 (de) Retardiertes freigabesystem mit kontrollierter initialabgabe
MX2009007292A (es) Composicion anestesica en aerosol.
MX2013014518A (es) Composiciones y metodos para tratar, controlar, reducir, o mejorar el dolor inflamatorio.
DE602006016817D1 (de) 2-hydroxy-propionsäure-derivate und 3-hydroxy-benzofuran-2-on-derivate mit affinität für den gaba-b-rezeptor
BRPI0702847A (pt) formas de dosagem unitária de temozolomida
HK1136203A1 (en) Compositions for the treatment of vaginal infections with chronic inflammation
ATE375787T1 (de) Zusammensetzung enthaltend antiphlogistisch und analgetisch wirkende bestandteile zur topischen anwendung am tierischen bewegungsapparat