DK2037946T3 - ANTIMICROBIAL ACTIVITIES DERIVED BY PHAGER - Google Patents

ANTIMICROBIAL ACTIVITIES DERIVED BY PHAGER Download PDF

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Publication number
DK2037946T3
DK2037946T3 DK07794592.1T DK07794592T DK2037946T3 DK 2037946 T3 DK2037946 T3 DK 2037946T3 DK 07794592 T DK07794592 T DK 07794592T DK 2037946 T3 DK2037946 T3 DK 2037946T3
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DK
Denmark
Prior art keywords
phage
protein
polypeptide
cell wall
bacterial
Prior art date
Application number
DK07794592.1T
Other languages
Danish (da)
English (en)
Inventor
Vivek Daniel Paul
R Sanjeev Saravanan
Sriram Padmanabhan
Bharathi Sriram
Original Assignee
Gangagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38668376&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2037946(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gangagen Inc filed Critical Gangagen Inc
Application granted granted Critical
Publication of DK2037946T3 publication Critical patent/DK2037946T3/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462Lysozyme (3.2.1.17)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44Guanidine; Derivatives thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50Isolated enzymes; Isolated proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/50Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06Lysis of microorganisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017Lysozyme (3.2.1.17)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/33Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK07794592.1T 2006-05-05 2007-05-04 ANTIMICROBIAL ACTIVITIES DERIVED BY PHAGER DK2037946T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79788506P 2006-05-05 2006-05-05
US90934007P 2007-03-30 2007-03-30
PCT/US2007/010972 WO2007130655A2 (en) 2006-05-05 2007-05-04 Phage derived antimicrobial activities

Publications (1)

Publication Number Publication Date
DK2037946T3 true DK2037946T3 (en) 2015-04-27

Family

ID=38668376

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07794592.1T DK2037946T3 (en) 2006-05-05 2007-05-04 ANTIMICROBIAL ACTIVITIES DERIVED BY PHAGER

Country Status (10)

Country Link
US (6) US8202516B2 (OSRAM)
EP (1) EP2037946B2 (OSRAM)
JP (4) JP5383481B2 (OSRAM)
CN (3) CN101437532B (OSRAM)
CA (1) CA2651125C (OSRAM)
DK (1) DK2037946T3 (OSRAM)
ES (1) ES2536852T3 (OSRAM)
MX (1) MX2008014150A (OSRAM)
PT (1) PT2037946E (OSRAM)
WO (1) WO2007130655A2 (OSRAM)

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DE102007061929A1 (de) * 2007-12-21 2009-06-25 Profos Ag Proteasestabile Zellwand lysierende Enzyme
EP2157100A1 (en) * 2008-08-19 2010-02-24 Profos AG Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins
CA2739717A1 (en) * 2008-10-10 2010-04-15 Lusomedicamenta, S.A. Antibacterial phage peptides and methods of use thereof
EP2338916A1 (en) 2009-12-23 2011-06-29 Hyglos Invest GmbH Chimeric polypeptides and their use in bacterial decoloniation
EP2397548A1 (en) 2010-06-18 2011-12-21 Hyglos Invest GmbH Methods of generating and screening for lytic chimeric polypeptides
EP3443970B1 (en) 2010-09-17 2020-09-09 Tecnifar-Indústria Técnica Farmacêutica, S.A. Antibacterial phage, phage peptides and methods of use thereof
EP2697387B1 (en) * 2011-04-12 2021-09-15 Bactoclear Holdings PTE. LTD. Chimeric antibacterial polypeptides
PL394619A1 (pl) 2011-04-19 2012-10-22 Miedzynarodowy Instytut Biologii Molekularnej I Komórkowej Sposób proteolizy, peptydaza, kompozycja do stosowania jako srodek bakteriostatyczny lub bakteriobójczy, zestaw oraz zastosowania aktywnej formy LytM z S. aureus lub jej pochodnej
AU2013240280A1 (en) 2012-03-27 2014-10-16 Genentech, Inc. Improved harvest operations for recombinant proteins
KR101381336B1 (ko) 2012-06-25 2014-04-25 주식회사 씨티씨바이오 신규한 박테리오파지 pvp-1 및 이의 비브리오 파라헤몰리티쿠스 증식 억제 용도
KR101466620B1 (ko) 2012-06-22 2014-11-28 주식회사 씨티씨바이오 신규한 박테리오파지 및 이의 아에로모나스 히드로필라 증식 억제 용도
WO2013191363A1 (ko) * 2012-06-22 2013-12-27 주식회사 씨티씨바이오 신규한 박테리오파지 및 병원성 박테리아 증식 억제 용도
US8980614B2 (en) * 2012-09-06 2015-03-17 The United States Of America, As Represented By The Secretary Of Agriculture Staphylococcus haemolyticus prophage φSH2 endolysin is lytic for Staphylococcus aureus
CN112626055A (zh) * 2014-05-14 2021-04-09 达特茅斯学院理事会 去免疫化溶葡萄球菌酶和使用方法
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US10689670B2 (en) * 2016-06-14 2020-06-23 Dsm Ip Assets B.V. Recombinant yeast cell
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CN106635942B (zh) * 2016-12-05 2020-05-29 齐鲁工业大学 一种芽孢表面稳定展示海藻糖合酶的工程菌及其构建方法
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11236314B2 (en) * 2017-03-30 2022-02-01 Bactoclear Holdings Pte. Ltd Chimeric lysm polypeptides
KR20200012844A (ko) * 2017-04-03 2020-02-05 사시나파스 컴퍼니 리미티드 조작된 그람-음성 엔도리신
CN107502603B (zh) * 2017-09-06 2018-06-05 江苏省农业科学院 一种大肠杆菌裂解酶及其制备方法与应用
CN107828769B (zh) * 2017-09-28 2021-03-02 昆明理工大学 一种耐热裂解酶MMPpgh和编码此酶的多核苷酸
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CN113366103A (zh) 2018-12-21 2021-09-07 诺维信公司 具有肽聚糖降解活性的多肽以及编码其的多核苷酸
MA55951A (fr) * 2019-05-08 2022-03-23 Biontech R&D Austria Gmbh Nouveau gardnerella endolysins et utilisations correspondantes
US20220333120A1 (en) * 2019-09-11 2022-10-20 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Bactericidal phage vectors
PL243303B1 (pl) * 2019-10-13 2023-07-31 Miedzynarodowy Inst Biologii Molekularnej I Komorkowej Rekombinowany polipeptyd do zastosowania do leczenia, kompozycje go zawierające oraz jego zastosowania
WO2021084558A2 (en) * 2019-10-31 2021-05-06 Bactoclear Holdings Pte. Ltd Chimeric proteins for selective lysis of bacteria
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Also Published As

Publication number Publication date
WO2007130655A2 (en) 2007-11-15
US8748150B2 (en) 2014-06-10
CN101437532A (zh) 2009-05-20
US20190297896A1 (en) 2019-10-03
CN103436507A (zh) 2013-12-11
MX2008014150A (es) 2009-02-04
US20220053775A1 (en) 2022-02-24
JP2016112020A (ja) 2016-06-23
US20140369986A1 (en) 2014-12-18
US20120237491A1 (en) 2012-09-20
JP5882968B2 (ja) 2016-03-09
JP2009536033A (ja) 2009-10-08
EP2037946A4 (en) 2010-09-22
US8202516B2 (en) 2012-06-19
US9622486B2 (en) 2017-04-18
JP2014050388A (ja) 2014-03-20
CN105884904B (zh) 2020-06-16
ES2536852T3 (es) 2015-05-28
JP5383481B2 (ja) 2014-01-08
CA2651125C (en) 2016-06-28
EP2037946A2 (en) 2009-03-25
US10278398B2 (en) 2019-05-07
CN105884904A (zh) 2016-08-24
EP2037946B2 (en) 2023-11-01
CN101437532B (zh) 2013-08-21
US20090324576A1 (en) 2009-12-31
JP2018201525A (ja) 2018-12-27
CA2651125A1 (en) 2007-11-15
JP6685360B2 (ja) 2020-04-22
CN103436507B (zh) 2016-04-20
US20170318817A1 (en) 2017-11-09
PT2037946E (pt) 2015-06-04
WO2007130655A3 (en) 2008-07-17
EP2037946B1 (en) 2015-02-25
JP6416803B2 (ja) 2018-10-31

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