DK200001149A - Concentrated and stabilized veterinary antipyretic composition to be incorporated into animal feed, as well as - Google Patents

Concentrated and stabilized veterinary antipyretic composition to be incorporated into animal feed, as well as Download PDF

Info

Publication number
DK200001149A
DK200001149A DK200001149A DKPA200001149A DK200001149A DK 200001149 A DK200001149 A DK 200001149A DK 200001149 A DK200001149 A DK 200001149A DK PA200001149 A DKPA200001149 A DK PA200001149A DK 200001149 A DK200001149 A DK 200001149A
Authority
DK
Denmark
Prior art keywords
concentrated
incorporated
stabilized
well
animal feed
Prior art date
Application number
DK200001149A
Other languages
Danish (da)
Inventor
Lucas Frederic
Payan Stephen
Daoudal Jose
Original Assignee
So Ge Val Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by So Ge Val Sa filed Critical So Ge Val Sa
Publication of DK200001149A publication Critical patent/DK200001149A/en
Application granted granted Critical
Publication of DK177041B1 publication Critical patent/DK177041B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Description

PATENTKRAV 1. Antipyretisk sammensætning til veterinær brug, der er velegnet til behandling af stordriftshusdyr, som er tiltænkt til human konsumption, især grise, fjerkræ eller kalve, kendetegnet ved, at den udgøres af en koncentreret og stabiliseret ikke-vandig opløsning, som på den ene side skal inkorporeres i dyrenes foder, især i deres drikkevand, eller sprøjtes på granuleret foder, og på den anden side indeholder fra 15 til 25 vægt%, fortrinsvis omkring 20 vægt% paracetamol (4-hydroxyacetanilid) opløst i et opløsningsmiddel, der udgøres af en lavmolekylær polyethylenglycol, fortrinsvis af PEG 200, og/ellerpolypropylenglycol. 2. Sammensætning ifølge krav 1,kendetegnet ved, at den i vægtandele indeholder fra 40 til 85 % polyethylenglycol og fra 0 til 45 % polypropylenglycol. 3. Sammensætning ifølge krav 1 eller 2, kendetegnet ved, at den indeholder op til 5% excipienser, f.eks. appetitfremmende midler. 4. Anvendelse af en koncentreret og stabiliseret, ikke-vandig opløsning indeholdende fra 15 til 25 vægt%, fortrinsvis omkring 20 vægt% paracetamol (4-hydroxyacetanilid) opløsti et opløsningsmiddel, der udgøres af en lavmolekylær polyethylenglycol, fortrinsvis af PEG 200 og/eller af polypropylenglycol, til fremstilling af en antipyretisk sammensætning til veterinær brug, som er velegnet til behandling af stordriftshusdyr til human konsumption, især grise, fjerkræ eller kalve, og som skal inkorporeres i dyrenes foder, især i deres drikkevand, eller som skal sprøjtes på granuleret foder. 5. Fremgangsmåde ved inkorporering af den antipyretiske sammensætning ifølge ethvert af kravene 1-3 i dyrenes drikkevand på en gård, der er udstyret med et vandcirkulationskredsløb, som på den ene side kan aktiveres automatisk ved hjælp af regule-ringsindretninger, og som på den anden side er forbundet til et reservoir indeholdende den vandmængde, som er nødvendig for en gruppe dyr for et specifikt tidsrum, især én dag, kendetegnet ved, at: en ønsket koncentration af paracetamol i drikkevandet bestemmes under hensyntagen til den foreskrevne dosis, væksttabeller og også det gennemsnitlige vandforbrug for de dyr, der skal behandles, den mængde koncentreret opløsning, som skal sættes til vandet indeholdt i reservoiret til opnåelse af drikkevand med den ønskede paracetamolkoncentration, beregnes, denne mængde koncentreret opløsning indføres i reservoiret, og den således opnåede fortyndede opløsning omrøres. 6. Fremgangsmåde til inkorporering af den antipyretiske sammensætning ifølge ethvert af kravene 1-4 i dyrenes drikkevand på en gård, der er udstyret med et vandcirkulationskredsløb, som på den ene side kan aktiveres automatisk ved hjælp af reguleringsindretninger, og som på den anden side er forbundet til vandhovedledningen, kendetegnet ved, at: en forsyningskanal, som på den ene side er forbundet til en tank, der skal modtage en stamopløsning af paracetamol, og som på den anden side omfatter en doseringspumpe med et specifikt doseringsforhold, forbindes til vandcirkulationskredsløbet, en ønsket koncentration af paracetamol i drikkevandet bestemmes under hensyntagen til den foreskrevne dosis, væksttabeller og også det gennemsnitlige vandforbrug af de dyr, der skal behandles, der udføres en beregning for at fastlægge, hvad koncentrationen af paracetamol-stamopløsningen, der er til stede i tanken, må være for at opnå drikkevand med den ønskede paracetamolkoncentration under hensyntagen til doseringspumpens do-seringsforhold, der udføres en beregning for at fastlægge, hvordan den koncentrerede opløsning skal fortyndes til opnåelse af stamopløsningen, en sådan stamopløsning med en mellemliggende paracetamolkoncentration fremstilles ved fortynding af den koncentrerede opløsning, og den indføres i tanken. 7. Fremgangsmåde ifølge krav 6, kendetegnet ved, at doseringspumpen har et doseringsforhold i størrelsesordenen fra 1 til 5%. 8. Fremgangsmåde ifølge krav 6 eller 7, kendetegnet ved, at doseringspum-pen er en kommerciel pumpe, hvis doseringsforhold er justerbart. 9. Fremgangsmåde til inkorporering af den antipyretiske sammensætning ifølge ethvert af kravene 1-4 i dyrekost ved at sprøjte den på granuleret foder, kendetegnet ved, at den antipyretiske sammensætning sprøjtes på foderet ved afslutningen af sidstnævntes fremstillingsproces på fabrikken under anvendelse af en sprøjteindretning, især i en tragt, som er udstyret med sprøjtedyser, og hvori det granulerede foder strømmer ved hjælp af tyngdekraften med henblik på at forsyne en tømmeindretning, såsom en lastvogn eller et transportbånd. 10. Fremgangsmåde ifølge krav 9, kendetegnet ved, at: en ønsket koncentration af paracetamol i det granulerede foder bestemmes under hensyntagen til den foreskrevne dosis, væksttabeller og også det gennemsnitlige foderforbrug af de dyr, der skal behandles, mængden af antipyretisk sammensætning, som skal påsprøjtes, bestemmes som funktion af mængden af foder, der skal behandles, især ved at måle strømningshastigheden af det granulerede foder, som strømmer i tragten, og sprøjteindretningen styres som reaktion herpå.PATENT REQUIREMENTS 1. Veterinary antipyretic composition suitable for the treatment of large-scale domestic animals intended for human consumption, in particular pigs, poultry or calves, characterized in that it is a concentrated and stabilized non-aqueous solution containing one side must be incorporated into the animal's feed, especially in their drinking water, or sprayed on granulated feed, and on the other hand contain from 15 to 25% by weight, preferably about 20% by weight, of paracetamol (4-hydroxyacetanilide) dissolved in a solvent constituting of a low molecular weight polyethylene glycol, preferably of PEG 200, and / or polypropylene glycol. Composition according to claim 1, characterized in that it contains in weight proportions from 40 to 85% polyethylene glycol and from 0 to 45% polypropylene glycol. Composition according to claim 1 or 2, characterized in that it contains up to 5% excipients, e.g. appetite stimulants. Use of a concentrated and stabilized non-aqueous solution containing from 15 to 25% by weight, preferably about 20% by weight of paracetamol (4-hydroxyacetanilide), in a solvent constituted by a low molecular weight polyethylene glycol, preferably of PEG 200 and / or of polypropylene glycol, for the preparation of a veterinary antipyretic composition suitable for the treatment of large scale domestic animals for human consumption, in particular pigs, poultry or calves, to be incorporated into animal feed, especially in their drinking water or to be sprayed on granulated feed. A method of incorporating the antipyretic composition according to any one of claims 1-3 in the drinking water of the animals on a farm equipped with a water circulation circuit which, on the one hand, can be activated automatically by means of regulators and which on the other side is connected to a reservoir containing the amount of water needed for a group of animals for a specific period of time, especially one day, characterized in that: a desired concentration of paracetamol in the drinking water is determined taking into account the prescribed dose, growth tables and also the average water consumption for the animals to be treated, the amount of concentrated solution to be added to the water contained in the reservoir for obtaining drinking water at the desired paracetamol concentration is calculated, this amount of concentrated solution is introduced into the reservoir and the diluted solution thus obtained is stirred. A method of incorporating the antipyretic composition according to any one of claims 1-4 into the drinking water of the animals on a farm equipped with a water circulation circuit which, on the one hand, can be activated automatically by means of regulators and which on the other hand is connected to the water main conduit, characterized in that: a supply channel connected, on the one hand, to a tank which is to receive a stock solution of acetaminophen and which, on the other hand, comprises a metering pump having a specific dosage ratio, is connected to the water circulation circuit; the desired concentration of paracetamol in the drinking water is determined taking into account the prescribed dose, growth tables and also the average water consumption of the animals to be treated, a calculation is made to determine the concentration of the paracetamol stock solution present in the tank, must be to obtain drinking water with the desired acetaminol concentrate taking into account the dosage ratio of the dosing pump, a calculation is made to determine how to dilute the concentrated solution to obtain the stock solution, such stock solution having an intermediate paracetamol concentration is prepared by diluting the concentrated solution and introduced into the tank. Process according to claim 6, characterized in that the metering pump has a metering ratio in the order of 1 to 5%. Method according to claim 6 or 7, characterized in that the metering pump is a commercial pump whose metering ratio is adjustable. Method for incorporating the antipyretic composition according to any one of claims 1-4 in animal cost by spraying it onto granulated feed, characterized in that the antipyretic composition is sprayed onto the feed at the end of the latter's manufacturing process at the factory using a spray device, in particular. in a hopper equipped with spray nozzles in which the granulated feed flows by gravity to provide a discharge device such as a truck or conveyor belt. Process according to claim 9, characterized in that: a desired concentration of paracetamol in the granulated feed is determined taking into account the prescribed dose, growth tables and also the average feed consumption of the animals to be treated, the amount of antipyretic composition to be spraying is determined as a function of the amount of feed to be treated, in particular by measuring the flow rate of the granulated feed flowing into the hopper and the spraying device being controlled in response.

DKPA200001149A 1999-07-29 2000-07-28 Concentrated and stabilized veterinary antipyretic composition to be incorporated into animal feed, and method of incorporating the composition into animal drinking water and spraying on granulated feed DK177041B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9909840 1999-07-29
FR9909840A FR2796843B1 (en) 1999-07-29 1999-07-29 CONCENTRATED AND STABILIZED ANTIPYRETIC COMPOSITION FOR VETERINARY USE INTENDED TO BE INCORPORATED IN ANIMAL FEEDING AS WELL AS A METHOD OF INCORPORATING THIS COMPOSITION INTO ANIMAL BEVERAGE WATER

Publications (2)

Publication Number Publication Date
DK200001149A true DK200001149A (en) 2001-01-30
DK177041B1 DK177041B1 (en) 2011-02-28

Family

ID=9548654

Family Applications (1)

Application Number Title Priority Date Filing Date
DKPA200001149A DK177041B1 (en) 1999-07-29 2000-07-28 Concentrated and stabilized veterinary antipyretic composition to be incorporated into animal feed, and method of incorporating the composition into animal drinking water and spraying on granulated feed

Country Status (12)

Country Link
BE (1) BE1012818A3 (en)
CA (1) CA2316731C (en)
DE (1) DE10037121B4 (en)
DK (1) DK177041B1 (en)
ES (1) ES2336164B1 (en)
FR (1) FR2796843B1 (en)
GB (1) GB2354710B (en)
HU (1) HU230460B1 (en)
IT (1) IT1318645B1 (en)
NL (1) NL1015790C2 (en)
PL (1) PL221309B1 (en)
RU (1) RU2218154C2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107669634A (en) * 2016-09-30 2018-02-09 青岛大学 A kind of paracetamol oral spray and preparation method thereof
RU2736423C1 (en) * 2020-04-24 2020-11-17 Федеральное государственное бюджетное научное учреждение "Поволжский научно-исследовательский институт производства и переработки мясомолочной продукции" (ГНУ НИИММП) Method of using non-steroidal anti-inflammatory preparations "paracetam - avz" and "ketokvin 10 %" in breeding of replacement chicks of parent flock of chickens

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2410812A1 (en) * 1977-12-05 1979-06-29 Garhin Sarl METHOD AND DEVICE FOR AUTOMATIC DOSING OF THE QUANTITIES OF A LIQUID ADDITIVE ADDED TO THE FLOW OF A LIQUID TO BE TREATED
IE48567B1 (en) * 1980-02-03 1985-03-06 An Foras Taluntais Apparatus and method for dosing livestock
JPH0714872B2 (en) * 1990-02-06 1995-02-22 昭和薬品化工株式会社 Syrup composition
AU7880991A (en) * 1990-05-10 1991-11-27 Novo Nordisk A/S A pharmaceutical preparation containing n-glycofurols and n-ethylene glycols
US5505976A (en) * 1992-12-30 1996-04-09 Anitox Corporation Contamination-resistant animal feedstuffs
SK96196A3 (en) * 1994-01-24 1997-03-05 Procter & Gamble Process for solubilizing difficultly soluble pharmaceutical actives
JPH09286724A (en) * 1996-04-19 1997-11-04 Takeda Chem Ind Ltd Liquid stablizer for oral administration
IT1301976B1 (en) * 1998-07-31 2000-07-20 Angelini Ricerche Spa INJECTABLE PHARMACEUTICAL COMPOSITION BASED ON PARACETAMOL

Also Published As

Publication number Publication date
ITMI20001712A0 (en) 2000-07-26
DE10037121A1 (en) 2001-02-08
NL1015790A1 (en) 2001-01-30
FR2796843B1 (en) 2003-05-09
DE10037121B4 (en) 2006-03-23
HUP0002994A2 (en) 2002-11-28
HUP0002994A3 (en) 2008-04-28
DK177041B1 (en) 2011-02-28
GB0018504D0 (en) 2000-09-13
NL1015790C2 (en) 2001-03-20
HU230460B1 (en) 2016-07-28
GB2354710B (en) 2004-05-12
ES2336164B1 (en) 2011-01-24
PL221309B1 (en) 2016-03-31
CA2316731C (en) 2003-07-15
PL341728A1 (en) 2001-02-12
CA2316731A1 (en) 2001-01-29
BE1012818A3 (en) 2001-03-06
IT1318645B1 (en) 2003-08-27
FR2796843A1 (en) 2001-02-02
HU0002994D0 (en) 2000-10-28
ITMI20001712A1 (en) 2002-01-26
RU2218154C2 (en) 2003-12-10
ES2336164A1 (en) 2010-04-08
GB2354710A (en) 2001-04-04

Similar Documents

Publication Publication Date Title
KR100778279B1 (en) Apparatus and method for supplying drinking water 0f domestic animal
DK1372378T3 (en) Method and apparatus for feeding pigs
Comes et al. Residues and persistence of glyphosate in irrigation water
ES2928464T3 (en) liquid application
ATE290310T1 (en) METHOD AND DEVICE FOR INTEGRATED AGRICULTURE
CN210170509U (en) Agricultural is bred and uses liquid medicine spraying device
JP2004511412A (en) Method for mitigating the release of ammonia from animal fertilizers, plant for performing the method, and use of such a plant
DK200001149A (en) Concentrated and stabilized veterinary antipyretic composition to be incorporated into animal feed, as well as
CN1164175A (en) New synergistic herbicidal compositions comprising 4-benzoylisoxazoles and 2,6-dinitroaniline compounds
RU2000120573A (en) CONCENTRATED AND STABILIZED FERRY-DROPING COMPOSITION FOR USE IN VETERINARIUM, INTENDED FOR ADMINISTRATION IN ANIMAL FEED, AND ALSO THE METHOD FOR INTRODUCING THIS COMPOSITION IN DRINKING WATER
CN107094777A (en) A kind of composition for preventing and treating agricultural bacterial evil and the spiral shell that goes out
US20080103045A1 (en) Preparation For Eradicating Algae And Microorganisms In Aqueous Environment
JPH0730159Y2 (en) Water treatment device for promoting growth of cultivated plants and livestock
US9018239B2 (en) Treatment of edible crops
CN212414476U (en) Agricultural pesticide spraying device
PL181415B1 (en) Selectively acting herbicide
Gopalakrishnan et al. Some experimental observations on the use of activated sludge as fertilizer for fish culture
NL1013744C2 (en) Method for preparing a nutriment, the nutriment itself and a method of dispensing a nutriment means that a predetermined dose can be fed easily and equally to a wide range of organisms
Johansson et al. Reduced high-intensity training distance in growing horses had no effect on IGF-1 concentrations, but training onset interrupted time-dependent IGF-1 decline
JPH01501475A (en) Plant diseases and methods of controlling microorganisms in the presence of plants
Reid Bloat in New Zealand cattle
Owen Phytotoxicity and persistence of the herbicide endothall: A simultaneous microcosm, mesocosm and whole-pond experiment
EP2269957A1 (en) Solid composition for pH neutralisation of acid fluids
Lynch Jr Chemical control of aquatic plants
Schultz et al. Dissipation of Residues of 2, 4-D in Water, Hydrosoil and Fish

Legal Events

Date Code Title Description
PUP Patent expired

Expiry date: 20200728