DK198282A - Penicillin- eller cephalosporinderivater, deres fremstilling og anvendelse som farmaceutika - Google Patents
Penicillin- eller cephalosporinderivater, deres fremstilling og anvendelse som farmaceutika Download PDFInfo
- Publication number
- DK198282A DK198282A DK198282A DK198282A DK198282A DK 198282 A DK198282 A DK 198282A DK 198282 A DK198282 A DK 198282A DK 198282 A DK198282 A DK 198282A DK 198282 A DK198282 A DK 198282A
- Authority
- DK
- Denmark
- Prior art keywords
- penicillin
- pharmaceuticals
- preparation
- cephalosporine derivatives
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Description
H, alkyl eller eventuelt med halogen, OH, alkoxy eller alkyl 4 substitueret phenyl, Q er 0, S eller Se, R er H, alkyl 5 5 eller -COOR , R er alkyl, benzyl, benzhydryl eller eventuelt som R^· substitueret phenyl, R6 er phenyl, alkyl, cyclo-alkyl, alkenyl, naphthyl, heteroaryl, heterocyclyl eller adamantyl, hvorhos phenyl eventuelt er substitueret med halogen, alkyl, nitro, alkoxycarbonyl, CF3, dialkylamino, OH, COOh eller SO^H, alkyl eventuelt er substitueret med alkoxycarbonyl, OH, dialkylamino eller alkoxy, og heterocyclyl eventuelt er substitueret med én eller flere phenyl-grupper og/eller er substitueret, R er H, eller -N(R R ) er en fortrinsvis substitueret heterocyclisk gruppe med 4-8 led og eventuelt yderligere N-, O- og/eller S-atomer og eventuelt kondenseret med en eller flére phenylgrupper, Z er OH, n er 0 eller 1, og t er 0-2, eller farmakologisk acceptable salte eller biologisk aktive estre deraf fremstilles ved en række fremgangsmåder.
Forbindelserne med formel (I) er farmaceutisk aktive, idet de har antibakterielle og β-lactamasehammende virkninger .
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU115481 | 1981-05-04 | ||
| HU115481 | 1981-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK198282A true DK198282A (da) | 1982-11-05 |
Family
ID=10953073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198282A DK198282A (da) | 1981-05-04 | 1982-05-03 | Penicillin- eller cephalosporinderivater, deres fremstilling og anvendelse som farmaceutika |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5813590A (da) |
| AU (1) | AU8321282A (da) |
| BE (1) | BE893057A (da) |
| BG (1) | BG37227A1 (da) |
| DE (1) | DE3215941A1 (da) |
| DK (1) | DK198282A (da) |
| ES (1) | ES8307814A1 (da) |
| FI (1) | FI821551L (da) |
| FR (1) | FR2509311A1 (da) |
| GB (1) | GB2101586A (da) |
| GR (1) | GR78166B (da) |
| IL (1) | IL65602A0 (da) |
| IT (1) | IT1156467B (da) |
| NL (1) | NL8201810A (da) |
| NO (1) | NO821456L (da) |
| PL (1) | PL236277A1 (da) |
| SE (1) | SE8202674L (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3137376C2 (de) * | 1981-09-19 | 1986-02-27 | Degussa Ag, 6000 Frankfurt | Verfahren zur Herstellung von 1,5-Alkylen-3-aryl-hydantoin-Derivaten |
| AU577105B2 (en) * | 1985-04-02 | 1988-09-15 | T.P.O. :Pharmachim: | Acylaminic penicillin derivatives |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1476312A (en) * | 1974-06-03 | 1977-06-10 | Beecham Group Ltd | Penicillins and cephalosporins |
| CA1074298A (en) * | 1974-09-20 | 1980-03-25 | E.R. Squibb And Sons | 3-heterothio-7-ureido cephalosporins |
| CA1075679A (en) * | 1975-07-30 | 1980-04-15 | E.R. Squibb And Sons | 3-heterothio-7-thioureido cephalosporins |
| JPS5239694A (en) * | 1975-08-29 | 1977-03-28 | Toyama Chem Co Ltd | Producing novel penicillins and cephalosporins |
| US4063019A (en) * | 1976-03-30 | 1977-12-13 | E. R. Squibb & Sons, Inc. | [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives |
| PT67170B (de) * | 1976-11-06 | 1979-03-21 | Merck Patent Gmbh | Lactame verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel |
| ES477520A1 (es) * | 1978-02-25 | 1979-06-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevas penicilinas. |
| DE2828261A1 (de) * | 1978-06-28 | 1980-01-10 | Thomae Gmbh Dr K | Neue penicilline, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1982
- 1982-03-17 GR GR68048A patent/GR78166B/el unknown
- 1982-04-26 IL IL65602A patent/IL65602A0/xx unknown
- 1982-04-28 SE SE8202674A patent/SE8202674L/ not_active Application Discontinuation
- 1982-04-29 DE DE19823215941 patent/DE3215941A1/de not_active Withdrawn
- 1982-05-03 BG BG8256468A patent/BG37227A1/xx unknown
- 1982-05-03 ES ES511884A patent/ES8307814A1/es not_active Expired
- 1982-05-03 AU AU83212/82A patent/AU8321282A/en not_active Abandoned
- 1982-05-03 NO NO821456A patent/NO821456L/no unknown
- 1982-05-03 PL PL23627782A patent/PL236277A1/xx unknown
- 1982-05-03 BE BE0/207990A patent/BE893057A/fr not_active IP Right Cessation
- 1982-05-03 FR FR8207659A patent/FR2509311A1/fr not_active Withdrawn
- 1982-05-03 NL NL8201810A patent/NL8201810A/nl not_active Application Discontinuation
- 1982-05-03 IT IT67577/82A patent/IT1156467B/it active
- 1982-05-03 FI FI821551A patent/FI821551L/fi not_active Application Discontinuation
- 1982-05-03 DK DK198282A patent/DK198282A/da not_active Application Discontinuation
- 1982-05-04 GB GB08212825A patent/GB2101586A/en not_active Withdrawn
- 1982-05-04 JP JP57073490A patent/JPS5813590A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI821551A0 (fi) | 1982-05-03 |
| ES511884A0 (es) | 1983-08-16 |
| GR78166B (da) | 1984-09-26 |
| JPS5813590A (ja) | 1983-01-26 |
| BE893057A (fr) | 1982-08-30 |
| GB2101586A (en) | 1983-01-19 |
| IT8267577A0 (it) | 1982-05-03 |
| BG37227A1 (en) | 1985-04-15 |
| ES8307814A1 (es) | 1983-08-16 |
| IT1156467B (it) | 1987-02-04 |
| SE8202674L (sv) | 1982-11-05 |
| FI821551L (fi) | 1982-11-05 |
| PL236277A1 (en) | 1983-08-15 |
| NL8201810A (nl) | 1982-12-01 |
| NO821456L (no) | 1982-11-05 |
| IL65602A0 (en) | 1982-07-30 |
| AU8321282A (en) | 1982-11-11 |
| FR2509311A1 (fr) | 1983-01-14 |
| DE3215941A1 (de) | 1983-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ATS | Application withdrawn |