DK198282A - PENICILLIN OR CEPHALOSPORINE DERIVATIVES, THEIR PREPARATION AND USE AS PHARMACEUTICALS - Google Patents
PENICILLIN OR CEPHALOSPORINE DERIVATIVES, THEIR PREPARATION AND USE AS PHARMACEUTICALS Download PDFInfo
- Publication number
- DK198282A DK198282A DK198282A DK198282A DK198282A DK 198282 A DK198282 A DK 198282A DK 198282 A DK198282 A DK 198282A DK 198282 A DK198282 A DK 198282A DK 198282 A DK198282 A DK 198282A
- Authority
- DK
- Denmark
- Prior art keywords
- penicillin
- pharmaceuticals
- preparation
- cephalosporine derivatives
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Description
H, alkyl eller eventuelt med halogen, OH, alkoxy eller alkyl 4 substitueret phenyl, Q er 0, S eller Se, R er H, alkyl 5 5 eller -COOR , R er alkyl, benzyl, benzhydryl eller eventuelt som R^· substitueret phenyl, R6 er phenyl, alkyl, cyclo-alkyl, alkenyl, naphthyl, heteroaryl, heterocyclyl eller adamantyl, hvorhos phenyl eventuelt er substitueret med halogen, alkyl, nitro, alkoxycarbonyl, CF3, dialkylamino, OH, COOh eller SO^H, alkyl eventuelt er substitueret med alkoxycarbonyl, OH, dialkylamino eller alkoxy, og heterocyclyl eventuelt er substitueret med én eller flere phenyl-grupper og/eller er substitueret, R er H, eller -N(R R ) er en fortrinsvis substitueret heterocyclisk gruppe med 4-8 led og eventuelt yderligere N-, O- og/eller S-atomer og eventuelt kondenseret med en eller flére phenylgrupper, Z er OH, n er 0 eller 1, og t er 0-2, eller farmakologisk acceptable salte eller biologisk aktive estre deraf fremstilles ved en række fremgangsmåder.H, alkyl or optionally with halogen, OH, alkoxy or alkyl 4 substituted phenyl, Q is 0, S or Se, R is H, alkyl 5 or -COOR, R is alkyl, benzyl, benzhydryl or optionally substituted with R phenyl, R6 is phenyl, alkyl, cycloalkyl, alkenyl, naphthyl, heteroaryl, heterocyclyl or adamantyl, wherein phenyl is optionally substituted with halogen, alkyl, nitro, alkoxycarbonyl, CF3, dialkylamino, OH, COOh or SO3H, alkyl optionally is substituted by alkoxycarbonyl, OH, dialkylamino or alkoxy, and heterocyclyl is optionally substituted by one or more phenyl groups and / or is substituted, R is H, or -N (RR) is a preferably substituted 4-8 membered heterocyclic group and optionally additional N, O and / or S atoms and optionally condensed with one or more phenyl groups, Z is OH, n is 0 or 1, and t is 0-2, or pharmacologically acceptable salts or biologically active esters thereof are prepared. by a variety of methods.
Forbindelserne med formel (I) er farmaceutisk aktive, idet de har antibakterielle og β-lactamasehammende virkninger .The compounds of formula (I) are pharmaceutically active, having antibacterial and β-lactamase inhibitory effects.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU115481 | 1981-05-04 | ||
| HU115481 | 1981-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK198282A true DK198282A (en) | 1982-11-05 |
Family
ID=10953073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198282A DK198282A (en) | 1981-05-04 | 1982-05-03 | PENICILLIN OR CEPHALOSPORINE DERIVATIVES, THEIR PREPARATION AND USE AS PHARMACEUTICALS |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5813590A (en) |
| AU (1) | AU8321282A (en) |
| BE (1) | BE893057A (en) |
| BG (1) | BG37227A1 (en) |
| DE (1) | DE3215941A1 (en) |
| DK (1) | DK198282A (en) |
| ES (1) | ES511884A0 (en) |
| FI (1) | FI821551L (en) |
| FR (1) | FR2509311A1 (en) |
| GB (1) | GB2101586A (en) |
| GR (1) | GR78166B (en) |
| IL (1) | IL65602A0 (en) |
| IT (1) | IT1156467B (en) |
| NL (1) | NL8201810A (en) |
| NO (1) | NO821456L (en) |
| PL (1) | PL236277A1 (en) |
| SE (1) | SE8202674L (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3137376C2 (en) * | 1981-09-19 | 1986-02-27 | Degussa Ag, 6000 Frankfurt | Process for the preparation of 1,5-alkylene-3-aryl-hydantoin derivatives |
| AU577105B2 (en) * | 1985-04-02 | 1988-09-15 | T.P.O. :Pharmachim: | Acylaminic penicillin derivatives |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1476312A (en) * | 1974-06-03 | 1977-06-10 | Beecham Group Ltd | Penicillins and cephalosporins |
| CA1074298A (en) * | 1974-09-20 | 1980-03-25 | E.R. Squibb And Sons | 3-heterothio-7-ureido cephalosporins |
| CA1075679A (en) * | 1975-07-30 | 1980-04-15 | E.R. Squibb And Sons | 3-heterothio-7-thioureido cephalosporins |
| JPS5239694A (en) * | 1975-08-29 | 1977-03-28 | Toyama Chem Co Ltd | Producing novel penicillins and cephalosporins |
| US4063019A (en) * | 1976-03-30 | 1977-12-13 | E. R. Squibb & Sons, Inc. | [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives |
| PT67170B (en) * | 1976-11-06 | 1979-03-21 | Merck Patent Gmbh | LACTAME METHOD FOR THE PRODUCTION THEREOF AND MEDIUM CONTAINING THESE COMPOUNDS |
| ES477520A1 (en) * | 1978-02-25 | 1979-06-01 | Thomae Gmbh Dr K | Penicillins, their salts, process for their preparation and pharmaceutical compositions containing them. |
| DE2828261A1 (en) * | 1978-06-28 | 1980-01-10 | Thomae Gmbh Dr K | NEW PENICILLINE, ITS SALTS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
-
1982
- 1982-03-17 GR GR68048A patent/GR78166B/el unknown
- 1982-04-26 IL IL65602A patent/IL65602A0/en unknown
- 1982-04-28 SE SE8202674A patent/SE8202674L/en not_active Application Discontinuation
- 1982-04-29 DE DE19823215941 patent/DE3215941A1/en not_active Withdrawn
- 1982-05-03 BG BG8256468A patent/BG37227A1/en unknown
- 1982-05-03 ES ES511884A patent/ES511884A0/en active Granted
- 1982-05-03 NO NO821456A patent/NO821456L/en unknown
- 1982-05-03 FI FI821551A patent/FI821551L/en not_active Application Discontinuation
- 1982-05-03 FR FR8207659A patent/FR2509311A1/en not_active Withdrawn
- 1982-05-03 PL PL23627782A patent/PL236277A1/en unknown
- 1982-05-03 BE BE0/207990A patent/BE893057A/en not_active IP Right Cessation
- 1982-05-03 NL NL8201810A patent/NL8201810A/en not_active Application Discontinuation
- 1982-05-03 DK DK198282A patent/DK198282A/en not_active Application Discontinuation
- 1982-05-03 AU AU83212/82A patent/AU8321282A/en not_active Abandoned
- 1982-05-03 IT IT67577/82A patent/IT1156467B/en active
- 1982-05-04 JP JP57073490A patent/JPS5813590A/en active Pending
- 1982-05-04 GB GB08212825A patent/GB2101586A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| GB2101586A (en) | 1983-01-19 |
| PL236277A1 (en) | 1983-08-15 |
| IT1156467B (en) | 1987-02-04 |
| AU8321282A (en) | 1982-11-11 |
| ES8307814A1 (en) | 1983-08-16 |
| BE893057A (en) | 1982-08-30 |
| FI821551A0 (en) | 1982-05-03 |
| BG37227A1 (en) | 1985-04-15 |
| FI821551L (en) | 1982-11-05 |
| ES511884A0 (en) | 1983-08-16 |
| GR78166B (en) | 1984-09-26 |
| SE8202674L (en) | 1982-11-05 |
| FR2509311A1 (en) | 1983-01-14 |
| DE3215941A1 (en) | 1983-05-05 |
| JPS5813590A (en) | 1983-01-26 |
| IL65602A0 (en) | 1982-07-30 |
| NO821456L (en) | 1982-11-05 |
| NL8201810A (en) | 1982-12-01 |
| IT8267577A0 (en) | 1982-05-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX9306831A (en) | NEW HETERO CYCLIC COMPOUNDS. | |
| DE3873612D1 (en) | DITHIOACETAL COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. | |
| DK114783A (en) | UNKNOWN RELATIONSHIPS, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | |
| ES2082780T3 (en) | DERIVATIVES OF HISEROCICLIC BISPHOSPHONIC ACID. | |
| FI891980A (en) | Process for the preparation of therapeutically active N1- (1,2-cis-2-halocyclopropyl) substituted pyridonecarboxylic acid derivatives | |
| EA200601235A1 (en) | TIAZOLE DERIVATIVES | |
| HRP20021023B1 (en) | Sulfonyl-pyrrolidine derivatives useful for the treatment of neurological disorders | |
| FI832648A0 (en) | DIHYDROPYRIDINER SOM ANTIISCHEMISKA OCH ANTIHYPERTENSIVA CEILING MODEL | |
| DK616388A (en) | QUINOLINCARBOXYLIC ACID DERIVATIVES AND PHYSIOLOGICALLY ACCEPTABLE SALTS THEREOF WITH ANTIBACTERIAL EFFECT | |
| AU546057B2 (en) | Dihydropyridine derivatives | |
| NO20016389L (en) | Process for the preparation of substituted cyclopentane derivatives and new crystalline structures thereof | |
| DK452687A (en) | DIHYDROPYRIDINE COMPOUNDS, ISOMERS, ISOMER MIXTURES, OPTICAL ANTIPODES AND RACEMATES THEREOF, THEIR PREPARATION AND USE AS MEDICINES | |
| ATE402151T1 (en) | 2-(ARYLPHENYL)AMINO-IMIDAZOLINE DERIVATIVES | |
| NO921159D0 (en) | TIAZOLIDINON AND OXSAZOLIDINON DERIVATIVES, PROCEDURES FOR PREPARING THEREOF, AND USING THE DERIVATIVES AS VASODILATORS | |
| DK198282A (en) | PENICILLIN OR CEPHALOSPORINE DERIVATIVES, THEIR PREPARATION AND USE AS PHARMACEUTICALS | |
| DK0388298T3 (en) | Azetidinyl-substituted derivatives of pyridonecarboxylic acids, their preparation and use as drugs | |
| DK0541263T3 (en) | 5-Piperazinylalkyl-1,5-benzothiazepinones useful as calcium antagonists | |
| NO20053302L (en) | Imidazole derivatives with affinity for alpha 2 receptor activity. | |
| NO922358L (en) | TERT.-BUTYLPHENYL-1-AMINO-4-HYDROXYBUTANE DERIVATIVES, PROCEDURES OF THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THE COMPOUNDS | |
| NO20013601L (en) | New morpholinobenzamide salts | |
| NO934227L (en) | Pyrrole derivatives, processes for their preparation and therapeutic use | |
| NO913644L (en) | PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE AMINO ACID DERIVATIVES. | |
| NO171502C (en) | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE THIADIAZOLYLACETAMIDE CEFEM DERIVATIVES | |
| SE8406046D0 (en) | NEW AZABIOCYCLIC COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF | |
| EP0235347A3 (en) | Dihydropyridine lactols, processes for their preparation, and their use as pharmaceutical compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ATS | Application withdrawn |