DK1931206T3 - Forbedret antifungal sammensætning - Google Patents

Forbedret antifungal sammensætning Download PDF

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Publication number
DK1931206T3
DK1931206T3 DK06793924T DK06793924T DK1931206T3 DK 1931206 T3 DK1931206 T3 DK 1931206T3 DK 06793924 T DK06793924 T DK 06793924T DK 06793924 T DK06793924 T DK 06793924T DK 1931206 T3 DK1931206 T3 DK 1931206T3
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DK
Denmark
Prior art keywords
natamycin
acid
release rate
biomass
carrier
Prior art date
Application number
DK06793924T
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English (en)
Inventor
Van Ferdinand Theodorus Jozef Rijn
Willem Johannes Wildeboer
Original Assignee
Dsm Ip Assets Bv
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Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of DK1931206T3 publication Critical patent/DK1931206T3/da

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B4/00—General methods for preserving meat, sausages, fish or fish products
    • A23B4/14—Preserving with chemicals not covered by groups A23B4/02 or A23B4/12
    • A23B4/18—Preserving with chemicals not covered by groups A23B4/02 or A23B4/12 in the form of liquids or solids
    • A23B4/20—Organic compounds; Microorganisms; Enzymes
    • A23B4/22—Microorganisms; Enzymes; Antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B7/00—Preservation or chemical ripening of fruit or vegetables
    • A23B7/14—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10
    • A23B7/153—Preserving or ripening with chemicals not covered by groups A23B7/08 or A23B7/10 in the form of liquids or solids
    • A23B7/154—Organic compounds; Microorganisms; Enzymes
    • A23B7/155—Microorganisms; Enzymes; Antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/34635—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Claims (15)

1. Fremgangsmåde til fremstilling af natamycin fra en fermenteringssuppe, der indeholder biomasse og natamycin, hvilken fremgangsmåde omfatter trinene: (a) sønderdeling af biomassen; (b) separering af natamycin fra den således behandlede fermenteringssuppe til opnåelse af en natamycinsuspension; (c) justering af pH i natamycinsuspensionen til en værdi, der er over 10, og tilsætning af en mængde af et i det væsentlige vandblandbart opløsningsmiddel, der er tilstrækkelig til opløsning af natamycin i natamycinsuspensionen; (d) fjernelse af uopløselig faststoffer fra natamycinopløsningen, der er opnået i trin (c); (e) sænkning af pH i natamycinopløsningen, der er opnået i trin (d), til et pH på 5 til 8 til fældning af natamycin; (f) fjernelse af natamycin fra natamycinsuspensionen; (g) eventuelt tørring af den fjernede natamycin; og (h) eventuelt reducering af størrelsen af den tørrede natamycin.
2. Fremgangsmåde ifølge krav 1, der er kendetegnet ved, at sønderdelingen af biomassen i trin (a) omfatter én eller en kombination af følgende teknikker og/eller behandlinger: homogenisering, høj forskydningsblanding, ultrasonikering, opvarmning, alkalisk behandling, enzymatisk behandling eller en behandling med et overfladeaktivt middel.
3. Fremgangsmåde ifølge krav 1 eller 2, der er kendetegnet ved, at separeringen af natamycin i trin (b) omfatter en tyngdegradientsepareringsteknik.
4. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 3, der er kendetegnet ved, at det vandblandbare opløsningsmiddel, der anvendes i trin (c) , er udvalgt fra gruppen, der består af acetone, methanol, ethanol, propanol, propandiol, isopropanol, tetrahydrofuran og kombinationer deraf.
5. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 4, der er kendetegnet ved, at fjernelsen af uopløselige faststoffer i trin (d) udføres ved hjælp af membranfiltrering, dybdefiltrering eller centrifugering.
6. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 5, der er kendetegnet ved, at trin (f) udføres ved hjælp af membranfiltrering.
7. Natamycin, der kan opnås ved hjælp af fremgangsmåden ifølge et hvilket som helst af kravene 1 til 6, hvilket natamycin har en frigivelseshastighed på 0,1-1,0 yg pr. 24 timer over de første 24 timer, når det kommer i kontakt på et bæremateriale med en agaroverflade på 0,6 cm i diameter ved 6 °C og en bærematerialelastning på 10 yg natamycin, hvilket natamycin har en frigivelseshastighed, der falder med 1 til 45 procent efter mindst 9 dage, når det kommer i kontakt på et bæremateriale med en agaroverflade på 0,6 cm i diameter og en bærematerialelastning på 5 til 40 yg natamycin, og natamycin har en frigivelseshastighed i intervallet mellem 0,1 og 2,0 yg pr. 24 timer over de første 24 timer, når det kommer i kontakt på et bæremateriale med en agaroverflade på 0,6 cm i diameter ved 6 °C og en bærematerialelastning på 40 yg natamycin.
8. Antifungal sammensætning, der omfatter natamycin ifølge krav 7.
9. Antifungal sammensætning ifølge krav 8, der er kendetegnet ved, at sammensætningen yderligere omfatter et vandblandbart opløsningsmiddel.
10. Antifungal sammensætning ifølge krav 7 eller 8, der er kendetegnet ved, at sammensætningen endvidere omfatter mindst et andet antimikrobielt middel, der er udvalgt fra gruppen, der består af et svag syre-konserveringsmiddel, svovldioxid, sulfit, nitrat, nitrit, dimethyldicarbonat, biphenyl, diphenyl, orthophenylphenol, thiobendazol, en uorganisk syre, en imidazol og en bacteriocin.
11. Antifungal sammensætning ifølge et hvilket som helst af kravene 8 til 10, der er kendetegnet ved, at svag syrekonserveringsmidlet er udvalgt fra gruppen, der består af sorbinsyre, propionsyre, benzoesyre, en p-hydroxybenzoesyre, mælkesyre, citronsyre, eddikesyre og et alkalimetal- eller jordalkalimetalsalt deraf.
12. Produkt behandlet med en antifungal sammensætning ifølge et hvilket som helst af kravene 8 til 11.
13. Produkt ifølge krav 12, der er kendetegnet ved, at det er udvalgt fra gruppen, der består af ost, revet ost, yoghurt, smør, forarbejdede kødprodukter, sovse, korn, grøntsager, frugt, frugtprodukter, færdigretter, drikkevarer, bønner, nødder, urter, blomster, planter, frø, blomsterløg, læggekartofter, lotions, cremer, salver, shampoer og sæber.
14. Fødevareovertræk med inkorporeret natamycin ifølge krav 7 .
15. Fremgangsmåde til konservering af et produkt, der er modtageligt for fungal nedbrydning, ved behandling af produktet med en antifungal sammensætning ifølge et hvilket som helst af kravene 8 til 11.
DK06793924T 2005-10-04 2006-09-29 Forbedret antifungal sammensætning DK1931206T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05109190 2005-10-04
PCT/EP2006/066909 WO2007039572A1 (en) 2005-10-04 2006-09-29 Improved anti-fungal composition

Publications (1)

Publication Number Publication Date
DK1931206T3 true DK1931206T3 (da) 2015-03-23

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Application Number Title Priority Date Filing Date
DK06793924T DK1931206T3 (da) 2005-10-04 2006-09-29 Forbedret antifungal sammensætning
DK10178203.5T DK2260706T3 (da) 2005-10-04 2006-09-29 Forbedret antifungal sammensætning

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Application Number Title Priority Date Filing Date
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Country Status (6)

Country Link
US (3) US8187844B2 (da)
EP (2) EP1931206B1 (da)
CN (1) CN101282645B (da)
DK (2) DK1931206T3 (da)
ES (1) ES2586203T3 (da)
WO (1) WO2007039572A1 (da)

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CN101569311B (zh) * 2009-06-11 2012-04-18 北京市农林科学院 一种抗光解杀菌悬乳剂及制备和使用方法
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CN109400458B (zh) * 2018-11-30 2021-11-23 内蒙古金达威药业有限公司 一种从微生物发酵液中分离提取辅酶q10的方法
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JP2024504059A (ja) 2021-01-21 2024-01-30 ジェイピー ラボラトリーズ インコーポレイテッド 食物の貯蔵寿命を延長するための材料および方法

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Also Published As

Publication number Publication date
ES2586203T3 (es) 2016-10-13
WO2007039572A1 (en) 2007-04-12
CN101282645B (zh) 2013-06-12
EP2260706B1 (en) 2016-05-04
US8187844B2 (en) 2012-05-29
US20120207860A1 (en) 2012-08-16
DK2260706T3 (da) 2016-08-22
US8536144B2 (en) 2013-09-17
EP1931206B1 (en) 2014-12-17
EP2260706A2 (en) 2010-12-15
EP1931206A1 (en) 2008-06-18
US20080234210A1 (en) 2008-09-25
CN101282645A (zh) 2008-10-08
US20130309379A1 (en) 2013-11-21
EP2260706A3 (en) 2011-05-04

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